Regulation of fuel metabolism by preexercise muscle glycogen content and exercise intensity

Journal of Applied Physiology

Volumn 97, Issue 6, 2004, Pages 2275-2283

  Arkinstall, Melissa J ^a   Bruce, Clinton R ^a   Clark, Sally A ^a   Rickards, Caroline A ^a   Burke, Louise M ^b   Hawley, John A ^a  

^a RMIT UNIVERSITY   (Australia)

^b DEAKIN UNIVERSITY   (Australia)

Author keywords

Diet; Glucose rate of disappearance; Training status

Indexed keywords

FATTY ACID; GLUCOSE; GLYCOGEN; INSULIN; LACTIC ACID;

ARTICLE; BICYCLE ERGOMETRY; BLOOD SAMPLING; CATECHOLAMINE BLOOD LEVEL; CONTROLLED STUDY; DIET; ENERGY EXPENDITURE; EXERCISE; FATTY ACID BLOOD LEVEL; FATTY ACID OXIDATION; GLUCOSE OXIDATION; GLUCOSE UTILIZATION; GLYCOGEN ANALYSIS; GLYCOGEN MUSCLE LEVEL; HEART RATE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INSULIN BLOOD LEVEL; LACTATE BLOOD LEVEL; LUNG GAS EXCHANGE; MALE; MUSCLE BIOPSY; MUSCLE METABOLISM; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

ADULT; BLOOD GLUCOSE; DIETARY CARBOHYDRATES; DIETARY FATS; ENERGY METABOLISM; EPINEPHRINE; EXERCISE; EXERTION; FATTY ACIDS, NONESTERIFIED; GLYCOGEN; HEART RATE; HUMANS; INSULIN; LACTIC ACID; MALE; MUSCLE, SKELETAL; NOREPINEPHRINE; OXIDATION-REDUCTION; OXYGEN; OXYGEN CONSUMPTION;

EID: 9244239217     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00421.2004     Document Type: Article

References (34)

1. Bergman BC and Brooks GA. Respiratory gas-exchange ratios during graded exercise in fed and fasted trained and untrained men. J Appl Physiol 86: 479-487, 1999.
2. Blomstrand E and Saltin B. Effect of muscle glycogen on glucose, lactate and amino acid metabolism during exercise and recovery in human subjects. J Physiol 514: 293-302, 1999.
3. Bosch AN, Dennis SC, and Noakes TD. Influence of carbohydrate loading on fuel substrate turnover and oxidation during prolonged exercise. J Appl Physiol 74: 1921-1927, 1993.
4. Brooks GA. Importance of the 'crossover' concept in exercise metabolism. Clin Exp. Pharmacol Physiol 24: 889-895, 1997.
5. Brooks GA and Mercier J. Balance of carbohydrate and lipid utilization during exercise: the "crossover" concept. J Appl Physiol 76: 2253-2261, 1994.
6. Coyle EF. Reply to letter to the editor. J Appl Physiol 81: 1451-1452, 1996.
7. Deuster PA, Chrousos GP, Luger A, DeBolt JE, Bernier LL, Trostmann UH, Kyle SB, Montgomery LC, and Loriaux DL. Hormonal and metabolic responses of untrained, moderately trained, and highly trained men to three exercise intensities. Metabolism 38: 141-148, 1989.
8. Gollnick PD, Pernow B, Essen B, Jansson E, and Saltin B. Availability of glycogen and plasma FFA for substrate utilization in leg muscle of man during exercise, Clin Physiol 1: 27-42, 1981.
9. Gollnick PD, Piehl K, Saubert CW IV, Armstrong RB, and Saltin B. Diet, exercise, and muscle glycogen. J Appl Physiol 33: 421-425, 1972.
10. Hargreaves M, McConell G, and Proietto J. Influence of muscle glycogen on glycogenolysis and glucose uptake during exercise in humans. J Appl Physiol 78: 288-292, 1995.
11. Hawley JA, Bosch AN, Weltan SM, Dennis SC, and Noakes TD. Effects of glucose ingestion or glucose infusion on fuel substrate kinetics during prolonged exercise. Eur J Appl Physiol 68: 381-389, 1994.
12. Hawley JA, Burke LM, Angus DJ, Fallen KE, Martin DT, and Febbraio MA. Effect of altering substrate availability on metabolism and performance during intense exercise. Br J Nutr 84: 829-838, 2000.
13. Horowitz JF and Coyle EF. Metabolic responses to pre-exercise meals containing various carbohydrates and fat. Am J Clin Nutr 58: 235-241, 1993.
14. Hultman E and Spriet LL. Skeletal muscle metabolism, contraction force and glycogen utilization during prolonged electrical stimulation in humans. J Physiol 374: 493-501, 1986.
15. Jansson E and Kaijser L. Effect of diet on utilization of blood-borne and intramuscular substrates during exercise in man. Acta Physiol Scand 115: 19-30, 1982.
16. Jeukendrup AE, Wagenmakers AJM, Stegen JHCH, Gijsen A, Brouns F, and Saris WHM. Carbohydrate ingestion can completely suppress endogenous glucose production during exercise. Am J Physiol Endocrinol Metab 276: E672-E683, 1999.
17. Karlsson J and Saltin B. Diet, muscle glycogen, and endurance performance. J Appl Physiol 31: 203-206, 1971.
18. Katz A, Sahlin K, and Broberg S. Regulation of glucose utilization in human skeletal muscle during moderate dynamic exercise. Am J Physiol Endocrinol Metab 260: E411-E415, 1991.
19. Kristiansen S, Gade J, Wojtaszewski JFP, Kiens B, and Richter EA. Glucose uptake is increased in trained vs. untrained muscle during heavy exercise. J Appl Physiol 89: 1151-1158, 2000.
20. Kuipers H, Keizer HA, Brouns F, and Saris WHM. Carbohydrate feeding and glycogen synthesis during exercise in man. Pflügers Arch 410: 652-656, 1987.
21. Lowry OH, and Passonneau JV. A Flexible System of Enzymatic Analysis. New York: Academic, 1972.
22. Madsen K, Pedersen PK, Rose P, and Richter EA. Carbohydrate supercompensation and muscle glycogen utilization during exhaustive running in highly trained athletes. Eur J Appl Physiol 61: 467-472, 1990.
23. Odland LM, Heigenhauser GJF, and Spriet LL. Effects of high fat provision on muscle PDH activation and malonyl-CoA content in moderate exercise. J Appl Physiol 89: 2352-2358, 2000.
24. Odland LM, Hewlett RA, Heigenhauser GJF, Hultman E, and Spriet LL. Skeletal muscle malonyl-CoA content at the onset of exercise at varying power outputs in humans. Am J Physiol Endocrinol Metab 274: E1080-E1085, 1998.
25. Péronnet F and Massicotte D. Table of nonprotein respiratory quotient: an update. Can J Sport Sci 16: 23-29, 1991.
26. Romijn JA, Coyle EF, Sidossis S, Gastaldelli A, Horowitz JF, Endert E, and Wolfe RR. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am J Physiol Endocrinol Metab 265: E380-E391, 1993.
27. Spencer MK, Yan Z, and Katz A. Effect of low glycogen on carbohydrate and energy metabolism in human muscle during exercise. Am J Physiol Cell Physiol 262: C975-C979, 1992.
28. Steele R, Wall JS, DeBodo RC, and Altszuler N. Measurement of size and turnover rate of body glucose pool by the isotope dilution method. Am J Physiol 187: 15-24, 1956.
29. Steensberg A, van Hall G, Keller C, Osada T, Schjerling P, Pedersen BK, Saltin B, and Febbraio MA. Muscle glycogen content and glucose uptake during exercise in humans: influence of prior exercise and dietary manipulation. J Physiol 541: 273-281, 2002.
30. Tarnopolsky LJ, MacDougall JD, Atkinson SA, Tarnopolsky MA, and Sutton JR. Gender differences in substrate for endurance exercise. J Appl Physiol 68: 302-308, 1990.
31. Van Loon LJC, Greenhaff PL, Constantin-Teodosiu D, Saris WHM, and Wagenmakers AJM. The effects of increasing exercise intensity on muscle fuel utilisation in humans. J Physiol 536: 295-304, 2001.
32. Weltan SM, Bosch AN, Dennis SC, and Noakes TD. Influence of muscle glycogen content on metabolic regulation. Am J Physiol Endocrinol Metab 274: E72-E82, 1998.
33. Weltan SM, Bosch AN, Dennis SC, and Noakes TD. Preexercise muscle glycogen content affects metabolism during exercise despite maintenance of hyperglycemia. Am J Physiol Endocrinol Metab 274: E83-E88, 1998.
34. Wojtaszewski JFP, MacDonald C, Nielsen JN, Hellsten Y, Hardie DG, Kemp BE, Kiens B, and Richter EA. Regulation of 5′ AMP-activated-protein kinase activity and substrate utilization in exercising human skeletal muscle. Am J Physiol Endocrinol Metab 284: E813-E822, 2003.