Utilization of long-chain fatty acids in human skeletal muscle during exercise

Acta Physiologica Scandinavica

Volumn 178, Issue 4, 2003, Pages 391-396

  Kiens, B ^a,b   Roepstorff, C ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Acetylcarnitine; Exercise; Gender; Lipids; Malonyl CoA; Training

Indexed keywords

ACETYLCARNITINE; CARBOHYDRATE; CARNITINE; CARNITINE ACETYLTRANSFERASE; CARNITINE PALMITOYLTRANSFERASE; CREATININE; FATTY ACID BINDING PROTEIN; LONG CHAIN FATTY ACID; LONG CHAIN FATTY ACID COENZYME A LIGASE; MALONYL COENZYME A;

CITRIC ACID CYCLE; CONFERENCE PAPER; DIFFUSION; ENERGY METABOLISM; EXERCISE; FATTY ACID METABOLISM; FATTY ACID OXIDATION; FATTY ACID TRANSPORT; HUMAN; MEMBRANE TRANSPORT; MUSCLE CONTRACTION; MUSCLE MITOCHONDRION; PRIORITY JOURNAL; SKELETAL MUSCLE; TRAINING;

BIOLOGICAL TRANSPORT, ACTIVE; CARNITINE; CELL MEMBRANE; ENERGY METABOLISM; EXERCISE; FATTY ACIDS; HUMANS; MALE; MALONYL COENZYME A; MITOCHONDRIA; MUSCLE, SKELETAL; OXIDATION-REDUCTION; PHYSICAL ENDURANCE;

EID: 0042160178     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-201X.2003.01156.x     Document Type: Conference Paper

References (47)

1. Abumrad, N.A., El-Maghrabi, M.R., Amri, E.Z., Lopez, E. & Grimaldi, P.A. 1993. Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. J Biol Chem 268, 17665-17668.
2. Ahlborg, G., Felig, P., Hagenfeldt, L., Hendler, R. & Wahren, J. 1974. Substrate turnover during prolonged exercise in man. Splanchinc and leg metabolism of glucose, free fatty acids and amino acids. J Clin Invest 53, 1080-1090.
3. Bavenholm, P.N., Pigon, J., Saha, A.K., Ruderman, N.B. & Efendic, S. 2000. Fatty acid oxidation and the regulation of malonyl-CoA in human muscle. Diabetes 49, 1078-1083.
4. Berk, P.D., Wada, H., Horio, Y. et al. 1990. Plasma membrane fatty acid-binding protein and mitochondrial glutamic-oxaloacetic transaminase of rat liver are related. Proc Natl Acad Sci USA 87, 3484-3488.
5. Bonen, A., Benton, C.R., Campbell, S.E. et al. 2003. Plasma-lemmal fatty acid transport is regulated in heart and skeletal muscle by contraction, insulin and leptin, and in obesity and diabetes. Acta Physiol Scand 178, 347-356.
6. Bonen, A., Dyck, D.J. & Luiken, J.J. 1998. Skeletal muscle fatty acid transport and transporters. Adv Exp Med Biol 441, 193-205.
7. Bonen, A., Luiken, J.J., Arumugam, Y., Glatz, J.F. & Tandon, N.N. 2000. Acute regulation of fatty acid uptake involves the cellular redistribution of fatty acid translocase. J Biol Chem 275, 14501-14508.
8. Chen, Z.P., McConell, G.K., Michell, B.J., Snow, R.J., Canny, B.J. & Kemp, B.E. 2000. AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation. Am J Physiol Endocrinol Metab 279, E1202-E1206.
9. Chien, D., Dean, D., Saha, A.K., Flatt, J.P. & Ruderman, N.B. 2000. Malonyl-CoA content and fatty acid oxidation in rat muscle and liver in vivo. Am J Physiol Endocrinol Metab 279, E259-E265.
10. Constantin-Teodosiu, D., Carlin, J.I., Cederblad, G., Harris, R.C. & Hultman, E. 1991. Acetyl group accumulation and pyruvate dehydrogenase activity in human muscle during incremental exercise. Acta Physiol Scand 143, 367-372.
11. Dean, D., Daugaard, J.R., Young, M.E. et al. 2000. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. Diabetes 49, 1295-1300.
12. Friedman, S. & Fraenkel, G. 1955. Reversible enzymatic acetylation of carnitine. Arch Biochem Biophys 59, 491-501.
13. Fujii, N., Hayashi, T., Hirshman, M.F. et al. 2000. Exercise induces isoform-specific increase in 5′AMP-activated protein kinase activity in human skeletal muscle. Biochem Biophys Res Commun 273, 1150-1155.
14. Gargiulo, C.E., Stuhlsatz-Krouper, S.M. & Schaffer, J.E. 1999. Localization of adipocyte long-chain fatty acyl-CoA synthetase at the plasma membrane. J Lipid Res 40, 881-892.
15. Glatz, J.F.C., Schaap, F.G., Binas, B. et al. 2003. Cytoplasmic fatty acid-binding protein facilitates fatty acid utilization by skeletal muscle. Acta Physiol Scand 178, 367-371.
16. Glatz, J.F. & Van der Vusse, G.J. 1996. Cellular fatty acid-binding proteins: their function and physiological significance. Prog Lipid Res 35, 243-282.
17. Ha, J., Lee, J.K., Kim, K.S., Witters, L.A. & Kim, K.H. 1996. Cloning of human acetyl-CoA carboxylase-beta and its unique features. Proc Natl Acad Sci USA 93, 11466-11470.
18. Hagenfeldt, L. 1979. Metabolism of free fatty acids and ketone bodies during exercise in normal and diabetic man. Diabetes 28 (Suppl. 1), 66-70.
19. Hagenfeldt, L. & Wahren, J. 1968. Human forearm muscle metabolism during exercise II. Uptake, release and oxidation of individual FFA and glycerol. Scand J Clin Lab Invest 21, 263-276.
20. Hamilton, J.A., Guo, W. & Kamp, F. 2002. Mechanism of cellular uptake of long-chain fatty acids: do we need cellular proteins? Mol Cell Biochem 239, 17-23.
21. Havel, R.J., Ekelund, L.G. & Holmgren, A. 1967. Kinetic analysis of the oxidation of palmitate-1-14C in man during prolonged heavy muscular exercise. J Lipid Res 8, 366-373.
22. Hiatt, W.R., Regensteiner, J.G., Wolfel, E.E., Ruff, L. & Brass, E.P. 1989. Carnitine and acylcarnitine metabolism during exercise in humans. Dependence on skeletal muscle metabolic state. J Clin Invest 84, 1167-1173.
23. Iijima, H., Fujino, T., Minekura, H., Suzuki, H., Kang, M.J. & Yamamoto, T. 1996. Biochemical studies of two rat acyl-CoA synthetases, ACS1 and ACS2. Eur J Biochem 242, 186-190.
24. Kiens, B. 1998. Training and fatty acid metabolism. Adv Exp Med Biol 441, 229-238.
25. Kiens, B., Essen-Gustavsson, B., Christensen, N.J. & Saltin, B. 1993. Skeletal muscle substrate utilization during submaximal exercise in man: effect of endurance training. J Physiol (Lond) 469, 459-478.
26. Kiens, B., Kristiansen, S., Richter, E.A. & Turcotte, L.P. 1997. Membrane associated FABP in human skeletal muscle is increased by endurance training. Biochem Biophys Res Com 231, 463-465.
27. Kiens, B., Roemen, T.H.M. & Van der Vusse, G.J. 1999. Muscular long-chain fatty acid content during graded exercise in humans. Am J Physiol 276, E352-E357.
28. van Loon, L.J., Greenhaff, P.L., Constantin-Teodosiu, D., Saris, W.H. & Wagenmakers, A.J. 2001. The effects of increasing exercise intensity, on muscle fuel utilisation in humans. J Physiol 536, 295-304.
29. Luiken, J.J., Glatz, J.F. & Bonen, A. 2000. Fatty acid transport proteins facilitate fatty acid uptake in skeletal muscle. Can J Appl Physiol 25, 333-352.
30. McGarry, J.D. 2002. Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51, 7-18.
31. McGarry, J.D. & Brown, N.F. 1997. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur J Biochem 244, 1-14.
32. Odland, L.M., Heigenhauser, G.J.F., Lopaschuk, G.D. & Spriet, L.L. 1996. Human skeletal muscle malonyl-CoA at rest and during prolonged submaximal exercise. Am J Physiol 270, E541-E544.
33. Odland, L.M., Howlett, R.A., Heigenhauser, G.J., Hultman, E. & Spriet, L.L. 1998. Skeletal muscle malonyl-CoA content at the onset of exercise at varying power outputs in humans. Am J Physiol 274, E1080-E1085.
34. Paul, P. 1970. FFA metabolism of normal dogs during steady-state exercise at different work loads. J Appl Physiol 28, 127-132.
35. Rasmussen, B.B. & Winder, W.W. 1997. Effect of exercise intensity on skeletal muscle malonyl-CoA and acetyl-CoA carboxylase. J Appl Physiol 83, 1104-1109.
36. Sahlin, K. 1990. Muscle carnitine metabolism during incremental dynamic exercise in humans. Acta Physiol Scand 138, 259-262.
37. Schaap, F.G., Van der Vusse, G.J. & Glatz, J.F. 1998. Fatty acid-binding proteins in the heart. Mol Cell Biochem 180, 43-51.
38. Storch, J. & Thumser, A.E. 2000. The fatty acid transport function of fatty acid-binding proteins. Biochim Biophys Acta 1486, 28-44.
39. Stremmel, W., Strohmeyer, G., Borchard, F., Kochwa, S. & Berk, P.D. 1985. Isolation and partial characterization of a fatty acid binding protein in rat liver plasma membranes. Proc Natl Acad Sci USA 82, 4-8.
40. Stump, D.D., Zhou, S.L. & Berk, P.D. 1993. Comparison of plasma membrane FABP and mitochondrial isoform of aspartate aminotransferase from rat liver. Am J Physiol 265, G894-G902.
41. Turcotte, L.P., Kiens, B. & Richter, E.A. 1991. Saturation kinetics of palmitate uptake in perfused skeletal muscle. FEBS Lett 279, 327-329.
42. Turcotte, L.P., Richter, E.A. & Kiens, B. 1992. Increased plasma FFA uptake and oxidation during prolonged exercise in trained vs. untrained humans. Am J Physiol 262, E791-E799.
43. max of palmitate uptake and oxidation in perfused skeletal muscle. J Appl Physiol 84, 1788-1794.
44. Winder, W.W. & Hardie, D.G. 1996. Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise. Am J Physiol 270, E299-E304.
45. Winder, W.W. & Hardie, D.G. 1999. AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol 277, E1-E10.
46. Wojtaszewski, J.F., Nielsen, P., Hansen, B.F., Richter, E.A. & Kiens, B. 2000. Isoform-specific and exercise intensity-dependent activation of 5′-AMP-activated protein kinase in human skeletal muscle. J Physiol 528 (Pt 1), 221-226.
47. Wojtaszewski, J.F., Mourtzakis, M., Hillig, T., Saltin, B. & Pilegaard, H. 2002. Dissociation of AMPK activity and ACCbeta phosphorylation in human muscle during prolonged exercise. Biochem Biophys Res Commun 298, 309-316.