Fat and carbohydrate metabolism during submaximal exercise in children

Sports Medicine

Volumn 38, Issue 3, 2008, Pages 213-238

  Aucouturier, Julien ^a   Baker, Julien S ^b   Duché, Pascale ^a  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b UNIVERSITY OF GLAMORGAN   (United Kingdom)

Author keywords

Carbohydrate metabolism; Children; Exercise; Lipid metabolism

Indexed keywords

CALORIMETRY; CARBOHYDRATE METABOLISM; DIET; ENZYME ACTIVITY; EXERCISE; FAT INTAKE; FATTY ACID OXIDATION; GENDER; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN RESISTANCE; LIPID METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OXIDATIVE PHOSPHORYLATION; REVIEW; SKELETAL MUSCLE; TRAINING;

EID: 39349095106     PISSN: 01121642     EISSN: None     Source Type: Journal    
DOI: 10.2165/00007256-200838030-00003     Document Type: Review

References (169)

1. Brooks GA, Mercier J. Balance of carbohydrate and lipid utilization during exercise: the 'crossover' concept. J Appl Physiol 1994; 76: 2253-61
2. Astrand PO. Experimental studies of the physical working capacity in relation to sex and age. Copenhagen: Munksgaard, 1952
3. Bailey RC, Olson J, Pepper SL, et al. The level and tempo of children's physical activities: an observational study. Med Sci Sports Exerc 1995; 27: 1033-41
4. Van Praagh E, Doré E. Short-term muscle power during growth and maturation. Sports Med 2002; 32 (11): 701-28
5. Burdette HL, Whitaker RC. Resurrecting free play in young children: looking beyond fitness and fatness to attention, affiliation, and affect. Arch Pediatr Adolesc Med 2005; 159 (1): 46-50
6. Ratel S, Bedu M, Hennegrave A, et al. Effects of age and recovery duration on peak power output during repeated cycling sprints. Int J Sports Med 2002 Aug; 23 (6): 397-402
7. Scheett TP, Nemet D, Stoppani J, et al. The effect of endurance-type exercise training on growth mediators and inflammatory cytokines in pre-pubertal and early pubertal males. Pediatr Res 2002 Oct; 52 (4): 491-7
8. Cooper DM, Nemet D, Galassetti P. Exercise, stress, and inflammation in the growing child: from the bench to the playground. Curr Opin Pediatr 2004 Jun; 16 (3): 286-92
9. Nemet D, Rose-Gottron CM, Mills PJ, et al. Effect of water polo practice on cytokines, growth mediators, and leukocytes in girls. Med Sci Sports Exerc 2003 Feb; 35 (2): 356-63
10. Nemet D, Oh Y, Kim HS, et al. The effect of intense exercise on inflammatory cytokines and growth mediators in adolescent boys. Pediatrics 2002; 110: 681-9
11. Graf C, Rost SV, Koch B, et al. Data from the STEP TWO programme showing the effect on blood pressure and different parameters for obesity in overweight and obese primary school children. Cardiol Young 2005 Jun; 15 (3): 291-8
12. Blimkie CJ. Resistance training during pre- and early puberty: efficacy, trainability, mechanisms, and persistence. Can J Sport Sci 1992 Dec; 17 (4): 264-79
13. 2 in prepubertal children. Int J Sports Med 2002 Aug; 23 (6): 439-44
14. Maffeis C, Zaffanello M, Pellegrino M, et al. Nutrient oxidation during moderately intense exercise in obese prepubertal boys. J Clin Endocrinol Metab 2005; 90: 231-6
15. Watts K, Jones TW, Davis EA, et al. Exercise training in obese children and adolescents: current concepts. Sports Med 2005; 35 (5): 375-92
16. Andersen LB, Harro M, Sardinha LB, et al. Physical activity and clustered cardiovascular risk in children: a cross-sectional study (The European Youth Heart Study). Lancet 2006; 22; 368 (9532): 299-304
17. Thomas NE, Baker JS, Davies B. Established and recently identified coronary heart disease risk factors in young people: the influence of physical activity. Sports Med 2003; 33 (9): 633-50
18. Poortmans JR. Protein metabolism. In: Poortmans JR, editor. Principles of exercise biochemistry. 3rd rev ed. Basel: Karger, 2004: 227-8
19. Jeukendrup AE, Wallis GA. Measurement of substrate oxidation during exercise by means of gas exchange measurements. Int J Sports Med 2004; 26: 28-37
20. Fawkner SG, Armstrong N, Potter CR, et al. Oxygen uptake kinetics in children and adults after the onset of moderate-intensity exercise. J Sports Sci 2002; 20 (4): 319-26
21. Fawkner SG, Armstrong N. Sex differences in the oxygen uptake kinetics response to heavy-intensity exercise in prepubertal children. Eur J Appl Physiol 2004; 93: 210-6
22. Fawkner SG, Armstrong N. Longitudinal changes in the kinetics response to heavy-intensity exercise in children. J Appl Physiol 2004; 97: 460-6
23. 2 slow component: physiological and functional significance. Med Sci Sports Exerc 1994; 26: 1354-8
24. Fawkner SG, Armstrong N. Oxygen uptake kinetic response to exercise in children. Sports Med 2003; 33: 651-69
25. Péronnet F, Aguilaniu B. Lactic acid buffering, nonmetabolic CO2 and exercise hyperventilation: a critical reappraisal. Respir Physiol Neurobiol 2006; 150: 4-18
26. Armon Y, Cooper DM, Zanconato S. Maturation of ventilatory response to one minute exercise. Pediatr Res 1991; 29: 362-8
27. Zanconato S, Cooper DM, Bartstow TJ, et al. 13CO2 washout dynamics during intermittent exercise in children and adults. J Appl Physiol 1992; 73: 2476-82
28. Inbar O, Bar-Or O. Anaerobic characteristics in male children and adolescents. Med Sci Sports Exerc 1986; 18: 264-9
29. Eriksson BO, Karlsson J, Saltin B. Muscle metabolites during exercise in pubertal boys. Acta Paediatr Scand 1971; 217: 154-7
30. Eriksson BO, Gollnick PD, Saltin B. Muscle metabolism and enzymes activities after training in boys 11-13 years old. Acta Physiol Scand 1973; 87: 485-97
31. Eriksson BO. Muscle metabolism in children: a review. Acta Paediatr Scand Suppl 1980; 283: 20-8
32. Lundberg A, Eriksson BO, Mellgren G. Metabolic substrates, muscle fibre composition and fibre size in late walking and normal children. Eur J Pediatr 1979; 130 (2): 79-92
33. Arner P, Kriegholm E, Engfeldt P, et al. Adrenergic regulation of lipolysis in situ at rest and during exercise. J Clin Invest 1990; 85: 893-8
34. Hersberger AM, McCammon MR, Garry JP, et al. Response of lipolysis and salivary cortisol to food intake and physical activity in lean and obese children. J Clin Endocrinol Metab 2004; 89: 4701-7
35. Lott ME, Sinoway LI. What has microdialysis shown us about the metabolic milieu within exercising skeletal muscle? Exerc Sport Sci Rev 2004; 32: 69-74
36. Riddell MC, Ba-Or O, Hollidge-Horvat M, et al. Glucose ingestion and substrate utilization during exercise in boys with IDDM. J Appl Physiol 2000; 88: 1239-46
37. Riddell MC, Bar-Or O, Wilk B, et al. Substrate utilization during exercise with glucose and glucose plus fructose ingestion in boys of age 10-14 yr. J Appl Physiol 2001; 90: 903-11
38. Timmons BW, Bar-Or O, Riddell MC. Oxidation rate of exogenous carbohydrate during exercise is higher in boys than in men. J Appl Physiol 2003; 94: 278-84
39. Venables M, Rowlands D, Jeukendrup A. Fat-oxidation during exercise: comparison of RER 13C-glycogen enrichment method [abstract]. Proceedings of the 9th Annual Congress of the European College of Sport Science; 2004 Jul 3-6; Clermont-Ferrand, 115
40. Cooper DM, Kaplan MR, Baumgarten L, et al. Coupling of ventilation and CO2 production during exercise in children. Pediatr Res 1987 Jun; 21 (6): 568-72
41. Pritzlaff CJ, Wideman L, Blumer J, et al. Catecholamine release, growth hormone secretion, and energy expenditure during exercise vs recovery in men. J Appl Physiol 2000; 89: 937-46
42. Randle PJ, Garland PB, Hales CN, et al. The glucose fatty-acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963; I: 785-9
43. Coyle EF, Jeukendrup AE, Wagenmakers AJ, et al. Fatty acid oxidation is directly regulated by carbohydrate metabolism during exercise. Am J Physiol 1997; 273: 268-75
44. Sidossis LS, Gastaldelli A, Klein S, et al. Regulation of plasma fatty acid oxidation during low- and high-intensity exercise. Am J Physiol Endocrinol Metab 1997; 272: 1065-70
45. Sidossis LS, Stuart CA, Shulman GI, et al. Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. J Clin Invest 1996; 98: 2244-50
46. Romijn JA, Coyle EF, Sidosis LS, et al. Relationship between fatty acid delivery and fatty acid oxidation during strenuous exercise. J Appl Physiol 1995; 79: 1939-45
47. Winder WW, Braiden RW, Cartmill DC, et al. Effect of adrenodemedullation on decline in muscle malonyl-CoA during exercise. J Appl Physiol 1993; 74 (5): 2548-51
48. Kiens B. Skeletal muscle lipid metabolism in exercise and insulin resistance. Physiol Rev 2006; 86: 205-243
49. Kiens B, Roepstorff C. Utilization of long-chain fatty acids in human skeletal muscle during exercise. Acta Physiol Scand 2003; 178: 391-6
50. Roepstorff C, Halberg N, Hillig T, et al. Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise. Am J Physiol Endocrinol Metab 2005; 288: 133-342
51. Foster CV, Harris RC. Formation of acetylcarnitine in muscle of horse during high intensity exercise. Eur J Appl Physiol Occup Physiol 1987; 56: 639-42
52. Sahlin K. Muscle carnitine metabolism during incremental dynamic exercise in human. Acta Physiol Scand 1990; 138: 259-62
53. Newsholme EA. Enzymes, energy and endurance: some provocative thoughts. In: Poortmans JR, editor. Principles of exercise biochemistry. 3rd rev ed. Basel: Karger, 2004: 1-35
54. Stephens BR, Cole AS, Mahon AD. The influence of biological maturation on fat and carbohydrate metabolism during exercise in males. Int J Sport Nutr Exerc Metab 2006; 16 (2): 166-79
55. Macek M, Vavra J. Prolonged exercise in 14-year-old girls. Int J Sports Med 1981; 2: 228-30
56. Macek J, Vavra J, Novosadova J. Prolonged exercise in prepubertal boys I: cardiovascular and metabolic adjustment. Eur J Appl Physiol 1976; 35: 291-8
57. Martinez LR, Haymes EM. Substrate utilization during treadmill running in prepubertal girls and women. Med Sci Sports Exerc 1992; 24: 975-83
58. Foricher JM, Ville N, Gratas-Delamarche A, et al. Effects of submaximal intensity cycle ergometry for one hour on substrate utilisation in trained prepubertal boys versus trained adults. J Sports Med Phys Fitness 2003 Mar; 43 (1): 36-43
59. Morse M, Schlutz FW, Cassels DE. Relation of age to physiological responses of the older boy (10-17 years) to exercise. J Appl Physiol 1949; 1: 683-709
60. Rowland TW, Rimani TA. Physiological response to prolonged exercise in premenarchal and adults females. Pediatr Exerc Sci 1995; 7: 183-91
61. Armstrong N, Kirby B, Welsman JR, et al. Submaximal exercise in prepubertal children. In: Armstrong N, Kirby B, Welsman JR, editors. Children and exercise XIX: promoting exercise and well-being. Proceedings of the XIXth International Symposium of the European Group of Pediatric Work Physiology; 1997 Sep 16-21; Moretonhampstead. London: E. and F.N Spon, 1997: 7
62. Nevill AM. The appropriate use of scaling techniques in exercise physiology. Pediatr Exerc Sci 1997; 9: 295-8
63. 2 for differences in body size. Med Sci Sports Exerc 1996; 28: 259-65
64. Friedlander AL, Casazza GA, Horning MA, et al. Training-induced alterations of carbohydrate metabolism in women: women respond differently from men. J Appl Physiol 1998; 85: 1175-86
65. Roepstorff C, Steffensen CH, Madsen M, et al. Gender differences in substrate utilization during submaximal exercise in endurance-trained subjects. Am J Physiol Endocrinol Metab 2002; 282: 435-47
66. Suh SH, Casazza GA, Horning MA, et al. Luteal and follicular glucose fluxes during rest and exercise in 3-h postabsorptive women. J Appl Physiol 2002; 93: 42-50
67. Carter SL, Rennie C, Tarnopolsky MA. Substrate utilization during endurance exercise in men and women after endurance training. Am J Physiol Endocrinol Metab 2001 Jun; 280 (6): E898-907
68. Mittendorfer B, Horowitz JF, Klein S. Effect of gender on lipid kinetics during endurance exercise of moderate intensity in untrained subjects. Am J Physiol Endocrinol Metab 2002 Jul; 283 (1): E58-65
69. Campbell SE, Febbraio MA. Effects of ovarian hormones on exercise metabolism. Curr Opin Clin Nutr Metab Care 2001; 4: 515-20
70. Zderic TW, Coggan AR, Ruby BC. Glucose kinetics and substrate oxidation during exercise in the follicular and luteal phases. J Appl Physiol 2001; 90: 447-53
71. Horton TJ, Miller EK, Glueck D, et al. No effect of menstrual cycle phase on glucose kinetics and fuel oxidation during moderate-intensity exercise. Am J Physiol Endocrinol Metab 2002; 282: 752-62
72. D'Eon TM, Sharoff C, Chipkin SR, et al. Regulation of exercise carbohydrate metabolism by estrogen and progesterone in women. Am J Physiol Endocrinol Metab 2002; 283 (5): 1046-55
73. Suh SH, Casazza GA, Horning MA, et al. Effects of oral contraceptives on glucose flux and substrate oxidation rates during rest and exercise. J Appl Physiol 2003; 94: 285-94
74. Nybo L, Moller K, Pedersen BK, et al. Association between fatigue and failure to preserve cerebral energy turnover during prolonged exercise. Acta Physiol Scand 2003; 179 (1): 67-74
75. Rauch HG, St Clair Gibson A, Lambert EV, et al. A signalling role for muscle glycogen in the regulation of pace during prolonged exercise. Br J Sports Med 2005 Jan; 39 (1): 34-8
76. Cheatham CC, Mahon AD, Brown JD, et al. Cardiovascular responses during prolonged exercise at ventilatory threshold in boys and men. Med Sci Sports Exerc 2000 Jun; 32 (6): 1080-7
77. Timmons BW, Bar-Or O. RPE during prolonged cycling with and without carbohydrate ingestion in boys and men. Med Sci Sports Exerc 2003 Nov; 35 (11): 1901-7
78. Nehlig A. Cerebral energy metabolism, glucose transport and blood flow: changes with maturation and adaptation to hypoglycaemia. Diabetes Metab 1997; 23 (1): 18-29
79. Essen B, Hagenfeldt L, Kaijser L. Utilization of blood-borne and intramuscular substrates during continuous and intermittent exercise in man. J Physiol 1977 Feb; 265 (2): 489-506
80. Essen B, Kaijser L. Regulation of glycolysis in intermittent exercise in man. J Physiol 1978 Aug; 281: 499-511
81. Balsom PD, Gaitanos GC, Soderlund K, et al. High-intensity exercise and muscle glycogen availability in humans. Acta Physiol Scand 1999 Apr; 165 (4): 337-45
82. Bangsbo J. Regulation of muscle glycogenolysis and glycolysis during intense exercise: in vivo studies using repeated intense exercise. In: Maughan RJ, Shireffs SM, editors. Biochemistry of exercise IX. Champaign (IL): Human Kinetics Publishers, 1994, 76
83. Thomas TR, Feiock CW, Araujo J. Metabolic responses associated with four modes of prolonged exercise. J Sports Med Phys Fitness 1989; 29: 77-82
84. Achten J, Venables MC, Jeukendrup AE. Fat oxidation rates are higher during running compared with cycling over a wide range of intensities. Metabolism 2003 Jun; 52 (6): 747-52
85. Knechtle B, Muller G, Willmann F, et al. Fat oxidation in men and women endurance athletes in running and cycling. Int J Sports Med 2004 Jan; 25 (1): 38-44
86. Derman KD, Hawley JA, Noakes TD, et al. Fuel kinetics during intense running and cycling when fed carbohydrate. Eur J Appl Physiol Occup Physiol 1996; 74 (1-2): 36-43
87. Ratel S, Williams CA, Oliver J, et al. Effects of age and mode of exercise on power output profiles during repeated sprints. Eur J Appl Physiol 2004 Jun; 92 (1-2): 204-10
88. Bergman BC, Butterfield GE, Wolfel EE, et al. Evaluation of exercise and training on muscle lipid metabolism. Am J Physiol 1999; 276 (39): E106-17
89. Katch VL. Physical conditioning of children. J Adolesc Health Care 1983; 3: 241-6
90. Arkinstall MJ, Bruce CR, Clark SA, et al. Regulation of fuel metabolism by preexercise muscle glycogen content and exercise intensity. J Appl Physiol 2004; 97: 2275-83
91. Weltan SM, Bosch AN, Dennis SC, et al. Influence of muscle glycogen content on metabolic regulation. Am J Physiol 1998; (37): 72-82
92. Coyle EF. Fat oxidation during exercise: role of lipolysis, FFA availability and glycolytic flux. In: Hargreaves M, Thompson M, editors. Biochemistry of exercise, vol. X. Champaign (IL): Human Kinetics, 1999:73
93. Jeukendrup AE, Borghouts LB, Saris WHM, et al. Reduced oxidation rates of ingested glucose during prolonged exercise with low endogenous CHO availability. J Appl Physiol 1996; 81 (5): 1952-7
94. Coyle EF, Jeukendrup AE, Oseto MC, et al. Low-fat diet alters intramuscular substrates and reduces lipolysis and fat oxidation during exercise. Am J Physiol Endocrinol Metab 2001; 280(3): E391-8
95. Arkinstall MJ, Tunstall RJ, Cameron-Smith D, et al. Regulation of metabolic genes in human skeletal muscle by short-term exercise and diet manipulation. Am J Physiol Endocrinol Metab 2004; 287(1): E25-31
96. Cameron-Smith D, Burke LM, Angus DJ, et al. A short-term, high-fat diet up-regulates lipid metabolism and gene expression in human skeletal muscle. Am J Clin Nutr 2003; 77 (2): 313-8
97. Smith SR, De Jonge L, Zachwetja JF, et al. Fat and carbohydrate balances during adaptation to a high-fat diet. Am J Clin Nutr 2000; 71: 450-7
98. Helge JW, Watt PW, Richter EA, et al. Fat utilization during exercise: adaptation to a fat-rich diet increases utilization of plasma fatty acids and very low density lipoprotein-triacylglycerol in humans. J Physiol 2001; 537: 1009-20
99. Schrauwen P, Wagenmakers AJM. Increase in fat oxidation on a high-fat diet is accompanied by an increase in triglyceride-derived fatty acid oxidation. Diabetes 2000; 49: 640-6
100. Kiens B, Essen-Gustavsson B, Gad P, et al. Lipoprotein lipase activity and intramuscular triglyceride stores after long-term high-fat and high-carbohydrate diets in physically trained men. Clin Physiol 1987 Feb; 7 (1): 1-9
101. Zderic TW, Davidson CJ, Schenk S, et al. High-fat diet elevates resting intramuscular triglyceride concentration and whole body lipolysis during exercise. Am J Physiol Endocrinol Metab 2004 Feb; 286 (2): E217-25
102. Helge JW, Fraser AM, Kriketos AD, et al. Interrelationships between muscle fibre type, substrate oxidation and body fat. Int J Obes Relat Metab Disord 1999 Sep; 23 (9): 986-91
103. Venables MC, Achten J, Jeukendrup AE. Determinants of fat oxidation during exercise in healthy men and women: a cross-sectional study. J Appl Physiol 2005 Jan; 98 (1): 160-7
104. Goedecke JH, St Clair Gibson A, Grobler L, et al. Determinants of the variability in respiratory exchange ratio at rest and during exercise in trained athletes. Am J Physiol Endocrinol Metab 2000 Dec; 279 (6): E1325-34
105. Spriet LL, Watt MJ. Regulatory mechanisms in the interaction between carbohydrate and lipid oxidation during exercise. Acta Physiol. Scand 2003; 178 (4): 443-52
106. Bell RD, MacDougall JD, Billeter R, et al. Muscle fiber types and morphometric analysis of skeletal muscle in six-years-old children. Med Sci Sports Exerc 1980; 12 (1): 28-31
107. Bonen A, Luiken JJ, Liu S, et al. Palmitate transport and fatty acid transporters in red and white muscles. Am J Physiol 1998; 275: 471-8
108. Lexell J, Sjostrom M, Nordlund AS, et al. Growth and development of human muscle: a quantitative morphological study of whole vastus lateralis from childhood to adult age. Muscle Nerve 1992; 15: 404-9
109. Oertel G. Morphometric analysis of normal skeletal muscles in infancy, childhood and adolescence: an autopsy study. J Neurol Sci 1988; 88: 303-13
110. Kaczor JJ, Ziolkowski W, Popinigis J, et al. Anaerobic and aerobic enzyme activities in human skeletal muscle from children and adults. Pediatr Res 2005; 57: 331-5
111. Delamarche P, Monnier M, Gratas-Delamarche A, et al. Glucose and free fatty acid utilization during prolonged exercise in prepubertal boys in relation to catecholamine responses. Eur J Appl Physiol Occup Physiol 1992; 65 (1): 66-72
112. Boisseau N, Rannou F, Delamarche P, et al. Peripubertal period decreases insulin sensitivity and glucose utilization during exercise. In: Armstrong N, Kirby B, Welsman JR, editors. Children and exercise XIX: promoting exercise and well-being. Proceedings of the XIXth International Symposium of the European Group of Pediatric Work Physiology; 1997 Sep 16-21; Moretonhampstead. London: E. and F.N. Spon, 1997: 412-7
113. Amiel SA, Sherwin RS, Simonson DC, et al. Impaired insulin action in puberty: a contributing factor to poor glycemic control in adolescents with diabetes. N Engl J Med 1986; 315: 215-9
114. Moran A, Jacobs DR, Steinberger J, et al. Association between the insulin resistance of puberty and the insulin-like growth factor-I/ growth hormone axis. J Clin Endocrinol Metab 2002; 87: 4817-20
115. Karlsson J, Diamant B, Saltin B. Muscle metabolites during submaximal and maximal exercise in man. Scand J Clin Lab Invest 1970; 26 (4): 385-94
116. Bak JF, Moller N, Schmitz O. Effects of growth hormone on fuel utilization and muscle glycogen synthase activity in normal humans. Am J Physiol Endocrinol Metab 1991; 260: E736-42
117. Eriksson O, Saltin B. Muscle metabolism during exercise in boys aged 11 to 16 years compared to adults. Acta Paediatr Belg 1974; 28: 257-65
118. Hargreaves M, McConnell G, Proietto J. Influence of muscle glycogen on glycogenolysis and glucose during exercise in humans. J Appl Physiol 1995; 78: 288-92
119. Helie R, Lavoie JM, Cousineau D. Effects of 24-h carbohydrate poor diet on metabolic and hormonales responses during prolonged glucose-infused leg exercise. Eur J Appl Physiol 1994; 54: 42-426
120. Eriksson BO, Gollnick PD, Saltin B. The effect of physical training on muscle enzyme activities and fiber composition in 11-year-old boys. Acta Paediatr Belg 1974; 28: 245-52
121. Haralambie G. Skeletal muscle enzyme activities in female subjects. Bull Europ Physiopathol Resp 1979; 15: 259-67
122. Haralambie G. Enzyme activities in skeletal muscle of 13-15 years old adolescents. Bull Physiopathol Respir 1982; 18: 65-74
123. Berg A, Kim SS, Keul J. Skeletal muscle enzyme activities in healthy young subjects. Int J Sports Med 1986; 7: 236-9
124. Weltman SM, Bosch AN, Dennis SC, et al. Influence of muscle glycogen content on metabolic regulation. Am J Physiol Endocrinol Metab 1998; 37: E72-82
125. Kristiansen S, Gade J, Wojtaszewski JFP, et al. Glucose uptake is increased in trained vs. untrained muscle during heavy exercise. J Appl Physiol 2000; 89: 1151-8
126. Richter EA, Nielsen JN, Jorgensen SB, et al. Signalling to glucose transport in skeletal muscle during exercise. Acta Physiol Scand 2003; 178: 329-35
127. Reed MJ, Reaven GM, Mondon CE, et al. Why does insulin resistance develop during maturation? J Gerontol 1993; 48: 139-44
128. Cartee GD, Wetter TJ, Guerra AN, et al. Decline in muscle insulin-dependent and -independent glucose uptake but not GLUT-4 in 21- vs 28-day-old rats. Am J Physiol 1997; 272: 446-52
129. Derave W, Lund S, Holman GD, et al. Contraction-stimulated muscle glucose transport and GLUT-4 surface content are dependent on glycogen content. Am J Physiol 1999; 277: 1103-10
130. Hawley JA. Effect of increased fat availability on metabolism on metabolism and exercise capacity. Med Sci Sports Exerc 2002; 34 (9): 1485-91
131. Groot PH, Hulsmann WC. The activation and oxidation of octonoate and palmitate by rat skeletal muscle mitochondria. Biochim Biophys Acta 1973; 316 (2): 124-35
132. Boyd AE, Giamber SR, Mager M, et al. Lactate inhibition of lipolysis in exercising man. Metabolism 1974; 23: 531-42
133. Issekutz Jr B, Shaw WA, Issekutz TB. Effect of lactate on FFA and glycerol turnover in resting and exercising dogs. J Appl Physiol 1975; 39: 349-53
134. Trudeau F, Bernier S, De Glisezinski I, et al. Lack of antilipolytic effect of lactate in subcutaneous adipose tissue during exercise. J Appl Physiol 1999; 86 (6): 1800-4
135. De Pergola G, Cignarelli M, Nardelli G, et al. Influence of lactate on isoprotenerol-induced lipolysis and beta-adrenoceptor distribution in human fat cells. Hormon Metab Res 1989; 21: 210-3
136. Wirth A, Trager E, Scheele K, et al. Cardiopulmonary adjustment and metabolic response to maximal and submaximal physical exercise of boys and girls at different stages of maturity. Eur J Appl Physiol 1978; 39: 229-40
137. Watt MJ, Heigenhauser GJF, Spriet LL. Intramuscular triacylglycerol utilization in human skeletal muscle during exercise: is there a controversy? J Appl Physiol 2002; 93: 1185-95
138. Boschmann M, Rosenbaum M, Leibel RL, et al. Metabolic and hemodynamic responses to exercise in subcutaneous adipose tissue and skeletal muscle. Int J Sports Med 2002; 23 (8): 537-43
139. Stallknecht B, Kiens B, Helge JW, et al. Interstitial glycerol concentrations in human skeletal muscle and adipose tissue during graded exercise. Acta Physiol Scand 2004; 180: 367-77
140. Brechtel K, Niess AM, Machann J, et al. Utilisation of intramyocellular lipids (IMCLs) during exercise as assessed by proton magnetic resonance spectroscopy (1H-MRS). Horm Metab Res 2001; 33 (2): 63-6
141. Haralambie G. Activités enzymatiques dans le muscle squelet-tique des enfants de divers âges. In: Bourgeois JM, Wagner P, Domergue A, et al. editors. Le sport et l'enfant. Montpellier: Euromed 1980: 243-58
142. Hochachka PW, Stanley C, McKenzie DC, et al. Enzyme mechanisms for pyruvate-to-lactate flux attenuation: a study of Sherpas, Quechuas, and hummingbirds. Int J Sports Med 1992; 13: S119-22
143. Heberstreit H, Mimura K, Bar-Or O. Recovery of muscle anaerobic muscle power following 30-S supramaximal exercise: comparison between boys and men. J Appl Physiol 1993; 74: 2875-80
144. Mero A. Blood lactate production and recovery from anaerobic exercise in trained and untrained boys. Eur J Appl Physiol Occup Physiol 1988; 57 (6): 660-6
145. Beneke R, Hütler M, Jung M, et al. Modelling the blood lactate kinetics at maximal short-term exercise conditions in children, adolescents, and adults. J Appl Physiol 2005; 99: 499-504
146. Zanconato S, Buchthal S, Barstow TJ, et al. 31P-magnetic resonance spectroscopy of leg muscle metabolism during exercise in children and adults. J Appl Physiol 1993; 74 (5): 2214-8
147. Kuno S, Takahashi H, Fujimoto K, et al. Muscle metabolism during exercise using phosphorus-31 nuclear magnetic resonance spectroscopy in adolescents. Eur J Appl Phsiol 1995; 70: 301-4
148. Petersen SR, Gaul CA, Stanton MM, et al. Skeletal muscle metabolism during short-term, high intensity exercise in prepubertal and pubertal girls. J Appl Physiol 1999; 87: 2151-6
149. Williams CA, Armstrong N, Powell J. Aerobic responses of prepubertal boys to two modes of training. Br J Sports Med 2000 Jun; 34 (3): 168-73
150. Duncan GE, Howley ET. Metabolic and perceptual responses to short-term cycle training in children. Pediatr Exerc Sci 1998; 10: 110-22
151. Duncan GE, Howley ET. Substrate metabolism during exercise in children and the 'crossover-concept'. Pediatr Exerc Sci 1999; 11: 12-21
152. Hickner RC, Fisher JS, Hansen PA, et al. Muscle glycogen accumulation after endurance exercise in trained and untrained individuals. J Appl Physiol 1997; 83: 897-903
153. Brandou F, Dumortier M, Garandeau P, et al. Effects of a two-month rehabilitation program on substrate utilization during exercise in obese adolescents. Diabetes Metab 2003 Feb; 29 (1): 20-7
154. Kelley DE. Skeletal muscle fat oxidation: timing and flexibility are everything. J Clin Invest 2005; 115: 1699-702
155. Zurlo F, Larson K, Bogardus C, et al. Skeletal muscle metabolism is a major determinant of resting energy expenditure. J Clin Invest 1990; 86: 1423-7
156. Kelley DE, Reilly JP, Veneman T, et al. Effects of insulin on skeletal muscle glucose storage and glycolysis in humans. Am J Physiol 1990; 258: E923-9
157. Goodpaster BH, Theriault R, Watkins SC, et al. Intramuscular lipid content is increased in obesity and decreased by weight loss. Metabolism 2000; 49 (4): 467-72
158. Lillioja S, Young AA, Culter CL, et al. Skeletal muscle capillary density and fiber type are possible determinants of insulin resistance in man. J Clin Invest 1987; 80: 415-24
159. Maffeis C. Aetiology of overweight and obesity in children and adolescents. Eur J Pediatr 2000; 159: S35-44
160. Sinha R, Dufour S, Petersen KF, et al. Assessment of skeletal muscle triglyceride content by 1H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relation to insulin sensitivity, total body fat, and central adiposity. Diabetes 2002; 51: 1022-7
161. Kelley DE, He J, Menshikova EV, et al. Dysfunction of mitochondrial in human skeletal muscle in type 2 diabetes. Diabetes 2002 Oct; 51 (10): 2944-50
162. Simoneau JA, Colberg SR, Thaete FL, et al. Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women. FASEB J 1995; 9: 273-8
163. Kriketos AD, Baur LA, O'Connor J, et al. Muscle fibre type composition in infant and adult populations and relationships with obesity. Int J Obes Relat Metab Disord 1997; 21 (9): 796-801
164. Bougnères P, Le Stunff C, Pecqueur C, et al. In vivo resistance of lipolysis to epinephrine. J Clin Invest 1997; 99: 2568-73
165. Mauriege P, Prud'homme D, Lemieux S, et al. Regional differences in adipose tissue lipolysis from lean and obese women: existence of postreceptor alterations. Am J Physiol 1995; 269: 341-50
166. Enoksson S, Talbot M, Rife F, et al. Impaired in vivo stimulation of lipolysis in adipose tissue by selective β2-adrenergic agonist in obese adolescent girls. Diabetes 2000; 49: 2149-53
167. Rueda-Maza CM, Maffeis C, Zaffanello M, et al. Total and exogenous carbohydrate oxidation in obese prepubertal children. Am J Clin Nutr 1996; 64: 844-9
168. Avison MJ, Rothman DL, Nadel E, et al. Detection of human muscle glycogen by natural abundance 13C NMR. Proc Natl Acad Sci U S A 1988; 85: 1634-6
169. Krssak M, Petersen KF, Bergeron R, et al. Intramuscular glycogen and intramyocellular lipid utilization during prolonged exercise and recovery in man: a 13C and 1H nuclear magnetic resonance spectroscopy study. J Clin Endocrinol Metab 2000; 85: 748-54