Synthesis and characterization of novel hydrazide-hydrazones and the study of their structure-antituberculosis activity

European Journal of Medicinal Chemistry

Volumn 41, Issue 11, 2006, Pages 1253-1261

  Bedia, Koçyiǧit Kaymakçioǧlu ^a   Elçin, Oruç ^a   Seda, Unsalan ^a   Fatma, Kandemirli ^b   Nathaly, Shvets ^c   Sevim, Rollas ^a   Dimoglo, Anatholy ^c,d  

^a MARMARA UNIVERSITY   (Turkey)

^b KOCAELI UNIVERSITY   (Turkey)

^c GEBZE TECHNICAL UNIVERSITY   (Turkey)

^d INSTITUTE OF APPLIED PHYSICS   (Moldova)

Author keywords

Antituberculosis activity; Hydrazide hydrazones; Structure activity relationships

Indexed keywords

2 [(FLUOROBENZOYL)HYDRAZONO] 1,3 DIHYDRO INDOL 3 ONE; 3,4 FLUOROBENZOIC ACID[[(5 NITRO)THIOPHEN 2YL]METHYLENE]HYDRAZIDE; 4 FLUOROBENZOIC ACID[(2 FLUOROPHENYL)METHYLENE]HYDRAZIDE; 4 FLUOROBENZOIC ACID[(2 FURANYL)METHYLENE]HYDRAZIDE; 4 FLUOROBENZOIC ACID[(2 HYDROXYPHENYL)METHYLENE]HYDRAZIDE; 4 FLUOROBENZOIC ACID[(3 CHLOROPHENYL)METHYLENE]HYDRAZIDE; 4 FLUOROBENZOIC ACID[(4 BROMOPHENYL)METHYLENE]HYDRAZIDE; 4 FLUOROBENZOIC ACID[(4 CHLOROPHENYL)METHYLENE]HYDRAZIDE; 4 FLUOROBENZOIC ACID[(4 DIMETHYLAMINOCINNAMYL)METHYLENE]HYDRAZIDE; 4 FLUOROBENZOIC ACID[(4 DIMETHYLAMINOPHENYL)METHYLENE]HYDRAZIDE; 4 FLUOROBENZOIC ACID[(4 FLUOROPHENYL)METHYLENE]HYDRAZIDE; 4 FLUOROBENZOIC ACID[(4 HYDROXY 3 ETHOXYPHENYL)METHYLENE]HYDRAZIDE; 4 FLUOROBENZOIC ACID[(4 HYDROXY 3 METHOXYPHENYL)METHYLENE]HYDRAZIDE; 4 FLUOROBENZOIC ACID[(4 HYDROXYPHENYL)METHYLENE]HYDRAZIDE; 4 FLUOROBENZOIC ACID[(5 BROMOTHIOPHEN 2 YL)METHYLENE]HYDRAZIDE; 4 FLUOROBENZOIC ACID[(BENZYL)METHYLENE]HYDRAZIDE; 4 FLUOROBENZOIC ACID[(PYRIDYL 4 YL)METHYLENE]HYDRAZIDE; 4 FLUOROBENZOIC ACID[(PYROL 2 YL)METHYLENE]HYDRAZIDE; 4 FLUOROBENZOIC ACID[(THIOPHEN 2 YL)METHYLENE]HYDRAZIDE; 4 FLUOROBENZOIC ACID[[(5 NITRO)THIOPHEN 2 YL]METHYLENE]HYDRAZIDE; 4 NITROBENZOIC ACID[[(5 NITRO)THIOPHEN 2 YL]METHYLENE]HYDRAZIDE; BENZOIC ACID DERIVATIVE; HYDRAZIDE DERIVATIVE; HYDRAZONE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; INHIBITION KINETICS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHARMACOPHORE; RADIOMETRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ANIMAL; CERCOPITHECUS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; MICROBIOLOGICAL EXAMINATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS; VERO CELL;

ANIMALS; ANTITUBERCULAR AGENTS; CERCOPITHECUS AETHIOPS; HYDRAZONES; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MYCOBACTERIUM TUBERCULOSIS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

EID: 33751032349     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.06.009     Document Type: Article

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