Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway-dependent upregulation of HIF-1α expression and HIF-1 DNA-binding activity

Journal of Cellular Biochemistry

Volumn 103, Issue 2, 2008, Pages 564-575

  Li, Zhu ^a,c   Ya, Ke ^b,c   Xiao Mei, Wu ^a   Lei, Yang ^c   Yang, Lu ^a,c   Qian, Zhong Ming ^a,c  

^a NANTONG UNIVERSITY   (China)

^b and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^c HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Activation of p42 p44 (ERK) MAPK pathway; Extracellular signal regulated kinase (ERK); Ginkgolides; HIF 1 expression and modification; Neuroprotection

Indexed keywords

COBALT CHLORIDE; FLAVONE; GINKGO BILOBA EXTRACT; GINKGOLIDE DERIVATIVE; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P42; PROTEIN P44;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL HYPOXIA; CELL METABOLISM; CELL PROTECTION; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVATION; GINKGO BILOBA; HOMEOSTASIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; UPREGULATION;

ANIMALS; CELL HYPOXIA; COBALT; DNA; ENZYME INDUCTION; FLAVONOIDS; GENISTEIN; GINKGOLIDES; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURONS; NEUROPROTECTIVE AGENTS; PC12 CELLS; PLANT EXTRACTS; RATS; RNA, MESSENGER;

GINKGO BILOBA; GINKGOACEAE;

EID: 38649120509     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21427     Document Type: Article

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