Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3,4- tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N- methyltransferase versus the α2-adrenoceptor

Journal of Medicinal Chemistry

Volumn 42, Issue 17, 1999, Pages 3315-3323

  Grunewald, Gary L ^a   Caldwell, Timothy M ^a   Li, Qifang ^a   Criscione, Kevin R ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4 TETRAHYDRO 7 ISOQUINOLINESULFONAMIDE; 3 TRIFLUOROMETHYL 7 BROMO 1,2,3,4 TETRAHYDROISOQUINOLINE HYDROCHLORIDE; 3 TRIFLUOROMETHYL 7 NITRO 1,2,3,4 TETRAHYDROISOQUINOLINE HYDROCHLORIDE; 7,8 DICHLORO 1,2,3,4 TETRAHYDROISOQUINOLINE; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; CLONIDINE; ISOQUINOLINE DERIVATIVE; PHENYLETHANOLAMINE N METHYLTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD BRAIN BARRIER; DRUG PENETRATION; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; LIPOPHILICITY; PKA; RECEPTOR AFFINITY; STEREOSPECIFICITY;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; CATTLE; CEREBRAL CORTEX; CLONIDINE; ENZYME INHIBITORS; ISOQUINOLINES; MALE; PHENYLETHANOLAMINE N-METHYLTRANSFERASE; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 0033606946     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980734a     Document Type: Article

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