Protein splicing: Occurrence, mechanisms and related phenomena

Chemistry and Biology

Volumn 4, Issue 3, 1997, Pages 187-194

  Shao, Yang ^a   Kent, Stephen B H ^a  

^a Gryphon Therapeutics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0031105467     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(97)90287-8     Document Type: Review

References (47)

1. Perler, F.B., et al., & Belfort, M. (1994). Protein splicing elements: inteins and exteins - a definition of terms and recommended nomenclature. Nucleic Acids Res. 22, 1125-1127.
2. Cooper, A.A. & Stevens, T.H. (1995). Protein splicing: self-splicing of genetically mobile elements at the protein level. Trends Biochem. Sci. 20, 351-356.
3. Kane, P.M., et al., & Stevens, T.H. (1990). Protein splicing converts the yeast TFP1 gene product to the 69-kD subunit of the vacuolar H(+)-adenosine triphosphatase. Science 250, 651-657.
4. Hirata, R., et al., & Anraku, Y. (1990). Molecular structure of a gene, VMA1, encoding the catalytic subunit of H(+)- translocating adenosine triphosphatase from vacuolar membranes of Saccharomyces cerevisiae. J. Biol. Chem, 265, 6726-6733.
5. Gu, H.H., Xu, J., Gallagher, M. & Dean, G.E. (1993). Peptide splicing in the vacuolar ATPase subunit A from Candida tropicalis. J. Biol. Chem. 268, 7372-7381.
6. Davis, E.O., Sedgwick, S.G. & Colston, M.J. (1991). Novel structure of the recA locus of Mycobacterium tuberculosis implies processing of the gene product. J. Bacteriol. 173, 5653-5662.
7. Davis, E.O., Jenner, P.J., Brooks, P.C., Colston, M.J. & Sedgwick, S.G. (1992). Protein splicing in the maturation of M. tuberculosis recA protein: a mechanism for tolerating a novel class of intervening sequence. Cell 71, 201-210.
8. Davis, E.O., Thangaraj, H.S., Brooks, P.C. & Colston, M.J. (1994). Evidence of selection for protein introns in the recAs of pathogenic mycobacteria. EMBO J. 13, 699-703.
9. Hodges, R.A., Perler, F.B., Noren, C.J. & Jack, W.E. (1992). Protein splicing removes intervening sequences in an archaea DNA polymerase. Nucleic Acids Res. 20, 6153-6157.
10. Perler, F.B., et al., & Jannasch. J. (1992). Intervening sequences in an Archaea DNA polymerase gene. Proc. Natl Acad. Sci. USA 89, 5577-5581.
11. Pietrokovski, S. (1994). Conserved sequence features of inteins (protein introns) and their use in identifying new inteins and related proteins. Protein Sci. 3, 2340-2350.
12. Gimble, F.S. & Thorner, J. (1992). Homing of a DNA endonuclease gene by meiotic gene conversion in Saccharomyces cerevisiae. Nature 357, 301-306.
13. Fsihi, H., Vincent, V. & Cole, S.T. (1996). Homing events in the gyrA gene of some mycobacteria. Proc. Natl Acad. Sci. USA 93, 3410-3415.
14. Huang, C., et al., & Liu, X.-Q. (1994). The Chlamydomonas chloroplast clpP gene contains translated large insertion sequences and is essential for cell growth. Mol. Gen. Genet. 244, 151-159.
15. Reith, M.E. & Munholland, J. (1995). Complete nucleotide sequence of of the Porphyra purpurea chloroplast genome. Plant Mol. Biol. Rep. 13, 333-335.
16. Pietrokovski, S. (1996). A new intein in cyanobacteria and its significance for the spread of inteins. Trends Genet., 12, 287-288.
17. Bult, C.J., et al., & Venter, J.C. (1996). Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii. Science 273, 1058-1073.
18. Wallace, C.J. (1993). The curious case of protein splicing: mechanistic insights suggested by protein semisynthesis. Protein Sci. 2, 697-705.
19. Cooper, A.A., Chen, Y.-J., Lindorfer, M.A. & Stevens, T.H. (1993). Protein splicing of the yeast TFP1 intervening protein sequence: a model for self-excision. EMBO J. 12, 2575-2583.
20. Clarke, N.D. (1994). A proposed mechanism for the self-splicing of proteins. Proc. Natl Acad. Sci. USA 91, 11084-11088.
21. Xu, M.-Q., et al., & Perler, F.B. (1994). Protein splicing: an analysis of the branched intermediate and its resolution by succinimide formation. EMBO J. 13, 5517-5522.
22. Xu, M.-Q., Southworth, M.W., Mersha, F.B., Hornstra, L.J., & Perler, F.B. (1993). In vitro protein splicing of purified precursor and the identification of a branched intermediate. Cell 75, 1371-1377.
23. Bergmann, M., Brand, E. & Dreyer, F. (1921). Synthase von alpha, beta-diglyceriden und symmetrischen triglyceriden. [Title translation: Synthesis of alpha, beta-diglyceride and unsymmetric triglyceride.] Berichete 54, 936-965.
24. Desnuelle, P. & Casal, A. (1948). Sur la moindre resistance a l'hydrolyse acide des liason peptidiques situees à côté d'une fonction hydroxyle. [Title translation: On the least resistance to acidic hydrolysis of peptide bonds situated next to a hydroxyl group.] Biochim. Biophys. Acta 2, 64-75.
25. Elliott, D.F. (1952). A search for specific chemical methods for fission of peptide bonds. Biochem. J. 50, 542-550.
26. Iwai, K. & Ando, T. (1967). N-O acyl shifts. Meth. Enzymol. 11, 262-282.
27. Van Poelje, P.D. & Snell, E.E. (1990). Cloning, sequencing, expression, and site-directed mutagenesis of the gene from Clostridium perfringens encoding pyruvoyl-dependent histidine decarboxylase. Biochemistry 29, 132-139.
28. Shao, Y., Xu, M.-Q. & Paulus, H. (1996). Protein splicing: evidence for an N-O acyl rearrangement as the initial step in the splicing process. Biochemistry 35, 3810-3815.
29. Jencks, W.P., Cordes, S. & Carriulo, J. (1960). The free energy of thioester hydrolysis. J. Biol. Chem. 235, 3608-3614.
30. Xu, M.-Q. & Perler, F.B. (1996). The mechanism of protein splicing and its modulation by mutation. EMBO J. 15, 5146-5153.
31. Fersht, A. (1985). In Enzyme Structure and Mechanism (2nd edn), pp. 201-208 and 405-413. W.H. Freeman and Company, NY, USA.
32. Voorter, C.E.M., De Haard-Hoekman, W.A., Van den Oetelaar, P.J.M., Bloemendal, H. & De Jong, W.W. (1988). Spontaneous peptide bond cleavage in aging alpha-crystallin through a succinimide intermediate. J. Biol. Chem. 263, 19020-19023.
33. Shao, Y., Xu, M.-Q. & Paulus, H. (1995). Protein splicing: characterization of the aminosuccinimide residue at the carboxyl terminus of the excised intervening sequence. Biochemistry 34, 10844-10850.
34. Liu, C.F. & Tam, J.P. (1994). Peptide segment ligation strategy without use of protecting groups. Proc. Natl Acad. Sci. USA 91, 6584-6588.
35. Dawson, P.E., Muir, T.W., Clark-Lewis, I. & Kent, S.B. (1994). Synthesis of proteins by native chemical ligation. Science 266, 776-779.
36. Chong, S., Shao, Y., Paulus, H., Benner, J., Perler, F.B. & Xu, M.-Q. (1996). Protein splicing involving the Saccharomyces cerevisiae VMA intein. The steps in the splicing pathway, side reactions leading to protein cleavage, and establishment of an in vitro splicing system. J. Biol. Chem. 271, 22159-22168.
37. Lee, J.J., Ekker, S.C., Kessler, D.P., Porter, J.A., Sun, B.I. & Beachy, P.A. (1994). Autoproteolysis in Hedgehog protein biogenesis. Science 266, 1528-1537.
38. Porter, J.A., et al., & Beachy, P.A. (1995). The product of Hedgehog autoproteolytic cleavage active in local and long-range signalling. Nature 374, 363-366.
39. Koonin, E.V. (1995). A protein splice-junction motif in Hedgehog family proteins. Trends Biochem. Sci. 20, 141-142.
40. Porter, J.A., et al., & Beachy, P.A. (1996). Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxyterminal autoprocessing domain. Cell 86, 21-34.
41. Porter, J.A., Young, K.E. & Beachy, P.A. (1996). Cholesterol modification of Hedgehog signaling proteins in animal development. Science 274, 255-259.
42. Guan, C., et al., & Comb, D. (1996). Activation of glycosylasparaginase. Formation of active N-terminal threonine by intramolecular autoproteolysis. J. Biol. Chem. 271, 1732-1737.
43. Oinonen, C., Tikkanen, R., Rouvinen, J. & Peltonen, L. (1995). Crystal structure of human glycosylasparaginase. Nat. Struct. Biol. 2, 1102-1106.
44. Duggleby, H.J., Tolley, S.P., Hill, C.P., Dodson, E.J., Dodson, G. & Moody, P.C. (1995). Penicillin acylase has a single-amino acid catalytic centre. Nature 373, 264-268.
45. Lowe, J., Stock, D., Jap, B., Zwickl, P., Baumeister, W. & Huber, R. (1995). Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 Å resolution. Science 268, 533-539.
46. Smith, J.L., et al., & Satow, Y. (1994). Structure of the allosteric regulatory enzyme of purine biosynthesis. Science 264, 1427-1433.
47. Artymiuk, P.J. (1995). A sting in the (N-terminal) tail. Nat. Struct. Biol. 2, 1035-1038.