Gluthatione level is altered in lymphoblasts from patients with familial Alzheimer's disease

Neuroscience Letters

Volumn 275, Issue 2, 1999, Pages 152-154

  Cecchi, Cristina ^a   Latorraca, Stefania ^a   Sorbi, Sandro ^a   Iantomasi, Teresa ^a   Favilli, Fabio ^a   Vincenzini, Maria Teresa ^a   Liguri, Gianfranco ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Glutamyl cysteine synthetase; Amyloid precursor protein; Familial Alzheimer's disease; Glutathione; Lymphoblasts; Presenilin gene

Indexed keywords

AMYLOID PRECURSOR PROTEIN; GLUTAMATE CYSTEINE LIGASE; GLUTAMIC ACID; GLUTATHIONE; GLUTATHIONE DISULFIDE;

ALZHEIMER DISEASE; ARTICLE; FAMILIAL DISEASE; GENE MUTATION; GLUTATHIONE METABOLISM; HUMAN; LYMPHOBLAST; OXIDATIVE STRESS; PRIORITY JOURNAL;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; GLUTAMATE-CYSTEINE LIGASE; GLUTAMIC ACID; GLUTATHIONE; GLUTATHIONE DISULFIDE; HUMANS; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MEMBRANE PROTEINS; OXIDATION-REDUCTION; PRESENILIN-1;

EID: 0032692216     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00751-X     Document Type: Article

References (19)

1. Bains J.S., Shaw C.A. Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death. Brain Res. Brain Res. Rev. 25:1997;335-358.
2. Benzi G., Moretti A. Are reactive oxygens species involved in Alzheimer's disease? Neurobiol. Aging. 16:1995;661-674.
3. Bracco, L., Amaducci, L. and the SMID group. Italian multicenter study on dementia. A protocol for data collection and clinical diagnosis of Alzheimer's disease. Neuroepidemiology, 11 (1992) 39-45.
4. Cruts M., Van Broeckoven C. Molecular genetics of Alzheimer's disease. Ann. Med. 30:1998;560-565.
5. Fariss M.W., Reed D.J. High performance liquid chromatography of thiols and disulfides: dinitrophenol derivatives. Methods Enzymol. 143:1987;101-109.
6. Gu M., Owen A.D., Toffa S.E., Cooper J.M., Dexter D.T., Jenner P., Marsden C.D., Schapira A.H. Mitochondrial function, GSH and iron in neurodegeneration and lewy body diseases. J. Neurol. Sci. 11:1998;24-29.
7. Guo G., Sopher B.L., Pham D.G., Furukawa K., Robinson N., Martin G.M., Mattson M.P. Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid β-peptide: involvement of calcium and oxyradicals. J. Neurosci. 17:1997;4212-4222.
8. Guo Q., Furukawa K., Sopher B.L., Pham D.G., Xie J., Robinson N., Martin G.M., Mattson M.P. Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β-peptide. NeuroReport. 8:1996;379-383.
9. Hardy J. Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci. 20:1997;154-159.
10. Harman D. Free radical theory of aging. Age. 16:1993;23-30.
11. Iantomasi T., Marraccini P., Favilli F., Vincenzini M.T., Ferretti P., Tonelli F. Glutathione metabolism in Crohn's disease. Biochem. Med. Metab. Biol. 53:1994;87-91.
12. Marcus D.L., Thomas C., Rodriguez C., Simberkoff K., Tsai J.S., Strafaci J.A., Freedman M.L. Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease. Exper. Neurol. 150:1998;40-44.
13. 2+ homeostasis and cell death. J. Neurosci. 15:1995;6239-6249.
14. Mattson M.P., Guo Q., Furukawa K., Pedersen W.A. Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease. J. Neurochem. 70:1998;1-14.
15. Perry T.L., Young V.W., Bergeron C., Hansen S., Jones K. Amino acids, glutathione, and glutathione transferase activity in the brains of patients with Alzheimer's disease. Ann. Neurol. 21:1987;331-336.
16. Sagara Y., Dargusch R., Chambers D., Davis J., Schubert D., Maher P. Cellular mechanisms of resistance to chronic oxidative stress. Free Rad. Biol. Med. 24:1998;1375-1389.
17. Selkoe D.J. Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease. Annu. Rev. Cell. Biol. 10:1994;373-404.
18. Volicer M. Free radicals in the development of Alzheimer's disease. Neurobiol. Aging. 11:1990;567-571.
19. Wolozin B., Iwasaki K., Vito P., Ganjei J.K., Lacana E., Sunderland T., Zhao B., Kusiak J.W., Wasco W., D'Adamio L. Partecipation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science. 274:1996;1710-1713.