Enhanced apoptosis, oxidative stress and mitochondrial dysfunction in lymphocytes as potential biomarkers for Alzheimer's disease

Journal of Neural Transmission, Supplementa

Volumn , Issue 72, 2007, Pages 207-215

  Leuner, K ^a   Pantel, J ^a   Frey, C ^a   Schindowski, K ^a   Schulz, K ^a   Wegat, T ^a   Maurer, K ^a   Eckert, A ^b   Muller W E ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Alzheimer's disease; biomarker; Lymphocytes

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BIOLOGICAL MARKER; CELL SURFACE RECEPTOR; OLIGOPEPTIDE; PROTEASE NEXINS; PS1 ANTIGEN; UNCLASSIFIED DRUG;

AGE; AGED; ALZHEIMER DISEASE; ANIMAL; APOPTOSIS; BRAIN; CELL STRAIN; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENETICS; HUMAN; LYMPHOCYTE; MENTAL HEALTH; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE CELL; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; REVIEW; RISK FACTOR; SYNAPSE;

AGE FACTORS; AGED; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; BRAIN; DNA MUTATIONAL ANALYSIS; HUMANS; LYMPHOCYTES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MENTAL STATUS SCHEDULE; MITOCHONDRIAL DISEASES; NEURONS; OLIGOPEPTIDES; OXIDATIVE STRESS; PC12 CELLS; RATS; RECEPTORS, CELL SURFACE; RISK FACTORS; SYNAPSES;

EID: 38449101620     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-211-73574-9_27     Document Type: Review

References (73)

1. 2 and kainic acid: implications for Alzheimer's disease. J Neurochem 96:1322-1335
2. Aksenov MY, Tucker HM, Nair P, Aksenova MV, Butterfield DA, Estus S, Markesbery WR (1998) The expression of key oxidative stress-handling genes in different brain regions in Alzheimer's disease. J Mol Neurosci 11:151-164
3. Anandatheerthavarada HK, Biswas G, Robin MA, Avadhani NG (2003) Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells. J Cell Biol 161:41-54
4. Beal MF (2000) Energetics in the pathogenesis of neurodegenerative diseases. Trends Neurosci 23:298-304
5. Blanchard V, Moussaoui S, Czech C, Touchet N, Bonici B, Planche M, Canton T, Jedidi I, Gohin M, Wirths O, Bayer TA, Langui D, Duyckaerts C, Tremp G, Pradier L (2003) Time sequence of maturation of dystrophic neurites associated with A beta deposits in APP/PS1 transgenic mice. Exp Neurol 184:247-263
6. Blass JP, Gibson GE, Hoyer S (2002) The role of the metabolic lesion in Alzheimer's disease. J Alzheimers Dis 4:225-232
7. Borroni B, Di Luca M, Padovani A (2006) Predicting Alzheimer dementia in mild cognitive impairment patients. Are biomarkers useful? Eur J Pharmacol 545:73-80
8. Bosetti F, Brizzi F, Barogi S, Mancuso M, Siciliano G, Tendi EA, Murri L, Rapoport SI, Solaini G (2002) Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease. Neurobiol Aging 23:371-376
9. Bubber P, Haroutunian V, Fisch G, Blass JP, Gibson GE (2005) Mitochondrial abnormalities in Alzheimer brain: mechanistic implications. Ann Neurol 57:695-703
10. Butterfield DA, Aksenov M, Markesbery WR (2001) Altered expression of cytochrome c oxidase and NADH dehydrogenase in Alzheimer's disease brain: implications for oxidative stress and neurodegeneration. J Neurochem 77:16
11. Cardoso SM, Proenca MT, Santos S, Santana I, Oliveira CR (2004) Cytochrome c oxidase is decreased in Alzheimer's disease platelets. Neurobiol Aging 25:105-110
12. Casademont J, Miro O, Rodriguez-Santiago B, Viedma P, Blesa R, Cardellach F (2003) Cholinesterase inhibitor rivastigmine enhance the mitochondrial electron transport chain in lymphocytes of patients with Alzheimer's disease. J Neurol Sci 206:23-26
13. Cecchi C, Fiorillo C, Sorbi S, Latorraca S, Nacmias B, Bagnoli S, Nassi P, Liguri G (2002) Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer's patients. Free Radic Biol Med 33:1372-1379
14. Cecchi C, Latorraca S, Sorbi S, Iantomasi T, Favilli F, Vincenzini MT, Liguri G (1999) Gluthatione level is altered in lymphoblasts from patients with familial Alzheimer's disease. Neurosci Lett 275:152-154
15. Culmsee C, Landshamer S (2006) Molecular insights into mechanisms of the cell death program: role in the progression of neurodegenerative disorders. Curr Alzheimer Res 3:269-283
16. David DC, Hauptmann S, Scherping I, Schuessel K, Keil U, Rizzu P, Ravid R, Drose S, Brandt U, Muller WE, Eckert A, Gotz J (2005) Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L Tau transgenic mice. J Biol Chem 280:23802-23814
17. De Leo ME, Borrello S, Passantino M, Palazzotti B, Mordente A, Daniele A, Filippini V, Galeotti T, Masullo C (1998) Oxidative stress and overexpression of manganese superoxide dismutase in patients with Alzheimer's disease. Neurosci Lett 250:173-176
18. Deshpande A, Mina E, Glabe C, Busciglio J (2006) Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons. J Neurosci 26:6011-6018
19. Drouet M, Lauthier F, Charmes JP, Sauvage P, Ratinaud MH (1999) Ageassociated changes in mitochondrial parameters on peripheral human lymphocytes. Exp Gerontol 34:843-852
20. Eckert A, Cotman CW, Zerfass R, Hennerici M, Muller WE (1998) Lymphocytes as cell model to study apoptosis in Alzheimer's disease: vulnerability to programmed cell death appears to be altered. J Neural Transm 259-267
21. Eckert A, Oster M, Zerfass R, Hennerici M, Muller WE (2001a) Elevated levels of fragmented DNA nucleosomes in native and activated lymphocytes indicate an enhanced sensitivity to apoptosis in sporadic Alzheimer's disease - Specific differences to vascular dementia. Dement Geriatr Cogn 12:98-105
22. Eckert A, Schindowski K, Leutner S, Luckhaus C, Touchet N, Czech C, Muller WE (2001b) Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice. Neurobiol Dis 8:331-342
23. Eckert A, Steiner B, Marques C, Leutz S, Romig H, Haass C, Muller WE (2001d) Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation. J Neurosci Res 64:183-192
24. Eckert A, Keil U, Marques CA, Bonert A, Frey C, Schussel K, Muller WE (2003) Mitochondrial dysfunction, apoptotic cell death, and Alzheimer's disease. Biochem Pharmacol 66:1627-1634
25. Ferris SH, Yan B (2003) Differential diagnosis and clinical assessment of patients with severe Alzheimer disease. Alz Dis Assoc Dis 17 Suppl 3: S92-S95
26. Frey C, Bonert A, Kratzsch T, Rexroth G, Rosch W, Muller-Spahn F, Maurer K, Muller WE, Eckert A (2006) Apolipoprotein E epsilon 4 is associated with an increased vulnerability to cell death in Alzheimer's disease. J Neural Transm 113:1753-1761
27. Frisoni GB, Padovani A, Wahlund LO (2004) The predementia diagnosis of Alzheimer disease. Alz Dis Assoc Dis 18:51-53
28. Guo Q, Sopher BL, Furukawa K, Pham DG, Robinson N, Martin GM, Mattson MP (1997) Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: Involvement of calcium and oxyradicals. J Neurosci 17:4212-4222
29. Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Muller WE (2006) Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease. Exp Gerontol 41:668-673
30. Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PLR, Jones PK, Petersen RB, Perry G, Smith MA (2001) Mitochondrial abnormalities in Alzheimer's disease. J Neurosci 21:3017-3023
31. Hoyer S (2000) Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an update. Exp Gerontol 35:1363-1372
32. Huang HM, Fowler C, Xu H, Zhang H, Gibson GE (2005) Mitochondrial function in fibroblasts with aging in culture and/or Alzheimer's disease. Neurobiol Aging 26:839-848
33. Huang YD (2006) Apolipoprotein E and Alzheimer disease. Neurology 66: S79-S85
34. Ilic TV, Jovanovic M, Jovicic A, Tomovic M (1999) Oxidative stress indicators are elevated in de novo Parkinson's disease patients. Funct Neurol 14:141-147
35. Jellinger KA (2006) Challenges in neuronal apoptosis. Curr Alzheimer Res 3:377-391
36. Kadioglu E, Sardas S, Aslan S, Isik E, Esat KA (2004) Detection of oxidative DNA damage in lymphocytes of patients with Alzheimer's disease. Biomarkers 9:203-209
37. Keil U, Bonert A, Marques CA, Scherping I, Weyermann J, Strosznajder JB, Muller-Spahn F, Haass C, Czech C, Pradier L, Muller WE, Eckert A (2004) Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis. J Biol Chem 279:50310-50320
38. Kikuchi A, Takeda A, Onodera H, Kimpara T, Hisanaga K, Sato N, Nunomura A, Castellani RJ, Perry G, Smith MA, Itoyama Y (2002) Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy. Neurobiol Dis 9:244-248
39. Kriem B, Sponne I, Fifre A, Malaplate-Armand C, Lozac'h-Pillot K, Koziel V, Yen-Potin FT, Bihain B, Oster T, Olivier JL, Pillot T (2005) Cytosolic phospholipase A2 mediates neuronal apoptosis induced by soluble oligomers of the amyloid-beta peptide. FASEB J 19:85-87
40. Leutner S, Schindowski K, Frolich L, Maurer K, Kratzsch T, Eckert A, Muller WE (2005) Enhanced ROS-generation in lymphocytes from Alzheimer's patients. Pharmacopsychiatry 38:312-315
41. Leutz S, Steiner B, Marques CA, Haass C, Muller WE, Eckert A (2002) Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporineinduced cell death. J Mol Neurosci 18:189-201
42. Lombardi VR, Fernandez-Novoa L, Etcheverria I, Seoane S, Cacabelos R (2004) Association between APOE epsilon4 allele and increased expression of CD95 on T cells from patients with Alzheimer's disease. Method Find Exp Clin 26:523-529
43. Malaplate-Armand C, Florent-Bechard S, Youssef I, Koziel V, Sponne I, Kriem B, Leininger-Muller B, Olivier JL, Oster T, Pillot T (2006) Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway. Neurobiol Dis 23:178-189
44. Mancuso M, Filosto M, Bosetti F, Ceravolo R, Rocchi A, Tognoni G, Manca ML, Solaini G, Siciliano G, Murri L (2003) Decreased platelet cytochrome c oxidase activity is accompanied by increased blood lactate concentration during exercise in patients with Alzheimer disease. Exp Neurol 182:421-426
45. Marques CA, Keil U, Bonert A, Steiner B, Haass C, Muller WE, Eckert A (2003) Neurotoxic mechanisms caused by the Alzheimer's diseaselinked Swedish amyloid precursor protein mutation - Oxidative stress, caspases, and the JNK pathway. J Biol Chem 278:28294-28302
46. Martin MA, Molina JA, Jimenez-Jimenez FJ, Benito-Leon J, Orti-Pareja M, Campos Y, Arenas J (1996) Respiratory-chain enzyme activities in isolated mitochondria of lymphocytes from untreated Parkinson's disease patients. Grupo-Centro de Trastornos del Movimiento. Neurology 46:1343-1346
47. Mattson MP (2002) Oxidative stress, perturbed calcium homeostasis, and immune dysfunction in Alzheimer's disease. J Neurovirol 8:539-550
48. Mattson MP (2004) Pathways towards and away from Alzheimer's disease. Nature 430:631-639
49. Maurer I, Zierz S, Moller HJ (2000) A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients. Neurobiol Aging 21:455-462
50. Mecocci P, Cherubini A, Senin U (1997) Increased oxidative damage in lymphocytes of Alzheimer's disease patients. J Am Geriatr Soc 45:1536-1537
51. Mecocci P, Polidori MC, Cherubini A, Ingegni T, Mattioli P, Catani M, Rinaldi P, Cecchetti R, Stahl W, Senin U, Beal MF (2002) Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease. Arch Neurol 59:794-798
52. Migliore L, Fontana I, Colognato R, Coppede F, Siciliano G, Murri L (2005A) Searching for the role and the most suitable biomarkers of oxidative stress in Alzheimer's disease and in other neurodegenerative diseases. Neurobiol Aging 26:587-595
53. Migliore L, Fontana I, Trippi F, Colognato R, Coppede F, Tognoni G, Nucciarone B, Siciliano G (2005b) Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients. Neurobiol Aging 26:567-573
54. Molina JA, de Bustos F, Jimenez Jimenez FJ, Benito Leon J, Gasalla T, Orti Pareja M, Vela L, Bermejo F, Martin MA, Campos Y, Arenas J (1997) Respiratory chain enzyme activities in isolated mitochondria of lymphocytes from patients with Alzheimer's disease. Neurology 48:636-638
55. Morocz M, Kalman J, Juhasz A, Sinko I, McGlynn AP, Downes CS, Janka Z, Rasko I (2002) Elevated levels of oxidative DNA damage in lymphocytes from patients with Alzheimer's disease. Neurobiol Aging 23:47-53
56. Murray IVJ, Sindoni ME, Axelsen PH (2005) Promotion of oxidative lipid membrane damage by amyloid beta proteins. Biochemistry 44:12606-12613
57. Parker WD Jr (1991) Cytochrome oxidase deficiency in Alzheimer's disease. Ann NY Acad Sci 640:59-64
58. Parker WD Jr, Parks J, Filley CM, Kleinschmidt-De Masters BK (1994) Electron transport chain defects in Alzheimer's disease brain. Neurology 44:1090-1096
59. Parshad R, Sanford KK, Price FM, Melnick LK, Nee LE, Schapiro MB, Tarone RE, Robbins JH (1996) Fluorescent light-induced chromatid breaks distinguish Alzheimer disease cells from normal cells in tissue culture. Proc Nat Acad Sci USA 93:5146-5150
60. Perry G, Nunomura A, Hirai K, Takeda A, Aliev G, Smith MA (2000) Oxidative damage in Alzheimer's disease: the metabolic dimension. Int J Devel Neurosci 18:417-421
61. Petrozzi L, Lucetti C, Scarpato R, Gambaccini G, Trippi F, Bernardini S, Del Dotto P, Migliore L, Bonuccelli U (2002) Cytogenetic alterations in lymphocytes of Alzheimer's disease and Parkinson's disease patients. Neurol Sci 23 Suppl 2: S97-S98
62. Rodriguez-Santiago B, Nunes V (2005) Expression of mitochondrial genes and transcription estimation in different brain areas in Alzheimer's disease patients. Neurobiol Dis 18:296-304
63. Schindowski K, Leutner S, Muller WE, Eckert A (2000) Age-related changes of apoptotic cell death in human lymphocytes. Neurobiol Aging 21:661-670
64. Schindowski K, Frohlich L, Maurer K, Muller WE, Eckert A (2002) Age-related impairment of human T lymphocytes' activation: specific differences between CD4 (+) and CD8 (+) subsets. Mech Ageing Dev 123:375-390
65. Schindowski K, Kratzsch T, Peters J, Steiner B, Leutner S, Touchet N, Maurer K, Czech C, Pradier L, Frolich L, Muller WE, Eckert A (2003) Impact of aging: sporadic, and genetic risk factors on vulnerability to apoptosis in Alzheimer's disease. Neuromol Med 4:161-178
66. Schindowski K, Peters J, Gorriz C, Schramm U, Weinandi T, Leutner S, Maurer K, Frolich L, Muller WE, Eckert A (2006) Apoptosis of CD4+ T and natural killer cells in Alzheimer's disease. Pharmacopsychiatry 39:220-228
67. Schuessel K, Schafer S, Bayer TA, Czech C, Pradier L, Muller-Spahn F, Muller WE, Eckert A (2005) Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice. Neurobiol Dis 18:89-99
68. Schuessel K, Frey C, Jourdan C, Keil U, Weber CC, Muller-Spahn F, Muller WE, Eckert A (2006) Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice. Free Radic Biol Med 40:850-862
69. Selkoe DJ (2004) Alzheimer disease: Mechanistic understanding predicts novel therapies. Ann Int Med 140:627-638
70. Straface E, Matarrese P, Gambardella L, Vona R, Sgadari A, Silveri MC, Malorni W (2005) Oxidative imbalance and cathepsin D changes as peripheral blood biomarkers of Alzheimer disease: A pilot study. FEBS Lett 579:2759-2766
71. Tacconi S, Perri R, Balestrieri E, Grelli S, Bernardini S, Annichiarico R, Mastino A, Caltagirone C, Macchi B (2004) Increased caspase activation in peripheral blood mononuclear cells of patients with Alzheimer's disease. Exp Nephrol 190:254-262
72. Turner RS (2006) Alzheimer's disease. Semin Neurol 26:499-506
73. Wimo A, Winblad B, Aguero-Torres H, von Strauss E (2003) The magnitude of dementia occurrence in the world. Alz Dis Assoc Dis 17:63-67