APC/C-Cdh1-mediated degradation of the Polo kinase Cdc5 promotes the return of Cdc14 into the nucleolus

Genes and Development

Volumn 22, Issue 1, 2008, Pages 79-90

  Visintin, Clara ^a   Tomson, Brett N ^b   Raha, Rami ^b   Paulson, Jennifer ^c   Cohen, Michael ^c   Taunton, Jack ^c   Amon, Angelika ^b   Visintin, Rosella ^a  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cdc14; Cdc5; Cell cycle; Mitosis

Indexed keywords

ANAPHASE PROMOTING COMPLEX; PHOSPHOPROTEIN PHOSPHATASE CDC14;

ARTICLE; ENZYME ACTIVITY; METAPHASE; MITOSIS; NUCLEOLUS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS;

ALLELES; CELL CYCLE PROTEINS; CELL NUCLEOLUS; ENDOPEPTIDASES; METAPHASE; MICROSCOPY, FLUORESCENCE; MITOSIS; MODELS, BIOLOGICAL; PROTEIN BIOSYNTHESIS; PROTEIN KINASES; PROTEIN TYROSINE PHOSPHATASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; UBIQUITIN-PROTEIN LIGASE COMPLEXES;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 38149094169     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1601308     Document Type: Article

References (41)

1. Amon, A., Irniger, S., and Nasmyth, K. 1994. Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle. Cell 77: 1037-1050.
2. Azzam, R., Chen, S.L., Shou, W., Mah, A.S., Alexandru, G., Nasmyth, K., Annan, R.S., Carr, S.A., and Deshaies, R.J. 2004. Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus. Science 305: 516-519.
3. Bachmair, A., Finley, D., and Varshavsky, A. 1986. In vivo half-life of a protein is a function of its amino-terminal residue. Science 234: 179-186.
4. Bardin, A.J. and Amon, A. 2001. Men and sin: What's the difference? Nat. Rev. Mol. Cell Biol. 2: 815-826.
5. Bishop, A.C., Buzko, O., and Shokat, K.M. 2001. Magic bullets for protein kinases. Trends Cell Biol. 11: 167-172.
6. Charles, J.F., Jaspersen, S.L., Tinker-Kulberg, R.L., Hwang, L., Szidon, A., and Morgan, D.O. 1998. The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae. Curr. Biol. 8: 497-507.
7. Cohen-Fix, O., Peters, J.M., Kirschner, M.W., and Koshland, D. 1996. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes & Dev. 10: 3081-3093.
8. Geymonat, M., Spanos, A., Walker, P.A., Johnston, L.H., and Sedgwick, S.G. 2003. In vitro regulation of budding yeast Bfa1/Bub2 GAP activity by Cdc5. J. Biol. Chem. 278: 14591-14594.
9. Gietz, R.D. and Sugino, A. 1988. New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74: 527-534.
10. Gruneberg, U., Campbell, K., Simpson, C., Grindlay, J., and Schiebel, E. 2000. Nud1p links astral microtubule organization and the control of exit from mitosis. EMBO J. 19: 6475-6488.
11. Harper, J.W., Burton, J.L., and Solomon, M.J. 2002. The anaphase-promoting complex: It's not just for mitosis any more. Genes & Dev. 16: 2179-2206.
12. Hu, F. and Elledge, S.J. 2002. Bub2 is a cell cycle regulated phospho-protein controlled by multiple checkpoints. Cell Cycle 1: 351-355.
13. Hu, F., Wang, Y., Liu, D., Li, Y., Qin, J., and Elledge, S.J. 2001. Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints. Cell 107: 655-665.
14. Jaspersen, S.L., Charles, J.F., Tinker-Kulberg, R.L., and Morgan, D.O. 1998. A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae. Mol. Biol. Cell 9: 2803-2817.
15. Johnson, E.S., Bartel, B., Seufert, W., and Varshavsky, A. 1992. Ubiquitin as a degradation signal. EMBO J. 11: 497-505.
16. Longtine, M.S., McKenzie III, A., Demarini, D.J., Shah, N.G., Wach, A., Brachat, A., Philippsen, P., and Pringle, J.R. 1998. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14: 953-961.
17. Nasmyth, K. 2001. Disseminating the genome: Joining, resolving, and separating sister chromatids during mitosis and meiosis. Annu. Rev. Genet. 35: 673-745.
18. Nasmyth, K., Peters, J.M., and Uhlmann, F. 2001. Splitting the chromosome: Cutting the ties that bind sister chromatids. Novartis Found. Symp. 237: 113-133.
19. Pereira, G., Tanaka, T.U., Nasmyth, K., and Schiebel, E. 2001. Modes of spindle pole body inheritance and segregation of the Bfa1p-Bub2p checkpoint protein complex. EMBO J. 20: 6359-6370.
20. Pereira, G., Manson, C., Grindlay, J., and Schiebel, E. 2002. Regulation of the Bfa1p-Bub2p complex at spindle pole bodies by the cell cycle phosphatase Cdc14p. J. Cell Biol. 157: 367-379.
21. Peters, J.M. 2002. The anaphase-promoting complex: Proteolysis in mitosis and beyond. Mol. Cell 9: 931-943.
22. Queralt, E., Lehane, C., Novak, B., and Uhlmann, F. 2006. Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast. Cell 125: 719-732.
23. Ross, K.E. and Cohen-Fix, O. 2004. A role for the FEAR pathway in nuclear positioning during anaphase. Dev. Cell 6: 729-735.
24. Schwab, M., Lutum, A.S., and Seufert, W. 1997. Yeast Hct1 is a regulator of Clb2 cyclin proteolysis. Cell 90: 683-693.
25. Shah, R., Jensen, S., Frenz, L.M., Johnson, A.L., and Johnston, L.H. 2001. The Spo12 protein of Saccharomyces cerevisiae: A regulator of mitotic exit whose cell cycle-dependent degradation is mediated by the anaphase-promoting complex. Genetics 159: 965-980.
26. Shirayama, M., Zachariae, W., Ciosk, R., and Nasmyth, K. 1998. The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae. EMBO J. 17: 1336-1349.
27. Shirayama, M., Toth, A., Galova, M., and Nasmyth, K. 1999. APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5. Nature 402: 203-207.
28. Shou, W., Seol, J.H., Shevchenko, A., Baskerville, C., Moazed, D., Chen, Z.W., Jang, J., Shevchenko, A., Charbonneau, H., and Deshaies, R.J. 1999. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell 97: 233-244.
29. Stegmeier, F. and Amon, A. 2004. Closing mitosis: The functions of the Cdc14 phosphatase and its regulation. Annu. Rev. Genet. 38: 203-232.
30. Stegmeier, F., Visintin, R., and Amon, A. 2002. Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase. Cell 108: 207-220.
31. Stegmeier, F., Huang, J., Rahal, R., Zmolik, J., Moazed, D., and Amon, A. 2004. The replication fork block protein Fob1 functions as a negative regulator of the FEAR network. Curr. Biol. 14: 467-480.
32. Sullivan, M. and Uhlmann, F. 2003. A non-proteolytic function of separase links the onset of anaphase to mitotic exit. Nat. Cell Biol. 5: 249-254.
33. Visintin, R. and Amon, A. 2001. Regulation of the mitotic exit protein kinases Cdc15 and Dbf2. Mol. Biol. Cell 12: 2961-2974.
34. Visintin, R., Craig, K., Hwang, E.S., Prinz, S., Tyers, M., and Amon, A. 1998. The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Mol. Cell 2: 709-718.
35. Visintin, R., Hwang, E.S., and Amon, A. 1999. Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus. Nature 398: 818-823.
36. Visintin, R., Stegmeier, F., and Amon, A. 2003. The role of the polo kinase Cdc5 in controlling Cdc14 localization. Mol. Biol. Cell 14: 4486-4498.
37. Wang, Y., Shirogane, T., Liu, D., Harper, J.W., and Elledge, S.J. 2003. Exit from exit: Resetting the cell cycle through Amn1 inhibition of G protein signaling. Cell 112: 697-709.
38. Wasch, R. and Cross, F.R. 2002. APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit. Nature 418: 556-562.
39. Yoshida, S. and Toh-e, A. 2002. Budding yeast Cdc5 phosphorylates Net1 and assists Cdc14 release from the nucleolus. Biochem. Biophys. Res. Commun. 294: 687-691.
40. Zachariae, W., Schwab, M., Nasmyth, K., and Seufert, W. 1998. Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex. Science 282: 1721-1724.
41. Zhang, C., Kenski, D.M., Paulson, J.L., Bonshtien, A., Sessa, G., Cross, J.V., Templeton, D.J., and Shokat, K.M. 2005. A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases. Nat. Methods 2: 435-441.