The role of disulfide bonds in the assembly and function of MD-2

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 7, 2003, Pages 3919-3924

  Mullen, Gregory E D ^a   Kennedy, Margaret N ^a   Visintin, Alberto ^a,b   Mazzoni, Alessandra ^a   Leifer, Cynthia A ^a   Davies, David R ^a   Segal, David M ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; DIMER; GLYCOPROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; OLIGOMER; PROTEIN MD 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; DISULFIDE; LY96 PROTEIN, HUMAN; MEMBRANE ANTIGEN; RECOMBINANT PROTEIN; SERINE;

AMINO ACID SUBSTITUTION; ARTICLE; CELL LINE; COMPLEX FORMATION; CONTROLLED STUDY; DISULFIDE BOND; HUMAN; HUMAN CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; CHEMISTRY; GENE VECTOR; GENETICS; KIDNEY; METABOLISM; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; ANTIGENS, SURFACE; CELL LINE; CYSTEINE; DISULFIDES; GENETIC VECTORS; HUMANS; KIDNEY; LYMPHOCYTE ANTIGEN 96; MUTAGENESIS, SITE-DIRECTED; NF-KAPPA B; RECOMBINANT PROTEINS; SERINE;

EID: 0037388127     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0630495100     Document Type: Article

References (23)

1. Akira, S., Takeda, K. & Kaisho, T. (2001) Nat. Immunol. 2, 675-680.
2. Imler, J. L. & Hoffmann, J. A. (2001) Trends Cell Biol. 11, 304-311.
3. Medzhitov, R. (2001) Nat. Rev. Immunol. 1, 135-145.
4. Dziarski, R. & Gupta, D. (2000) J. Endotoxin Res. 6, 401-405.
5. Poltorak, A., He, X., Smirnova, I., Liu, M. Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) Science 282, 2085-2088.
6. Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K. & Akira, S. (1999) J. Immunol. 162, 3749-3752.
7. Shimazu, R., Akashi, S., Ogata, H., Nagai, Y., Fukudome, K., Miyake, K. & Kimoto, M. (1999) J. Exp. Med. 189, 1777-1782.
8. Nagai, Y., Akashi, S., Nagafuku, M., Ogata, M., Iwakura, Y., Akira, S., Kitamura, T., Kosugi, A., Kimoto, M. & Miyake, K. (2002) Nat. Immunol. 3, 667-672.
9. Schromm, A. B., Lien, E., Henneke, P., Chow, J. C., Yoshimura, A., Heine, H., Latz, E., Monks, B. G., Schwartz, D. A., Miyake, K., et al. (2001) J. Exp. Med. 194, 79-88.
10. da Silva Correia, J., Soldau, K., Christen, U., Tobias, P. S. & Ulevitch, R. J. (2001) J. Biol. Chem. 276, 21129-21135.
11. Viriyakosol, S., Tobias, P. S., Kitchens, R. L. & Kirkland, T. N. (2001) J. Biol. Chem. 276, 38044-38051.
12. Mancek, M., Pristovsek, P. & Jerala, R. (2002) Biochem. Biophys. Res. Commun. 292, 880-885.
13. Akashi, S., Nagai, Y., Ogata, H., Oikawa, M., Fukase, K., Kusumoto, S., Kawasaki, K., Nishijima, M., Hayashi, S., Kimoto, M., et al. (2001) Int. Immunol. 13, 1595-1599.
14. Kawasaki, K., Akashi, S., Shimazu, R., Yoshida, T., Miyake, K. & Nishijima, M. (2001) J. Endotoxin Res. 7, 232-236.
15. Muroi, M., Ohnishi, T. & Tanamoto, K. (2002) Infect. Immun. 70, 3546-3550.
16. Fenton, M. J. & Golenbock, D. T. (1998) J. Leukocyte Biol. 64, 25-32.
17. da Silva, C. J. & Ulevitch, R. J. (2002) J. Biol. Chem. 277, 1845-1854.
18. Ohnishi, T., Muroi, M. & Tanamoto, K. (2001) J. Immunol. 167, 3354-3359.
19. Visintin, A., Mazzoni, A., Spitzer, J. A. & Segal, D. M. (2001) Proc. Natl. Acad. Sci. USA 98, 12156-12161.
20. Chow, J. C., Young, D. W., Golenbock, D. T., Christ, W. J. & Gusovsky, F. (1999) J. Biol. Chem. 274, 10689-10692.
21. Re, F. & Strominger, J. L. (2002) J. Biol. Chem. 277, 23427-23432.
22. Ellgaard, L., Molinari, M. & Helenius, A. (1999) Science 286, 1882-1888.
23. Wickner, S., Maurizi, M. R. & Gottesman, S. (1999) Science 286, 1888-1893.