Exploring the active site of phenylethanolamine N-methyltransferase: 3-alkyl-7-substituted-1,2,3,4-tetrahydroisoquinoline inhibitors

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 4, 2005, Pages 1261-1273

  Grunewald, Gary L ^a   Romero, F Anthony ^a   Chieu, Alex D ^a   Fincham, Kelcie J ^a   Bhat, Seema R ^a   Criscione, Kevin R ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Enzyme inhibitors; Phenylethanolamine N methyltransferase; Structure based design; Tetrahydroisoquinolines

Indexed keywords

3 (1 METHYL)ETHYL 7 NITRO 1,2,3,4 TETRAHYDROISOQUINOLINE; 3 BUTYL 7 NITRO 1,2,3,4 TETRAHYDROISOQUINOLINE; 3 ETHYL 7 N (2,2,2 TRIFLUOROETHYLAMINOSULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLINE; 3 ETHYL 7 NITRO 1,2,3,4 TETRAHYDROISOQUINOLINE HYDROBROMIDE; 3 METHYL 7 N (2,2,2 TRIFLUOROETHYLAMINOSULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLINE; 3 PROPYL 7 N (2,2,2 TRIFLUOROETHYLAMINOSULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLINE; ALPHA 2 ADRENERGIC RECEPTOR; METHYL GROUP; PHENYLETHANOLAMINE N METHYLTRANSFERASE; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; MALE; NONHUMAN; RAT;

BINDING SITES; ENZYME INHIBITORS; ISOQUINOLINES; MAGNETIC RESONANCE SPECTROSCOPY; PHENYLETHANOLAMINE N-METHYLTRANSFERASE; RADIOLIGAND ASSAY;

EID: 12844269318     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.11.015     Document Type: Article

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