Synthesis, biochemical evaluation, and classical and three-dimensional quantitative structure-activity relationship studies of 7-substituted- 1,2,3,4-tetrahydroisoquinolines and their relative affinities toward phenylethanolamine N-methyltransferase and the α2-adrenoceptor

Journal of Medicinal Chemistry

Volumn 42, Issue 1, 1999, Pages 118-134

  Grunewald, Gary L ^a   Dahanukar, Vilas H ^a   Jalluri, Ravi K ^a   Criscione, Kevin R ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4 TETRAHYDRO 5,8 DIMETHOXYISOQUINOLINE; 1,2,3,4 TETRAHYDRO 7 ISOQUINOLINESULFONAMIDE; 7,8 DICHLORO 1,2,3,4 TETRAHYDROISOQUINOLINE; ALPHA 2 ADRENERGIC RECEPTOR; PHENYLETHANOLAMINE N METHYLTRANSFERASE; TETRAHYDROISOQUINOLINE DERIVATIVE; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CATECHOLAMINE SYNTHESIS; CATTLE; DRUG DESIGN; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEPTOR AFFINITY;

ANIMALS; BINDING SITES; BRAIN; ENZYME INHIBITORS; ISOQUINOLINES; LIGANDS; MALE; MODELS, MOLECULAR; PHENYLETHANOLAMINE N-METHYLTRANSFERASE; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2; REGRESSION ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033552856     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980429p     Document Type: Article

References (60)

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