Synthesis and anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities of some new 2-[(2,6-dichloroanilino) phenyl]acetic acid derivatives

European Journal of Medicinal Chemistry

Volumn 39, Issue 6, 2004, Pages 535-545

  Amir, Mohd ^a   Shikha, Kumar ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

1,2,4 Triazine; 1,2,4 Triazole; 1,3,4 Oxadiazole; 1,3,4 Thiadiazole; Analgesic activity; Anti inflammatory activity; Diclofenac; Lipid peroxidation; Ulcerogenic activity

Indexed keywords

5 [2 (2,6 DICHLOROANILINO)BENZYL] 2 AMINO 1,3,4 OXADIAZOLE; 5 [2 (2,6 DICHLOROANILINO)BENZYL] 2 MERCAPTO 1,3,4 OXADIAZOLE; [2 (2,6 DICHLOROANILINO)PHENYL]ACETIC ACID HYDRAZIDE; ACETIC ACID DERIVATIVE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; DICLOFENAC; ETHYL [2 (2,6 DICHLOROANILINO)PHENYL]ACETIC ACID; MALONALDEHYDE; OXADIAZOLE DERIVATIVE; PYRROLE DERIVATIVE; THIADIAZOLE DERIVATIVE; TRIAZINE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; INFRARED SPECTROMETRY; LIPID PEROXIDATION; NONHUMAN; PAW EDEMA; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STOMACH MUCUS; STOMACH ULCER; STRUCTURE ANALYSIS; ULCEROGENESIS; WRITHING TEST;

ACETIC ACIDS; ANALGESICS; ANILINE COMPOUNDS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DICLOFENAC; DISEASE MODELS, ANIMAL; GASTRIC MUCOSA; GASTROINTESTINAL DISEASES; LIPID PEROXIDATION; MALONDIALDEHYDE; PAIN; PROTECTIVE AGENTS; RATS; THIADIAZOLES;

EID: 2942596597     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2004.02.008     Document Type: Article

References (30)

1. Palomer A., Cabre F., Pascual J., Campos J., Trugillo M.A., Entrena A., Gallo M.A., Garcia L., Macleon D., Espinosa A. J. Med. Chem. 45:2002;1402-1411
2. Sorbera L.A., Lesson P.A., Castanar J., Castanar R.M. Drug Future. 26:2001;133-140
3. Talley J.J., Brown D.L., Carter J.S., Graneto M.J., Koboldt C.M., Masferrer J.L., Perkins W.E., Rogers R.S., Shaffer A.F., Zhang Y.Y., Zweifel B.S., Seibert K. J. Med. Chem. 43:2000;775-777
4. Tammara V.K., Narurkar M.M., Crider A.M., Khan M.A. J. Pharm. Sci. 83:1994;644-648
5. Smith C.J., Zhang Y., Koboldt C.M., Muhammad J., Zwefel B.S., Shaffer A., Talley J.J., Masferrer J.L., Serbert K., Isakson P.C. Proc. Natl. Acad. Sci. USA. 95:1998;13313-13318
6. Warner T.D., Giuliano F., Vaynovie I., Bukasa A., Mitchell J.A., Vave J.R. Proc. Natl. Acad. Sci. USA. 96:1999;7563-7568
7. Marnett L.J., Kalgutkar A.S. Trends Pharmacol. Sci. 20:1999;465-469
8. Dannhardt G., Kiefer W. Eur. J. Med. Chem. 36:2001;109-126
9. Marnett L.J., Kalgutkar A.S. Curr. Opin. Chem. Biol. 2:1998;482-490
10. Parsit P., Reindeau D. Annu. Rep. Med. Chem. 32:1997;211-220
11. Habeeb A.G., Parveen Rao P.N., Knaus E.D. J. Med. Chem. 44:2001;2921-2927
12. Almansa C., Alfon J., de Arriba A.F., Cavalcanti F.L., Escamilla I., Gomez L.A., Miralles A., Soliva R., Bartroli J., Carceller E., Merlos M., Rafanell J.G. J. Med. Chem. 46:2003;3463-3475
13. Jackson L.M., Hawkey C.J. Exp. Opin. Invest. Drugs. 8:1999;963-971
14. Allison M.C., Howatson A.G., Torrance C.J., Lee F.D., Russell R.I.G. N. Engl. J. Med. 327:1992;749-754
15. Hawkey C., Laine L., Simon T., Beaulieu A., Maldonado-Cocco J., Acevedo E., Shahane A., Quan H., Bolognese J., Mortensen E. Arthritis Rheum. 43:2000;370-377
16. Kalgutkar A.S., Marnett A.B., Crews B.C., Remmel R.P., Marnett L.J. J. Med. Chem. 43:2000;2860-2870
17. Duflos M., Nourrisson M.R., Brelet J., Courant J., Le Baut G., Grimaud N., Petit J.Y. Eur. J. Med. Chem. 36:2001;545-553
18. Kalgutkar A.S., Crews B.C., Rowlinson S.W., Garner C., Seibert K., Marnett L.J. Science. 280:1998;1268-1270
19. Mullican M.D., Wilson M.W., Connor D.T., Kostlan C.R., Shrier D.J., Dyer R.D. J. Med. Chem. 36:1993;1090-1099
20. Omar F.A., Mahfouz N.M., Rahman M.A. Eur. J. Med. Chem. 31:1996;819-825
21. Amir M., Oberoi A., Alam S. Indian J. Chem. 38B:1999;237-239
22. Tozkoparan B., Gokhan N., Aktay G., Yesilada E., Ertan M. Eur. J. Med. Chem. 35:2000;743-750
23. Palaska E., Sahin G., Kelicen P., Durlu N.T., Altinok G. Farmaco. 57:2002;101-107
24. Naito Y., Yoshikawa T., Yoshida N., Kondo M. Dig. Dis. Sci. 43:1998;30s-34s
25. Pohle T., Brzozowski T., Becker J.C., Vander Voort I.R., Markmann A., Konturek S.J., Moniczewski A., Domschke W., Konturek J.W. Aliment Pharmacol. Ther. 15:2001;677-687
26. Furniss B., Hannaford A.H., Smith P.W.G., Tatchell A.R. Vogel's Text book of Practical Organic Chemistry. fifth ed:1998;1077 Addison Wesley Longman, Inc
27. Winter C.A., Risley E.A., Nus G.N. Proc. Soc. Exp. Biol. 111:1962;544-547
28. Koster R., Anderson M., De Beer E.J. Fed. Proc. 18:1959;412
29. Cioli V., Putzolu S., Rossi V., Sorza Barcellona P., Corradino C. Toxicol. Appl. Pharmacol. 50:1979;283-289
30. Ohkawa H., Ohishi N., Yagi K. Anal. Biochem. 95:1979;351-358