Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing notch signaling

Stem Cells

Volumn 26, Issue 1, 2008, Pages 279-289

  Liotta, Francesco ^a   Angeli, Roberta ^a   Cosmi, Lorenzo ^a   Filì, Lucia ^a   Manuelli, Cinzia ^a   Frosali, Francesca ^a   Mazzinghi, Benedetta ^a   Maggi, Laura ^a   Pasini, Annalisa ^b   Lisi, Veronica ^b   Santarlasci, Veronica ^a   Consoloni, Lara ^a   Angelotti, Maria Lucia ^a   Romagnani, Paola ^a   Parronchi, Paola ^a   Krampera, Mauro ^b   Maggi, Enrico ^a   Romagnani, Sergio ^a   Annunziato, Francesco ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

Author keywords

Anergy; Notch; Stem cells; Suppression; T cells; Tolerance

Indexed keywords

ESTER DERIVATIVE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JAGGED1; NEUTRALIZING ANTIBODY; NOTCH RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; GRAM NEGATIVE BACTERIUM; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; INFECTION; LYMPHOCYTE PROLIFERATION; MESENCHYMAL STEM CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA VIRUS; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

BONE MARROW CELLS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CHEMOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; LYMPHOCYTE ACTIVATION; MESENCHYMAL STEM CELLS; MICROSCOPY, CONFOCAL; MULTIPOTENT STEM CELLS; RECEPTORS, NOTCH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4;

NEGIBACTERIA; RNA VIRUSES;

EID: 38349060182     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2007-0454     Document Type: Article

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