메뉴 건너뛰기




Volumn 6, Issue 1, 2008, Pages 71-84

New insights and therapeutics for immune-mediated thrombocytopenia

Author keywords

AMG531; Eltrombopag; Immune mediated thrombocytopenia; Thrombocytopenia; Thrombopoeitin mimetics; Thrombopoietin

Indexed keywords

AKR 501; AMGEN MEGAKARYOPOIESIS PROTEIN 531; AUTOANTIBODY; CARBOPLATIN; CD40 LIGAND MONOCLONAL ANTIBODY; CORTICOSTEROID; CORTICOTROPIN; CORTISONE; DANAZOL; DAPSONE; DEXAMETHASONE; ELTROMBOPAG; ERYTHROPOIETIN; ETANERCEPT; GENE PRODUCT; GW 395058; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PACLITAXEL; PLACEBO; POLYETHYLENE GLYCOL RECOMBINANT HUMAN MEGAKARYOCYTE GROWTH DEVELOPMENT FACTOR; PREDNISONE; RECOMBINANT THROMBOPOIETIN; RITUXIMAB; SB 559448; STEROID; THROMBOPOIETIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRUS PROTEIN MPL;

EID: 38049153586     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/14779072.6.1.71     Document Type: Review
Times cited : (2)

References (146)
  • 1
    • 0037187949 scopus 로고    scopus 로고
    • Immune thrombocytopenic purpura
    • Cines DB, Blanchette VS. Immune thrombocytopenic purpura. N. Engl. J. Med 346(13), 995-1008 (2002).
    • (2002) N. Engl. J. Med , vol.346 , Issue.13 , pp. 995-1008
    • Cines, D.B.1    Blanchette, V.S.2
  • 2
    • 8944225498 scopus 로고    scopus 로고
    • Idiopathic thrombocytopenic purpura: A practice guideline developed by explicit methods for the American Society of Hematology
    • George JN, Woolf SH, Raskob GE et al. Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology. Blood 88(1), 3-40 (1996).
    • (1996) Blood , vol.88 , Issue.1 , pp. 3-40
    • George, J.N.1    Woolf, S.H.2    Raskob, G.E.3
  • 3
    • 0037648477 scopus 로고    scopus 로고
    • Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy
    • Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy. Br. J. Haematol. 120(4), 574-596 (2003).
    • (2003) Br. J. Haematol , vol.120 , Issue.4 , pp. 574-596
  • 4
    • 0347860314 scopus 로고
    • Splenectomy as a therapeutic measure in thrombocytopenic purpura haemorrhagica
    • Whipple A. Splenectomy as a therapeutic measure in thrombocytopenic purpura haemorrhagica. Surg. Gynecol. Obstet. 42, 329-341 (1926).
    • (1926) Surg. Gynecol. Obstet , vol.42 , pp. 329-341
    • Whipple, A.1
  • 5
    • 38049138872 scopus 로고
    • Administration of ACTH in hypersplenic syndromes
    • Meyers MM, Bethell FH. Administration of ACTH in hypersplenic syndromes. J. Lab. Clin. Med. 36(6), 965-966 (1950).
    • (1950) J. Lab. Clin. Med , vol.36 , Issue.6 , pp. 965-966
    • Meyers, M.M.1    Bethell, F.H.2
  • 7
    • 0017261528 scopus 로고
    • Treatment of refractory thrombocytopenic purpura with cyclophosphamine
    • Verlin M, Laros RK Jr, Penner JA. Treatment of refractory thrombocytopenic purpura with cyclophosphamine. Am. J. Hematol. 1(1), 97-104 (1976).
    • (1976) Am. J. Hematol , vol.1 , Issue.1 , pp. 97-104
    • Verlin, M.1    Laros Jr, R.K.2    Penner, J.A.3
  • 8
    • 0014214997 scopus 로고
    • Azathioprine in refractory idiopathic thrombocytopenic purpura
    • Sussman LN. Azathioprine in refractory idiopathic thrombocytopenic purpura. JAMA 202(4), 259-263 (1967).
    • (1967) JAMA , vol.202 , Issue.4 , pp. 259-263
    • Sussman, L.N.1
  • 9
    • 0006598818 scopus 로고
    • Short-course α-interferon therapy in severe unresponsive immune thrombocytopenic purpura
    • Proctor SJ, Jackson G, Carey P, Stark A. Short-course α-interferon therapy in severe unresponsive immune thrombocytopenic purpura. Lancet 1(8591), 947 (1988).
    • (1988) Lancet , vol.1 , Issue.8591 , pp. 947
    • Proctor, S.J.1    Jackson, G.2    Carey, P.3    Stark, A.4
  • 10
    • 0022254215 scopus 로고
    • Refractory idiopathic thrombocytopenic purpura. (ITP) treated with cyclosporine
    • Kelsey PR, Schofield KP, Geary CG. Refractory idiopathic thrombocytopenic purpura. (ITP) treated with cyclosporine. Br. J. Haematol. 60(1), 197-198 (1985).
    • (1985) Br. J. Haematol , vol.60 , Issue.1 , pp. 197-198
    • Kelsey, P.R.1    Schofield, K.P.2    Geary, C.G.3
  • 11
    • 0036098780 scopus 로고    scopus 로고
    • Mycophenolate mofetil for treatment of refractory auto-immune haemolytic anaemia and auto-immune thrombocytopenia purpura
    • Howard J, Hoffbrand AV, Prentice HG, Mehta A. Mycophenolate mofetil for treatment of refractory auto-immune haemolytic anaemia and auto-immune thrombocytopenia purpura. Br. J. Haematol. 117(3), 712-715 (2002).
    • (2002) Br. J. Haematol , vol.117 , Issue.3 , pp. 712-715
    • Howard, J.1    Hoffbrand, A.V.2    Prentice, H.G.3    Mehta, A.4
  • 12
    • 0027279551 scopus 로고
    • Dapsone for autoimmune thrombocytopenic purpura
    • Godeau B, Oksenhendler E, Bierling P. Dapsone for autoimmune thrombocytopenic purpura. Am. J. Hematol. 44(1), 70-72 (1993).
    • (1993) Am. J. Hematol , vol.44 , Issue.1 , pp. 70-72
    • Godeau, B.1    Oksenhendler, E.2    Bierling, P.3
  • 13
    • 0038623928 scopus 로고    scopus 로고
    • Complete recovery from refractory immune thrombocytopenic purpura in three patients treated with etanercept
    • McMinn JR Jr, Cohen S, Moore J et al. Complete recovery from refractory immune thrombocytopenic purpura in three patients treated with etanercept. Am. J. Hematol. 73(2), 135-140 (2003).
    • (2003) Am. J. Hematol , vol.73 , Issue.2 , pp. 135-140
    • McMinn Jr, J.R.1    Cohen, S.2    Moore, J.3
  • 14
    • 0020636872 scopus 로고
    • Danazol for the treatment of idiopathic thrombocytopenic purpura
    • Ahn YS, Harrington WJ, Simon SR et al. Danazol for the treatment of idiopathic thrombocytopenic purpura. N. Eng. J. Med. 308(23), 1396-1399 (1983).
    • (1983) N. Eng. J. Med , vol.308 , Issue.23 , pp. 1396-1399
    • Ahn, Y.S.1    Harrington, W.J.2    Simon, S.R.3
  • 15
    • 33746642069 scopus 로고    scopus 로고
    • Management of patients with refractory immune thrombocytopenic purpura
    • George JN. Management of patients with refractory immune thrombocytopenic purpura. J. Thromb. Haemost. 4(8), 1664-1672 (2006).
    • (2006) J. Thromb. Haemost , vol.4 , Issue.8 , pp. 1664-1672
    • George, J.N.1
  • 16
    • 0035353206 scopus 로고    scopus 로고
    • Morbidity and mortality in adults with idiopathic thrombocytopenic purpura
    • Portielje JE, Westendorp RG, Kluin-Nelemans HC, Brand A. Morbidity and mortality in adults with idiopathic thrombocytopenic purpura. Blood 97(9), 2549-2554 (2001).
    • (2001) Blood , vol.97 , Issue.9 , pp. 2549-2554
    • Portielje, J.E.1    Westendorp, R.G.2    Kluin-Nelemans, H.C.3    Brand, A.4
  • 17
    • 0042932665 scopus 로고    scopus 로고
    • Immune thrombocytopenic purpura - let the treatment fit the patient
    • George JN, Vesely SK. Immune thrombocytopenic purpura - let the treatment fit the patient. N. Engl. J. Med. 349(9), 903-905 (2003).
    • (2003) N. Engl. J. Med , vol.349 , Issue.9 , pp. 903-905
    • George, J.N.1    Vesely, S.K.2
  • 18
    • 0008781796 scopus 로고
    • The megakaryocytes in idiopathic thrombocytopenic purpura, a from of hypersplenism
    • Dameshek W, Miller EB. The megakaryocytes in idiopathic thrombocytopenic purpura, a from of hypersplenism. Blood 1(1), 27-51 (1946).
    • (1946) Blood , vol.1 , Issue.1 , pp. 27-51
    • Dameshek, W.1    Miller, E.B.2
  • 19
    • 0021918452 scopus 로고
    • Platelet kinetics in patients with idiopathic thrombocytopenic purpura and moderate thrombocytopenia
    • Stoll D, Cines DB, Aster RH, Murphy S. Platelet kinetics in patients with idiopathic thrombocytopenic purpura and moderate thrombocytopenia. Blood 65 (3), 584-588 (1985).
    • (1985) Blood , vol.65 , Issue.3 , pp. 584-588
    • Stoll, D.1    Cines, D.B.2    Aster, R.H.3    Murphy, S.4
  • 20
    • 0020031045 scopus 로고
    • 111Indium-oxine-labeled platelets in idiopathic thrombocytopenic purpura: A quantitative study
    • 111Indium-oxine-labeled platelets in idiopathic thrombocytopenic purpura: a quantitative study. Am. J. Hematol. 12(2), 167-177 (1982).
    • (1982) Am. J. Hematol , vol.12 , Issue.2 , pp. 167-177
    • Heyns, A.D.1    Lotter, M.G.2    Badenhorst, P.N.3
  • 22
    • 0024554747 scopus 로고
    • Mechanisms of response to treatment in autoimmune thrombocytopenic purpura
    • Gernsheimer T, Stratton J, Ballem PJ, Slichter SJ. Mechanisms of response to treatment in autoimmune thrombocytopenic purpura. N. Engl. J. Med. 320(15), 974-980 (1989).
    • (1989) N. Engl. J. Med , vol.320 , Issue.15 , pp. 974-980
    • Gernsheimer, T.1    Stratton, J.2    Ballem, P.J.3    Slichter, S.J.4
  • 23
    • 0023218341 scopus 로고
    • Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance
    • Ballem PJ, Segal GM, Stratton JR et al. Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance. J. Clin. Invest. 80(1), 33-40 (1987).
    • (1987) J. Clin. Invest , vol.80 , Issue.1 , pp. 33-40
    • Ballem, P.J.1    Segal, G.M.2    Stratton, J.R.3
  • 24
    • 0842328846 scopus 로고    scopus 로고
    • Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP
    • McMillan R, Wang L, Tomer A, Nichol J, Pistillo J. Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP. Blood 103(4), 1364-1369 (2004).
    • (2004) Blood , vol.103 , Issue.4 , pp. 1364-1369
    • McMillan, R.1    Wang, L.2    Tomer, A.3    Nichol, J.4    Pistillo, J.5
  • 25
    • 0000009286 scopus 로고
    • Demonstration and some properties of human thrombopoietin in thrombocythaemic sera
    • Keleman EC, I.; Tanos, B. Demonstration and some properties of human thrombopoietin in thrombocythaemic sera. Acta. Haematol. 20(6), 350-355 (1958).
    • (1958) Acta. Haematol , vol.20 , Issue.6 , pp. 350-355
    • Keleman, E.I.1    Tanos, B.2
  • 26
    • 0014066563 scopus 로고
    • Physiology of the regulation of platelet production
    • De Gabriele G, Penington DG. Physiology of the regulation of platelet production. Br. J. Haematol. 13(2), 202-209 (1967).
    • (1967) Br. J. Haematol , vol.13 , Issue.2 , pp. 202-209
    • De Gabriele, G.1    Penington, D.G.2
  • 27
    • 0022624954 scopus 로고
    • MPLV: A retrovirus complex inducing an acute myeloproliferative leukemic disorder in adult mice
    • Wendling F, Varlet P, Charon M, Tambourin P. MPLV: a retrovirus complex inducing an acute myeloproliferative leukemic disorder in adult mice. Virology 149(2), 242-246 (1986).
    • (1986) Virology , vol.149 , Issue.2 , pp. 242-246
    • Wendling, F.1    Varlet, P.2    Charon, M.3    Tambourin, P.4
  • 28
    • 0024378304 scopus 로고
    • The human homolog of the myeloproliferative virus maps to chromosome band 1p34
    • Le Coniat M, Souyri M, Vigon I et al. The human homolog of the myeloproliferative virus maps to chromosome band 1p34. Hum. Genet. 83(2), 194-196 (1989).
    • (1989) Hum. Genet , vol.83 , Issue.2 , pp. 194-196
    • Le Coniat, M.1    Souyri, M.2    Vigon, I.3
  • 29
    • 0025674093 scopus 로고
    • A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors
    • Souyri M, Vigon I, Penciolelli JF et al. A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 63(6), 1137-1147 (1990).
    • (1990) Cell , vol.63 , Issue.6 , pp. 1137-1147
    • Souyri, M.1    Vigon, I.2    Penciolelli, J.F.3
  • 30
    • 0026684707 scopus 로고
    • Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily
    • Vigon I, Mornon JP, Cocault L et al. Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Proc. Natl. Acad. Sci. USA 89(12), 5640-5644 (1992).
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , Issue.12 , pp. 5640-5644
    • Vigon, I.1    Mornon, J.P.2    Cocault, L.3
  • 31
    • 0027225872 scopus 로고
    • Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis
    • Methia N, Louache F, Vainchenker W, Wendling F. Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 82(5), 1395-1401 (1993).
    • (1993) Blood , vol.82 , Issue.5 , pp. 1395-1401
    • Methia, N.1    Louache, F.2    Vainchenker, W.3    Wendling, F.4
  • 33
    • 0029960265 scopus 로고    scopus 로고
    • Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl
    • Alexander WS, Roberts AW, Nicola NA, Li R, Metcalf D. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Blood 87(6), 2162-2170 (1996).
    • (1996) Blood , vol.87 , Issue.6 , pp. 2162-2170
    • Alexander, W.S.1    Roberts, A.W.2    Nicola, N.A.3    Li, R.4    Metcalf, D.5
  • 34
    • 0032477741 scopus 로고    scopus 로고
    • Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin
    • Kimura S, Roberts AW, Metcalf D, Alexander WS. Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin. Proc. Natl. Acad. Sci. USA 95(3), 1195-1200 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , Issue.3 , pp. 1195-1200
    • Kimura, S.1    Roberts, A.W.2    Metcalf, D.3    Alexander, W.S.4
  • 35
    • 0028910991 scopus 로고
    • The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl
    • Drachman JG, Griffin JD, Kaushansky K. The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl. J. Biol. Chem. 270(10), 4979-4982 (1995).
    • (1995) J. Biol. Chem , vol.270 , Issue.10 , pp. 4979-4982
    • Drachman, J.G.1    Griffin, J.D.2    Kaushansky, K.3
  • 36
    • 0034644694 scopus 로고    scopus 로고
    • A structure-function analysis of serine/threonine phosphorylation of the thrombopoietin receptor, c-Mpl
    • Miyakawa Y, Drachman JG, Gallis B, Kaushansky A, Kaushansky K. A structure-function analysis of serine/threonine phosphorylation of the thrombopoietin receptor, c-Mpl. J. Biol. Chem. 275(41), 32214-32219 (2000).
    • (2000) J. Biol. Chem , vol.275 , Issue.41 , pp. 32214-32219
    • Miyakawa, Y.1    Drachman, J.G.2    Gallis, B.3    Kaushansky, A.4    Kaushansky, K.5
  • 37
    • 0029049709 scopus 로고
    • Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation
    • Gurney AL, Wong SC, Henzel WJ, de Sauvage FJ. Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation. Proc. Natl. Acad. Sci. USA 92(12), 5292-5296 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , Issue.12 , pp. 5292-5296
    • Gurney, A.L.1    Wong, S.C.2    Henzel, W.J.3    de Sauvage, F.J.4
  • 38
    • 0029584186 scopus 로고
    • Thrombopoietin induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in a human thrombopoietin-dependent cell line
    • Yamada M, Komatsu N, Okada K et al. Thrombopoietin induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in a human thrombopoietin-dependent cell line. Biochem. Biophys. Res. Commun. 217(1), 230-237 (1995).
    • (1995) Biochem. Biophys. Res. Commun , vol.217 , Issue.1 , pp. 230-237
    • Yamada, M.1    Komatsu, N.2    Okada, K.3
  • 39
    • 0035798667 scopus 로고    scopus 로고
    • The roles of phosphatidylinositol 3-kinase and protein kinase Cζ for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine megakaryocytes
    • Rojnuckarin P, Miyakawa Y, Fox NE et al. The roles of phosphatidylinositol 3-kinase and protein kinase Cζ for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine megakaryocytes. J. Biol. Chem. 276(44), 41014-41022 (2001).
    • (2001) J. Biol. Chem , vol.276 , Issue.44 , pp. 41014-41022
    • Rojnuckarin, P.1    Miyakawa, Y.2    Fox, N.E.3
  • 40
    • 0141609830 scopus 로고    scopus 로고
    • Thrombopoietin: A tool for understanding thrombopoiesis
    • Kaushansky K. Thrombopoietin: a tool for understanding thrombopoiesis. J. Thromb. Haemost. 1(7), 1587-1592 (2003).
    • (2003) J. Thromb. Haemost , vol.1 , Issue.7 , pp. 1587-1592
    • Kaushansky, K.1
  • 41
    • 0028302409 scopus 로고
    • Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand
    • de Sauvage FJ, Hass PE, Spencer SD et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369(6481), 533-538 (1994).
    • (1994) Nature , vol.369 , Issue.6481 , pp. 533-538
    • de Sauvage, F.J.1    Hass, P.E.2    Spencer, S.D.3
  • 42
    • 0028199208 scopus 로고
    • Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
    • Lok S, Kaushansky K, Holly RD et al. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369(6481), 565-568 (1994).
    • (1994) Nature , vol.369 , Issue.6481 , pp. 565-568
    • Lok, S.1    Kaushansky, K.2    Holly, R.D.3
  • 43
    • 0028332474 scopus 로고
    • Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin
    • Kaushansky K, Lok S, Holly RD et al. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 369(6481), 568-571 (1994).
    • (1994) Nature , vol.369 , Issue.6481 , pp. 568-571
    • Kaushansky, K.1    Lok, S.2    Holly, R.D.3
  • 44
    • 0028343099 scopus 로고
    • Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl
    • Bartley TD, Bogenberger J, Hunt P et al. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 77(7), 1117-1124 (1994).
    • (1994) Cell , vol.77 , Issue.7 , pp. 1117-1124
    • Bartley, T.D.1    Bogenberger, J.2    Hunt, P.3
  • 45
    • 0028176283 scopus 로고
    • cMpl ligand is a humoral regulator of megakaryocytopoiesis
    • Wendling F, Maraskovsky E, Debili N et al. cMpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369(6481), 571-574 (1994).
    • (1994) Nature , vol.369 , Issue.6481 , pp. 571-574
    • Wendling, F.1    Maraskovsky, E.2    Debili, N.3
  • 46
    • 0027992924 scopus 로고
    • Molecular cloning and chromosomal localization of the human thrombopoietin gene
    • Sohma Y, Akahori H, Seki N et al. Molecular cloning and chromosomal localization of the human thrombopoietin gene. FEBS Lett. 353(1), 57-61 (1994).
    • (1994) FEBS Lett , vol.353 , Issue.1 , pp. 57-61
    • Sohma, Y.1    Akahori, H.2    Seki, N.3
  • 47
    • 31044439372 scopus 로고    scopus 로고
    • The molecular mechanisms that control thrombopoiesis
    • Kaushansky K. The molecular mechanisms that control thrombopoiesis. J. Clin. Invest. 115(12), 3339-3347 (2005).
    • (2005) J. Clin. Invest , vol.115 , Issue.12 , pp. 3339-3347
    • Kaushansky, K.1
  • 48
    • 0028909690 scopus 로고
    • Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance routine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro
    • Broudy VC, Lin NL, Kaushansky K. Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance routine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 85(7), 1719-1726 (1995).
    • (1995) Blood , vol.85 , Issue.7 , pp. 1719-1726
    • Broudy, V.C.1    Lin, N.L.2    Kaushansky, K.3
  • 49
    • 0034081703 scopus 로고    scopus 로고
    • Thrombopoietin incrcases platelet sensitivity to α-thrombin via activation of the ERK2-cPLA2 pathway
    • van Willigen G, Gorter G, Akkerman JW. Thrombopoietin incrcases platelet sensitivity to α-thrombin via activation of the ERK2-cPLA2 pathway. Thromb. Haemost. 83(4), 610-616 (2000).
    • (2000) Thromb. Haemost , vol.83 , Issue.4 , pp. 610-616
    • van Willigen, G.1    Gorter, G.2    Akkerman, J.W.3
  • 50
    • 33646468244 scopus 로고    scopus 로고
    • Thrombopoietin and platelet function
    • Akkerman JW. Thrombopoietin and platelet function. Semin. Thromb. Hemost. 32(3), 295-304 (2006).
    • (2006) Semin. Thromb. Hemost , vol.32 , Issue.3 , pp. 295-304
    • Akkerman, J.W.1
  • 51
    • 0029035989 scopus 로고
    • Purification and biologic characterization of plasma-derived megakaryocyte growth and development factor
    • Hunt P, Li YS, Nichol JL et al. Purification and biologic characterization of plasma-derived megakaryocyte growth and development factor. Blood 86(2), 540-547 (1995).
    • (1995) Blood , vol.86 , Issue.2 , pp. 540-547
    • Hunt, P.1    Li, Y.S.2    Nichol, J.L.3
  • 52
    • 17744409936 scopus 로고    scopus 로고
    • Concentrations of thrombopoietin in bone marrow in normal subjects and in patients with idiopathic thrombocytopenic purpura, aplastic anemia, and essential thrombocythemia correlate with its mRNA expression of bone marrow stromal cells
    • Hirayama Y, Sakamaki S, Matsunaga T et al. Concentrations of thrombopoietin in bone marrow in normal subjects and in patients with idiopathic thrombocytopenic purpura, aplastic anemia, and essential thrombocythemia correlate with its mRNA expression of bone marrow stromal cells. Blood 92(1), 46-52 (1998).
    • (1998) Blood , vol.92 , Issue.1 , pp. 46-52
    • Hirayama, Y.1    Sakamaki, S.2    Matsunaga, T.3
  • 53
    • 9344231924 scopus 로고    scopus 로고
    • Circulating thrombopoietin level in chronic immune thrombocytopenic purpura
    • Kosugi S, Kurata Y, Tomiyama Y et al. Circulating thrombopoietin level in chronic immune thrombocytopenic purpura. Br. J. Haematol. 93(3), 704-706 (1996).
    • (1996) Br. J. Haematol , vol.93 , Issue.3 , pp. 704-706
    • Kosugi, S.1    Kurata, Y.2    Tomiyama, Y.3
  • 54
    • 8944258119 scopus 로고    scopus 로고
    • A sensitive sandwich ELISA for measuring thrombopoietin in human serum: Serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders
    • Tahara T, Usuki K, Sato H et al. A sensitive sandwich ELISA for measuring thrombopoietin in human serum: serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders. Br. J. Haematol. 93(4), 783-788 (1996).
    • (1996) Br. J. Haematol , vol.93 , Issue.4 , pp. 783-788
    • Tahara, T.1    Usuki, K.2    Sato, H.3
  • 55
    • 0029881744 scopus 로고    scopus 로고
    • Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction
    • Emmons RV, Reid DM, Cohen RL et al. Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood 87(10), 4068-4071 (1996).
    • (1996) Blood , vol.87 , Issue.10 , pp. 4068-4071
    • Emmons, R.V.1    Reid, D.M.2    Cohen, R.L.3
  • 56
    • 33644786946 scopus 로고    scopus 로고
    • Circulating thrombopoietin as an in vivo growth factor for blast cells in acute myeloid leukemia
    • Corazza F, Hermans C, D'Hondt S et al. Circulating thrombopoietin as an in vivo growth factor for blast cells in acute myeloid leukemia. Blood 107(6), 2525-2530 (2006).
    • (2006) Blood , vol.107 , Issue.6 , pp. 2525-2530
    • Corazza, F.1    Hermans, C.2    D'Hondt, S.3
  • 57
    • 0014060190 scopus 로고    scopus 로고
    • De Gabriele G, Penington DG. Regulation of platelet production: 'thrombopoietin'. Br J. Haematol. 13(2), 210-215 (1967).
    • De Gabriele G, Penington DG. Regulation of platelet production: 'thrombopoietin'. Br J. Haematol. 13(2), 210-215 (1967).
  • 58
    • 7144229346 scopus 로고    scopus 로고
    • Serum thrombopoietin level is mainly regulated by megakaryocyte mass rather than platelet mass in human subjects
    • Nagasawa T, Hasegawa Y, Shimizu S et al. Serum thrombopoietin level is mainly regulated by megakaryocyte mass rather than platelet mass in human subjects. Br. J. Haematol. 101(2), 242-244 (1998).
    • (1998) Br. J. Haematol , vol.101 , Issue.2 , pp. 242-244
    • Nagasawa, T.1    Hasegawa, Y.2    Shimizu, S.3
  • 59
    • 0037630266 scopus 로고    scopus 로고
    • Internalization of the thrombopoietin receptor is regulated by 2 cytoplasmic motifs
    • Dahlen DD, Broudy VC, Drachman J. Internalization of the thrombopoietin receptor is regulated by 2 cytoplasmic motifs. Blood 103(1), 102-108 (2003).
    • (2003) Blood , vol.103 , Issue.1 , pp. 102-108
    • Dahlen, D.D.1    Broudy, V.C.2    Drachman, J.3
  • 60
    • 0029030356 scopus 로고
    • The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit
    • Kuter DJ, Rosenberg RD. The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 8500), 2720-2730 (1995).
    • (1995) Blood 8500) , pp. 2720-2730
    • Kuter, D.J.1    Rosenberg, R.D.2
  • 61
    • 0029865443 scopus 로고    scopus 로고
    • Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets
    • Fielder PJ, Gurney AL, Stefanich E et al. Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood 87(6), 2154-2161 (1996).
    • (1996) Blood , vol.87 , Issue.6 , pp. 2154-2161
    • Fielder, P.J.1    Gurney, A.L.2    Stefanich, E.3
  • 62
    • 0032906946 scopus 로고    scopus 로고
    • Close association between clearance of recombinant human granulocyte colony-stimulating factor (G-CSF) and G-CSF receptor on neutrophils in cancer patients
    • Terashi K, Oka M, Ohdo S et al. Close association between clearance of recombinant human granulocyte colony-stimulating factor (G-CSF) and G-CSF receptor on neutrophils in cancer patients. Antimicrob. Agents Chemother. 43(1), 21-24 (1999).
    • (1999) Antimicrob. Agents Chemother , vol.43 , Issue.1 , pp. 21-24
    • Terashi, K.1    Oka, M.2    Ohdo, S.3
  • 63
    • 0345770235 scopus 로고    scopus 로고
    • Therapeutic cytokine stimulation of thrombocytopoiesis
    • Harker LA. Therapeutic cytokine stimulation of thrombocytopoiesis. Transfus. Sci. 19(2), 149-162 (1998).
    • (1998) Transfus. Sci , vol.19 , Issue.2 , pp. 149-162
    • Harker, L.A.1
  • 64
    • 10344235968 scopus 로고    scopus 로고
    • Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer
    • Basset RL, Rasko JE, Clarke K et al. Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer. Lancet 348(9037), 1279-1281 (1996).
    • (1996) Lancet , vol.348 , Issue.9037 , pp. 1279-1281
    • Basset, R.L.1    Rasko, J.E.2    Clarke, K.3
  • 65
    • 0028803099 scopus 로고
    • Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice
    • Hokom MM, Lacey D, Kinstler OB et al. Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice. Blood 86(12), 4486-4492 (1995).
    • (1995) Blood , vol.86 , Issue.12 , pp. 4486-4492
    • Hokom, M.M.1    Lacey, D.2    Kinstler, O.B.3
  • 66
    • 0031049879 scopus 로고    scopus 로고
    • Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer
    • Fanucchi M, Glaspy J, Crawford J et al. Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer. N. Engl. J. Med. 336(6), 404-409 (1997).
    • (1997) N. Engl. J. Med , vol.336 , Issue.6 , pp. 404-409
    • Fanucchi, M.1    Glaspy, J.2    Crawford, J.3
  • 67
    • 0037111558 scopus 로고    scopus 로고
    • Recombinant human thrombopoietin: Basic biology and evaluation of clinical studies
    • Kuter DJ, Begley CG. Recombinant human thrombopoietin: basic biology and evaluation of clinical studies. Blood 100(10), 3457-3469 (2002).
    • (2002) Blood , vol.100 , Issue.10 , pp. 3457-3469
    • Kuter, D.J.1    Begley, C.G.2
  • 68
    • 0034050651 scopus 로고    scopus 로고
    • Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer
    • Vadhan-Raj S, Verschraegen CF, Bueso-Ramos C et al. Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer. Ann. Intern. Med. 132(5), 364-368 (2000).
    • (2000) Ann. Intern. Med , vol.132 , Issue.5 , pp. 364-368
    • Vadhan-Raj, S.1    Verschraegen, C.F.2    Bueso-Ramos, C.3
  • 69
    • 0030966361 scopus 로고    scopus 로고
    • Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer
    • Vadhan-Raj S, Murray LJ, Bueso-Ramos C et al. Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer. Ann. Intern. Med. 126(9), 673-681 (1997).
    • (1997) Ann. Intern. Med , vol.126 , Issue.9 , pp. 673-681
    • Vadhan-Raj, S.1    Murray, L.J.2    Bueso-Ramos, C.3
  • 70
    • 0031810565 scopus 로고    scopus 로고
    • Treatment of thrombocytopenia in chimpanzees infected with human immunodeficiency virus by pegylated recombinant human megakaryocyte growth and development factor
    • Harker LA, Marzec UM, Novembre F et al. Treatment of thrombocytopenia in chimpanzees infected with human immunodeficiency virus by pegylated recombinant human megakaryocyte growth and development factor. Blood 91(12), 4427-4433 (1998).
    • (1998) Blood , vol.91 , Issue.12 , pp. 4427-4433
    • Harker, L.A.1    Marzec, U.M.2    Novembre, F.3
  • 71
    • 4243219531 scopus 로고    scopus 로고
    • Correction of thrombocytopenia and ineffective platelet production in patients infected with human immunodeficiency virus (HIV) by PEG-rHuMGDF therapy
    • Abstract 707a
    • Harker LA, Carter RA, Marzec UM et al. Correction of thrombocytopenia and ineffective platelet production in patients infected with human immunodeficiency virus (HIV) by PEG-rHuMGDF therapy. Blood 92, (1998) (Abstract 707a).
    • (1998) Blood , pp. 92
    • Harker, L.A.1    Carter, R.A.2    Marzec, U.M.3
  • 72
    • 0035469813 scopus 로고    scopus 로고
    • Thrombopoietin therapy increases platelet yields in healthy platelet donors
    • Kuter DJ, Goodnough LT, Romo J et al. Thrombopoietin therapy increases platelet yields in healthy platelet donors. Blood 98(5), 1339-1345 (2001).
    • (2001) Blood , vol.98 , Issue.5 , pp. 1339-1345
    • Kuter, D.J.1    Goodnough, L.T.2    Romo, J.3
  • 73
    • 0035469854 scopus 로고    scopus 로고
    • Prophylactic platelet transfusions from healthy apheresis platelet donors undergoing treatment with thrombopoietin
    • Goodnough LT, Kuter DJ, McCullough J et al. Prophylactic platelet transfusions from healthy apheresis platelet donors undergoing treatment with thrombopoietin. Blood 98(5), 1346-1351 (2001).
    • (2001) Blood , vol.98 , Issue.5 , pp. 1346-1351
    • Goodnough, L.T.1    Kuter, D.J.2    McCullough, J.3
  • 74
    • 0037100423 scopus 로고    scopus 로고
    • Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura
    • Nomura S, Dan K, Hotta T, Fujimura K, Ikeda Y. Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura. Blood 100(2), 728-730 (2002).
    • (2002) Blood , vol.100 , Issue.2 , pp. 728-730
    • Nomura, S.1    Dan, K.2    Hotta, T.3    Fujimura, K.4    Ikeda, Y.5
  • 75
    • 0034781155 scopus 로고    scopus 로고
    • Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy
    • Rice L, Nichol JL, McMillan R, Roskos LK, Bacile M. Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy. Am. J. Hematol. 68(3), 210-214 (2001).
    • (2001) Am. J. Hematol , vol.68 , Issue.3 , pp. 210-214
    • Rice, L.1    Nichol, J.L.2    McMillan, R.3    Roskos, L.K.4    Bacile, M.5
  • 76
    • 18944407713 scopus 로고    scopus 로고
    • Multiple cycles of recombinant human thrombopoietin therapy in a patient with chronic refractory idiopathic thrombocytopenic purpura
    • Hua B, Zou N, Wang S, Zhu T, Zhao Y. Multiple cycles of recombinant human thrombopoietin therapy in a patient with chronic refractory idiopathic thrombocytopenic purpura. Blood Coagul. Fibrinolyis 16(4), 291-295 (2005).
    • (2005) Blood Coagul. Fibrinolyis , vol.16 , Issue.4 , pp. 291-295
    • Hua, B.1    Zou, N.2    Wang, S.3    Zhu, T.4    Zhao, Y.5
  • 77
    • 19244377909 scopus 로고    scopus 로고
    • Analysis of megakaryocyte growth and development factor (thrombopoietin) effects on blast cell and megakaryocyte growth in myelodysplasia
    • Fontenay-Roupie M, Dupont JM, Picard F et al. Analysis of megakaryocyte growth and development factor (thrombopoietin) effects on blast cell and megakaryocyte growth in myelodysplasia. Leuk. Res. 22(6), 527-535 (1998).
    • (1998) Leuk. Res , vol.22 , Issue.6 , pp. 527-535
    • Fontenay-Roupie, M.1    Dupont, J.M.2    Picard, F.3
  • 78
    • 0031844968 scopus 로고    scopus 로고
    • Thrombopoietin stimulates myelodysplastic syndrome granulocyte-macrophage and erythroid progenitor proliferation
    • Ferrajoli A, Talpaz M, Kurzrock R et al. Thrombopoietin stimulates myelodysplastic syndrome granulocyte-macrophage and erythroid progenitor proliferation. Leuk. Lymphoma 30(3-4), 279-292 (1998).
    • (1998) Leuk. Lymphoma , vol.30 , Issue.3-4 , pp. 279-292
    • Ferrajoli, A.1    Talpaz, M.2    Kurzrock, R.3
  • 79
    • 0042914309 scopus 로고    scopus 로고
    • Long-term administration of pegylated recombinant human megakaryocyte growth and development factor dramatically improved cytopenias in a patient with myelodysplastic syndrome
    • Kizaki M, Miyakawa Y, Ikeda Y. Long-term administration of pegylated recombinant human megakaryocyte growth and development factor dramatically improved cytopenias in a patient with myelodysplastic syndrome. Br. J. Haematol. 122(5), 764-767 (2003).
    • (2003) Br. J. Haematol , vol.122 , Issue.5 , pp. 764-767
    • Kizaki, M.1    Miyakawa, Y.2    Ikeda, Y.3
  • 80
    • 3042636435 scopus 로고    scopus 로고
    • Long-term improvement of anaemia in a patient with aplastic anaemia by short-term administration of pegylated recombinant human megakaryocyte growth and development factor
    • Matsuda A, Misumi M, Ishikawa M et al. Long-term improvement of anaemia in a patient with aplastic anaemia by short-term administration of pegylated recombinant human megakaryocyte growth and development factor. Br. J. Haematol. 125(6), 818-819 (2004).
    • (2004) Br. J. Haematol , vol.125 , Issue.6 , pp. 818-819
    • Matsuda, A.1    Misumi, M.2    Ishikawa, M.3
  • 81
    • 0033485568 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study with pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) as an adjunct to chemotherapy for adults with de novo acute myeloid leukemia
    • Archimbaud E, Ottmann OG, Yin JA et al. A randomized, double-blind, placebo-controlled study with pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) as an adjunct to chemotherapy for adults with de novo acute myeloid leukemia. Blood 94(11), 3694-3701 (1999).
    • (1999) Blood , vol.94 , Issue.11 , pp. 3694-3701
    • Archimbaud, E.1    Ottmann, O.G.2    Yin, J.A.3
  • 82
    • 0034655649 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia
    • Schiffer CA, Miller K, Larson RA et al. A double-blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia. Blood 95(8), 2530-2535 (2000).
    • (2000) Blood , vol.95 , Issue.8 , pp. 2530-2535
    • Schiffer, C.A.1    Miller, K.2    Larson, R.A.3
  • 83
    • 0033930709 scopus 로고    scopus 로고
    • Phase 1 study of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in breast cancer patients after autologous peripheral blood progenitor cell (PBPC) transplantation
    • Bolwell B, Vredenburgh J, Overmoyer B et al. Phase 1 study of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in breast cancer patients after autologous peripheral blood progenitor cell (PBPC) transplantation. Bone Marrow Transplant. 26(2), 141-145 (2000).
    • (2000) Bone Marrow Transplant , vol.26 , Issue.2 , pp. 141-145
    • Bolwell, B.1    Vredenburgh, J.2    Overmoyer, B.3
  • 84
    • 0035760892 scopus 로고    scopus 로고
    • Thrombocytopenia caused by the development of antibodies to thrombopoietin
    • Li J, Yang C, Xia Y et al. Thrombocytopenia caused by the development of antibodies to thrombopoietin. Blood 98(12), 3241-3248 (2001).
    • (2001) Blood , vol.98 , Issue.12 , pp. 3241-3248
    • Li, J.1    Yang, C.2    Xia, Y.3
  • 85
    • 0036530040 scopus 로고    scopus 로고
    • Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor
    • Basser RL, O'Flaherty E, Green M et al. Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor. Blood 99(7), 2599-2602 (2002).
    • (2002) Blood , vol.99 , Issue.7 , pp. 2599-2602
    • Basser, R.L.1    O'Flaherty, E.2    Green, M.3
  • 86
    • 8844263239 scopus 로고    scopus 로고
    • Pathogenic antibodies to coagulation factors. Part one: Factor VIII and factor IX
    • Lollar P. Pathogenic antibodies to coagulation factors. Part one: factor VIII and factor IX. J. Thromb. Haemost. 2, 1082-1095 (2004).
    • (2004) J. Thromb. Haemost , vol.2 , pp. 1082-1095
    • Lollar, P.1
  • 87
    • 9144232123 scopus 로고    scopus 로고
    • Inhibitors in congenital coagulation disorders
    • Key NS. Inhibitors in congenital coagulation disorders. Br. J. Haematol. 127(4), 379-391 (2004).
    • (2004) Br. J. Haematol , vol.127 , Issue.4 , pp. 379-391
    • Key, N.S.1
  • 88
    • 0030773876 scopus 로고    scopus 로고
    • Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine
    • Cwirla SE, Balasubramanian P, Duffin DJ et al. Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine. Science 276(5319), 1696-1699 (1997).
    • (1997) Science , vol.276 , Issue.5319 , pp. 1696-1699
    • Cwirla, S.E.1    Balasubramanian, P.2    Duffin, D.J.3
  • 89
    • 0032797771 scopus 로고    scopus 로고
    • Immunogenicity of thrombopoietin mimetic peptide GW395058 in BALB/c mice and New Zealand white rabbits: Evaluation of the potential for thrombopoietin neutralizing antibody production in man
    • de Setres M, Ellis B, Dillberger JE et al. Immunogenicity of thrombopoietin mimetic peptide GW395058 in BALB/c mice and New Zealand white rabbits: evaluation of the potential for thrombopoietin neutralizing antibody production in man. Stem Cells 17(4), 203-209 (1999).
    • (1999) Stem Cells , vol.17 , Issue.4 , pp. 203-209
    • de Setres, M.1    Ellis, B.2    Dillberger, J.E.3
  • 90
    • 3543123430 scopus 로고    scopus 로고
    • An agonist murine monoclonal antibody to the human c-Mpl receptor stimulates megakaryocytopoiesis
    • Deng B, Banu N, Malloy B et al. An agonist murine monoclonal antibody to the human c-Mpl receptor stimulates megakaryocytopoiesis. Blood 92(6), 1981-1988 (1998).
    • (1998) Blood , vol.92 , Issue.6 , pp. 1981-1988
    • Deng, B.1    Banu, N.2    Malloy, B.3
  • 91
    • 33748674848 scopus 로고    scopus 로고
    • Drug evaluation: AMG-531 for the treatment of thrombocytopenias
    • Rice L. Drug evaluation: AMG-531 for the treatment of thrombocytopenias. Curr. Opin. Investig. Drugs 7(9), 834-841 (2006).
    • (2006) Curr. Opin. Investig. Drugs , vol.7 , Issue.9 , pp. 834-841
    • Rice, L.1
  • 92
    • 33748517860 scopus 로고    scopus 로고
    • AMG 531: An investigational thrombopoiesis-stimulating peptibody
    • Nichol JL. AMG 531: an investigational thrombopoiesis-stimulating peptibody. Pediatr. Blood Cancer 47(5 Suppl.), 723-725 (2006).
    • (2006) Pediatr. Blood Cancer , vol.47 , Issue.5 SUPPL. , pp. 723-725
    • Nichol, J.L.1
  • 93
    • 10044296968 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand
    • Wang B, Nichol JL, Sullivan JT. Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand. Clin. Pharmacol. Ther. 76(6), 628-638 (2004).
    • (2004) Clin. Pharmacol. Ther , vol.76 , Issue.6 , pp. 628-638
    • Wang, B.1    Nichol, J.L.2    Sullivan, J.T.3
  • 94
    • 0346881171 scopus 로고    scopus 로고
    • AMG531 stimulates megakaryopoiesis in vitro by binding to Mpl
    • Broudy VC, Lin NL. AMG531 stimulates megakaryopoiesis in vitro by binding to Mpl. Cytokine 25(2), 52-60 (2004).
    • (2004) Cytokine , vol.25 , Issue.2 , pp. 52-60
    • Broudy, V.C.1    Lin, N.L.2
  • 95
    • 33750051618 scopus 로고    scopus 로고
    • An open-label, unit dose-finding study of AMG 531, a novel thrombopoiesis-stimulating peptibody, in patients with immune thrombocytopenic purpura
    • Newland A, Caulier MT, Kappers-Klunne M et al. An open-label, unit dose-finding study of AMG 531, a novel thrombopoiesis-stimulating peptibody, in patients with immune thrombocytopenic purpura. Br. J. Haematol. 135(4), 547-553 (2006).
    • (2006) Br. J. Haematol , vol.135 , Issue.4 , pp. 547-553
    • Newland, A.1    Caulier, M.T.2    Kappers-Klunne, M.3
  • 96
    • 33750035507 scopus 로고    scopus 로고
    • AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP
    • Bussel JB, Kuter DJ, George JN et al. AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP. N. Engl. J. Med. 355(16), 1672-1681 (2006).
    • (2006) N. Engl. J. Med , vol.355 , Issue.16 , pp. 1672-1681
    • Bussel, J.B.1    Kuter, D.J.2    George, J.N.3
  • 97
    • 34250642228 scopus 로고    scopus 로고
    • Long-term dosing of AMG 531 in thrombocytopenic patients with immune thrombocytopenic purpura: 48-week update
    • Presented at:, Orlando, FL, USA, 9-12 December, Abstract 476
    • Kuter D, Bussel JB, George J et al. Long-term dosing of AMG 531 in thrombocytopenic patients with immune thrombocytopenic purpura: 48-week update. Presented at: 48th Annual Meeting of the American Society of Hematology, Orlando, FL, USA, 9-12 December 2006 (Abstract 476).
    • (2006) 48th Annual Meeting of the American Society of Hematology
    • Kuter, D.1    Bussel, J.B.2    George, J.3
  • 98
    • 0028843848 scopus 로고
    • Chronic exposure to retroviral vector encoded MGDF (mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice
    • Yan XQ, Lacey D, Fletcher F et al. Chronic exposure to retroviral vector encoded MGDF (mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice. Blood 86(11), 4025-4033 (1995).
    • (1995) Blood , vol.86 , Issue.11 , pp. 4025-4033
    • Yan, X.Q.1    Lacey, D.2    Fletcher, F.3
  • 99
    • 0029897491 scopus 로고    scopus 로고
    • Systemic hematologic effects of PEG-rHuMGDF-induced megakaryocyte hyperplasia in mice
    • Ulich TR, del Castillo J, Senaldi G et al. Systemic hematologic effects of PEG-rHuMGDF-induced megakaryocyte hyperplasia in mice. Blood 87(12), 5006-5015 (1996).
    • (1996) Blood , vol.87 , Issue.12 , pp. 5006-5015
    • Ulich, T.R.1    del Castillo, J.2    Senaldi, G.3
  • 100
    • 6844250789 scopus 로고    scopus 로고
    • The role of transforming growth factor-β in PEG-rHuMGDF-induced reversible myelofibrosis in rats
    • Yanagida M, Ide Y, Imai A et al. The role of transforming growth factor-β in PEG-rHuMGDF-induced reversible myelofibrosis in rats. Br. J. Haematol. 99(4), 739-745 (1997).
    • (1997) Br. J. Haematol , vol.99 , Issue.4 , pp. 739-745
    • Yanagida, M.1    Ide, Y.2    Imai, A.3
  • 101
    • 34250644242 scopus 로고    scopus 로고
    • Platelet aggregation analysis of AMG 531 in a randomized, placebo-controlled study in healthy Japanese subjects
    • Presented at:, Orlando, FL, USA, 9-12 December
    • Kumagai Y, Fujita T, Ozaki M et al. Platelet aggregation analysis of AMG 531 in a randomized, placebo-controlled study in healthy Japanese subjects. Presented at: 48th Annual Meeting of the American Society of Hematology, Orlando, FL, USA, 9-12 December 2006
    • (2006) 48th Annual Meeting of the American Society of Hematology
    • Kumagai, Y.1    Fujita, T.2    Ozaki, M.3
  • 102
    • 0035950101 scopus 로고    scopus 로고
    • Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis
    • Duffy KJ, Darcy MG, Delorme E et al. Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis. J. Med. Chem. 44(22), 3730-3745 (2001).
    • (2001) J. Med. Chem , vol.44 , Issue.22 , pp. 3730-3745
    • Duffy, K.J.1    Darcy, M.G.2    Delorme, E.3
  • 103
    • 33746604143 scopus 로고    scopus 로고
    • Discovery of SB-497115, a small-molecule thrombopoietin (TPO) receptor agonist for the treatment of thrombocytopenia
    • Luengo JI, Duffy KJ, Shaw AN et al. Discovery of SB-497115, a small-molecule thrombopoietin (TPO) receptor agonist for the treatment of thrombocytopenia. Blood 104(11), 2910 (2004).
    • (2004) Blood , vol.104 , Issue.11 , pp. 2910
    • Luengo, J.I.1    Duffy, K.J.2    Shaw, A.N.3
  • 104
    • 33749015400 scopus 로고    scopus 로고
    • Biological activity and selectivity for Tpo Receptor of the orally bioavailable, small molecule Tpo receptor agonist, SB-497115
    • Erickson-Miller C, Delorme E, Giampa L et al. Biological activity and selectivity for Tpo Receptor of the orally bioavailable, small molecule Tpo receptor agonist, SB-497115. Blood 104(11), 2912 (2004).
    • (2004) Blood , vol.104 , Issue.11 , pp. 2912
    • Erickson-Miller, C.1    Delorme, E.2    Giampa, L.3
  • 105
    • 33749024371 scopus 로고    scopus 로고
    • SB 497115-GR, a low molecular weight tpor agonist, does not induce platelet activation or enhance agonist-induced platelet aggregation in vitro
    • Erhardt J, Erickson-Miller CL, Tapley P. SB 497115-GR, a low molecular weight tpor agonist, does not induce platelet activation or enhance agonist-induced platelet aggregation in vitro. Blood 104(11), 3888 (2004).
    • (2004) Blood , vol.104 , Issue.11 , pp. 3888
    • Erhardt, J.1    Erickson-Miller, C.L.2    Tapley, P.3
  • 106
    • 22244475160 scopus 로고    scopus 로고
    • An oral, non-petide, small molecule thrombopoietin receptor agonist increases platelet counts in healthy subjects
    • Abstract 2916
    • Jenkins J, Nicholl R, Williams D et al. An oral, non-petide, small molecule thrombopoietin receptor agonist increases platelet counts in healthy subjects. Blood 104(11), 797a (2004) (Abstract 2916).
    • (2004) Blood , vol.104 , Issue.11
    • Jenkins, J.1    Nicholl, R.2    Williams, D.3
  • 107
    • 34249719511 scopus 로고    scopus 로고
    • Phase I clinical study of eltrombopag, an oral, non-peptide thrombopoietin receptor agonist
    • Jenkins JM, Williams D, Deng Y et al. Phase I clinical study of eltrombopag, an oral, non-peptide thrombopoietin receptor agonist. Blood 109(11), 4739-4741 (2007).
    • (2007) Blood , vol.109 , Issue.11 , pp. 4739-4741
    • Jenkins, J.M.1    Williams, D.2    Deng, Y.3
  • 108
    • 34250675169 scopus 로고    scopus 로고
    • Analysis of bleeding in patients with immune thrombocytopenic purpura (ITP): A randomized, double-blind, placebo-controlled trial of eltrombopag, an oral platelet growth factor
    • Presented at:, Orlando, FL, USA, 9-12 December
    • Bussel JB, Cheng G, Saleh M et al. Analysis of bleeding in patients with immune thrombocytopenic purpura (ITP): a randomized, double-blind, placebo-controlled trial of eltrombopag, an oral platelet growth factor. Presented at: 48th Annual Meeting of the American Society of Hematology, Orlando, FL, USA, 9-12 December 2006.
    • (2006) 48th Annual Meeting of the American Society of Hematology
    • Bussel, J.B.1    Cheng, G.2    Saleh, M.3
  • 109
    • 34249728003 scopus 로고    scopus 로고
    • Eltrombopag, an oral platelet growth factor, facilitates initiation of interferon therapy in subjects with HCV associated thrombocytopenia: Results from a Phase II placebo controlled, double-blind, dose-ranging study
    • Abstract LB693
    • McHutchison JA, Dusheiko G, Shiffman L et al. Eltrombopag, an oral platelet growth factor, facilitates initiation of interferon therapy in subjects with HCV associated thrombocytopenia: results from a Phase II placebo controlled, double-blind, dose-ranging study. Hepatology 44(S1), 692A, (2006) (Abstract LB693).
    • (2006) Hepatology , vol.44 , Issue.S1
    • McHutchison, J.A.1    Dusheiko, G.2    Shiffman, L.3
  • 110
    • 38049103412 scopus 로고    scopus 로고
    • A Phase I study to investigate the pharmacokinetics (PK) and pharmacodynamics (PD) of an oral platelet growth factor (SB-559448) in healthy subjects
    • Presented at:, Orlando, FL, USA, 9-12 December
    • Su S-F, Peng B, Williams D et al. A Phase I study to investigate the pharmacokinetics (PK) and pharmacodynamics (PD) of an oral platelet growth factor (SB-559448) in healthy subjects. Presented at: 48th Annual Meeting of the American Society of Hematology, Orlando, FL, USA, 9-12 December 2006.
    • (2006) 48th Annual Meeting of the American Society of Hematology
    • Su, S.-F.1    Peng, B.2    Williams, D.3
  • 111
    • 34250688634 scopus 로고    scopus 로고
    • Single and multiple oral doses of AKR-501 (YM477) increase the platelet count in healthy volunteers
    • Presented at:, Orlando, FL, USA, 9-12 December
    • Desjardins RE, Tempel DL, Lucek R, Kuter DJ. Single and multiple oral doses of AKR-501 (YM477) increase the platelet count in healthy volunteers. Presented at: 48th Annual Meeting of the American Society of Hematology, Orlando, FL, USA, 9-12 December 2006.
    • (2006) 48th Annual Meeting of the American Society of Hematology
    • Desjardins, R.E.1    Tempel, D.L.2    Lucek, R.3    Kuter, D.J.4
  • 112
    • 19944432021 scopus 로고    scopus 로고
    • Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist
    • Erickson-Miller CL, DeLorme E, Tian SS et al. Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Exp. Hematol. 33(1), 85-93 (2005).
    • (2005) Exp. Hematol , vol.33 , Issue.1 , pp. 85-93
    • Erickson-Miller, C.L.1    DeLorme, E.2    Tian, S.S.3
  • 113
    • 19944429567 scopus 로고    scopus 로고
    • A novel therapeutic approach for thrombocytopenia by minibody agonist of the thrombopoietin receptor
    • Orita T, Tsunoda H, Yabuta N et al. A novel therapeutic approach for thrombocytopenia by minibody agonist of the thrombopoietin receptor. Blood 105(2), 562-566 (2005).
    • (2005) Blood , vol.105 , Issue.2 , pp. 562-566
    • Orita, T.1    Tsunoda, H.2    Yabuta, N.3
  • 114
    • 33749249751 scopus 로고    scopus 로고
    • A rationally designed agonist antibody fragment that functionally mimics thrombopoietin
    • Frederickson S, Renshaw MW, Lin B et al. A rationally designed agonist antibody fragment that functionally mimics thrombopoietin. Proc. Natl Acad. Sci. USA 103(39), 14307-14312 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.39 , pp. 14307-14312
    • Frederickson, S.1    Renshaw, M.W.2    Lin, B.3
  • 115
    • 33744456732 scopus 로고    scopus 로고
    • A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis
    • Nakamura T, Miyakawa Y, Miyamura A et al. A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis. Blood 107(11), 4300-4307 (2006).
    • (2006) Blood , vol.107 , Issue.11 , pp. 4300-4307
    • Nakamura, T.1    Miyakawa, Y.2    Miyamura, A.3
  • 116
    • 0037251878 scopus 로고    scopus 로고
    • Rituximab: A review of its use in non-Hodgkin's lymphoma and chronic lymphocytic leukaemia
    • Plosker GL, Figgitt DP. Rituximab: a review of its use in non-Hodgkin's lymphoma and chronic lymphocytic leukaemia. Drugs 63(8), 803-843 (2003).
    • (2003) Drugs , vol.63 , Issue.8 , pp. 803-843
    • Plosker, G.L.1    Figgitt, D.P.2
  • 117
    • 0042173008 scopus 로고    scopus 로고
    • Eisenberg R. SLE - Rituximab in lupus. Arthritis Res. Ther. 5(4), 157-159 (2003).
    • Eisenberg R. SLE - Rituximab in lupus. Arthritis Res. Ther. 5(4), 157-159 (2003).
  • 118
    • 31544445804 scopus 로고    scopus 로고
    • B-cell targeted therapies in rheumatoid arthritis and systemic lupus erythematosus
    • Eisenberg R, Albert D. B-cell targeted therapies in rheumatoid arthritis and systemic lupus erythematosus. Nat. Clin. Pract. Rheumatol. 2(1), 20-27 (2006).
    • (2006) Nat. Clin. Pract. Rheumatol , vol.2 , Issue.1 , pp. 20-27
    • Eisenberg, R.1    Albert, D.2
  • 119
    • 2942537697 scopus 로고    scopus 로고
    • Efficacy ef B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
    • Edwards JC, Szczepanski L, Szechinski J et al. Efficacy ef B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N. Engl. J. Med. 350(25), 2572-2581 (2004).
    • (2004) N. Engl. J. Med , vol.350 , Issue.25 , pp. 2572-2581
    • Edwards, J.C.1    Szczepanski, L.2    Szechinski, J.3
  • 120
    • 33947132165 scopus 로고    scopus 로고
    • Successful repeat therapy with rituximab for relapsed thrombotic thrombocytopenic purpura
    • Patino W, Sarode R. Successful repeat therapy with rituximab for relapsed thrombotic thrombocytopenic purpura. J. Clin. Apher. 22(1), 17-20 (2007).
    • (2007) J. Clin. Apher , vol.22 , Issue.1 , pp. 17-20
    • Patino, W.1    Sarode, R.2
  • 121
    • 2042544763 scopus 로고    scopus 로고
    • The efficacy and safety of B-cell depletion with anti-CD20 monoclonal antibody in adults with chronic immune thrombocytopenic purpura
    • Cooper N, Stasi R, Cunningham-Rundles S et al. The efficacy and safety of B-cell depletion with anti-CD20 monoclonal antibody in adults with chronic immune thrombocytopenic purpura. Br. J. Haematol. 125(2), 232-239 (2004).
    • (2004) Br. J. Haematol , vol.125 , Issue.2 , pp. 232-239
    • Cooper, N.1    Stasi, R.2    Cunningham-Rundles, S.3
  • 122
    • 34250640168 scopus 로고    scopus 로고
    • Rituximab is an alternative to splenectomy in adults with chronic immune thrombocytopenic purpura: Results of a multicenter prospective Phase II study
    • Presented at:, Orlando, FL, USA, 9-12 December
    • Godeau B, Fain O, Porcher R et al. Rituximab is an alternative to splenectomy in adults with chronic immune thrombocytopenic purpura: results of a multicenter prospective Phase II study. Presented at: 48th Annual Meeting of the American Society of Hematology, Orlando, FL, USA, 9-12 December 2006.
    • (2006) 48th Annual Meeting of the American Society of Hematology
    • Godeau, B.1    Fain, O.2    Porcher, R.3
  • 123
    • 33846918681 scopus 로고    scopus 로고
    • Systematic review: Efficacy and safety of rituximab for adults with idiopathic thrombocytopenic purpura
    • Arnold DM, Dentali F, Crowther MA et al. Systematic review: efficacy and safety of rituximab for adults with idiopathic thrombocytopenic purpura. Ann. Intern. Med. 146(1), 25-33 (2007).
    • (2007) Ann. Intern. Med , vol.146 , Issue.1 , pp. 25-33
    • Arnold, D.M.1    Dentali, F.2    Crowther, M.A.3
  • 124
    • 0025771475 scopus 로고
    • Effect of high-dose dexamethasone in prednisone-resistant autoimmune thrombocytopenic purpura (ITP)
    • Dubbeld P, van der Heul C, Hillen HF. Effect of high-dose dexamethasone in prednisone-resistant autoimmune thrombocytopenic purpura (ITP). Neth. J. Med. 39(1-2), 6-10 (1991).
    • (1991) Neth. J. Med , vol.39 , Issue.1-2 , pp. 6-10
    • Dubbeld, P.1    van der Heul, C.2    Hillen, H.F.3
  • 125
    • 0028358131 scopus 로고
    • Response of resistant idiopathic thrombocytopenic purpura to pulsed high-dose dexamethasone therapy
    • Andersen JC. Response of resistant idiopathic thrombocytopenic purpura to pulsed high-dose dexamethasone therapy. N. Engl. J. Med. 330(22), 1560-1564 (1994).
    • (1994) N. Engl. J. Med , vol.330 , Issue.22 , pp. 1560-1564
    • Andersen, J.C.1
  • 126
    • 0036278155 scopus 로고    scopus 로고
    • Pulsed high-dose dexamethasone therapy in children with chronic idiopathic thrombocytopenic purpura
    • Wali YA, Al Lamki Z, Shah W, Zacharia M, Hassan A. Pulsed high-dose dexamethasone therapy in children with chronic idiopathic thrombocytopenic purpura. Pediatr. Hematol. Oncol. 19(5), 329-335 (2002).
    • (2002) Pediatr. Hematol. Oncol , vol.19 , Issue.5 , pp. 329-335
    • Wali, Y.A.1    Al Lamki, Z.2    Shah, W.3    Zacharia, M.4    Hassan, A.5
  • 127
    • 0030038481 scopus 로고    scopus 로고
    • High-dose oral dexamethasone therapy for chronic childhood idiopathic thrombocytopenic purpura
    • Adams DM, Kinney TR, O'Branski-Rupp E, Ware RE. High-dose oral dexamethasone therapy for chronic childhood idiopathic thrombocytopenic purpura. J. Pediatr. 128(2), 281-283 (1996).
    • (1996) J. Pediatr , vol.128 , Issue.2 , pp. 281-283
    • Adams, D.M.1    Kinney, T.R.2    O'Branski-Rupp, E.3    Ware, R.E.4
  • 128
    • 0030785539 scopus 로고    scopus 로고
    • Platelet and immune responses to oral cyclic dexamethasone therapy in childhood chronic immune thrombocytopenic purpura
    • Kuhne T, Freedman J, Semple JW et al. Platelet and immune responses to oral cyclic dexamethasone therapy in childhood chronic immune thrombocytopenic purpura. J. Pediatr. 130(1), 17-24 (1997).
    • (1997) J. Pediatr , vol.130 , Issue.1 , pp. 17-24
    • Kuhne, T.1    Freedman, J.2    Semple, J.W.3
  • 129
    • 8444229275 scopus 로고    scopus 로고
    • High-dose dexamethasone as a first- and second-line treatment of idiopathic thrombocytopenic purpura in adults
    • Borst F, Keuning JJ, van Hulsteijn H, Sinnige H, Vreugdenhil G. High-dose dexamethasone as a first- and second-line treatment of idiopathic thrombocytopenic purpura in adults. Ann. Hematol. 83(12), 764-768 (2004).
    • (2004) Ann. Hematol , vol.83 , Issue.12 , pp. 764-768
    • Borst, F.1    Keuning, J.J.2    van Hulsteijn, H.3    Sinnige, H.4    Vreugdenhil, G.5
  • 130
    • 0028880079 scopus 로고
    • Pulsed high-dose dexamethasone in refractory chronic idiopathic thrombocytopenic purpura: A report on 10 cases
    • Caulier MT, Rose C, Roussel MT et al. Pulsed high-dose dexamethasone in refractory chronic idiopathic thrombocytopenic purpura: a report on 10 cases. Br. J. Haematol. 91(2), 477-479 (1995).
    • (1995) Br. J. Haematol , vol.91 , Issue.2 , pp. 477-479
    • Caulier, M.T.1    Rose, C.2    Roussel, M.T.3
  • 131
    • 0029800536 scopus 로고    scopus 로고
    • Poor response to pulsed high-dose dexamethasone therapy in children with resistant immune thrombocytopenic purpura
    • Bode C, Koerholz D, Janssen G, Schwamborn D, Goebel U. Poor response to pulsed high-dose dexamethasone therapy in children with resistant immune thrombocytopenic purpura. Eur. J. Pediatr. 155(10), 917 (1996).
    • (1996) Eur. J. Pediatr , vol.155 , Issue.10 , pp. 917
    • Bode, C.1    Koerholz, D.2    Janssen, G.3    Schwamborn, D.4    Goebel, U.5
  • 132
    • 0029932725 scopus 로고    scopus 로고
    • High-dose dexamethasone in adult refractory idiopathic thrombocytopenic purpura
    • Schiavotto C, Ruggeri M, Castaman G, Rodeghiero F. High-dose dexamethasone in adult refractory idiopathic thrombocytopenic purpura. Br. J. Haematol. 93(2), 491-492 (1996).
    • (1996) Br. J. Haematol , vol.93 , Issue.2 , pp. 491-492
    • Schiavotto, C.1    Ruggeri, M.2    Castaman, G.3    Rodeghiero, F.4
  • 133
    • 0030812617 scopus 로고    scopus 로고
    • A trial of high-dose dexamethasone therapy for chronic idiopathic thrombocytopenic purpura in childhood
    • Borgna-Pignatti C, Rugolotto S, Nobili B et al. A trial of high-dose dexamethasone therapy for chronic idiopathic thrombocytopenic purpura in childhood. J. Pediatr. 130(1), 13-16 (1997).
    • (1997) J. Pediatr , vol.130 , Issue.1 , pp. 13-16
    • Borgna-Pignatti, C.1    Rugolotto, S.2    Nobili, B.3
  • 134
    • 0031425150 scopus 로고    scopus 로고
    • Pulsed high-dose dexamethasone therapy in children with chronic idiopathic thrombocytopenic purpura
    • Chen JS, Wu JM, Chen YJ, Yeh TF. Pulsed high-dose dexamethasone therapy in children with chronic idiopathic thrombocytopenic purpura. J. Pediatr. Hematol. Oncol. 19(6), 526-529 (1997).
    • (1997) J. Pediatr. Hematol. Oncol , vol.19 , Issue.6 , pp. 526-529
    • Chen, J.S.1    Wu, J.M.2    Chen, Y.J.3    Yeh, T.F.4
  • 135
    • 0030853821 scopus 로고    scopus 로고
    • High-dose pulsed dexamethasone for immune thrombocytopenia
    • Demiroglu H, Dundar S. High-dose pulsed dexamethasone for immune thrombocytopenia. N. Engl. J. Med. 337(6), 425-427 (1997).
    • (1997) N. Engl. J. Med , vol.337 , Issue.6 , pp. 425-427
    • Demiroglu, H.1    Dundar, S.2
  • 136
    • 0030937564 scopus 로고    scopus 로고
    • Failure of pulse high-dose dexamethasone in chronic idiopathic immune thrombocytopenia
    • Warner M, Wasi P, Couban S et al. Failure of pulse high-dose dexamethasone in chronic idiopathic immune thrombocytopenia. Am. J. Hematol. 54(4), 267-270 (1997).
    • (1997) Am. J. Hematol , vol.54 , Issue.4 , pp. 267-270
    • Warner, M.1    Wasi, P.2    Couban, S.3
  • 137
    • 0034474172 scopus 로고    scopus 로고
    • Pulsed intravenous high-dose dexamethasone in adults with chronic idiopathic thrombocytopenic purpura
    • Stasi R, Brunetti M, Pagano A et al. Pulsed intravenous high-dose dexamethasone in adults with chronic idiopathic thrombocytopenic purpura. Blood Cells Mol. Dis. 26(6), 582-586 (2000).
    • (2000) Blood Cells Mol. Dis , vol.26 , Issue.6 , pp. 582-586
    • Stasi, R.1    Brunetti, M.2    Pagano, A.3
  • 138
    • 0041429528 scopus 로고    scopus 로고
    • Initial treatment of immune thrombocytopenic purpura with high-dose dexamethasone
    • Cheng Y, Wong RS, Soo YO et al. Initial treatment of immune thrombocytopenic purpura with high-dose dexamethasone. N. Engl. J. Med. 349(9), 831-836 (2003).
    • (2003) N. Engl. J. Med , vol.349 , Issue.9 , pp. 831-836
    • Cheng, Y.1    Wong, R.S.2    Soo, Y.O.3
  • 139
    • 33846925496 scopus 로고    scopus 로고
    • Therapy with high-dose dexamethasone (HD-DXM) in previously untreated patients affected by idiopathic thrombocytopenic purpura: A GIMEMA experience
    • Mazzucconi MG, Fazi P, Bernasconi S et al. Therapy with high-dose dexamethasone (HD-DXM) in previously untreated patients affected by idiopathic thrombocytopenic purpura: a GIMEMA experience. Blood 109(4), 1401-1407 (2007).
    • (2007) Blood , vol.109 , Issue.4 , pp. 1401-1407
    • Mazzucconi, M.G.1    Fazi, P.2    Bernasconi, S.3
  • 141
    • 0026772133 scopus 로고
    • A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells
    • Noelle RJ, Roy M, Shepherd DM et al. A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc. Natl Acad. Sci. USA 89(14), 6550-6554 (1992).
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , Issue.14 , pp. 6550-6554
    • Noelle, R.J.1    Roy, M.2    Shepherd, D.M.3
  • 142
    • 0026528181 scopus 로고
    • Molecular and biological characterization of a murine ligand for CD40
    • Armitage RJ, Fanslow WC, Strockbine L et al. Molecular and biological characterization of a murine ligand for CD40. Nature 357(6373), 80-82 (1992).
    • (1992) Nature , vol.357 , Issue.6373 , pp. 80-82
    • Armitage, R.J.1    Fanslow, W.C.2    Strockbine, L.3
  • 143
    • 0028222917 scopus 로고
    • Mechanisms of T cell contact-dependent B cell activation
    • Kato T, Kokuho T, Tamura T, Nariuchi H. Mechanisms of T cell contact-dependent B cell activation. J. Immunol. 152(5), 2130-2138 (1994).
    • (1994) J. Immunol , vol.152 , Issue.5 , pp. 2130-2138
    • Kato, T.1    Kokuho, T.2    Tamura, T.3    Nariuchi, H.4
  • 144
    • 0037438507 scopus 로고    scopus 로고
    • Suppression of autoreactive T-cell response to glycoprotein IIb/IIIa by blockade of CD40/CD154 interaction: Implications for treatment of immune thrombocytopenic purpura
    • Kuwana M, Kawakami Y, Ikeda Y. Suppression of autoreactive T-cell response to glycoprotein IIb/IIIa by blockade of CD40/CD154 interaction: implications for treatment of immune thrombocytopenic purpura. Blood 101(2), 621-623 (2003).
    • (2003) Blood , vol.101 , Issue.2 , pp. 621-623
    • Kuwana, M.1    Kawakami, Y.2    Ikeda, Y.3
  • 145
    • 0041562489 scopus 로고    scopus 로고
    • Induction of T-cell tolerance in a patient with idiopathic thrombocytopenic purpura by single injection of humanized monoclonal antibody to CD40 ligand
    • Nomura S, Kuwana M, Ikeda Y. Induction of T-cell tolerance in a patient with idiopathic thrombocytopenic purpura by single injection of humanized monoclonal antibody to CD40 ligand. Autoimmunity 36(5), 317-319 (2003).
    • (2003) Autoimmunity , vol.36 , Issue.5 , pp. 317-319
    • Nomura, S.1    Kuwana, M.2    Ikeda, Y.3
  • 146
    • 0842264044 scopus 로고    scopus 로고
    • Effect of a single injection of humanized anti-CD154 monoclonal antibody on the platelet-specific autoimmune response in patients with immune thrombocytopenic purpura
    • Kuwana M, Nomura S, Fujimura K et al. Effect of a single injection of humanized anti-CD154 monoclonal antibody on the platelet-specific autoimmune response in patients with immune thrombocytopenic purpura. Blood 103(4), 1229-1236 (2004).
    • (2004) Blood , vol.103 , Issue.4 , pp. 1229-1236
    • Kuwana, M.1    Nomura, S.2    Fujimura, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.