Dehydrogenation of indoline by cytochrome P450 enzymes: A novel "aromatase" process

Journal of Pharmacology and Experimental Therapeutics

Volumn 322, Issue 2, 2007, Pages 843-851

  Sun, Hao ^a   Ehlhardt, William J ^b   Kulanthaivel, Palaniappan ^b   Lanza, Diane L ^a   Reilly, Christopher A ^a   Yost, Garold S ^a  

^a UNIVERSITY OF UTAH   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,4,7 TETRAHYDRO 4,5 EPOXY 1H INDOLE; [1,4,2,5]DIOXADIAZINO[2,3 A:5,6 A']DIINDOLE; ALKANOL; AROMATASE; CYTOCHROME P450 3A4; CYTOCHROME P450 ISOENZYME; DIMETHYLANILINE MONOOXYGENASE; INDOLE DERIVATIVE; N HYDROXYINDOLE; N HYDROXYINDOLINE; NITRONE DERIVATIVE; OXYGEN; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; UNCLASSIFIED DRUG;

ALCOHOL PRODUCTION; AROMATIZATION; ARTICLE; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; DEHYDROGENATION; DIMERIZATION; ENZYME METABOLISM; HUMAN; LIVER MICROSOME; OXIDATION KINETICS; PRIORITY JOURNAL; TAUTOMERIC SHIFT;

ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; GLUTATHIONE; HUMANS; INDOLES; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; OXIDOREDUCTASES, N-DEMETHYLATING; OXYGENASES; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 34547133252     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.121723     Document Type: Article

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