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Volumn 35, Issue 9, 2005, Pages 1147-1154

Common human Toll-like receptor 9 polymorphisms and haplotypes: Association with atopy and functional relevance

Author keywords

Atopy; Cytokines; Haplotype; Polymorphism; TLR9

Indexed keywords

ALLERGEN; BACTERIAL DNA; CPG OLIGODEOXYNUCLEOTIDE; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOLOGICAL ADJUVANT; TOLL LIKE RECEPTOR 9; VIRUS DNA; CPG OLIGONUCLEOTIDE; CPG-OLIGONUCLEOTIDE; OLIGODEOXYRIBONUCLEOTIDE; TLR9 PROTEIN, HUMAN;

EID: 33644811344     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2005.02325.x     Document Type: Article
Times cited : (51)

References (49)
  • 1
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • Akira S Takeda K Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2001 2 : 675 80.
    • (2001) Nat Immunol , vol.2 , pp. 675-80
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 2
    • 0242351615 scopus 로고    scopus 로고
    • Toll-like receptors and their signaling mechanisms
    • Akira S Sato S. Toll-like receptors and their signaling mechanisms. Scand J Infect Dis 2003 35 : 555 62.
    • (2003) Scand J Infect Dis , vol.35 , pp. 555-62
    • Akira, S.1    Sato, S.2
  • 3
    • 2342558523 scopus 로고    scopus 로고
    • Antitumor applications of stimulating toll-like receptor 9 with CpG oligodeoxynucleotides
    • Krieg A. Antitumor applications of stimulating toll-like receptor 9 with CpG oligodeoxynucleotides. Curr Oncol Rep 2004 6 : 88 95.
    • (2004) Curr Oncol Rep , vol.6 , pp. 88-95
    • Krieg, A.1
  • 4
    • 0035903288 scopus 로고    scopus 로고
    • Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens
    • Kadowaki N Ho S Antonenko S et al. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 2001 194 : 863 9.
    • (2001) J Exp Med , vol.194 , pp. 863-9
    • Kadowaki, N.1    Ho, S.2    Antonenko, S.3
  • 5
    • 0035979192 scopus 로고    scopus 로고
    • Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
    • Bauer S Kirschning CJ Hacker H et al. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci USA 2001 98 : 9237 42.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9237-42
    • Bauer, S.1    Kirschning, C.J.2    Hacker, H.3
  • 6
    • 0034777579 scopus 로고    scopus 로고
    • Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12
    • Krug A Towarowski A Britsch S et al. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur J Immunol 2001 31 : 3026 37.
    • (2001) Eur J Immunol , vol.31 , pp. 3026-37
    • Krug, A.1    Towarowski, A.2    Britsch, S.3
  • 7
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung V Rothenfusser S Britsch S et al. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 2002 168 : 4531 7.
    • (2002) J Immunol , vol.168 , pp. 4531-7
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3
  • 8
    • 0036318851 scopus 로고    scopus 로고
    • Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments
    • Ahmad-Nejad P Hacker H Rutz M Bauer S Vabulas RM Wagner H. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur J Immunol 2002 32 : 1958 68.
    • (2002) Eur J Immunol , vol.32 , pp. 1958-68
    • Ahmad-Nejad, P.1    Hacker, H.2    Rutz, M.3    Bauer, S.4    Vabulas, R.M.5    Wagner, H.6
  • 9
    • 10744219675 scopus 로고    scopus 로고
    • TLR9 signals after translocating from the ER to CpG DNA in the lysosome
    • Latz E Schoenemeyer A Visintin A et al. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat Immunol 2004 5 : 190 208.
    • (2004) Nat Immunol , vol.5 , pp. 190-208
    • Latz, E.1    Schoenemeyer, A.2    Visintin, A.3
  • 11
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg AM. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 2002 20 : 709 60.
    • (2002) Annu Rev Immunol , vol.20 , pp. 709-60
    • Krieg, A.M.1
  • 12
    • 1842631153 scopus 로고    scopus 로고
    • Immunotherapeutic uses of CpG oligodeoxynucleotides
    • Klinman DM. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat Rev Immunol 2004 4 : 249 58.
    • (2004) Nat Rev Immunol , vol.4 , pp. 249-58
    • Klinman, D.M.1
  • 13
    • 0033546053 scopus 로고    scopus 로고
    • The nature of the principal type 1 interferon-producing cells in human blood
    • Siegal FP Kadowaki N Shodell M et al. The nature of the principal type 1 interferon-producing cells in human blood. Science 1999 284 : 1835 7.
    • (1999) Science , vol.284 , pp. 1835-7
    • Siegal, F.P.1    Kadowaki, N.2    Shodell, M.3
  • 14
    • 0034933019 scopus 로고    scopus 로고
    • Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells
    • Krug A Rothenfusser S Hornung V et al. Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells. Eur J Immunol 2001 31 : 2154 63.
    • (2001) Eur J Immunol , vol.31 , pp. 2154-63
    • Krug, A.1    Rothenfusser, S.2    Hornung, V.3
  • 15
    • 0028070714 scopus 로고
    • Functional role of type I and type II interferons in antiviral defense
    • Muller U Steinhoff U Reis LF et al. Functional role of type I and type II interferons in antiviral defense. Science 1994 264 : 1918 21.
    • (1994) Science , vol.264 , pp. 1918-21
    • Muller, U.1    Steinhoff, U.2    Reis, L.F.3
  • 17
    • 0034679566 scopus 로고    scopus 로고
    • Natural interferon alpha/beta-producing cells link innate and adaptive immunity
    • Kadowaki N Antonenko S Lau JY Liu YJ. Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J Exp Med 2000 192 : 219 26.
    • (2000) J Exp Med , vol.192 , pp. 219-26
    • Kadowaki, N.1    Antonenko, S.2    Lau, J.Y.3    Liu, Y.J.4
  • 18
    • 0036926154 scopus 로고    scopus 로고
    • Natural type I interferon-producing cells as a link between innate and adaptive immunity
    • Kadowaki N Liu YJ. Natural type I interferon-producing cells as a link between innate and adaptive immunity. Hum Immunol 2002 63 : 1126 32.
    • (2002) Hum Immunol , vol.63 , pp. 1126-32
    • Kadowaki, N.1    Liu, Y.J.2
  • 20
    • 0031948647 scopus 로고    scopus 로고
    • Therapeutic applications of CpG-containing oligodeoxynucleotides
    • Klinman DM. Therapeutic applications of CpG-containing oligodeoxynucleotides. Antisense Nucleic Acid Drug Dev 1998 8 : 181 4.
    • (1998) Antisense Nucleic Acid Drug Dev , vol.8 , pp. 181-4
    • Klinman, D.M.1
  • 22
    • 3142675843 scopus 로고    scopus 로고
    • CpG-oligonucleotides for cancer immunotherapy: Review of the literature and potential applications in malignant glioma
    • Carpentier AF Auf G Delattre JY. CpG-oligonucleotides for cancer immunotherapy: review of the literature and potential applications in malignant glioma. Front Biosci 2003 8 : e115 27.
    • (2003) Front Biosci , vol.8
    • Carpentier, A.F.1    Auf, G.2    Delattre, J.Y.3
  • 23
    • 17044447484 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides for immune stimulation in cancer immunotherapy
    • Jahrsdorfer B Weiner GJ. CpG oligodeoxynucleotides for immune stimulation in cancer immunotherapy. Curr Opin Investig Drugs 2003 4 : 686 90.
    • (2003) Curr Opin Investig Drugs , vol.4 , pp. 686-90
    • Jahrsdorfer, B.1    Weiner, G.J.2
  • 24
    • 0033563211 scopus 로고    scopus 로고
    • Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides
    • Sur S Wild JS Choudhury BK Sur N Alam R Klinman DM. Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides. J Immunol 1999 162 : 6284 93.
    • (1999) J Immunol , vol.162 , pp. 6284-93
    • Sur, S.1    Wild, J.S.2    Choudhury, B.K.3    Sur, N.4    Alam, R.5    Klinman, D.M.6
  • 25
    • 0032521274 scopus 로고    scopus 로고
    • Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma
    • Kline JN Waldschmidt TJ Businga TR et al. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J Immunol 1998 160 : 2555 9.
    • (1998) J Immunol , vol.160 , pp. 2555-9
    • Kline, J.N.1    Waldschmidt, T.J.2    Businga, T.R.3
  • 26
    • 0034827459 scopus 로고    scopus 로고
    • Immunostimulatory DNA inhibits IL-4-dependent IgE synthesis by human B cells
    • Horner AA Widhopf GF Burger JA et al. Immunostimulatory DNA inhibits IL-4-dependent IgE synthesis by human B cells. J Allergy Clin Immunol 2001 108 : 417 23.
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 417-23
    • Horner, A.A.1    Widhopf, G.F.2    Burger, J.A.3
  • 27
    • 0036803563 scopus 로고    scopus 로고
    • Immunopharmacology of CpG DNA
    • Dalpke A Zimmermann S Heeg K. Immunopharmacology of CpG DNA. Biol Chem 2002 383 : 1491 500.
    • (2002) Biol Chem , vol.383 , pp. 1491-500
    • Dalpke, A.1    Zimmermann, S.2    Heeg, K.3
  • 28
    • 0032521881 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis
    • Zimmermann S Egeter O Hausmann S et al. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis. J Immunol 1998 160 : 3627 30.
    • (1998) J Immunol , vol.160 , pp. 3627-30
    • Zimmermann, S.1    Egeter, O.2    Hausmann, S.3
  • 29
    • 0033558121 scopus 로고    scopus 로고
    • Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria
    • Elkins KL Rhinehart-Jones TR Stibitz S Conover JS Klinman DM. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. J Immunol 1999 162 : 2291 8.
    • (1999) J Immunol , vol.162 , pp. 2291-8
    • Elkins, K.L.1    Rhinehart-Jones, T.R.2    Stibitz, S.3    Conover, J.S.4    Klinman, D.M.5
  • 30
    • 0034650433 scopus 로고    scopus 로고
    • CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism
    • Chiaramonte MG Hesse M Cheever AW Wynn TA. CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism. J Immunol 2000 164 : 973 85.
    • (2000) J Immunol , vol.164 , pp. 973-85
    • Chiaramonte, M.G.1    Hesse, M.2    Cheever, A.W.3    Wynn, T.A.4
  • 31
    • 0033536013 scopus 로고    scopus 로고
    • Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-gamma-dependent mechanisms
    • Walker PS Scharton-Kersten T Krieg AM et al. Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-gamma-dependent mechanisms. Proc Natl Acad Sci USA 1999 96 : 6970 5.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 6970-5
    • Walker, P.S.1    Scharton-Kersten, T.2    Krieg, A.M.3
  • 32
    • 0042208151 scopus 로고    scopus 로고
    • Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2
    • Ashkar AA Bauer S Mitchell WJ Vieira J Rosenthal KL. Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2. J Virol 2003 77 : 8948 56.
    • (2003) J Virol , vol.77 , pp. 8948-56
    • Ashkar, A.A.1    Bauer, S.2    Mitchell, W.J.3    Vieira, J.4    Rosenthal, K.L.5
  • 33
    • 0034456693 scopus 로고    scopus 로고
    • Three novel mammalian toll-like receptors: Gene structure, expression, and evolution
    • Du X Poltorak A Wei Y Beutler B. Three novel mammalian toll-like receptors: gene structure, expression, and evolution. Eur Cytokine Netw 2000 11 : 362 71.
    • (2000) Eur Cytokine Netw , vol.11 , pp. 362-71
    • Du, X.1    Poltorak, A.2    Wei, Y.3    Beutler, B.4
  • 34
    • 0034457684 scopus 로고    scopus 로고
    • Cloning and characterization of a sub-family of human toll-like receptors: HTLR7, hTLR8 and hTLR9
    • Chuang TH Ulevitch RJ. Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur Cytokine Netw 2000 11 : 372 8.
    • (2000) Eur Cytokine Netw , vol.11 , pp. 372-8
    • Chuang, T.H.1    Ulevitch, R.J.2
  • 35
    • 0037289001 scopus 로고    scopus 로고
    • Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): Frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies
    • Lazarus R Klimecki WT Raby BA et al. Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies. Genomics 2003 81 : 85 91.
    • (2003) Genomics , vol.81 , pp. 85-91
    • Lazarus, R.1    Klimecki, W.T.2    Raby, B.A.3
  • 36
    • 1542285261 scopus 로고    scopus 로고
    • An association study of asthma and total serum immunoglobin e levels for Toll-like receptor polymorphisms in a Japanese population
    • Noguchi E Nishimura F Fukai H et al. An association study of asthma and total serum immunoglobin E levels for Toll-like receptor polymorphisms in a Japanese population. Clin Exp Allergy 2004 34 : 177 83.
    • (2004) Clin Exp Allergy , vol.34 , pp. 177-83
    • Noguchi, E.1    Nishimura, F.2    Fukai, H.3
  • 37
    • 0029130796 scopus 로고
    • Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population
    • Excoffier L Slatkin M. Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol Biol Evol 1995 12 : 921 7.
    • (1995) Mol Biol Evol , vol.12 , pp. 921-7
    • Excoffier, L.1    Slatkin, M.2
  • 38
    • 0036155283 scopus 로고    scopus 로고
    • Score tests for association between traits and haplotypes when linkage phase is ambiguous
    • Schaid DJ Rowland CM Tines DE Jacobson RM Poland GA. Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 2002 70 : 425 34.
    • (2002) Am J Hum Genet , vol.70 , pp. 425-34
    • Schaid, D.J.1    Rowland, C.M.2    Tines, D.E.3    Jacobson, R.M.4    Poland, G.A.5
  • 39
    • 0036438889 scopus 로고    scopus 로고
    • CpG motifs as possible adjuvants for the treatment of allergic diseases
    • Bohle B. CpG motifs as possible adjuvants for the treatment of allergic diseases. Int Arch Allergy Immunol 2002 129 : 198 203.
    • (2002) Int Arch Allergy Immunol , vol.129 , pp. 198-203
    • Bohle, B.1
  • 40
    • 5444262511 scopus 로고    scopus 로고
    • Toll-like receptor control of the adaptive immune responses
    • Iwasaki A Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol 2004 5 : 987 95.
    • (2004) Nat Immunol , vol.5 , pp. 987-95
    • Iwasaki, A.1    Medzhitov, R.2
  • 41
    • 0029934754 scopus 로고    scopus 로고
    • Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides
    • Cowdery JS Chace JH Yi AK Krieg AM. Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides. J Immunol 1996 156 : 4570 5.
    • (1996) J Immunol , vol.156 , pp. 4570-5
    • Cowdery, J.S.1    Chace, J.H.2    Yi, A.K.3    Krieg, A.M.4
  • 42
    • 0030239828 scopus 로고    scopus 로고
    • Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
    • Ballas ZK Rasmussen WL Krieg AM. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J Immunol 1996 157 : 1840 5.
    • (1996) J Immunol , vol.157 , pp. 1840-5
    • Ballas, Z.K.1    Rasmussen, W.L.2    Krieg, A.M.3
  • 43
    • 0031964257 scopus 로고    scopus 로고
    • CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen
    • Davis HL Weeratna R Waldschmidt TJ et al. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J Immunol 1998 160 : 870 6.
    • (1998) J Immunol , vol.160 , pp. 870-6
    • Davis, H.L.1    Weeratna, R.2    Waldschmidt, T.J.3
  • 44
    • 0033485399 scopus 로고    scopus 로고
    • Phosphorothioate oligodeoxynucleotides promote the in vitro development of human allergen-specific CD4+ T cells into Th1 effectors
    • Parronchi P Brugnolo F Annunziato F et al. Phosphorothioate oligodeoxynucleotides promote the in vitro development of human allergen-specific CD4+ T cells into Th1 effectors. J Immunol 1999 163 : 5946 53.
    • (1999) J Immunol , vol.163 , pp. 5946-53
    • Parronchi, P.1    Brugnolo, F.2    Annunziato, F.3
  • 45
    • 0035184904 scopus 로고    scopus 로고
    • Type I interferon is required to mount an adaptive response to immunostimulatory DNA
    • Van Uden JH Tran CH Carson DA Raz E. Type I interferon is required to mount an adaptive response to immunostimulatory DNA. Eur J Immunol 2001 31 : 3281 9.
    • (2001) Eur J Immunol , vol.31 , pp. 3281-9
    • Van Uden, J.H.1    Tran, C.H.2    Carson, D.A.3    Raz, E.4
  • 46
    • 0036118734 scopus 로고    scopus 로고
    • Atopic phenotype in children is associated with decreased virus-induced interferon-alpha release
    • Bufe A Gehlhar K Grage-Griebenow E Ernst M. Atopic phenotype in children is associated with decreased virus-induced interferon-alpha release. Int Arch Allergy Immunol 2002 127 : 82 8.
    • (2002) Int Arch Allergy Immunol , vol.127 , pp. 82-8
    • Bufe, A.1    Gehlhar, K.2    Grage-Griebenow, E.3    Ernst, M.4
  • 47
    • 0027263737 scopus 로고
    • Effects of interferon-alpha-2b on the clinical course, inflammatory skin infiltrates and peripheral blood lymphocytes in patients with severe atopic eczema
    • Gruschwitz MS Peters KP Heese A Stosiek N Koch HU Hornstein OP. Effects of interferon-alpha-2b on the clinical course, inflammatory skin infiltrates and peripheral blood lymphocytes in patients with severe atopic eczema. Int Arch Allergy Immunol 1993 101 : 20 30.
    • (1993) Int Arch Allergy Immunol , vol.101 , pp. 20-30
    • Gruschwitz, M.S.1    Peters, K.P.2    Heese, A.3    Stosiek, N.4    Koch, H.U.5    Hornstein, O.P.6
  • 49
    • 0037947560 scopus 로고    scopus 로고
    • Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility
    • Smirnova I Mann N Dols A et al. Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Proc Natl Acad Sci USA 2003 100 : 6075 80.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6075-80
    • Smirnova, I.1    Mann, N.2    Dols, A.3


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