Role of reactive oxygen metabolites in aspirin-induced gastric damage in humans: Gastroprotection by vitamin C

Alimentary Pharmacology and Therapeutics

Volumn 15, Issue 5, 2001, Pages 677-687

  Pohle, T ^a   Brzozowski, T ^b   Becker, J C ^a   Van Der Voort, I R ^a   Markmann, A ^a   Konturek, S J ^b   Moniczewski, A ^b   Domschke, W ^a   Konturek, J W ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ASCORBIC ACID; GLUTATHIONE PEROXIDASE; MYELOPEROXIDASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN EXPERIMENT; LIPID PEROXIDATION; MALE; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL; STOMACH BLOOD FLOW; STOMACH INJURY;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASCORBIC ACID; ASPIRIN; BIOLOGICAL MARKERS; FEMALE; FREE RADICALS; GASTRIC MUCOSA; GLUTATHIONE PEROXIDASE; HUMANS; LIPID PEROXIDATION; MALE; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; STOMACH; SUPEROXIDE DISMUTASE;

EID: 0035037927     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.2001.00975.x     Document Type: Article

References (28)

1. Risk of aspirin-associated major upper-gastrointestinal bleeding with enteric-coated or buffered product
2. NSAID gastropathy
3. Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury
4. Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC
5. Comparison of prostaglandin E2 and ranitidine in prevention of gastric bleeding by aspirin in man
6. Mucosal adaptation to aspirin induced gastric damage in humans: Studies on blood flow, gastric mucosal growth, and neutrophil activation
7. Endoscopic studies of gastric and duodenal injury after the use of ibuprofen, aspirin and other nonsteroidal antiinflammatory agents
8. Endoscopic measurement of gastric blood flow by laser Doppler velocimetry: Effect of chronic esophageal variceal sclerosis
9. Pathologic basis of gastric mucosal adaptation to topical injury
10. Ascorbic acid analysis using high-performance liquid chromatography with coulometric detection
11. In vivo treatment with endotoxin induces nitric oxide synthase in rat main pulmonary artery
12. Portal hypertension activates the nitric oxide synthase genes in the esophageal mucosa of rats
13. Ischemia-reperfusion injury and free radical involvement in gastric mucosal disorders
14. Gastric mucosal cytoprotection in the rat by scavenging oxygen-derived free radicals
15. Role of active oxygen, lipid peroxidation and antioxidants in the pathogenesis of gastric injury induced by indomethacin in rats
16. Microvascular basis of gastric mucosal protection
17. Involvement of the xanthine-xanthine oxidase system and neutrophils in the development of acute gastric mucosal lesions in rats with water immersion restraint stress
18. Gastric ulceration induced by non-steroidal anti-inflammatory drugs is a neutrophil-dependent process
19. Effect of allopurinol, sulphasalazine, and vitamin C on aspirin induced gastroduodenal injury in human volunteers
20. Levels of nitrite, nitrate, N-nitroso compounds, ascorbic acid and total bile acids in gastric juice of patients with and without precancerous conditions of the stomach
21. Vitamin C concentration in the human stomach: Relation to gastric pH, gastroduodenal disease, and possible sources
22. Effect of eradication of Helicobacter pylori on gastric juice ascorbic acid concentrations
23. Vitamin C concentration in gastric juice before and after anti-Helicobacter pylori treatment
24. Protective effect of taurine on indomethacin-induced gastric mucosal injury
25. Lipid peroxidation in gastric mucosal lesions induced by indomethacin in rat
26. Role of free radicals and lipid peroxidation in gastric mucosal injury induced by ischemia-reperfusion in rats
27. Protective effect of melatonin on indomethacin-induced gastric injury in rats
28. Role of oxidative stress in the pathogenesis of caerulein-induced acute pancreatitis