Conformation analysis of aspartame-based sweeteners by NMR spectroscopy, molecular dynamics simulations, and X-ray diffraction studies

ChemBioChem

Volumn 7, Issue 2, 2006, Pages 377-387

  De Capua, Antonia ^b,c   Goodman, Murray ^b   Amino, Yusuke ^d   Saviano, Michele ^a   Benedetti, Ettore ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

^d AJINOMOTO CO INC   (Japan)

Author keywords

Artificial sweeteners; Conformation analysis; Molecular dynamics; Peptides; Structure property relationships

Indexed keywords

AMPHOLYTE; ASPARTAME DERIVATIVE; LIGAND; N (3,3 DIMETHYLBUTYL) ALPHA ASPARTYL 1 METHYL 2 HYDROXY 4 PHENYLHEXYLAMIDE; N [3 (3 HYDROXY 4 METHOXYPHENYL) 3 METHYLBUTYL] ALPHA ASPARTYL 1 METHYL 2 HYDROXY 4 PHENYLHEXYLAMIDE; N [3 (3 HYDROXY 4 METHOXYPHENYL) 3 METHYLBUTYL] ALPHA ASPARTYL 4 CYAN PHENYLALANINE 1 METHYL ESTER; N [3 (3 HYDROXY 4 METHOXYPHENYL) 3 METHYLBUTYL] ALPHA ASPARTYL BETA CYCLOHEXYLALANINE 1 METHYL ESTER; N [3 (3 HYDROXY 4 METHOXYPHENYL) 3 METHYLBUTYL] ALPHA ASPARTYL S TERT BUTYL CYSTEINE 1 METHYL ESTER; N [3 (3 HYDROXY 4 METHOXYPHENYL)PROPYL] ALPHA ASPARTYL 1 METHYL 2 HYDROXY 4 PHENYLHEXYLAMIDE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; SUCROSE; SWEETENING AGENT; UNCLASSIFIED DRUG;

ALKYLATION; ANALYTIC METHOD; ARTICLE; BINDING SITE; COMPUTER SIMULATION; CONFORMATION; CRYSTAL STRUCTURE; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SWEETNESS; X RAY DIFFRACTION;

ASPARTAME; COMPUTER SIMULATION; HYDROGEN BONDING; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SWEETENING AGENTS; X-RAY DIFFRACTION;

EID: 32344444694     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbic.200500332     Document Type: Article

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