Molecular Recognition of Sub-micromolar Inhibitors by the Epinephrine-Synthesizing Enzyme Phenylethanolamine N-Methyltransferase

Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2004, Pages 37-44

  McMillan, Fiona M ^a   Archbold, Julia ^a,d   McLeish, Michael J ^b,e   Caine, Joanne M ^b,f   Criscione, Kevin R ^c   Grunewald, Gary L ^c   Martin, Jennifer L ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF KANSAS   (United States)

^d GRIFFITH UNIVERSITY   (Australia)

^e UNIVERSITY OF MICHIGAN   (United States)

^f CSIRO   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4 TETRAHYDRO 7 ISOQUINOLINESULFONAMIDE; 7 IODO 1,2,3,4 TETRAHYDROISOQUINOLINE; 8,9 DICHLORO 2,3,4,5 TETRAHYDRO 1H 2 BENZAZEPINE; ADRENALIN; PHENYLETHANOLAMINE N METHYLTRANSFERASE; S ADENOSYLHOMOCYSTEINE; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVITY; MOLECULAR RECOGNITION; PROTEIN BINDING; STRUCTURE ANALYSIS;

BENZAZEPINES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; EPINEPHRINE; HUMANS; ISOQUINOLINES; MODELS, MOLECULAR; PHENYLETHANOLAMINE N-METHYLTRANSFERASE; PROTEIN BINDING; QUINOLINES; S-ADENOSYLHOMOCYSTEINE; SUBSTRATE SPECIFICITY;

EID: 0347991966     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0205752     Document Type: Article

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