Small-molecule inhibition of Aurora kinases triggers spindle checkpoint-independent apoptosis in cancer cells

Biochemical Pharmacology

Volumn 75, Issue 5, 2008, Pages 1027-1034

  Sun, Lei ^a   Li, Dengwen ^a   Dong, Xin ^a   Yu, Haiyang ^a   Dong, Jin Tang ^a   Zhang, Chuanmao ^b   Lu, Xianyu ^a   Zhou, Jun ^a  

^a NANKAI UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Apoptosis; Aurora kinases; Breast cancer; Mitosis; Spindle checkpoint

Indexed keywords

4 (4' BENZAMIDOANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4',6 DIAMIDINO 2 PHENYLINDOLE; ADENOSINE TRIPHOSPHATE; AURORA A KINASE; AURORA B KINASE; AURORA INHIBITOR; BETA ACTIN; BETA GALACTOSIDASE; BUB1 RELATED PROTEIN; CASPASE 3; ENZYME INHIBITOR; PACLITAXEL; PROTEIN MAD2; SMALL INTERFERING RNA; TAXANE DERIVATIVE; UNCLASSIFIED DRUG; VINCA ALKALOID;

ADENOVIRUS; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME ACTIVITY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; MOLECULAR MODEL; MULTINUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CALCIUM-BINDING PROTEINS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; MITOTIC SPINDLE APPARATUS; MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; QUINAZOLINES; REPRESSOR PROTEINS; RNA, SMALL INTERFERING; VINBLASTINE;

EID: 38949118291     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.11.007     Document Type: Article

References (29)

1. Carmena M., and Earnshaw W.C. The cellular geography of aurora kinases. Nat Rev Mol Cell Biol 4 (2003) 842-854
2. Fu J., Bian M., Jiang Q., and Zhang C. Roles of Aurora kinases in mitosis and tumorigenesis. Mol Cancer Res 5 (2007) 1-10
3. Marumoto T., Zhang D., and Saya H. Aurora-A-a guardian of poles. Nat Rev Cancer 5 (2005) 42-50
4. Adams R.R., Carmena M., and Earnshaw W.C. Chromosomal passengers and the (Aurora) ABCs of mitosis. Trends Cell Biol 11 (2001) 49-54
5. Giet R., Petretti C., and Prigent C. Aurora kinases, aneuploidy and cancer, a coincidence or a real link?. Trends Cell Biol 15 (2005) 241-250
6. Meraldi P., Honda R., and Nigg E.A. Aurora kinases link chromosome segregation and cell division to cancer susceptibility. Curr Opin Genet Dev 14 (2004) 29-36
7. Keen N., and Taylor S. Aurora-kinase inhibitors as anticancer agents. Nat Rev Cancer 4 (2004) 927-936
8. Ewart-Toland A., Briassouli P., de Koning J.P., Mao J.H., Yuan J., Chan F., et al. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat Genet 34 (2003) 403-412
9. Harrington E.A., Bebbington D., Moore J., Rasmussen R.K., Ajose-Adeogun A.O., Nakayama T., et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat Med 10 (2004) 262-267
10. Walter A.O., Seghezzi W., Korver W., Sheung J., and Lees E. The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation. Oncogene 19 (2000) 4906-4916
11. Zhou J., Yao J., and Joshi H.C. Attachment and tension in the spindle assembly checkpoint. J Cell Sci 115 (2002) 3547-3555
12. Musacchio A., and Salmon E.D. The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 8 (2007) 379-393
13. Kops G.J., Weaver B.A., and Cleveland D.W. On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer 5 (2005) 773-785
14. Liu M., Aneja R., Liu C., Sun L., Gao J., Wang H., et al. Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells. J Biol Chem 281 (2006) 18090-18097
15. Nowakowski J., Cronin C.N., McRee D.E., Knuth M.W., Nelson C.G., Pavletich N.P., et al. Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography. Structure 10 (2002) 1659-1667
16. Kick E.K., Roe D.C., Skillman A.G., Liu G., Ewing T.J., Sun Y., et al. Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin D. Chem Biol 4 (1997) 297-307
17. Zhou J., Liu M., Aneja R., Chandra R., Lage H., and Joshi H.C. Reversal of P-glycoprotein-mediated multidrug resistance in cancer cells by the c-Jun NH2-terminal kinase. Cancer Res 66 (2006) 445-452
18. Chou T.C., and Talalay P. Generalized equations for the analysis of inhibitions of Michaelis-Menten and higher-order kinetic systems with two or more mutually exclusive and nonexclusive inhibitors. Eur J Biochem 115 (1981) 207-216
19. Heron N.M., Anderson M., Blowers D.P., Breed J., Eden J.M., Green S., et al. SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors. Bioorg Med Chem Lett 16 (2006) 1320-1323
20. Fornari Jr. F.A., Jarvis D.W., Grant S., Orr M.S., Randolph J.K., White F.K., et al. Growth arrest and non-apoptotic cell death associated with the suppression of c-myc expression in MCF-7 breast tumor cells following acute exposure to doxorubicin. Biochem Pharmacol 51 (1996) 931-940
21. Mansilla S., Priebe W., and Portugal J. Mitotic catastrophe results in cell death by caspase-dependent and caspase-independent mechanisms. Cell Cycle 5 (2006) 53-60
22. Kasai T., Iwanaga Y., Iha H., and Jeang K.T. Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors. J Biol Chem 277 (2002) 5187-5193
23. Sudo T., Nitta M., Saya H., and Ueno N.T. Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint. Cancer Res 64 (2004) 2502-2508
24. Strebhardt K., and Ullrich A. Targeting polo-like kinase 1 for cancer therapy. Nat Rev Cancer 6 (2006) 321-330
25. Weaver B.A., and Cleveland D.W. Decoding the links between mitosis, cancer, and chemotherapy: the mitotic checkpoint, adaptation, and cell death. Cancer Cell 8 (2005) 7-12
26. Yamada H.Y., and Gorbsky G.J. Spindle checkpoint function and cellular sensitivity to antimitotic drugs. Mol Cancer Ther 5 (2006) 2963-2969
27. Wilson L., and Jordan M.A. New microtubule/tubulin-targeted anticancer drugs and novel chemotherapeutic strategies. J Chemother 16 Suppl. 4 (2004) 83-85
28. Jordan M.A., and Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer 4 (2004) 253-265
29. Zhou J., and Giannakakou P. Targeting microtubules for cancer chemotherapy. Curr Med Chem Anticancer Agents 5 (2005) 65-71