Activation of the furin endoprotease is a multiple-step process: Requirements for acidification and internal propeptide cleavage

EMBO Journal

Volumn 16, Issue 7, 1997, Pages 1508-1518

  Anderson, Eric D ^a   VanSlyke, Judy K ^a   Thulin, Craig D ^a,b   Jean, François ^a   Thomas, Gary ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b BRIGHAM YOUNG UNIVERSITY   (United States)

Author keywords

Activation; Endoplasmic reticulum; Furin; Propeptide; Trans Golgi network

Indexed keywords

CALCIUM; FURIN; PEPTIDE; PROTEINASE; TRYPSIN;

ACIDIFICATION; ANIMAL CELL; ARTICLE; CONSENSUS SEQUENCE; ENDOSOME; ENZYME ACTIVATION; IMMUNOPRECIPITATION; MASS SPECTROMETRY; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN DENATURATION; VACCINIA VIRUS;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; CONSENSUS SEQUENCE; DNA PRIMERS; ENZYME ACTIVATION; ENZYME PRECURSORS; FURIN; GLUTATHIONE TRANSFERASE; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDES; PROTEASE INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT FUSION PROTEINS; SEQUENCE TAGGED SITES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBCELLULAR FRACTIONS; SUBTILISINS; TRANSFECTION; VACCINIA VIRUS;

EID: 0031001304     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.7.1508     Document Type: Article

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