The pharmacology of endosomal TLR agonists in viral disease

Biochemical Society Transactions

Volumn 35, Issue 6, 2007, Pages 1468-1472

  Averett, D R ^a   Fletcher, S P ^a   Li, W ^a   Webber, S E ^a   Appleman, J R ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Antiviral immunity; Imiquimod; Interferon (IFN ); Isatoribine; Pattern recognition receptor; Toll like receptor agonism (TLR agonism)

Indexed keywords

AMPLIGEN; ANA 975; BIOLOGICAL MARKER; CPG 10101; DOUBLE STRANDED RNA; IMIQUIMOD; INTERFERON; ISATORIBINE; OLIGONUCLEOTIDE; PEGINTERFERON ALPHA; POLYINOSINIC POLYCYTIDYLIC ACID; RESIQUIMOD; RIBAVIRIN; SINGLE STRANDED RNA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9;

ADD ON THERAPY; AGONIST; CELLULAR DISTRIBUTION; CLINICAL TRIAL; CONFERENCE PAPER; DRUG DOSE ESCALATION; DRUG INDUCED HEADACHE; ENDOSOME; FLU LIKE SYNDROME; HUMAN; INJECTION SITE REACTION; INNATE IMMUNITY; INTERFERON INDUCTION; LOW DRUG DOSE; LYMPHOCYTOPENIA; NAUSEA; NONHUMAN; PRIORITY JOURNAL; UNSPECIFIED SIDE EFFECT; VERRUCA VULGARIS; VIRUS INFECTION;

ANIMALS; ANTIVIRAL AGENTS; CYTOKINES; ENDOSOMES; HUMANS; LIGANDS; TOLL-LIKE RECEPTORS; VIRUS DISEASES;

PAPILLOMAVIRIDAE;

EID: 37749012085     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0351468     Document Type: Conference Paper

References (53)

1. Zuany-Amorim, C., Hastewell, J. and Walker, C. (2002) Nat. Rev. Drug Discov. 10, 797-807
2. Ishii, K.J., Uematsu, S. and Akira, S. (2006) Curr. Pharm. Des. 32, 4135-4142
3. Alexopoulou, L., Holt, A.C., Medzhitov, R. and Flavell, R.A. (2001) Nature 6857, 732-738
4. Lampson, G.P., Tytell, A.A., Field, A.K., Nemes, M.M. and Hilleman, M.R. (1967) Proc. Natl. Acad. Sci. U.S.A. 58, 782-789
5. Field, A.K., Tytell, A.A., Lampson, G.P. and Hilleman, M.R. (1968) Proc. Natl. Acad. Sci. U.S.A. 61, 340-346
6. Levy, H.B., Baer, G., Baron, S., Buckler, C.E., Gibbs, C.J., Iadarola, M.J., London, W.T. and Rice, J. (1975) J. Infect. Dis. 132, 434-439
7. Carter, W.A., Pitha, P.M., Marshall, L.W., Tazawa, I., Tazawa, S. and Ts'o, P.O. (1972) J. Mol. Biol. 70, 567-587
8. Wild, J.S., Hyde, D.M. and Giri, S.N. (1994) Pharmacol. Toxicol. 75, 42-48
9. Pessina, G.P., Muscettola, M., Paulesu, L. and Bocci, V. (1989) J. Biol. Regul. Homeostatic Agents 3, 118-121
10. Purcell, R.H., London, W.T., McAuliffe, V.J., Palmer, A.E., Kaplan, P.M., Germ, J.L., Wagner, J., Popper, H., Lvovsky, E., Wong, D.C. and Levy, H.B. (1976) Lancet 1, 757-760
11. Kern, E.R., Overall, Jr, J.C. and Glasgow, L.A. (1975) Antimicrob. Agents Chemother. 7, 793-800
12. Hendrix, C.W., Margolick, J.B., Petty, B.G., Markham, R.B., Nerhood, L., Farzadegan, H., Ts'o, P.O. and Lietman, P.S. (1993) Antimicrob. Agents Chemother. 37, 429-435
13. Carter, W.A., Ventura, D., Shapiro, D.E., Strayer, D.R., Gillespie, D.H. and Hubbell, H.R. (1991) Int. J. Immunopharmacol. 13, (Suppl. 1), 69-76
14. Thompson, K.A., Strayer, D.R., Salvato, P.D., Thompson, C.E., Klimas, N., Molavi, A., Hamill, A.K., Zheng, Z., Ventura, D. and Carter, W.A. (1996) Eur. J. Clin. Microbiol. Infect. Dis. 15, 580-587
15. Tokunaga, T., Yamamoto, H., Shimada, S., Abe, H., Fukuda, T., Fujisawa, Y., Furutani, Y., Yano, O., Kataoka, T. and Sudo, T. (1984) J. Natl. Cancer Inst. 72, 955-962
16. Yamamoto, S., Yamamoto, T., Kataoka, T., Kuramoto, E., Yano, O. and Tokunaga, T. (1992) J. Immunol. 148, 4072-4076
17. Krieg, A.M., Yi, A.-K., Matson, S., Waldschmidt, T.J., Bishop, G.A., Teasdale, R., Koretzky, G.A. and Klinman, D.M. (1995) Nature 374, 546-549
18. Krug, A., Rothenfusser, S., Hornung, V., Jahrsdörfer, B., Blackwell, S., Ballas, Z.K., Endres, S., Krieg, A.M. and Hartmann, G. (2001) Eur. J. Immunol. 31, 2154-2163
19. Krug, A., Towarowski, A., Britsch, S., Rothenfussser, S., Hornung, V., Bals, R., Giese, T., Engelmann, H., Endres, S., Krieg, A.M. and Hartmann, G. (2001) Eur. J. Immunol. 31, 3026-3037
20. Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K. and Akira, S.A. (2000) Nature 408, 740-745
21. Dvorchik, B.H. (2000) Curr. Opin. Mol. Ther. 2, 253-257
22. Agrawal, S. and Zhang, R. (1997) Ciba Found. Symp. 209, 60-78
23. Mutwiri, G.K., Nichani, A.K., Babiuk, S. and Babiuk, L.A. (2004) J. Controlled Release 97, 1-17
24. Noll, B.O., McCluskie, M.J., Sniatala, T., Lohner, A., Yuill, S., Krieg, A.M., Schetter, C., Davis, H.L. and Uhlmann, E. (2005) Biochem. Pharmacol. 69, 981-991
25. Yu, R.Z., Kim, T.-W., Hong, A., Watanabe, T.A., Gaus, H.J. and Geary, R.S. (2007) Drug Metab. Dispos. 35, 460-468
26. von Beust, B.R., Johansen, P.I., Smith, K.A., Bot, A., Storm, T. and Kundig, T.M. (2005) Eur. J. Immunol. 35, 1869-1876
27. Pyles, R.B., Higgins, D., Chalk, C., Zalar, A., Eiden, J., Brown, C., Van Nest, G. and Stanberry, L. (2002) J. Virol. 76, 11387-11396
28. Bauer, S., Kirschning, C.J., Hackker, H., Redecke, V., Hausmann, S., Akira, S., Wagner, H. and Lipford, G.B. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 9237-9242
29. Abel, K., Wang, Y., Fritts, L., Sanchez, E., Chung, E., Fitzgerald-Bocarsly, P., Krieg, A.M. and Miller, C.J. (2005) Clin. Diagn. Lab. Immunol. 12, 606-621
30. McHutchison, J.G., Bacon, B.R., Gordon, S.C., Lawitz, E., Shiftman, M., Afdhal, N.H., Jacobson, L.M., Muir, A., Vicari, A., Efler, S. et al. (2006) 41st Annual Meeting of the European Association for the Study of the Liver, Vienna, Austria, 26-30 April 2006, Abstract 111
31. Jacobson, I.M., Ghalib, R., Lawitz, E., Freilich, B., Gordon, S.C., Kwo, P., Riley, T.R., Bright, D., Morris, M.L., Al-Adhami, M. et al. (2006) 57th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) 27-31 October, 2006, Boston, MA, U.S.A., Abstract 96
32. Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H. and Bauer, S. (2004) Science 303, 1526-1529
33. Diebold, S.S., Kaisho T., Hemmi, H., Akira, S. and Reise Sousa, C. (2004) Science 303, 1529-1531
34. Hemmi, H., Kaisho, I., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K. and Akira, S. (2002) Nat. Immunol. 3, 196-200
35. Lee, J., Chuang, T.H., Redecke, V., She, L., Pitha, P.M., Carson, D.A., Raz, E. and Cottam, H.B. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 6646-6651
36. Harrison, C.J., Jenski, L., Voychehovski, T. and Bernstein, D.I. (1988) Antiviral Res. 10, 209-223
37. Smee, D.F., Alaghamandan, H.A., Cottam, H.B., Sharma, B.S., Jolley, W.B. and Robins, R.K. (1989) Antimicrob. Agents Chemother. 33, 1487-1492
38. Stringfellow, D.A., Vanderberg, H.C. and Weed, S.D. (1980) J. Interferon Res. 1, 1-14
39. Gorden, K.B., Gorski, K.S., Gibson, S.J., Kedl, R.M., Kieper, W.C., Qiu, X., Tomai, M.A., Alkan, S.S. and Vasilakos, J.P. (2005) J. Immunol. 174, 1259-1268
40. Iwasaki, A. and Medzhitov, R. (2004) Nat. Immunol. 5, 987-995
41. Horsmans, Y., Berg, T., Desager, J.P., Mueller, T., Schott, E., Fletcher, S.P., Steffy, K.R., Bauman, L.A., Kerr, B.M. and Averett, D.R. (2005) Hepatology 42, 724-731
42. Schott, E., Witt, H., Neumann, K., Taube, S., Oh, D.Y., Schreir, E., Vierich, S., Puhl, G., Bergk, A., Halangk, J. et al. (2007) J. Hepatol. 47, 203-211
43. Berghöfer, B., Frommer, T., Königw, I.R., Zieglerw, A., Chakrabortyz, T., Bein, G. and Hackstein, H. (2005) Clin. Exp. Allergy 35, 1147-1154
44. Perry, C.M. and Lamb, H.M. (1999) Drugs 58, 375-390
45. Garland, S.M. (2003) Curr. Opin. Infect. Dis. 16, 85-89
46. Tran, H., Moreno, G. and Shumack, S. (2004) Expert Opin. Pharmacother. 5, 427-438
47. Savage, P., Horton, V., Moore, J., Owens, M., Witt, P. and Gore, M.E. (1996) Br. J. Cancer 74, 1482-1486
48. Witt, P.L., Ritch, P.S., Reding, D., McAuliffe, T.L., Westrick, L., Grossberg, S.E. and Borden, E.C. (1993) Cancer Res. 53, 5176-5180
49. Goldstein, D., Hertzog, P., Tomkinson, E., Couldwell, D., McCarville, S., Parrish, S., Cunningham, P., Newell, M., Owens, M. and Cooper, D.A. (1998) J. Infect. Dis. 178, 858-861
50. Averett, D.R. (2005) U.S, Pat. 20050054590
51. Kerr, B., Bauman, L., Ng, J., Fletcher, S. Aust, R. MacLeod, C., Hamed, K., Averett, D. and Worland, S. (2006) 2nd International Workshop on Clinical Pharmacology of Hepatitis Therapy, 25 April 2006, Vienna, Austria
52. Pockros, P.J., Guyader, D., Patton, H., Tong, M.J., Wright, T., McHutchison, J.G. and Meng, T.-C. (2007) J. Hepatol. 47, 174-182
53. Mark, K.E., Corey, L., Meng, T.C., Magaret, A.S., Huang, M.L., Selke, S., Slade, H.B., Tyring, S.K., Warren, T., Sacks, S.L. et al. (2007) J. Infect. Dis. 195, 1324-1331