Enantiospecific synthesis of 3-fluoromethyl-, 3-hydroxymethyl-, and 3- chloromethyl-1,2,3,4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the α2-adrenoceptor

Journal of Medicinal Chemistry

Volumn 42, Issue 21, 1999, Pages 4351-4361

  Grunewald, Gary L ^a   Caldwell, Timothy M ^a   Li, Qifang ^a   Dahanukar, Vilas H ^a   McNeil, Brynn ^a   Criscione, Kevin R ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4 TETRAHYDRO 7 ISOQUINOLINESULFONAMIDE; 7,8 DICHLORO 1,2,3,4 TETRAHYDROISOQUINOLINE; ALPHA 2 ADRENERGIC RECEPTOR; PHENYLETHANOLAMINE N METHYLTRANSFERASE; TETRAHYDROISOQUINOLINE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; MALE; NONHUMAN; RAT; RECEPTOR AFFINITY; STEREOCHEMISTRY;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; CATTLE; CEREBRAL CORTEX; ENZYME INHIBITORS; ISOQUINOLINES; MALE; MODELS, MOLECULAR; PHENYLETHANOLAMINE N-METHYLTRANSFERASE; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 0032742557     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990086a     Document Type: Article

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