A rationally designed agonist antibody fragment that functionally mimics thrombopoietin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 39, 2006, Pages 14307-14312

  Frederickson, Shana ^a   Renshaw, Mark W ^a   Lin, Bing ^a   Smith, Lynette M ^a   Calveley, Peter ^a   Springhorn, Jeremy P ^b   Johnson, Krista ^b   Wang, Yi ^b   Su, Xiao ^b   Shen, Yamin ^b   Bowdish, Katherine S ^a  

^a Alexion Antibody Technologies Inc   (United States)

^b ALEXION PHARMACEUTICALS   (United States)

Author keywords

cMpI receptor

Indexed keywords

AMINO ACID; CELL SURFACE RECEPTOR; CMPL RECEPTOR; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN F(AB) FRAGMENT 59; ISOLEUCYLGLUTAMYLGLYCYLPROLYLTHREONYLLYSYLARGINYLGLUTAMINYLTRYPTOPHYLLEUCYL ALANYLALANYLARGINYLALANINE; PEPTIDE AF12505; PEPTIDE DERIVATIVE; THROMBOPOIETIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL BASED PANNING; CELL STRAIN HEK293; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; IMMUNOASSAY; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHAGE DISPLAY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS;

ANIMALS; BLOOD PLATELETS; CELLS, CULTURED; CROSS-LINKING REAGENTS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MALE; MICE; MICE, INBRED BALB C; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; NIH 3T3 CELLS; PEPTIDES; RECEPTORS, CELL SURFACE; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOPOIETIN;

EID: 33749249751     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0602658103     Document Type: Article

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