Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: A potential route to new bone antiresorption and antiparasitic agents

Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2002, Pages 2185-2196

  Szabo, Christina M ^a   Matsumura, Yoshihiro ^b   Fukura, Sayaka ^b   Martin, Michael B ^a   Sanders, John M ^a   Sengupta, Suraj ^a   Cieslak, John A ^a   Loftus, Timothy C ^a   Lea, Christopher R ^a   Lee, Hyung Jae ^a   Koohang, Ali ^a   Coates, Robert M ^a   Sagami, Hiroshi ^b   Oldfield, Eric ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; ANTIPARASITIC AGENT; ATORVASTATIN; BISPHOSPHONIC ACID DERIVATIVE; ETIDRONIC ACID; FARNESYL TRANS TRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IBANDRONIC ACID; PAMIDRONIC ACID; PRAVASTATIN; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RISEDRONIC ACID; SIMVASTATIN;

ARTICLE; CORRELATION ANALYSIS; DRUG ACTIVITY; DRUG SCREENING; ENZYME INHIBITION; OSTEOLYSIS; PARASITOSIS; STRUCTURE ACTIVITY RELATION;

ALKYL AND ARYL TRANSFERASES; ANTIPARASITIC AGENTS; BONE RESORPTION; DIPHOSPHONATES; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; HUMANS; MODELS, MOLECULAR; PHOSPHORIC ACID ESTERS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECOMBINANT PROTEINS;

EID: 0037161612     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010412y     Document Type: Article

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