Regulation of plasma fatty acid oxidation during low- and high-intensity exercise

American Journal of Physiology - Endocrinology and Metabolism

Volumn 272, Issue 6 35-6, 1997, Pages

  Sidossis, Labros S ^a   Gastaldelli, Amalia ^b   Klein, Samuel ^b   Wolfe, Robert R ^b  

^a SHRINERS HOSPITALS FOR CHILDREN   (United States)

^b NONE

Author keywords

Carnitine palmitoyltransferase; Malonyl coenzyme A; Medium chain fatty acids; Mitochondria

Indexed keywords

FATTY ACID; HEPARIN; LIPID; LONG CHAIN FATTY ACID; MEDIUM CHAIN FATTY ACID; OCTANOIC ACID; OLEIC ACID;

ADULT; ARTICLE; EXERCISE; FATTY ACID BLOOD LEVEL; FATTY ACID OXIDATION; HUMAN; HUMAN EXPERIMENT; MALE; MITOCHONDRION; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

EID: 0030741642     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1997.272.6.e1065     Document Type: Article

References (23)

1. De Boer, A., C. Kluft, J. M. Kroon, F. J. Kasper, H. C. Schoemaker, J. Pruis, D. D. Breimer, P. A. Soons, J. J. Emeis, and A. F. Cohen. Liver blood flow as a major determinant of the clearance of recombinant human tissue-type plasminogen activator. Thromb. Haemostasis 67: 83-87, 1992.
2. Even, P. C., A. Decrouy, and A. Chinet. Defective regulation of energy metabolism in mdx-mouse skeletal muscles. Biochem. J. 304: 649-654, 1994.
3. Frayn, K. H. Calculation of substrate oxidation rates in vivo from gaseous exchange. J. Appl. Physiol. 55: 628-634, 1983.
4. Friolet, R., H. Hoppeler, and S. Krahenbuhl. Relationship between the coenzyme A and the carnitine pools in human skeletal muscle at rest and after exhaustive exercise under normoxic and acutely hypoxic conditions. J. Clin. Invest. 94: 1490-1495, 1994.
5. Fritz, I. B. Action of carnitine on long chain fatty acid oxidation by liver. Am. J. Physiol. 197: 297-304, 1959.
6. McGarry, J. D., and D. W. Foster. The metabolism of (-)-octanoylcarnitine in perfused livers from fed and fasted rats: evidence for a possible regulatory role of carnitine acyltransferase in the control of ketogenesis. J. Biol. Chem. 249: 7984-7990, 1974.
7. McGarry, J. D., G. P. Mannaerts, and D. W. Foster. A possible role for malonyl-CoA in the regulation of hepatic acid oxidation and ketogenesis. J. Clin. Invest. 60: 265-270, 1977.
8. McGarry, J. D., S. E. Milles, C. S. Long, and D. W. Foster. Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues. Biochem. J. 214: 21-28, 1983.
9. McGarry, J. D., K. F. Woeltje, M. Kuwajima, and D. W. Foster. Regulation of ketogenesis and the renaissance of carnitine palmitoyltransferase. Diabetes Metab. Rev. 5: 271-284, 1989.
10. Ockner, R. K., R. M. Kaikaus, and N. M. Bass. Fatty acid binding proteins: recent concepts of regulation and function. Prog. Clin. Biol. Res. 375: 189-204, 1992.
11. Pande, S. V. A mitochondrial carnitine acyltransferase translocase system. Proc. Natl. Acad. Sci. USA 72: 883-887, 1975.
12. Romijn, J. A., E. F. Coyle, L. S. Sidossis, A. Gastaldelli, J. F. Horowitz, E. Endert, and R. R. Wolfe. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E380-E391, 1993.
13. Romijn, J. A., E. F. Coyle, L. S. Sidossis, X. J. Zhang, and R. R. Wolfe. Relationship between fatty acid delivery and fatty acid oxidation during strenuous exercise. J. Appl. Physiol. 79: 1939-1945, 1995.
14. Saddik, M., J. Gamble, L. A Witters, and G. D. Lopaschuk. Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart. J. Biol. Chem. 268: 25836-25845, 1993.
15. Schulz, H. Regulation of fatty acid oxidation in heart. J. Nutr. 124: 165-171, 1994.
16. Sidossis, L. S., A. R. Coggan, A. Gastaldelli, and R. R. Wolfe. A new correction factor for use in tracer estimations of plasma fatty acid oxidation. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E649-E656, 1995.
17. Sidossis, L. S., C. A. Stuart, G. I. Shulman, G. D. Lopaschuk, and R. R. Wolfe. Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. J. Clin. Invest. 98: 2244-2250, 1996.
18. Sidossis, L. S., and R. R. Wolfe. Glucose and insulin-induced inhibition of fatty acid oxidation: the glucose-fatty acid cycle reversed. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E733-E738, 1996.
19. Van Kempen, T. A., and J. Odle. Carnitine affects octanoate oxidation to carbon dioxide and dicarboxylic acids in colostrum-deprived piglets: in vivo analysis of mechanisms involved based on CoA- and carnitine-ester profiles. J. Nutr. 125: 238-250, 1995.
20. 14C]octanoate oxidation and its application on tissue homogenates and fibroblasts. Biochim. Biophys. Acta 876: 133-137, 1986.
21. Wasserman, D. H., D. B. Lacy, and D. P. Bracy. Relationship between arterial and portal vein immunoreactive glucagon during exercise. J. Appl. Physiol. 75: 724-729, 1993.
22. Wolfe, R. R. Radioactive and Stable Isotope Tracers in Biomedicine. New York: Wiley-Liss, 1992, p. 422-424.
23. 2 enrichment. J. Appl. Physiol. 56:230-234, 1984.