-
1
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PLC, Coviello GM, Wright WE, Weinrich SL and Shay JW: Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015, 1994.
-
(1994)
Science
, vol.266
, pp. 2011-2015
-
-
Kim, N.W.1
Piatyszek, M.A.2
Prowse, K.R.3
Harley, C.B.4
West, M.D.5
Ho, P.L.C.6
Coviello, G.M.7
Wright, W.E.8
Weinrich, S.L.9
Shay, J.W.10
-
2
-
-
0031010342
-
A survey of telomerase activity in human cancer
-
Shay JW and Bacchetti S: A survey of telomerase activity in human cancer. Eur J Cancer 33: 787-791, 1997.
-
(1997)
Eur J Cancer
, vol.33
, pp. 787-791
-
-
Shay, J.W.1
Bacchetti, S.2
-
3
-
-
0030761351
-
ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase
-
DOI 10.1093/emboj/16.19.6018
-
Vaziri H, West MD, Allsopp RC, Davison TS, Wu YS, Arrowsmith CH, Poirier GG and Benchimol S: ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. EMBO J 16: 6018-6033, 1997. (Pubitemid 27427297)
-
(1997)
EMBO Journal
, vol.16
, Issue.19
, pp. 6018-6033
-
-
Vaziri, H.1
West, M.D.2
Allsopp, R.C.3
Davison, T.S.4
Wu, Y.-S.5
Arrowsmith, C.H.6
Poirier, G.G.7
Benchimol, S.8
-
4
-
-
0041966056
-
Reversal of human cellular senescence: Roles of the p53 and p16 pathways
-
DOI 10.1093/emboj/cdg417
-
Beausejour CM, Krtolica A, Galimi F, Narita M, Lowe SW, Yaswen P and Campisi J: Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J 22: 4212-4222, 2003. (Pubitemid 37021749)
-
(2003)
EMBO Journal
, vol.22
, Issue.16
, pp. 4212-4222
-
-
Beausejour, C.M.1
Krtolica, A.2
Galimi, F.3
Narita, M.4
Lowe, S.W.5
Yaswen, P.6
Campisi, J.7
-
5
-
-
0026054961
-
A role for both RB and p53 in the regulation of human cellular senescence
-
Shay JW, Pereira-Smith OM and Wright WE: A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res 196: 33-39, 1991.
-
(1991)
Exp Cell Res
, vol.196
, pp. 33-39
-
-
Shay, J.W.1
Pereira-Smith, O.M.2
Wright, W.E.3
-
6
-
-
0025787643
-
Telomerase loss: Mitotic clock or genetic time bomb?
-
Harley CB: Telomerase loss: mitotic clock or genetic time bomb? Mutat Res 256: 271-282, 1991.
-
(1991)
Mutat Res
, vol.256
, pp. 271-282
-
-
Harley, C.B.1
-
7
-
-
0033568462
-
Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
-
DOI 10.1101/gad.13.18.2388
-
Zhang X, Mar V, Zhou W, Harrington L and Robinson MO: Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev 13: 2388-2399, 1999. (Pubitemid 29453610)
-
(1999)
Genes and Development
, vol.13
, Issue.18
, pp. 2388-2399
-
-
Zhang, X.1
Mar, V.2
Zhou, W.3
Harrington, L.4
Robinson, M.O.5
-
8
-
-
0033553516
-
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
-
Chin L, Artandi SE, Shen Q, Tam A, Lee SL, Gottlieb GJ, Greider CW and De Pinho RA: p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97: 527-538, 1999.
-
(1999)
Cell
, vol.97
, pp. 527-538
-
-
Chin, L.1
Artandi, S.E.2
Shen, Q.3
Tam, A.4
Lee, S.L.5
Gottlieb, G.J.6
Greider, C.W.7
De Pinho, R.A.8
-
9
-
-
0033605145
-
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
-
Karlseder J, Broccoli D, Dai Y, Hardy S and De Lange T: p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283: 1321-1325, 1999. (Pubitemid 129507217)
-
(1999)
Science
, vol.283
, Issue.5406
, pp. 1321-1325
-
-
Karlseder, J.1
Broccoli, D.2
Dai, Y.3
Hardy, S.4
De Lange, T.5
-
10
-
-
0037144595
-
Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction
-
Elmore LW, Rehder CW, Di X, McChesney PA, Jackson-Cook CK, Gewirtz DA and Holt SE: Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction. J Biol Chem 277: 35509-35515, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 35509-35515
-
-
Elmore, L.W.1
Rehder, C.W.2
Di, X.3
McChesney, P.A.4
Jackson-Cook, C.K.5
Gewirtz, D.A.6
Holt, S.E.7
-
11
-
-
2942537690
-
Telomere erosion triggers growth arrest but not cell death in human cancer cells retaining wild-type p53: Implications for antitelomerase therapy
-
Preto A, Singhrao SK, Haughton MF, Kipling D, Wynford-Thomas D and Jones CJ: Telomere erosion triggers growth arrest but not cell death in human cancer cells retaining wild-type p53: implications for antitelomerase therapy. Oncogene 23: 4136-4145, 2004.
-
(2004)
Oncogene
, vol.23
, pp. 4136-4145
-
-
Preto, A.1
Singhrao, S.K.2
Haughton, M.F.3
Kipling, D.4
Wynford-Thomas, D.5
Jones, C.J.6
-
12
-
-
19944362494
-
p53-dependent down-regulation of telomerase is mediated by p21/waf1
-
Shats I, Milyavsky M, Tang X, Stambolsky P, Erez N, Brosh R, Kogan I, Braunstein I, Tzukerman M, Ginsberg D and Rotter V: p53-dependent down-regulation of telomerase is mediated by p21/waf1. J Biol Chem 279: 50976-50985, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 50976-50985
-
-
Shats, I.1
Milyavsky, M.2
Tang, X.3
Stambolsky, P.4
Erez, N.5
Brosh, R.6
Kogan, I.7
Braunstein, I.8
Tzukerman, M.9
Ginsberg, D.10
Rotter, V.11
-
13
-
-
0036787840
-
Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development
-
Gonzalez-Suarez E, Flores JM and Blasco MA: Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development. Mol Cell Biol 22: 7291-7301, 2002.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7291-7301
-
-
Gonzalez-Suarez, E.1
Flores, J.M.2
Blasco, M.A.3
-
14
-
-
0041353457
-
Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines
-
Stampfer MR, Garbe J, Nijjar T, Wigington D, Swisshelm K and Yaswen P: Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines. Oncogene 22: 5238-5251, 2003.
-
(2003)
Oncogene
, vol.22
, pp. 5238-5251
-
-
Stampfer, M.R.1
Garbe, J.2
Nijjar, T.3
Wigington, D.4
Swisshelm, K.5
Yaswen, P.6
-
15
-
-
0033822365
-
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
-
Wong KK, Chang S, Weiler SR, Ganesan S, Chaudhuri J, Zhu C, Artandi SE, Rudolph KL, Gottlieb GJ, Chin L, Alt FW and De Pinho RA: Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nat Genet 26: 85-88, 2000.
-
(2000)
Nat Genet
, vol.26
, pp. 85-88
-
-
Wong, K.K.1
Chang, S.2
Weiler, S.R.3
Ganesan, S.4
Chaudhuri, J.5
Zhu, C.6
Artandi, S.E.7
Rudolph, K.L.8
Gottlieb, G.J.9
Chin, L.10
Alt, F.W.11
De Pinho, R.A.12
-
16
-
-
0036317093
-
The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA
-
Offer H, Erez N, Zurer I, Tang X, Milyavsky M, Goldfinger N and Rotter V: The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA. Carcinogenesis 23: 1025-1032, 2002.
-
(2002)
Carcinogenesis
, vol.23
, pp. 1025-1032
-
-
Offer, H.1
Erez, N.2
Zurer, I.3
Tang, X.4
Milyavsky, M.5
Goldfinger, N.6
Rotter, V.7
-
17
-
-
0027451668
-
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
-
Lowe SW, Ruley HE, Jacks T and Housman DE: p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74: 957-967, 1993.
-
(1993)
Cell
, vol.74
, pp. 957-967
-
-
Lowe, S.W.1
Ruley, H.E.2
Jacks, T.3
Housman, D.E.4
-
18
-
-
0000146723
-
Δ2/3 cancer-prone mouse
-
Δ2/3 cancer-prone mouse. Cell 97: 515-525, 1999.
-
(1999)
Cell
, vol.97
, pp. 515-525
-
-
Greenberg, R.A.1
Chin, L.2
Femino, A.3
Lee, K.H.4
Gottlieb, G.J.5
Singer, R.H.6
Greider, C.W.7
De Pinho, R.A.8
-
19
-
-
0035853058
-
Telomere dysfunction alters the chemotherapeutic profile of transformed cells
-
Lee KH, Rudolph KL, Ju YJ, Greenberg RA, Cannizzaro L, Chin L, Weiler SR and De Pinho RA: Telomere dysfunction alters the chemotherapeutic profile of transformed cells. Proc Natl Acad Sci USA 98: 3381-3386, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3381-3386
-
-
Lee, K.H.1
Rudolph, K.L.2
Ju, Y.J.3
Greenberg, R.A.4
Cannizzaro, L.5
Chin, L.6
Weiler, S.R.7
De Pinho, R.A.8
-
20
-
-
0030931491
-
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
-
Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, De Pinho RA and Greider CW: Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91: 25-34, 1997.
-
(1997)
Cell
, vol.91
, pp. 25-34
-
-
Blasco, M.A.1
Lee, H.W.2
Hande, M.P.3
Samper, E.4
Lansdorp, P.M.5
De Pinho, R.A.6
Greider, C.W.7
-
21
-
-
0027538181
-
Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity
-
Dranoff G, Jaffee E, Lazenby A, Golumbek P, Levitsky H, Brose K, Jackson V, Hamada H, Pardoll D and Mulligan RC: Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc Natl Acad Sci USA 90: 3539-3543, 1993.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 3539-3543
-
-
Dranoff, G.1
Jaffee, E.2
Lazenby, A.3
Golumbek, P.4
Levitsky, H.5
Brose, K.6
Jackson, V.7
Hamada, H.8
Pardoll, D.9
Mulligan, R.C.10
-
22
-
-
0035793064
-
Pericentromeric organization at the fusion point of mouse robertsonian translocation chromosomes
-
Silvia G, Nicola M, Maurizio Z, Jeremy BS, Ernesto C and Carlo AR: Pericentromeric organization at the fusion point of mouse robertsonian translocation chromosomes. Proc Natl Acad Sci USA 98: 171-175, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 171-175
-
-
Silvia, G.1
Nicola, M.2
Maurizio, Z.3
Jeremy, B.S.4
Ernesto, C.5
Carlo, A.R.6
-
23
-
-
0031821009
-
Preferential accumulation of single-stranded regions in telomeres of human fibroblasts
-
Petersen S, Saretzki G and Zglinicki TV: Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. Exp Cell Res 239: 152-160, 1998.
-
(1998)
Exp Cell Res
, vol.239
, pp. 152-160
-
-
Petersen, S.1
Saretzki, G.2
Zglinicki, T.V.3
-
24
-
-
0030032422
-
Induced mitotic death of HeLa cells by abnormal expression of c-H-ras
-
Miranda EI, Santana C, Rojas E, Hernandez S, Ostrosky-Wegman P and Garcia-Carranca A: Induced mitotic death of HeLa cells by abnormal expression of c-H-ras. Mutat Res 349: 173-182, 1996.
-
(1996)
Mutat Res
, vol.349
, pp. 173-182
-
-
Miranda, E.I.1
Santana, C.2
Rojas, E.3
Hernandez, S.4
Ostrosky-Wegman, P.5
Garcia-Carranca, A.6
-
25
-
-
0030728468
-
ARF
-
ARF. Cell 91: 649-659, 1997.
-
(1997)
Cell
, vol.91
, pp. 649-659
-
-
Kamijo, T.1
Zindy, F.2
Roussel, M.F.3
Quelle, D.E.4
Downing, J.R.5
Ashmun, R.A.6
Grosveld, G.7
Sherr, C.J.8
-
26
-
-
0032169516
-
ARF, participates in a regulatory feedback loop with p53 and MDM2
-
ARF, participates in a regulatory feedback loop with p53 and MDM2. EMBO J 17: 5001-5014, 1998.
-
(1998)
EMBO J
, vol.17
, pp. 5001-5014
-
-
Stott, F.J.1
Bates, S.2
James, M.C.3
McConnell, B.B.4
Starborg, M.5
Brookes, S.6
Palmero, I.7
Ryan, K.8
Hara, E.9
Vousden, K.H.10
Peters, G.11
-
27
-
-
0345734276
-
Enhanced ubiquitinylation of heat shock protein 90 as a potential mechanism for mitotic cell death in cancer cells induced with hypericin
-
Blank M, Mandel M, Keisari Y, Meruelo D and Lavie G: Enhanced ubiquitinylation of heat shock protein 90 as a potential mechanism for mitotic cell death in cancer cells induced with hypericin. Cancer Res 63: 8241-8247, 2003.
-
(2003)
Cancer Res
, vol.63
, pp. 8241-8247
-
-
Blank, M.1
Mandel, M.2
Keisari, Y.3
Meruelo, D.4
Lavie, G.5
-
28
-
-
0033806120
-
Inactivation of 14-3-3σ influences telomere behavior and ionizing radiation-induced chromosomal instability
-
Dhar S, Squire JA, Hande MP, Wellinger RJ and Pandita TK: Inactivation of 14-3-3σ influences telomere behavior and ionizing radiation-induced chromosomal instability. Mol Cell Biol 20: 7764-7772, 2000.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 7764-7772
-
-
Dhar, S.1
Squire, J.A.2
Hande, M.P.3
Wellinger, R.J.4
Pandita, T.K.5
-
29
-
-
0037048302
-
Genomic instability, centrosome amplification, cell cycle checkpoints and Gadd45a
-
Hollander MC and Fornace AJ Jr: Genomic instability, centrosome amplification, cell cycle checkpoints and Gadd45a. Oncogene 21: 6228-6233, 2002.
-
(2002)
Oncogene
, vol.21
, pp. 6228-6233
-
-
Hollander, M.C.1
Fornace Jr., A.J.2
-
30
-
-
0028020151
-
p53 gene dosage modifies growth and malignant progression of keratinocytes expressing the v-rasHa oncogene
-
Weinberg WC, Azzoli CG, Kadiwar N and Yuspa SH: p53 gene dosage modifies growth and malignant progression of keratinocytes expressing the v-rasHa oncogene. Cancer Res 54: 5584-5592, 1994.
-
(1994)
Cancer Res
, vol.54
, pp. 5584-5592
-
-
Weinberg, W.C.1
Azzoli, C.G.2
Kadiwar, N.3
Yuspa, S.H.4
-
31
-
-
0023907342
-
Differential transformation of primary human embryo retinal cells by adenovirus E1 regions and combinations of E1A + ras
-
Byrd PJ, Grand RJ and Gallimore PH: Differential transformation of primary human embryo retinal cells by adenovirus E1 regions and combinations of E1A + ras. Oncogene 2: 477-484, 1988.
-
(1988)
Oncogene
, vol.2
, pp. 477-484
-
-
Byrd, P.J.1
Grand, R.J.2
Gallimore, P.H.3
-
32
-
-
0026495728
-
Cooperativity of SV40 T antigen and ras in progressive stages of transformation of human fibroblasts
-
White JA, Carter SG, Ozer HL and Boyd AL: Cooperativity of SV40 T antigen and ras in progressive stages of transformation of human fibroblasts. Exp Cell Res 203: 157-163, 1992.
-
(1992)
Exp Cell Res
, vol.203
, pp. 157-163
-
-
White, J.A.1
Carter, S.G.2
Ozer, H.L.3
Boyd, A.L.4
-
33
-
-
4243937106
-
A highly selective telomerase inhibitor limiting human cancer cell proliferation
-
Damm K, Hemmann U, Garin-Chesa P, Hauel N, Kauffmann I, Priepke H, Niestroj C, Daiber C, Enenkel B, Guilliard B, Lauritsch L, Muller E, Pascolo E, Sauter G, Pantic M, Martens UM, Wenz C, Lingner J, Kraut N, Rettig WJ and Schnapp A: A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J 20: 6958-6968, 2001.
-
(2001)
EMBO J
, vol.20
, pp. 6958-6968
-
-
Damm, K.1
Hemmann, U.2
Garin-Chesa, P.3
Hauel, N.4
Kauffmann, I.5
Priepke, H.6
Niestroj, C.7
Daiber, C.8
Enenkel, B.9
Guilliard, B.10
Lauritsch, L.11
Muller, E.12
Pascolo, E.13
Sauter, G.14
Pantic, M.15
Martens, U.M.16
Wenz, C.17
Lingner, J.18
Kraut, N.19
Rettig, W.J.20
Schnapp, A.21
more..
-
34
-
-
13544268344
-
Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532
-
El-Daly H, Kull M, Zimmermann S, Pantic M, Waller CF and Martens UM: Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532. Blood 105: 1742-1749, 2005.
-
(2005)
Blood
, vol.105
, pp. 1742-1749
-
-
El-Daly, H.1
Kull, M.2
Zimmermann, S.3
Pantic, M.4
Waller, C.F.5
Martens, U.M.6
-
35
-
-
0025143252
-
Telomere reduction in human colorectal carcinoma and with ageing
-
Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK and Allshire RC: Telomere reduction in human colorectal carcinoma and with ageing. Nature 346: 866-868, 1990. (Pubitemid 120006017)
-
(1990)
Nature
, vol.346
, Issue.6287
, pp. 866-868
-
-
Hastie, N.D.1
Dempster, M.2
Dunlop, M.G.3
Thompson, A.M.4
Green, D.K.5
Allshire, R.C.6
-
36
-
-
0025115349
-
Structure and variability of human chromosome ends
-
De Lange T, Shiue L, Myers RM, Cox DR, Naylor SL, Killery AM and Varmus HE: Structure and variability of human chromosome ends. Mol Cell Biol 10: 518-527, 1990. (Pubitemid 20034458)
-
(1990)
Molecular and Cellular Biology
, vol.10
, Issue.2
, pp. 518-527
-
-
De Lange, T.1
Shiue, L.2
Myers, R.M.3
Cox, D.R.4
Naylor, S.L.5
Killery, A.M.6
Varmus, H.E.7
-
37
-
-
0037413726
-
Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation
-
DOI 10.1093/emboj/cdg013
-
Leri AL, Franco S, Zacheo A, Barlucchi L, Chimenti S, Limana F, Nadal-Ginard B, Kajstura J, Anversa P and Blasco MA: Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation. EMBO J 22: 131-139, 2003. (Pubitemid 36091276)
-
(2003)
EMBO Journal
, vol.22
, Issue.1
, pp. 131-139
-
-
Leri, A.1
Franco, S.2
Zacheo, A.3
Barlucchi, L.4
Chimenti, S.5
Limana, F.6
Nadal-Ginard, B.7
Kajstura, J.8
Anversa, P.9
Blasco, M.A.10
-
38
-
-
2442511752
-
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
-
Herbig U, Jobling WA, Chen DJ and Sedivy JM: Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell 14: 501-513, 2004.
-
(2004)
Mol Cell
, vol.14
, pp. 501-513
-
-
Herbig, U.1
Jobling, W.A.2
Chen, D.J.3
Sedivy, J.M.4
-
39
-
-
0029029938
-
p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells
-
Harve PA, Yuan J, Hedrick L, Cho KR and Glazer PM: p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells. Cancer Res 55: 4420-4424, 1995.
-
(1995)
Cancer Res
, vol.55
, pp. 4420-4424
-
-
Harve, P.A.1
Yuan, J.2
Hedrick, L.3
Cho, K.R.4
Glazer, P.M.5
-
40
-
-
0035839132
-
Telomere dysfunction increases mutation rate and genomic instability
-
Hackett JA, Feldser DM and Greider CW: Telomere dysfunction increases mutation rate and genomic instability. Cell 106: 275-286, 2001.
-
(2001)
Cell
, vol.106
, pp. 275-286
-
-
Hackett, J.A.1
Feldser, D.M.2
Greider, C.W.3
|