Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB

Journal of Medicinal Chemistry

Volumn 51, Issue 3, 2008, Pages 545-552

  Mallari, Jeremy P ^a,c   Shelat, Anang A ^c   Obrien, Terri ^b   Caffrey, Conor R ^b   Kosinski, Aaron ^c   Connelly, Michele ^c   Harbut, Michael ^d   Greenbaum, Doron ^d   McKerrow, James H ^b   Guy, R Kiplin ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN B; NITRILE; PROTEINASE; PROTEINASE INHIBITOR; PURINE DERIVATIVE; TRYPANOSOMA BRUCEI CATHEPSIN B LIKE PROTEINASE; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; TRYPANOSOMA BRUCEI;

ANIMALS; CATHEPSIN B; CELL LINE; CELL LINE, TUMOR; ELECTROSTATICS; HUMANS; MODELS, MOLECULAR; NITRILES; PURINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

EID: 39149083105     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070760l     Document Type: Article

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