Modelling of taste receptor-ligands interactions

Agro Food Industry Hi-Tech

Volumn 18, Issue 6, 2007, Pages 14-16

  Morini, Gabriella ^a,b   Bassoli, Angela ^b  

^a UNIVERSITY OF GASTRONOMIC SCIENCES   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE COMPOUNDS; FUTURE PERSPECTIVES; HOMOLOGY MODELLING; MOLECULAR LEVELS; RECEPTOR PROTEINS; STATE OF THE ART; TASTE PERCEPTIONS; TASTE RECEPTORS;

FOOD TECHNOLOGY;

EID: 38849165236     PISSN: 17226996     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. G.L. Heck, S. Mierson et al., "Salt taste transduction occurs through an amilorlde-sensitive sodium transport pathway", Science, 223, pp. 403-405 (1984).
2. P. Avenet, B. Lindemann, "Amiloride-blockable sodium currents in isolated taste receptor cells", Journal of Membrane Biology, 105, pp. 245-255 (1988).
3. V. Lyall, G.L. Heck et al., "The mammalian amiloride-insensitive nonspecific salt taste receptor In a vanillold receptor-1 variant", Journal of Physiology, 558, pp. 147-159 (2004).
4. Y. Ishimaru, H. Inada et al., "Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor", Proc. Natl. Acad. Sci. U.S.A. 103, pp. 12569-12574 (2006).
5. A. Huang, X. Chen et al., "The cells and logic for mammalia sour taste detection", Nature, 442, pp. 934-938 (2006).
6. J. Chandrashekar, K.L. Mueller et al., "T2Rs function as bitter taste receptors", Cell, 100, pp. 703-711 (2000).
7. E. Adler, M.A. Hoon et al., "A novel family of mammalian taste receptors", Cell, 100, pp. 693-702 (2000).
8. H. Matsunami, J.P Montmayeur et al., "A family of candidate taste receptors in human and mouse", Nature, 404, pp. 601-604 (2000).
9. W. Meyerhof, "Elucidation of mammalian bitter taste", Rev. Physiol. Biochem. Pharmacol., 154, pp. 37-72 (2005).
10. X. Li, M. Inoue et al., "High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4", Mamm. Genome, 12, pp. 13-16 (2001).
11. J.P. Montmayeur, S.D. Liberles et al., "A candidate taste receptor gene near a sweet taste locus", Nat. Neurosci., 4, pp. 492-498, (2001).
12. G. Nelson, M.A. Hoon et al., "Mammalian sweet taste receptor", Cell, 106, pp. 381-390 (2001).
13. M. Max, Y.G. Shanker et al., "Tas1r3, encoding a new candidate taste receptor, is allelic to the sweetresponsiveness locus Sac", Nat. Genet., 28, pp. 58-63 (2001).
14. M. Kitagawa, Y. Kusakabe et al., "A. Molecular genetic identification of a candidate receptor gene for sweet taste", Biochem. Biophys. Res. Commun., 283, pp. 236-242 (2001).
15. E. Sainz, J.N. Korley et al., "Identification of a novel member of the T1R family of putative taste receptors", J. Neurochem., 77, pp. 896-903 (2001).
16. M.A. Hoon, E. Adler et al., "Putative mammalian taste receptors: a class of taste specific GPCRs with distinct topography selectivity", Cell, 96, pp. 541-551 (1999).
17. J. Chandrashekar, K.L. Mueller et al., "T2Rs functions as bitter taste receptors", Cell, 100, pp. 703-711 (2000).
18. X. Li, L. Staszewski et al., "Human receptors for sweet and umami taste", Proc. Natl. Acad. Sci. U.S.A. 99, pp. 4692-4696 (2002).
19. L. Miguet,Z. Ziding Zhang et al., "Computational studies of ligand-receptor interactions in bitter taste receptors", Journal of Receptors and Signal Transduction, 26, pp. 611-630 (2006).
20. W.B. Floriano, S. Hall et al., "Modeling the human PTC bitter-taste receptor interactions with bitter tastants", J. Mol. Model., 12(6), pp. 931-941 (2006).
21. C. McCabe, E.T. Rolls, "Umami: a delicious flavor formed by convergence of taste and olfactory pathways In the human brain", European Journal of Neurosciences, pp. 1855-1864 (2007).
22. R.S. Shallenberger, T.E. Aeree, "Molecular theory of sweet taste", Nature, 216, pp. 480-482 (1967).
23. L.B. Kier, "A molecular theory of sweet taste", J. Pharm. Sci., 61, pp. 1394-1397(1972).
24. J. Kamphuis, F. Lelj et al., "SAR of sweet molecules: conformational analysis of two hypersweet and two conformationally restricted aspartame analogues", Quant. Struc.-Act. Relat., 11, pp. 486-491 (1992).
25. T. Yamazaki, E. Benedetti et al., "Conformational requirements for sweet-tasting peptides and peptidomimetics", Angew. Chem., Int. Ed. Engl., 33, pp. 1437-1451 (1994).
26. J.M. Tinti, C. Nofre, "Why does a sweetener taste sweet? A new model", Sweeteners discovery, molecular design and chemoreception, American Chemical Society, Washington, DC, pp. 206-213 (1991).
27. A. Bassoli, M.G.B. Drew et al., "A general Pseudoreceptor Model for sweet compounds: a semi-quantitative prediction of binding aaffinity for sweet tasting molecules", J. Med. Chem., 45(20), pp. 4402-4409 (2002).
28. H. Xu, L. Staszewski et al., "Different functional roles of T1R subunits in the heteromeric taste receptors", Proc. Natl. Acad. Sci. U.S.A., 101, pp. 14258-14263 (2004).
29. P. Jiang, M. Cui et al., "Lactisole interacts with the transmembrane domain of human T1R3 to inhibit sweet taste", Journal of Biological Chemistry, 280, pp. 15238-15246 (2005).
30. M. Winning, B. Bufe et al., "Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivlty towards lactisole of the rat sweet taste receptor", BMC Neuroscience,6, p. 1-7 (2005).
31. P. Jiang, M. Cui et al., " Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3", Journal of Biological Chemistry, 280, pp. 342904-34305 (2005).
32. N. Kunishima, Y. Shimada et al., "Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor", Nature, 407, pp. 971-977 (2000).
33. D. Tsuchiya, N. Kunishima et al., "Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+", Proc. Natl. Acad. Sci. U.S.A., 99, pp. 2660-2665 (2002).
34. D.E. Walters, "Homology-based model of the extracellular domain of the taste receptor T1R3", Pure Appl. Chem., 74, pp. 1117-1123 (2002).
35. PA. Temussi, "Why are sweet proteins sweet? Interaction of brazzeln, monellin and thaumatin with the T1R2_T1R3 receptor", FEBS Lett., 526, pp. 1-3 (2002).
36. G. Morini, A. Bassoli et al., "From small sweeteners to sweet proteins: anatomy of the binding sites of the human T1R2-T1R3 receptor", Journal of Medicinal Chemistry, 48, pp. 5520-5529 (2005).
37. A De Capua, M. Goodman et al., "Conformational analysis of aspartame-based sweeteners by NMR spectroscopy, molecular dynamics simulations and X-ray diffraction studies", Chem.BioChem, 7, pp. 377-387 (2006).
38. Y. Nie, S. Vigues et al., "Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli", Current Biology, 15(21), pp. 1948-1952 (2005).
39. Y. Nie, J.R. Hobbs et al., "Expression and purification of functional ligand-binding domains of T1R3 taste receptors", Chem. Sens., 31(6), pp. 505-513 (2006).
40. V. Galindo-Cuspinera, M. Winnig et al., "A TAS1R receptor based explanation of sweet water taste", Nature, 18, 441(7091), pp. 354-357 (2006).