APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit

Nature

Volumn 418, Issue 6897, 2002, Pages 556-562

  Wäsch, Ralph ^a   Cross, Frederick R ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; DEGRADATION; ENZYME INHIBITION;

PROTEOLYSIS;

NATURAL SCIENCES;

APC PROTEIN; CYCLIN CLB2; CYCLIN CLB5; CYCLINE; PROTEIN SIC1; UNCLASSIFIED DRUG;

BIOLOGY; DEGRADATION;

ARTICLE; CELL CYCLE G1 PHASE; CELL DIVISION; CELL SIZE; CONTROLLED STUDY; ENZYME INACTIVATION; GENE DELETION; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SPINDLE CELL;

AMINO ACID MOTIFS; CELL CYCLE PROTEINS; CYCLIN B; FUNGAL PROTEINS; G1 PHASE; GTP-BINDING PROTEINS; KINETICS; LIGASES; MITOSIS; MODELS, BIOLOGICAL; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN SUBUNITS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE DELETION; UBIQUITIN-PROTEIN LIGASE COMPLEXES;

EID: 0036682094     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature00856     Document Type: Article

References (30)

1. Regulation of the APC and the exit from mitosis
2. Whose end is destruction: Cell division and the anaphase-promoting complex
3. APCCdc 20 promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin ClbS
4. Phosphorylation of Sic 2p by G1 Cdk required for its degradation and entry into S phase
5. The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation
6. Control of cyclin ubiquitination by CDK-regulated binding of Hct 1 to the anaphase promoting complex
7. Inhibitory phosphorylation of the APC regulator Hct 1 is controlled by the kinase Cdc28 and the phosphatase Cdc14
8. Cdc20 is essential for the cyclosome-mediated proteolysis of both Pds 1 and Clb2 during M phase in budding yeast
9. Specialization and targeting of B-type cyclins
10. Testing cyclin specificity in the exit from mitosis
11. The B-type cyclin kinase inhibitor p 40SIC1 controls the G1 to S transition in S. cerevisiae
12. Addition of extra origins of replication to a minichromoseme suppresses its mitotic loss in cdc 6 and cdc14 mutants of Saccharomyces cerevisiae
13. CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis
14. Yeast Hct1 is a regulator of Clb2 cyclin proteolysis
15. APC·mediated proteolysis of Ase 1 and the morphogenesis of the mitotic spindle
16. CDC20 and CDH1: A family of substrate-specific activators of APC-dependent proteolysis
17. Activity of the APC(Cdh1) form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc 20p
18. Early expressed Clb proteins allow accumulation of mitotic cyclin by inactivating proteolytic machinery during S phase
19. Cdc14 activates cdc15 to promote mitotic exit in budding yeast
20. Cdc6 cooperates with Sic1 and Hct1 to inactivate mitotic cydin-dependent kinases
21. Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC
22. The KEN box: An APC recognition signal distinct from the D box targeted by Cdh 1
23. Exit from mitosis in budding yeast: Biphasic inactivation of the Cdc28-Clb2 mitotic kinase and the role of Cdc20
24. Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles
25. Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons
26. Fission yeast Fizzy-related protein srw1p is a G(1)-specific promoter of mitotic cyclin B degradation
27. How proteolysis drives the cell cycle
28. Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts
29. Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the annphase-promoting complex
30. Ste 12 and Mcm1 regulate cell cycle dependent transcription of FAR1