Mechanism-based inactivation of cytochrome P450 3A4 by L-754,394

Biochemistry

Volumn 39, Issue 15, 2000, Pages 4276-4287

  Lightning, Luke Koenigs ^a,b   Jones, Jeffrey P ^c   Friedberg, Thomas ^d   Pritchard, Michael P ^d   Shou, Magang ^e   Rushmore, Thomas H ^e   Trager, William F ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c WASHINGTON STATE UNIVERSITY   (United States)

^d UNIVERSITY OF DUNDEE   (United Kingdom)

^e MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CARBON 14; CYTOCHROME P450; L 754394; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ARTICLE; DRUG METABOLISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INACTIVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; ISOTOPE LABELING; LIVER METABOLISM; MASS SPECTROMETRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; STOICHIOMETRY;

BINDING SITES; CATALYSIS; CELL MEMBRANE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPUTER SIMULATION; CYANOGEN BROMIDE; CYTOCHROME P-450 ENZYME SYSTEM; DIALYSIS; ESCHERICHIA COLI; HIV PROTEASE INHIBITORS; HUMANS; HYDROXYLATION; INDANS; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; MODELS, CHEMICAL; MODELS, MOLECULAR; NADP; PEPTIDE FRAGMENTS; PIPERAZINES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT FUSION PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRYPSIN;

EID: 0034681931     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi992412u     Document Type: Article

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