N-Arylaminonitriles as bioavailable peptidomimetic inhibitors of cathepsin B

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 22, 2003, Pages 4121-4124

  Greenspan, Paul D ^a,b   Clark, Kirk L ^a   Cowen, Scott D ^a   McQuire, Leslie W ^a   Tommasi, Ruben A ^a   Farley, David L ^a   Quadros, Elizabeth ^a   Coppa, David E ^a   Du, Zengming ^a   Fang, Zheng ^a   Zhou, Huanghai ^a   Doughty, John ^a   Toscano, Karen T ^a   Wigg, Andrew M ^a   Zhou, Siyuan ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; AROMATIC AMINE; CARBOXYL GROUP; CATHEPSIN B; CATHEPSIN B INHIBITOR; ENZYME INHIBITOR; NITRILE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG POTENCY; DRUG POTENTIATION; DRUG SELECTIVITY; DRUG SYNTHESIS; EXPERIMENTAL MODEL; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

EID: 10744225470     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.08.006     Document Type: Article

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