Long-term administration of pegylated recombinant human megakaryocyte growth and development factor dramatically improved cytopenias in a patient with myelodysplastic syndrome

British Journal of Haematology

Volumn 122, Issue 5, 2003, Pages 764-767

  Kizaki, Masahiro ^a   Miyakawa, Yoshitaka ^a   Ikeda, Yasuo ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cytopenia; Myelodysplastic syndrome; Neutralizing antibody; Recombinant human megakaryocyte growth and development factor; Thrombopoietin

Indexed keywords

MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR;

ADULT; ARTICLE; CASE REPORT; CHRONIC DRUG ADMINISTRATION; CYTOPENIA; ERYTHROCYTE TRANSFUSION; FEMALE; HEMOGLOBIN DETERMINATION; HUMAN; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; STEM CELL TRANSPLANTATION; THROMBOCYTE COUNT;

ADULT; BONE MARROW CELLS; FEMALE; HEMOGLOBINS; HUMANS; MYELODYSPLASTIC SYNDROMES; PLATELET COUNT; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; THROMBOPOIETIN;

EID: 0042914309     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2003.04504.x     Document Type: Article

References (12)

1. Alexander, W.S., Roberts, A.W., Nicola, N.A., Li, R. & Metcaf, D. (1996) Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-Mpl. Blood, 87, 2162-2170.
2. Archimbaudt, E., Ottmann, O.G., Yin, J.A.L., Lechner, K., Dombret, H., Sanz, M.A., Heil, G., Fenaux, P., Brugger, W., Barge, A., O'Brien-Ewen, C., Matcham, J. & Hoelzer, D. (1999) A randomized, double-blind, placebo-controlled study with pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) as an adjunct to chemotherapy for adults with de novo acute myeloid leukemia. Blood, 94, 3694-3701.
3. Basser, R.L., Rasko, J.E., Clarke, K., Cebon, J., Green, M.D., Hussein, S., Alt, C., Menchaca, D., Tomita, D., Marty, J., Fox, R.M. & Begley, C.G. (1996) Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer. Lancet, 348, 1279-1281.
4. Fox, N., Priestley, G., Papayannopoulou, T. & Kaushansky, K. (2002) Thrombopoietin expands hematopoietic stem cells after transplantation. Journal of Clinical Investigation, 110, 389-394.
5. Hellström-Lindberg, E., Ahlgren, T., Beguin, Y., Carlsson, M., Carneskog, J., Dahl, I.M., Debedal, I., Grimfors, G., Kanter-Lewensohn, L., Linder, O., Luthman, M., Lofvenberg, E., Nilsson-Ehle, H., Samuelsson, J., Tangen, J.M., Winqvist, I., Oberg, G., Osterborg, A. & Ost, A. (1998) Treatment of anemia in myelodysplastic syndromes with granulocyte colony-stimulating factor plus erythropoietin: results from a randomized phase II study and long-term follow-up of 71 patients. Blood, 92, 68-75.
6. Hellström-Lindberg, E., Gulbrandsen, N., Lindberg, G., Ahlgren, T., Dahl, I.M., Dybedal, G., Hesse-Sundin, E., Hjorth, M., Kanter-Lewensohn, L., Linder, O., Luthman, M., Löfvenberg, E., Öberg, G., Porwit-MacDonald, A., Pådlund, A., Samuelsson, L., Tangen, J.M., Winquist, I. & Wisdorff, F. (2003) A validated decision model for treating the anaemia of myelodysplastic syndromes with erythropoietin + granulocyte colony-stimulating factor: significant effects on quality of life. British Journal of Haematology, 120, 1037-1046.
7. Kizaki, M. & Koeffler, H.P. (1992) Differentiation-inducing agents in the treatment of myelodysplastic syndromes. Seminars in Oncology, 19, 95-105.
8. Koeffler, H.P. (1996) Myelodysplastic syndromes. Seminars in Hematology, 33, 87-94.
9. Schiffer, C.A., Miller, K., Larson, R.A., Amrein, P.C., Antin, J.H., Zani, V.A. & Stone, R.M. (2000) A double-blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia. Blood, 95, 2530-2535.
10. Shiozaki, H., Miyawaki, S., Kuwaki, T., Hagiwara, T., Kato, T. & Miyazaki, H. (2000) Autoantibodies neutralizing thrombopoietin in a patient with amegakaryocytic thrombocytopenia. Blood, 95, 2187-2188.
11. Su, R.J, Li, M., Yang, M., Zhang, X.B., Tsang, K.S., Fok, T., Li, C.K. & Yuen, P.M.P. (2001) Platelet-derived growth factor enhances ex vivo expansion of megakaryocytic progenitors from human cord blood. Bone Marrow Transplantation, 27, 1075-1080.
12. Yagi, M., Ritchie, K.A., Sitnicka, E., Storey, C., Roth, G.J. & Bartelmez, S. (1999) Sustained ex vivo expansion of hematopoietic stem cells mediated by thrombopoietin. Proceedings of the National Academy of Sciences of the USA, 96, 8126-8131.