Design and synthesis of 4,5-diphenyl-4-isoxazolines: Novel inhibitors of cyclooxygenase-2 with analgesic and antiinflammatory activity

Journal of Medicinal Chemistry

Volumn 44, Issue 18, 2001, Pages 2921-2927

  Habeeb, A G ^a   Praveen Rao, P N ^a   Knaus, E E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIMETHYL 4 (4 FLUOROPHENYL) 5 (4 METHYLSULFONYLPHENYL) 4 ISOXAZOLINE; 2,3 DIMETHYL 5 (4 METHYLSULFONYLPHENYL) 4 PHENYL 4 ISOXAZOLINE; 4,5 DIPHENYL 4 ISOXAZOLINE DERIVATIVE; ISOXAZOLINE DERIVATIVE; PHENYL GROUP; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; MOLECULAR MODEL; NONHUMAN; RAT;

ABDOMINAL MUSCLES; ANDROSTENOLS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; EDEMA; ISOENZYMES; MEMBRANE PROTEINS; MODELS, MOLECULAR; MUSCLE CONTRACTION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035974645     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0101287     Document Type: Article

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