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Volumn 6, Issue 24, 2007, Pages 3039-3042

CDC25A levels determine the balance of proliferation and checkpoint response

Author keywords

Breast cancer; CDC25; CDK; Checkpoint; Chk1; Phosphatase; Transformation

Indexed keywords

CHECKPOINT KINASE 1; PROTEIN TYROSINE PHOSPHATASE;

EID: 38149019798     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.6.24.5104     Document Type: Review
Times cited : (34)

References (54)
  • 3
    • 3242890575 scopus 로고    scopus 로고
    • Mammalian cell cycle checkpoints: Signalling pathways and their organization in space and time
    • Lukas J, Lukas C, Bartek J. Mammalian cell cycle checkpoints: Signalling pathways and their organization in space and time. DNA Repair (Amst) 2004; 3:997-1007.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 997-1007
    • Lukas, J.1    Lukas, C.2    Bartek, J.3
  • 4
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: Safeguarding genome integrity
    • Shiloh Y. ATM and related protein kinases: Safeguarding genome integrity. Nature Reviews 2003; 3:155-68.
    • (2003) Nature Reviews , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 5
    • 0034142034 scopus 로고    scopus 로고
    • The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
    • Shieh SY, Ahn J, Tamai K, Taya Y, Prives C. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 2000; 14:289-300.
    • (2000) Genes Dev , vol.14 , pp. 289-300
    • Shieh, S.Y.1    Ahn, J.2    Tamai, K.3    Taya, Y.4    Prives, C.5
  • 6
    • 0033598754 scopus 로고    scopus 로고
    • Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
    • Chehab NH, Malikzay A, Stavridi ES, Halazonetis TD. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc Natl Acad Sci USA 1999; 96:13777-82.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13777-13782
    • Chehab, N.H.1    Malikzay, A.2    Stavridi, E.S.3    Halazonetis, T.D.4
  • 11
    • 0347361537 scopus 로고    scopus 로고
    • SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase
    • Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge SJ, Harper JW. SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev 2003; 17:3062-74.
    • (2003) Genes Dev , vol.17 , pp. 3062-3074
    • Jin, J.1    Shirogane, T.2    Xu, L.3    Nalepa, G.4    Qin, J.5    Elledge, S.J.6    Harper, J.W.7
  • 12
    • 0043066731 scopus 로고    scopus 로고
    • Regulating mammalian checkpoints through Cdc25 inactivation
    • Donzelli M, Draetta GF. Regulating mammalian checkpoints through Cdc25 inactivation. EMBO Rep 2003; 4:671-7.
    • (2003) EMBO Rep , vol.4 , pp. 671-677
    • Donzelli, M.1    Draetta, G.F.2
  • 14
    • 0034102337 scopus 로고    scopus 로고
    • ATR disruption leads to chromosomal fragmentation and early embryonic lethality
    • Brown EJ, Baltimore D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev 2000; 14:397-402.
    • (2000) Genes Dev , vol.14 , pp. 397-402
    • Brown, E.J.1    Baltimore, D.2
  • 15
    • 4143051517 scopus 로고    scopus 로고
    • ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background
    • Fang Y, Tsao CC, Goodman BK, Furumai R, Tirado CA, Abraham RT, Wang XF. ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. Embo J 2004; 23:3164-74.
    • (2004) Embo J , vol.23 , pp. 3164-3174
    • Fang, Y.1    Tsao, C.C.2    Goodman, B.K.3    Furumai, R.4    Tirado, C.A.5    Abraham, R.T.6    Wang, X.F.7
  • 17
    • 3142552523 scopus 로고    scopus 로고
    • Chk1 is haploinsufficient for multiple functions critical to tumor suppression
    • Lam MH, Liu Q, Elledge SJ, Rosen JM. Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell 2004; 6:45-59.
    • (2004) Cancer Cell , vol.6 , pp. 45-59
    • Lam, M.H.1    Liu, Q.2    Elledge, S.J.3    Rosen, J.M.4
  • 19
    • 0022462146 scopus 로고
    • cdc25+ functions as an inducer in the mitotic control of fission yeast
    • Russell P, Nurse P. cdc25+ functions as an inducer in the mitotic control of fission yeast. Cell 1986; 45:145-53.
    • (1986) Cell , vol.45 , pp. 145-153
    • Russell, P.1    Nurse, P.2
  • 20
    • 0029048491 scopus 로고
    • Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle
    • Watanabe N, Broome M, Hunter T. Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. Embo J 1995; 14:1878-91.
    • (1995) Embo J , vol.14 , pp. 1878-1891
    • Watanabe, N.1    Broome, M.2    Hunter, T.3
  • 22
    • 0026319225 scopus 로고
    • Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: Evidence for multiple roles of mitotic cyclins
    • Galaktionov K, Beach D. Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: Evidence for multiple roles of mitotic cyclins. Cell 1991; 67:1181-94.
    • (1991) Cell , vol.67 , pp. 1181-1194
    • Galaktionov, K.1    Beach, D.2
  • 24
    • 0026234297 scopus 로고
    • An additional homolog of the fission yeast cdc25+ gene occurs in humans and is highly expressed in some cancer cells
    • Nagata A, Igarashi M, Jinno S, Suto K, Okayama H. An additional homolog of the fission yeast cdc25+ gene occurs in humans and is highly expressed in some cancer cells. New Biol 1991; 3:959-68.
    • (1991) New Biol , vol.3 , pp. 959-968
    • Nagata, A.1    Igarashi, M.2    Jinno, S.3    Suto, K.4    Okayama, H.5
  • 25
    • 34250865564 scopus 로고    scopus 로고
    • Boutros R, Lobjois V, Ducommun B. CDC25 phosphatases in cancer cells: Key players? Good targets? Nature Reviews 2007.
    • Boutros R, Lobjois V, Ducommun B. CDC25 phosphatases in cancer cells: Key players? Good targets? Nature Reviews 2007.
  • 26
    • 0030667428 scopus 로고    scopus 로고
    • Hyperphosphorylation of the N-terminal domain of Cdc25 regulates activity toward cyclin B1/Cdc2 but not cyclin A/Cdk2
    • Gabrielli BG, Clark JM, McCormack AK, Ellem KA. Hyperphosphorylation of the N-terminal domain of Cdc25 regulates activity toward cyclin B1/Cdc2 but not cyclin A/Cdk2. J Biol Chem 1997; 272:28607-14.
    • (1997) J Biol Chem , vol.272 , pp. 28607-28614
    • Gabrielli, B.G.1    Clark, J.M.2    McCormack, A.K.3    Ellem, K.A.4
  • 31
    • 1842486794 scopus 로고    scopus 로고
    • Cdc25A phosphatase: Combinatorial phosphorylation, ubiquitylation and proteolysis
    • Busino L, Chiesa M, Draetta GF, Donzelli M. Cdc25A phosphatase: Combinatorial phosphorylation, ubiquitylation and proteolysis. Oncogene 2004; 23:2050-6.
    • (2004) Oncogene , vol.23 , pp. 2050-2056
    • Busino, L.1    Chiesa, M.2    Draetta, G.F.3    Donzelli, M.4
  • 36
    • 15044365805 scopus 로고    scopus 로고
    • Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases
    • Ferguson AM, White LS, Donovan PJ, Piwnica-Worms H. Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases. Mol Cell Biol 2005; 25:2853-60.
    • (2005) Mol Cell Biol , vol.25 , pp. 2853-2860
    • Ferguson, A.M.1    White, L.S.2    Donovan, P.J.3    Piwnica-Worms, H.4
  • 40
    • 0344393475 scopus 로고    scopus 로고
    • Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines
    • Loffler H, Syljuasen RG, Bartkova J, Worm J, Lukas J, Bartek J. Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines. Oncogene 2003; 22:8063-71.
    • (2003) Oncogene , vol.22 , pp. 8063-8071
    • Loffler, H.1    Syljuasen, R.G.2    Bartkova, J.3    Worm, J.4    Lukas, J.5    Bartek, J.6
  • 41
    • 33749657631 scopus 로고    scopus 로고
    • Targeting cyclins and cyclin-dependent kinases in cancer: Lessons from mice, hopes for therapeutic applications in human
    • Lee YM, Sicinski P. Targeting cyclins and cyclin-dependent kinases in cancer: Lessons from mice, hopes for therapeutic applications in human. Cell Cycle 2006; 5:2110-4.
    • (2006) Cell Cycle , vol.5 , pp. 2110-2114
    • Lee, Y.M.1    Sicinski, P.2
  • 44
    • 34548211521 scopus 로고    scopus 로고
    • The DNA damage signaling pathway connects oncogenic stress to cellular senescence
    • Mallette FA, Ferbeyre G. The DNA damage signaling pathway connects oncogenic stress to cellular senescence. Cell Cycle 2007; 6.
    • (2007) Cell Cycle , pp. 6
    • Mallette, F.A.1    Ferbeyre, G.2
  • 46
    • 28544433465 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis
    • Reddy HK, Mettus RV, Rane SG, Grana X, Litvin J, Reddy EP. Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis. Cancer Res 2005; 65:10174-8.
    • (2005) Cancer Res , vol.65 , pp. 10174-10178
    • Reddy, H.K.1    Mettus, R.V.2    Rane, S.G.3    Grana, X.4    Litvin, J.5    Reddy, E.P.6
  • 47
    • 0035963435 scopus 로고    scopus 로고
    • Specific protection against breast cancers by cyclin D1 ablation
    • Yu Q, Geng Y, Sicinski P. Specific protection against breast cancers by cyclin D1 ablation. Nature 2001; 411:1017-21.
    • (2001) Nature , vol.411 , pp. 1017-1021
    • Yu, Q.1    Geng, Y.2    Sicinski, P.3
  • 48
    • 0029779280 scopus 로고    scopus 로고
    • Cdc25 cell-cycle phosphatase as a target of c-myc
    • Galaktionov K, Chen X, Beach D. Cdc25 cell-cycle phosphatase as a target of c-myc. Nature 1996; 382:511-7.
    • (1996) Nature , vol.382 , pp. 511-517
    • Galaktionov, K.1    Chen, X.2    Beach, D.3
  • 49
    • 7744220635 scopus 로고    scopus 로고
    • Shachaf CM, Kopelman AM, Arvanitis C, Karlsson A, Beer S, Mandl S, Bachmann MH, Borowsky AD, Ruebner B, Cardiff RD, Yang Q, Bishop JM, Contag CH, Felsher DW. MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. Nature 2004; 431:1112-7.
    • Shachaf CM, Kopelman AM, Arvanitis C, Karlsson A, Beer S, Mandl S, Bachmann MH, Borowsky AD, Ruebner B, Cardiff RD, Yang Q, Bishop JM, Contag CH, Felsher DW. MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. Nature 2004; 431:1112-7.
  • 50
    • 4243193742 scopus 로고    scopus 로고
    • Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype
    • Podsypanina K, Li Y, Varmus HE. Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype. BMC Medicine 2004; 2:24.
    • (2004) BMC Medicine , vol.2 , pp. 24
    • Podsypanina, K.1    Li, Y.2    Varmus, H.E.3
  • 52
    • 0031000554 scopus 로고    scopus 로고
    • Cyclin D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells
    • Sweeney KJ, Sarcevic B, Sutherland RL, Musgrove EA. Cyclin D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells. Oncogene 1997; 14:1329-40.
    • (1997) Oncogene , vol.14 , pp. 1329-1340
    • Sweeney, K.J.1    Sarcevic, B.2    Sutherland, R.L.3    Musgrove, E.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.