Scaffolding proteins in G-protein signaling

Journal of Molecular Signaling

Volumn 2, Issue , 2007, Pages

  Andreeva, Alexandra V ^a   Kutuzov, Mikhail A ^a   Voyno Yasenetskaya, Tatyana A ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIA;

EID: 38549158532     PISSN: None     EISSN: 17502187     Source Type: Journal    
DOI: 10.1186/1750-2187-2-13     Document Type: Review

References (90)

1. Faux MC Scott JD Molecular glue: Kinase anchoring and scaffold proteins Cell 1996, 85:9-12. 10.1016/S0092-8674(00)81075-2 8620541
2. Burack WR Shaw AS Signal transduction: Hanging on a scaffold Curr Opin Cell Biol 2000, 12(2):211-216. 10.1016/S0955-0674(99)00078-2 10712921
3. Hall RA Lefkowitz RJ Regulation of G protein-coupled receptor signaling by scaffold proteins Circ Res 2002, 91(8):672-680. 10.1161/ 01.RES.0000037000.74258.03 12386143
4. McCudden CR Hains MD Kimple RJ Siderovski DP Willard FS G-protein signaling: Back to the future Cell Mol Life Sci 2005, 62(5):551-577. 10.1007/s00018-004-4462-3 15747061
5. Oldham WM Hamm HE Structural basis of function in heterotrimeric G proteins Q Rev Biophys 2006, 39(2):117-166. 10.1017/S0033583506004306 16923326
6. Patel TB Single transmembrane spanning heterotrimeric G protein-coupled receptors and their signaling cascades Pharmacol Rev 2004, 56(3):371-385. 10.1124/pr.56.3.4 15317909
7. Hampoelz B Knoblich JA Heterotrimeric G proteins: New tricks for an old dog Cell 2004, 119(4):453-456. 10.1016/j.cell.2004.10.025 15537535
8. Willars GB Mammalian RGS proteins: Multifunctional regulators of cellular signalling Semin Cell Dev Biol 2006, 17(3):363-376. 10.1016/ j.semcdb.2006.03.005 16687250
9. Xie GX Palmer PP How regulators of G protein signaling achieve selective regulation J Mol Biol 2007, 366(2):349-365. 10.1016/j.jmb.2006.11.045 17173929
10. Blumer JB Smrcka AV Lanier SM Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling Pharmacol Ther 2007, 113(3):488-506. 10.1016/j.pharmthera.2006.11.001 17240454
11. Cismowski MJ Non-receptor activators of heterotrimeric G-protein signaling (AGS proteins) Semin Cell Dev Biol 2006, 17(3):334-344. 10.1016/j.semcdb.2006.03.003 16621626
12. Colledge M Scott JD AKAPs: From structure to function Trends Cell Biol 1999, 9(6):216-221. 10.1016/S0962-8924(99)01558-5 10354567
13. Tasken K Aandahl EM Localized effects of cAMP mediated by distinct routes of protein kinase A Physiol Rev 2004, 84(1):137-167. 10.1152/ physrev.00021.2003 14715913
14. Carr DW Stofkohahn RE Fraser IDC Bishop SM Acott TS Brennan RG Scott JD Interaction of the Regulatory Subunit (RII) of cAMP-Dependent Protein-Kinase with RII-Anchoring Proteins Occurs through an Amphipathic Helix Binding Motif J Biol Chem 199,1 266(22):14188-14192. 1860836
15. Newlon MG Roy M Morikis D Carr DW Westphal R Scott JD Jennings PA A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes Embo J 2001, 20(7):1651-1662. 145475 11285229 10.1093/emboj/20.7.1651
16. Alto N Carlisle Michel JJ Dodge KL Langeberg LK Scott JD Intracellular targeting of protein kinases and phosphatases Diabetes 2002, 51(Suppl 3):S385-8. 10.2337/diabetes.51.2007.S385 12475780
17. Dell'Acqua ML Faux MC Thorburn J Thorburn A Scott JD Membrane-targeting sequences on AKAP79 bind phosphatidylinositol-4,5-bisphosphate Embo J 1998, 17(8):2246-2260. 1170569 9545238 10.1093/emboj/17.8.2246
18. Kapiloff MS Schillace RV Westphal AM Scott JD mAKAP: An A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes J Cell Sci 1999, 112(16):2725-2736. 10413680
19. Westphal RS Coffee RL Jr. Marotta A Pelech SL Wadzinski BE Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A J Biol Chem 1999, 274(2):687-692. 10.1074/jbc.274.2.687 9873003
20. Westphal RS Soderling SH Alto NM Langeberg LK Scott JD Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold Embo J 2000, 19(17):4589-4600. 302050 10970852 10.1093/emboj/19.17.4589
21. Dodge KL Khouangsathiene S Kapiloff MS Mouton R Hill EV Houslay MD Langeberg LK Scott JD mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module Embo J 2001, 20(8):1921-1930. 125429 11296225 10.1093/emboj/20.8.1921
22. Schillace RV Scott JD Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220 Curr Biol 1999, 9(6):321-324. 10.1016/S0960-9822(99)80141-9 10209101
23. Tasken KA Collas P Kemmners WA Witczak O Conti M Tasken K Phosphodiesterase 4D and protein kinase A type II constitute a signaling unit in the centrosomal area J Biol Chem 2001, 276(25):21999-22002. 10.1074/jbc.C000911200 11285255
24. Carnegie GK Smith FD McConnachie G Langeberg LK Scott JD AKAP-Lbc nucleates a protein kinase D activation scaffold Mol Cell 2004, 15(6):889-899. 10.1016/j.molcel.2004.09.015 15383279
25. Wong W Scott JD AKAP signalling complexes: Focal points in space and time Nat Rev Mol Cell Biol 2004, 5(12):959-970. 10.1038/nrm1527 15573134
26. Appert-Collin A Baisamy L Diviani D Regulation of G protein-coupled receptor signaling by A-kinase anchoring proteins J Recept Signal Transduct Res 2006, 26(5-6):631-646. 10.1080/10799890600923211 17118802
27. Klussmann E Pepperle B Edemir B Bouchaala C Maric K Rosenthal W The protein kinase A anchoring protein Ht31, the Rho GEF factor proto-Lbc and the breast cancer auxillary protein Brx are encoded by a single gene N-S Arch Pharmacol 2001, 363(4):R66-R66.
28. Diviani D Soderling J Scott JD AKAP-Lbc anchors protein kinase A and nucleates G alpha(12)-selective Rho-mediated stress fiber formation J Biol Chem 2001, 276(47):44247-44257. 10.1074/jbc.M106629200 11546812
29. Diviani D Baisamy L Appert-Collin A AKAP-Lbc: A molecular scaffold for the integration of cyclic AMP and Rho transduction pathways Eur J Cell Biol 2006. 16460837
30. Appert-Collin A Cotecchia S Nenniger-Tosato M Pedrazzini T Diviani D The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy Proc Natl Acad Sci U S A 2007, 104(24):10140-10145. 10.1073/pnas.0701099104 17537920
31. Diviani D Abuin L Cotecchia S Pansier L Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex Embo J 2004, 23(14):2811-2820. 514948 15229649 10.1038/sj.emboj.7600287
32. Jin J Smith FD Stark C Wells CD Fawcett JP Kulkarni S Metalnikov P O'Donnell P Taylor P Taylor L Zougman A Woodgett JR Langeberg LK Scott JD Pawson T Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization Current Biology 2004, 14(16):1436-1450. 10.1016/ j.cub.2004.07.051 15324660
33. Baisamy L Jurisch N Diviani D Leucine zipper-mediated homo-oligomerization regulates the Rho-GEF activity of AKAP-Lbc J Biol Chem 2005, 280(15):15405-15412. 10.1074/jbc.M414440200 15691829
34. Niu JX Vaiskunaite R Suzuki N Kozasa T Carr DW Dulin N Voyno-Yasenetskaya TA Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation Current Biology 2001, 11(21):1686-1690. 10.1016/ S0960-9822(01)00530-9 11696326
35. Carr DW Fujita A Stentz CL Liberty GA Olson GE Narumiya S Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA J Biol Chem 2001, 276(20):17332-17338. 10.1074/jbc.M011252200 11278869
36. Fujita A Nakamura K Kato T Watanabe N Ishizaki T Kimura K Mizoguchi A Narumiya S Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella J Cell Sci 2000, 113(1):103-112. 10591629
37. Suzuki M Furuuchi K Tonoki H Ozaki T Iizuka K Murakami T Kitabatake A Kawaguchi H A novel A-kinase anchoring protein in the heart interacts with G alpha 13 Jpn Heart J 1999, 40(2):199-208. 10.1536/jhj.40.199 10420881
38. Chen L Kass RS Dual roles of the A kinase-anchoring protein Yotiao in the modulation of a cardiac potassium channel: A passive adaptor versus an active regulator Eur J Cell Biol 2006, 85(7):623-626. 10.1016/ j.ejcb.2006.03.002 16647783
39. Larocca MC Jin M Goldenring JR AKAP350 modulates microtubule dynamics Eur J Cell Biol 2006, 85(7):611-619. 10.1016/j.ejcb.2005.10.008 16356588
40. Murthy AE Bernards A Church D Wasmuth J Gusella JF Identification and characterization of two novel tetratricopeptide repeat-containing genes DNA Cell Biol 1996, 15(9):727-735. 8836031
41. Wu SJ Liu FH Hu SM Wang C Different combinations of the heat-shock cognate protein 70 (hsc70) C-terminal functional groups are utilized to interact with distinct tetratricopeptide repeat-containing proteins Biochem J 2001, 359:419-426. 1222162 11583590 10.1042/0264-6021:3590419
42. Oh WK Song J Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation Mol Cells 2003, 16(1):84-91. 14503850
43. Marty C Browning DD Ye RD Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras Mol Cell Biol 2003, 23(11):3847-3858. 155206 12748287 10.1128/MCB.23.11.3847-3858.2003
44. Du QS Taylor L Compton DA Macara IG LGN blocks the ability of NuMA to bind and stabilize microtubules: A mechanism for mitotic spindle assembly regulation Current Biology 2002, 12(22):1928-1933. 10.1016/ S0960-9822(02)01298-8 12445386
45. Du QS Macara IG Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins Cell 2004, 119(4):503-516. 10.1016/ j.cell.2004.10.028 15537540
46. Yamaguchi Y Katoh H Mori K Negishi M G alpha(12) and G alpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity Current Biology 2002, 12(15):1353-1358. 10.1016/ S0960-9822(02)01034-5 12176367
47. Wall MA Coleman DE Lee E Iniguezlluhi JA Posner BA Gilman AG Sprang SR The Structure of the G-Protein Heterotrimer G(I-Alpha-1)Beta(1)Gamma(2) Cell 1995, 83(6):1047-1058. 10.1016/0092-8674(95)90220-1 8521505
48. Pitcher JA Inglese J Higgins JB Arriza JL Casey PJ Kim C Benovic JL Kwatra MM Caron MG Lefkowitz RJ Role of Beta-Gamma-Subunits of G-Proteins in Targeting the Beta-Adrenergic-Receptor Kinase to Membrane-Bound Receptors Science 1992, 257(5074):1264-1267. 10.1126/ science.1325672 1325672
49. Chen S Dell EJ Lin F Sai J Hamm HE RACK1 regulates specific functions of Gbetagamma J Biol Chem 2004, 279(17):17861-17868. 10.1074/jbc.M313727200 14963031
50. Chen S Spiegelberg BD Lin F Dell EJ Hamm HE Interaction of Gbetagamma with RACK1 and other WD40 repeat proteins J Mol Cell Cardiol 2004, 37(2):399-406. 10.1016/j.yjmcc.2004.04.019 15276010
51. Dell EJ Connor J Chen S Stebbins EG Skiba NP Mochly-Rosen D Hamm HE The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins J Biol Chem 2002, 277(51):49888-49895. 10.1074/jbc.M202755200 12359736
52. Chen S Lin F Hamm HE RACK1 binds to a signal transfer region of G betagamma and inhibits phospholipase C beta2 activation J Biol Chem 2005, 280(39):33445-33452. 10.1074/jbc.M505422200 16051595
53. Thornton C Tang KC Phamluong K Luong K Vagts A Nikanjam D Yaka R Ron D Spatial and temporal regulation of RACK1 function and N-methyl-D-aspartate receptor activity through WD40 motif-mediated dimerization J Biol Chem 2004, 279(30):31357-31364. 10.1074/ jbc.M402316200 15140893
54. Adams J Kelso R Cooley L The kelch repeat superfamily of proteins: propellers of cell function Trends Cell Biol 2000, 10(1):17-24. 10.1016/ S0962-8924(99)01673-6 10603472
55. Harashima T Heitman J The G alpha protein GPa2 controls yeast differentiation by interacting with Kelch repeat proteins that mimic G beta subunits Molecular Cell 2002, 10(1):163-173. 10.1016/ S1097-2765(02)00569-5 12150916
56. Harashima T Heitman J G alpha subunit Gpa2 recruits kelch repeat subunits that inhibit receptor-G protein coupling during cAMP-induced dimorphic transitions in Saccharomyces cerevisiae Mol Biol Cell 2005, 16(10):4557-4571. 1237064 16030250 10.1091/mbc.E05-05-0403
57. Bretscher A Edwards K Fehon RG ERM proteins and merlin: Integrators at the cell cortex Nat Rev Mol Cell Bio 2002, 3(8):586-599. 10.1038/nrm882
58. Polesello C Payre F Small is beautiful: What flies tell us about ERM protein function in development Trends Cell Biol 2004, 14(6):294-302. 10.1016/j.tcb.2004.04.003 15183186
59. Khanna C Wan XL Bose S Cassaday R Olomu O Mendoza A Yeung C Gorlick R Hewitt SM Helman LJ The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis Nat Med 2004, 10(2):182-186. 10.1038/nm982 14704791
60. Yu YL Khan J Khanna C Helman L Meltzer PS Merlino G Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators Nat Med 2004, 10(2):175-181. 10.1038/nm966 14704789
61. Vaiskunaite R Adarichev V Furthmayr H Kozasa T Gudkov A Voyno-Yasenetskaya TA Conformational activation of radixin by G(13) protein alpha subunit J Biol Chem 2000, 275(34):26206-26212. 10.1074/ jbc.M001863200 10816569
62. Liu GQ Voyno-Yasenetskaya TA Radixin stimulates Rac1 and Ca2+/ calmodulin-dependent kinase, CaMKII - Cross-talk with G alpha(13) signaling J Biol Chem 2005, 280(47):39042-39049. 10.1074/jbc.M504341200 16186118
63. Weinman EJ Hall RA Friedman PA Liu-Chen LY Shenolikar S The Association of NHERF Adaptor Proteins with G Protein-Coupled Receptors and Receptor Tyrosine Kinases Annu Rev Physiol 2006, 68:491-505. 10.1146/ annurev.physiol.68.040104.131050 16460281
64. Rochdi MD Watier V La Madeleine C Nakata H Kozasa T Parent JL Regulation of GTP-binding protein alpha q (Galpha q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50) J Biol Chem 2002, 277(43):40751-40759. 10.1074/jbc.M207910200 12193606
65. Gage RM Matveeva EA Whiteheart SW von Zastrow M Type I PDZ ligands are sufficient to promote rapid recycling of G protein-coupled receptors independent of binding to N-ethylmaleimide-sensitive factor J Biol Chem 2005, 280(5):3305-3313. 10.1074/jbc.M406934200 15548537
66. Li JG Chen CG Liu-Chen LY Ezrin-radixin-moesin-binding phosphoprotein-50/ Na+/H+ exchanger regulatory factor (EBP50/NHERF) blocks U50,488H-induced down-regulation of the human kappa opioid receptor by enhancing its recycling rate J Biol Chem 2002, 277(30):7545-27552. 10.1074/ jbc.M200058200 12004055
67. Rochdi MD Parent JL G alpha(q)-coupled receptor internalization specifically induced by G alpha(q) signaling - Regulation by EBP50 J Biol Chem 2003, 278(20):17827-17837. 10.1074/jbc.M210319200 12626493
68. Liedtke CM Yun CH Kyle N Wang D Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor J Biol Chem 2002, 277(25):22925-22933. 10.1074/jbc.M201917200 11956211
69. Zhu D Kosik KS Meigs TE Yanamadala V Denker BM Galpha12 directly interacts with PP2A: Evidence for Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau J Biol Chem 2004, 279(53):54983-54986. 10.1074/jbc.C400508200 15525651
70. Zhu D Tate RI Ruediger R Meigs TE Denker BM Domains necessary for Galpha12 binding and stimulation of protein phosphatase-2A (PP2A): Is Galpha12 a novel regulatory subunit of PP2A? Mol Pharmacol 2007, 71(5):1268-1276. 10.1124/mol.106.033555 17303700
71. Lubert EJ Hong Y Sarge KD Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: Evidence for a heterotrimeric form of protein phosphatase 5 J Biol Chem 2001, 276(42):38582-38587. 10.1074/jbc.M106906200 11504734
72. Dhanasekaran DN Kashef K Lee CM Xu H Reddy EP Scaffold proteins of MAP-kinase modules Oncogene 2007, 26(22):3185-3202. 10.1038/ sj.onc.1210411 17496915
73. Elion EA The Ste5p scaffold J Cell Sci 2001, 114(22):3967-3978. 11739629
74. Morrison DK Davis RJ Regulation of MAP kinase signaling modules by scaffold proteins in mammals Annu Rev Cell Dev Bi 2003, 19:91-118. 10.1146/annurev.cellbio.19.111401.091942
75. Whitmarsh AJ Cavanagh L Tournier C Yasuda L Davis RJ Mammalian scaffold complex that selectively mediates MAP kinase activation Science 1998, 281(5383):1671-1674. 10.1126/science.281.5383.1671 9733513
76. Claperon A Therrien M KSR and CNK: Two scaffolds regulating RAS-mediated RAF activation Oncogene 2007, 26(22):3143-3158. 10.1038/sj.onc.1210408 17496912
77. Fusello AM Mandik-Nayak L Shih F Lewis RE Allen PM Shaw AS The MAPK scaffold kinase suppressor of Ras is involved in ERK activation by stress and proinflammatory cytokines and induction of arthritis J Immunol 2006, 177(9):6152-6158. 17056543
78. Shalin SC Hernandez CM Dougherty MK Morrison DK Sweatt JD Kinase suppressor of Ras1 compartmentalizes hippocampal signal transduction and subserves synaptic plasticity and memory formation Neuron 2006, 50(5):765-779. 10.1016/j.neuron.2006.04.029 16731514
79. Ritt DA Zhou M Conrads TP Veenstra TD Copeland TD Morrison DK CK2 is a component of the KSR1 scaffold complex that contributes to Raf kinase activation Curr Biol 2007, 17(2):179-184. 10.1016/j.cub.2006.11.061 17174095
80. Bell B Xing HM Yan K Gautam N Muslin AJ KSR-1 binds to G-protein beta gamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation J Biol Chem 1999, 274(12):7982-7986. 10.1074/ jbc.274.12.7982 10075696
81. Lee CM Onesime D Reddy CD Dhanasekaran N Reddy EP JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors Proc Natl Acad Sci U S A 2002, 99(22):14189-14194. 137859 12391307 10.1073/pnas.232310199
82. Nguyen Q Lee CM Le A Reddy EP JLP associates with kinesin light chain 1 through a novel leucine zipper-like domain J Biol Chem 2005, 280(34):30185-30191. 10.1074/jbc.M505499200 15987681
83. Kashef K Lee CM Ha JH Reddy EP Dhanasekaran DN JNK-interacting leucine zipper protein is a novel scaffolding protein in the Galpha13 signaling pathway Biochemistry 2005, 44(43):14090-14096. 10.1021/bi050604l 16245925
84. Kutuzov MA Andreeva AV Voyno-Yasenetskaya TA Regulation of apoptosis signal-regulating kinase 1 degradation by G{alpha}13 Faseb J 2007, 21:3727-36. 17595347 10.1096/fj.06-8029com
85. Kashef K Xu H Reddy EP Dhanasekaran DN Endodermal differentiation of murine embryonic carcinoma cells by retinoic acid requires JLP, a JNK-scaffolding protein J Cell Biochem 2006, 98(4):715-722. 10.1002/ jcb.20930 16619266
86. Jagadish N Rana R Selvi R Mishra D Garg M Yadav S Herr JC Okumura K Hasegawa A Koyama K Suri A Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein Biochem J 2005, 389(Pt 1):73-82. 1184539 15693750
87. Kelkar N Standen CL Davis RJ Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways Mol Cell Biol 2005, 25(7):2733-2743. 1061651 15767678 10.1128/ MCB.25.7.2733-2743.2005
88. Matheny SA Chen C Kortum RL Razidlo GL Lewis RE White MA Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP Nature 2004, 427(6971):256-260. 10.1038/nature02237 14724641
89. Dard N Peter M Scaffold proteins in MAP kinase signaling: More than simple passive activating platforms Bioessays 2006, 28(2):146-156. 10.1002/bies.20351 16435292
90. Rodriguez-Munoz M Bermudez D Sanchez-Blazquez P Garzon J Sumoylated RGS-Rz proteins act as scaffolds for Mu-opioid receptors and G-protein complexes in mouse brain Neuropsychopharmacology 2007, 32(4):842-850. 10.1038/sj.npp.1301184 16900103