-
1
-
-
4944230477
-
Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier
-
Bauer B., Hartz A.M., Fricker G., and Miller D.S. Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier. Mol. Pharmacol. 66 (2004) 413-419
-
(2004)
Mol. Pharmacol.
, vol.66
, pp. 413-419
-
-
Bauer, B.1
Hartz, A.M.2
Fricker, G.3
Miller, D.S.4
-
3
-
-
0032532134
-
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
-
Blumberg B., Sabbagh Jr. W., Juguilon H., Bolado Jr. J., van Meter C.M., Ong E.S., and Evans R.M. SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev. 12 (1998) 3195-3205
-
(1998)
Genes Dev.
, vol.12
, pp. 3195-3205
-
-
Blumberg, B.1
Sabbagh Jr., W.2
Juguilon, H.3
Bolado Jr., J.4
van Meter, C.M.5
Ong, E.S.6
Evans, R.M.7
-
5
-
-
0037113346
-
Localisation of breast cancer resistance protein in microvessel endothelium of human brain
-
Cooray H.C., Blackmore C.G., Maskell L., and Barrand M.A. Localisation of breast cancer resistance protein in microvessel endothelium of human brain. Neuroreport 13 (2002) 2059-2063
-
(2002)
Neuroreport
, vol.13
, pp. 2059-2063
-
-
Cooray, H.C.1
Blackmore, C.G.2
Maskell, L.3
Barrand, M.A.4
-
6
-
-
0034623288
-
Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor
-
Costet P., Luo Y., Wang N., and Tall A.R. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J. Biol. Chem. 275 (2000) 28240-28245
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 28240-28245
-
-
Costet, P.1
Luo, Y.2
Wang, N.3
Tall, A.R.4
-
7
-
-
0034672081
-
Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain
-
de Urquiza A.M., Liu S., Sjoberg M., Zetterstrom R.H., Griffiths W., Sjovall J., and Perlmann T. Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. Science 290 (2000) 2140-2144
-
(2000)
Science
, vol.290
, pp. 2140-2144
-
-
de Urquiza, A.M.1
Liu, S.2
Sjoberg, M.3
Zetterstrom, R.H.4
Griffiths, W.5
Sjovall, J.6
Perlmann, T.7
-
8
-
-
0035669389
-
Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy
-
Dombrowski S.M., Desai S.Y., Marroni M., Cucullo L., Goodrich K., Bingaman W., Mayberg M.R., Bengez L., and Janigro D. Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy. Epilepsia 42 (2001) 1501-1506
-
(2001)
Epilepsia
, vol.42
, pp. 1501-1506
-
-
Dombrowski, S.M.1
Desai, S.Y.2
Marroni, M.3
Cucullo, L.4
Goodrich, K.5
Bingaman, W.6
Mayberg, M.R.7
Bengez, L.8
Janigro, D.9
-
9
-
-
0035805536
-
Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
-
Geick A., Eichelbaum M., and Burk O. Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J. Biol. Chem. 276 (2001) 14581-14587
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 14581-14587
-
-
Geick, A.1
Eichelbaum, M.2
Burk, O.3
-
10
-
-
0032702726
-
The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module
-
Goodwin B., Hodgson E., and Liddle C. The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Mol. Pharmacol. 56 (1999) 1329-1339
-
(1999)
Mol. Pharmacol.
, vol.56
, pp. 1329-1339
-
-
Goodwin, B.1
Hodgson, E.2
Liddle, C.3
-
11
-
-
0026570218
-
9-cis Retinoic acid is a high affinity ligand for the retinoid X receptor
-
Heyman R.A., Mangelsdorf D.J., Dyck J.A., Stein R.B., Eichele G., Evans R.M., and Thaller C. 9-cis Retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 68 (1992) 397-406
-
(1992)
Cell
, vol.68
, pp. 397-406
-
-
Heyman, R.A.1
Mangelsdorf, D.J.2
Dyck, J.A.3
Stein, R.B.4
Eichele, G.5
Evans, R.M.6
Thaller, C.7
-
12
-
-
16244415183
-
Selective gene silencing of rat ATP-binding cassette G2 transporter in an in vitro blood-brain barrier model by short interfering RNA
-
Hori S., Ohtsuki S., Ichinowatari M., Yokota T., Kanda T., and Terasaki T. Selective gene silencing of rat ATP-binding cassette G2 transporter in an in vitro blood-brain barrier model by short interfering RNA. J. Neurochem. 93 (2005) 63-71
-
(2005)
J. Neurochem.
, vol.93
, pp. 63-71
-
-
Hori, S.1
Ohtsuki, S.2
Ichinowatari, M.3
Yokota, T.4
Kanda, T.5
Terasaki, T.6
-
13
-
-
0028920237
-
Endogenous distribution of retinoids during normal development and teratogenesis in the mouse embryo
-
Horton C., and Maden M. Endogenous distribution of retinoids during normal development and teratogenesis in the mouse embryo. Dev. Dyn. 202 (1995) 312-323
-
(1995)
Dev. Dyn.
, vol.202
, pp. 312-323
-
-
Horton, C.1
Maden, M.2
-
14
-
-
0034452792
-
mRNA expression and transport characterization of conditionally immortalized rat brain capillary endothelial cell lines; a new in vitro BBB model for drug targeting
-
Hosoya K.I., Takashima T., Tetsuka K., Nagura T., Ohtsuki S., Takanaga H., Ueda M., Yanai N., Obinata M., and Terasaki T. mRNA expression and transport characterization of conditionally immortalized rat brain capillary endothelial cell lines; a new in vitro BBB model for drug targeting. J. Drug Target. 8 (2000) 357-370
-
(2000)
J. Drug Target.
, vol.8
, pp. 357-370
-
-
Hosoya, K.I.1
Takashima, T.2
Tetsuka, K.3
Nagura, T.4
Ohtsuki, S.5
Takanaga, H.6
Ueda, M.7
Yanai, N.8
Obinata, M.9
Terasaki, T.10
-
15
-
-
0037169551
-
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
-
Kast H.R., Goodwin B., Tarr P.T., Jones S.A., Anisfeld A.M., Stoltz C.M., Tontonoz P., Kliewer S., Willson T.M., and Edwards P.A. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J. Biol. Chem. 277 (2002) 2908-2915
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 2908-2915
-
-
Kast, H.R.1
Goodwin, B.2
Tarr, P.T.3
Jones, S.A.4
Anisfeld, A.M.5
Stoltz, C.M.6
Tontonoz, P.7
Kliewer, S.8
Willson, T.M.9
Edwards, P.A.10
-
16
-
-
0036799870
-
The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism
-
Kliewer S.A., Goodwin B., and Willson T.M. The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocr. Rev. 23 (2002) 687-702
-
(2002)
Endocr. Rev.
, vol.23
, pp. 687-702
-
-
Kliewer, S.A.1
Goodwin, B.2
Willson, T.M.3
-
17
-
-
0037325403
-
Peroxisome proliferator-activated receptor α (PPARα)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice
-
Kok T., Bloks V.W., Wolters H., Havinga R., Jansen P.L., Staels B., and Kuipers F. Peroxisome proliferator-activated receptor α (PPARα)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice. Biochem. J. 369 (2003) 539-547
-
(2003)
Biochem. J.
, vol.369
, pp. 539-547
-
-
Kok, T.1
Bloks, V.W.2
Wolters, H.3
Havinga, R.4
Jansen, P.L.5
Staels, B.6
Kuipers, F.7
-
18
-
-
0037969631
-
22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid β secretion
-
Koldamova R.P., Lefterov I.M., Ikonomovic M.D., Skoko J., Lefterov P.I., Isanski B.A., DeKosky S.T., and Lazo J.S. 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid β secretion. J. Biol. Chem. 278 (2003) 13244-13256
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 13244-13256
-
-
Koldamova, R.P.1
Lefterov, I.M.2
Ikonomovic, M.D.3
Skoko, J.4
Lefterov, P.I.5
Isanski, B.A.6
DeKosky, S.T.7
Lazo, J.S.8
-
19
-
-
14244255485
-
The liver X receptor ligand T0901317 decreases amyloid β production in vitro and in a mouse model of Alzheimer's disease
-
Koldamova R.P., Lefterov I.M., Staufenbiel M., Wolfe D., Huang S., Glorioso J.C., Walter M., Roth M.G., and Lazo J.S. The liver X receptor ligand T0901317 decreases amyloid β production in vitro and in a mouse model of Alzheimer's disease. J. Biol. Chem. 280 (2005) 4079-4088
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 4079-4088
-
-
Koldamova, R.P.1
Lefterov, I.M.2
Staufenbiel, M.3
Wolfe, D.4
Huang, S.5
Glorioso, J.C.6
Walter, M.7
Roth, M.G.8
Lazo, J.S.9
-
20
-
-
0037623752
-
Liver X receptor agonists as potential therapeutic agents for dyslipidemia and atherosclerosis
-
Lund E.G., Menke J.G., and Sparrow C.P. Liver X receptor agonists as potential therapeutic agents for dyslipidemia and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 1169-1177
-
(2003)
Arterioscler. Thromb. Vasc. Biol.
, vol.23
, pp. 1169-1177
-
-
Lund, E.G.1
Menke, J.G.2
Sparrow, C.P.3
-
21
-
-
0029835410
-
Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
-
Lutjohann D., Breuer O., Ahlborg G., Nennesmo I., Siden A., Diczfalusy U., and Bjorkhem I. Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 9799-9804
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 9799-9804
-
-
Lutjohann, D.1
Breuer, O.2
Ahlborg, G.3
Nennesmo, I.4
Siden, A.5
Diczfalusy, U.6
Bjorkhem, I.7
-
22
-
-
0029562554
-
The RXR heterodimers and orphan receptors
-
Mangelsdorf D.J., and Evans R.M. The RXR heterodimers and orphan receptors. Cell 83 (1995) 841-850
-
(1995)
Cell
, vol.83
, pp. 841-850
-
-
Mangelsdorf, D.J.1
Evans, R.M.2
-
23
-
-
13844271333
-
Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues
-
Miki Y., Suzuki T., Tazawa C., Blumberg B., and Sasano H. Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues. Mol. Cell Endocrinol. 231 (2005) 75-85
-
(2005)
Mol. Cell Endocrinol.
, vol.231
, pp. 75-85
-
-
Miki, Y.1
Suzuki, T.2
Tazawa, C.3
Blumberg, B.4
Sasano, H.5
-
24
-
-
0032895533
-
Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes
-
Miyake K., Mickley L., Litman T., Zhan Z., Robey R., Cristensen B., Brangi M., Greenberger L., Dean M., Fojo T., and Bates S.E. Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes. Cancer Res. 59 (1999) 8-13
-
(1999)
Cancer Res.
, vol.59
, pp. 8-13
-
-
Miyake, K.1
Mickley, L.2
Litman, T.3
Zhan, Z.4
Robey, R.5
Cristensen, B.6
Brangi, M.7
Greenberger, L.8
Dean, M.9
Fojo, T.10
Bates, S.E.11
-
25
-
-
0036310592
-
LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells
-
Murthy S., Born E., Mathur S.N., and Field F.J. LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells. J. Lipid Res. 43 (2002) 1054-1064
-
(2002)
J. Lipid Res.
, vol.43
, pp. 1054-1064
-
-
Murthy, S.1
Born, E.2
Mathur, S.N.3
Field, F.J.4
-
26
-
-
1242314753
-
Liver-X-receptor-mediated increase in ATP-binding cassette transporter A1 expression is attenuated by fatty acids in CaCo-2 cells: effect on cholesterol efflux to high-density lipoprotein
-
Murthy S., Born E., Mathur S.N., and Field F.J. Liver-X-receptor-mediated increase in ATP-binding cassette transporter A1 expression is attenuated by fatty acids in CaCo-2 cells: effect on cholesterol efflux to high-density lipoprotein. Biochem. J. 377 (2004) 545-552
-
(2004)
Biochem. J.
, vol.377
, pp. 545-552
-
-
Murthy, S.1
Born, E.2
Mathur, S.N.3
Field, F.J.4
-
27
-
-
14844319827
-
mRNA expression of the ATP-binding cassette transporter subfamily A (ABCA) in rat and human brain capillary endothelial cells
-
Ohtsuki S., Watanabe Y., Hori S., Suzuki H., Bhongsatiern J., Fujiyoshi M., Kamoi M., Kamiya N., Takanaga H., and Terasaki T. mRNA expression of the ATP-binding cassette transporter subfamily A (ABCA) in rat and human brain capillary endothelial cells. Biol. Pharm. Bull. 27 (2004) 1437-1440
-
(2004)
Biol. Pharm. Bull.
, vol.27
, pp. 1437-1440
-
-
Ohtsuki, S.1
Watanabe, Y.2
Hori, S.3
Suzuki, H.4
Bhongsatiern, J.5
Fujiyoshi, M.6
Kamoi, M.7
Kamiya, N.8
Takanaga, H.9
Terasaki, T.10
-
28
-
-
33947096087
-
Establishing a method to isolate rat brain capillary endothelial cells by magnetic cell sorting and dominant mRNA expression of multidrug resistance-associated protein 1 and 4 in highly purified rat brain capillary endothelial cells
-
Ohtsuki S., Yamaguchi H., Asashima T., and Terasaki T. Establishing a method to isolate rat brain capillary endothelial cells by magnetic cell sorting and dominant mRNA expression of multidrug resistance-associated protein 1 and 4 in highly purified rat brain capillary endothelial cells. Pharm. Res. 24 (2007) 688-694
-
(2007)
Pharm. Res.
, vol.24
, pp. 688-694
-
-
Ohtsuki, S.1
Yamaguchi, H.2
Asashima, T.3
Terasaki, T.4
-
29
-
-
0037044840
-
ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells
-
Panzenboeck U., Balazs Z., Sovic A., Hrzenjak A., Levak-Frank S., Wintersperger A., Malle E., and Sattler W. ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells. J. Biol. Chem. 277 (2002) 42781-42789
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 42781-42789
-
-
Panzenboeck, U.1
Balazs, Z.2
Sovic, A.3
Hrzenjak, A.4
Levak-Frank, S.5
Wintersperger, A.6
Malle, E.7
Sattler, W.8
-
30
-
-
33646205692
-
Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells
-
Panzenboeck U., Kratzer I., Sovic A., Wintersperger A., Bernhart E., Hammer A., Malle E., and Sattler W. Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells. Int. J. Biochem. Cell Biol. 38 (2006) 1314-1329
-
(2006)
Int. J. Biochem. Cell Biol.
, vol.38
, pp. 1314-1329
-
-
Panzenboeck, U.1
Kratzer, I.2
Sovic, A.3
Wintersperger, A.4
Bernhart, E.5
Hammer, A.6
Malle, E.7
Sattler, W.8
-
31
-
-
0036138648
-
24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia
-
Papassotiropoulos A., Lutjohann D., Bagli M., Locatelli S., Jessen F., Buschfort R., Ptok U., Bjorkhem I., von Bergmann K., and Heun R. 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia. J. Psychiatr. Res. 36 (2002) 27-32
-
(2002)
J. Psychiatr. Res.
, vol.36
, pp. 27-32
-
-
Papassotiropoulos, A.1
Lutjohann, D.2
Bagli, M.3
Locatelli, S.4
Jessen, F.5
Buschfort, R.6
Ptok, U.7
Bjorkhem, I.8
von Bergmann, K.9
Heun, R.10
-
32
-
-
33750044862
-
Expression of the human ABCC6 gene is induced by retinoids through the retinoid X receptor
-
Ratajewski M., Bartosz G., and Pulaski L. Expression of the human ABCC6 gene is induced by retinoids through the retinoid X receptor. Biochem. Biophys. Res. Commun. 350 (2006) 1082-1087
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.350
, pp. 1082-1087
-
-
Ratajewski, M.1
Bartosz, G.2
Pulaski, L.3
-
33
-
-
0029892497
-
P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
-
Schinkel A.H., Wagenaar E., Mol C.A., and van Deemter L. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J. Clin. Invest. 97 (1996) 2517-2524
-
(1996)
J. Clin. Invest.
, vol.97
, pp. 2517-2524
-
-
Schinkel, A.H.1
Wagenaar, E.2
Mol, C.A.3
van Deemter, L.4
-
35
-
-
0035038919
-
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
-
Synold T.W., Dussault I., and Forman B.M. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat. Med. 7 (2001) 584-590
-
(2001)
Nat. Med.
, vol.7
, pp. 584-590
-
-
Synold, T.W.1
Dussault, I.2
Forman, B.M.3
-
36
-
-
0141923651
-
New approaches to in vitro models of blood-brain barrier drug transport
-
Terasaki T., Ohtsuki S., Hori S., Takanaga H., Nakashima E., and Hosoya K. New approaches to in vitro models of blood-brain barrier drug transport. Drug Discov. Today 8 (2003) 944-954
-
(2003)
Drug Discov. Today
, vol.8
, pp. 944-954
-
-
Terasaki, T.1
Ohtsuki, S.2
Hori, S.3
Takanaga, H.4
Nakashima, E.5
Hosoya, K.6
-
37
-
-
0026760889
-
P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells
-
Tsuji A., Terasaki T., Takabatake Y., Tenda Y., Tamai I., Yamashima T., Moritani S., Tsuruo T., and Yamashita J. P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells. Life Sci. 51 (1992) 1427-1437
-
(1992)
Life Sci.
, vol.51
, pp. 1427-1437
-
-
Tsuji, A.1
Terasaki, T.2
Takabatake, Y.3
Tenda, Y.4
Tamai, I.5
Yamashima, T.6
Moritani, S.7
Tsuruo, T.8
Yamashita, J.9
-
38
-
-
0034687397
-
The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
-
Wei P., Zhang J., Egan-Hafley M., Liang S., and Moore D.D. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature 407 (2000) 920-923
-
(2000)
Nature
, vol.407
, pp. 920-923
-
-
Wei, P.1
Zhang, J.2
Egan-Hafley, M.3
Liang, S.4
Moore, D.D.5
-
39
-
-
1942453212
-
Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism
-
Xie W., Uppal H., Saini S.P., Mu Y., Little J.M., Radominska-Pandya A., and Zemaitis M.A. Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism. Drug Discov. Today 9 (2004) 442-449
-
(2004)
Drug Discov. Today
, vol.9
, pp. 442-449
-
-
Xie, W.1
Uppal, H.2
Saini, S.P.3
Mu, Y.4
Little, J.M.5
Radominska-Pandya, A.6
Zemaitis, M.A.7
|