Semaphorins and their receptors in immune cell interactions

Nature Immunology

Volumn 9, Issue 1, 2008, Pages 17-23

  Suzuki, Kazuhiro ^a,c   Kumanogoh, Atsushi ^a,b   Kikutani, Hitoshi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 LIGAND; CD72 ANTIGEN; GENE PRODUCT; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PLEXIN; PLEXIN B1; RECEPTOR PROTEIN; SEMAPHORIN; SEMAPHORIN 4A; SEMAPHORIN 4D; SEMAPHORIN 7A; SEMAPHORIN RECEPTOR; UNCLASSIFIED DRUG;

ALLERGIC DISEASE; ANTIBODY AFFINITY; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL AGGREGATION; CELL INTERACTION; CELL MATURATION; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DENDRITIC CELL; DISEASE EXACERBATION; HOMEOSTASIS; HUMAN; IMMUNE DEFICIENCY; IMMUNOCOMPETENCE; IMMUNOCOMPETENT CELL; IMMUNOGENICITY; INFLAMMATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD; B-LYMPHOCYTES; CELL COMMUNICATION; CELL DIFFERENTIATION; DENDRITIC CELLS; HUMANS; IMMUNITY, CELLULAR; INFLAMMATION; LYMPHOCYTE ACTIVATION; MICE; SEMAPHORINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 37349054268     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1553     Document Type: Review

References (83)

1. Kolodkin, A.L., Matthes, D.J. & Goodman, C.S. The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. Cell 75, 1389-1399 (1993).
2. Pasterkamp, R.J. & Kolodkin, A.L. Semaphorin junction: Making tracks toward neural connectivity. Curr. Opin. Neurobiol. 13, 79-89 (2003).
3. Behar, O., Golden, J.A., Mashimo, H., Schoen, F.J. & Fishman, M.C. Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. Nature 383, 525-528 (1996).
4. Gitler, A.D., Lu, M.M. & Epstein, J.A. PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev. Cell 7, 107-116 (2004).
5. Gu, C. et al. Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev. Cell 5, 45-57 (2003).
6. Toyofuku, T. et al. Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2. Genes Dev. 18, 435-447 (2004).
7. Toyofuku, T. et al. Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling. Nat. Cell Biol. 6, 1204-1211 (2004).
8. Gu, C. et al. Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science 307, 265-268 (2005).
9. Serini, Q. et al. Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function. Nature 424, 391-397 (2003).
10. Sekido, Y. et al. Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns. Proc. Natl. Acad. Sci. USA 93, 4120-4125 (1996).
11. Tornizawa, Y. et al. Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B. Proc. Natl. Acad. Sci. USA 98, 13954-13959 (2001).
12. Tse, C., Xiang, R.H., Bracht, T. & Naylor, S.L. Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line. Cancer Res. 62, 542-546 (2002).
13. Xiang, R. et al. Semaphorin 3F gone from human 3p21.3 suppresses tumor formation in nude mice. Cancer Res. 62, 2637-2643 (2002).
14. Kikutani, H., Suzuki, K. & Kumanogoh, A. Immune semaphorins: Increasing members and their diverse roles. Adv. Immunol. 93, 121-143 (2007).
15. Semaphorin Nomenclature Committee. Unified nomenclature for the semaphorins/collapsins. Cell 97, 551-552 (1999).
16. Spriggs, M.K. Shared resources between the neural and immune systems: semaphorins join the ranks. Curr. Opin. Immunol. 11, 387-391 (1999).
17. Comeau, M.R. et al. A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR. Immunity 8, 473-482 (1998).
18. He, Z. & Tessier-Lavigne, M. Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell 90, 739-751 (1997).
19. Kolodkin, A.L. et al. Neuropilin is a semaphorin III receptor. Cell 90, 753-762 (1997).
20. Takahashi, T. et al. Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell 99, 59-69 (1999).
21. Tamagnone, L. et al. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell 99, 71-80 (1999).
22. Pasterkamp, R.J., Peschon, J.J., Spriggs, M.K. & Kolodkin, A.L. Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. Nature 424, 398-405 (2003).
23. Suzuki, K. et al. Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1 beta1 integrin. Nature 446, 680-684 (2007).
24. Kumanogoh, A. et al. Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: A novel mechanism for regulating B cell signaling. Immunity 13, 621-631 (2000).
25. Kumanogoh, A. et al. Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2. Nature 419, 629-633 (2002).
26. Bougeret, C. et al. Increased surface expression of a newly identified 150-kDa dimer early after human T lymphocyte activation. J. Immunol. 148, 318-323 (1992).
27. Delaire, S., Elhabazi, A., Bensussan, A. & Boumsell, L. CD100 is a leukocyte semaphorin. Cell. Mol. Life Sci. 54, 1265-1276 (1998).
28. Hall, K.T. et al. Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation. Proc. Natl. Acad. Sci. USA 93, 11780-11785 (1996).
29. Shi, W. et al. The class IV semaphorin CD100 plays nonredundant roles in the immune system: Defective B and T cell activation in CD100-deficient mice. Immunity 13, 633-642 (2000).
30. Oinuma, I., Ishikawa, Y., Katoh, H. & Negishi, M. The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras. Science 305, 862-865 (2004).
31. Swiercz, J.M., Kuner, R., Behrens, J. & Offermanns, S. Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology. Neuron 35, 51-63 (2002).
32. Adachi, T., Flaswinkel, H., Yakura, H., Reth, M. & Tsubata, T. The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation. J. Immunol. 160, 4662-4665 (1998).
33. Adachi, T. et al. SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates. J. Biol. Chem. 276, 26648-26655 (2001).
34. Doody, G.M. et al. A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. Science 269, 242-244 (1995).
35. Somani, A.K. et al. The SH2 domain containing tyrosine phosphatase-1 down-regulates activation of Lyn and Lyn-induced tyrosine phosphorylation of the CD19 receptor in B cells. J. Biol. Chem. 276, 1938-1944 (2001).
36. Tonks, N.K. & Neel, B.G. From form to function: Signaling by protein tyrosine phosphatase. Cell 87, 365-368 (1996).
37. Wu, Y. et al. The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1. Curr. Biol. 6, 1009-1017 (1998).
38. Kumanogoh, A. et al. Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment. Int. Immunol. 17 1277-1282 (2005).
39. Niiro, H. & Clark, E.A. Regulation of B-cell fate by antigen-receptor signals. Nat. Rev. Immunol. 2, 945-956 (2002).
40. Kurosaki, T. Regulation of B cell fates by BCR signaling components. Curr. Opin. Immunol. 14, 341-347 (2002).
41. O'Keefe, T.L., Williams, G.T., Davies, S.L. & Neuberger, M.S. Hyperresponsive B cells in CD22-deficient mice. Science 274, 798-801 (1996).
42. Pan, C., Baumgarth, N. & Parnes, J.R. CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation. Immunity 11, 495-506 (1999).
43. Sato, S. et al. CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: Altered signaling in CD22-deficient mice. Immunity 5, 551-562 (1996).
44. Kumanogoh, A. et al. Requirement for the lymphocyte semaphorin, CD100, in the induction of antigen-specific T cells and the maturation of dendritic cells. J. Immunol. 169, 1175-1181 (2002).
45. Watanabe, C. et al. Enhanced immune responses in transgenic mice expressing a truncated form of the lymphocyte semaphorin cd100. J. Immunol. 167, 4321-4328 (2001).
46. + B lymphocytes. Blood 101, 1962-1969 (2003).
47. Kruger, R.P., Aurandt, J. & Guan, K.L. Semaphorins command cells to move. Nat. Rev. Mol. Cell Biol. 6, 789-800 (2005).
48. Wong, A.W. et al. CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions. Nat. Immunol. 4, 891-898 (2003).
49. Takegahara, N. et al. Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis. Nat. Cell Biol. 8, 615-622 (2006).
50. Lanier, L.L. & Bakker, A.B. The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function. Immunol. Today 21, 611-614 (2000).
51. Colonna, M. TREMs in the immune system and beyond. Nat. Rev. Immunol. 3, 445-453 (2003).
52. Kumanogoh, A. et al. Nonredundant roles of Sema4A in the immune system: Defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice. Immunity 22, 305-316 (2005).
53. Szabo, S.J. et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100, 655-669 (2000).
54. Kuchroo, V.K., Meyers, J.H., Umetsu, D.T. & DeKruyff, R.H. TIM family of genes in immunity and tolerance. Adv. Immunol. 91, 227-249 (2006).
55. Chakravarti, S. et al. Tim-2 regulates T helper type 2 responses and autoimmunity. J. Exp. Med. 202, 437-444 (2005).
56. Rennert, P.D. et al. T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a novel mechanism for the regulation of Th2 immune responses and airway inflammation. J. Immunol. 177, 4311-4321 (2006).
57. Toyofuku, T. et al. Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via plexin-D1. EMBO J. 26, 1373-1384 (2007).
58. Lepelletier, Y. et al. Immunosuppressive role of semaphorin-3A on T cell proliferation is mediated by inhibition of actin cytoskeleton reorganization. Eur. J. Immunol. 36, 1782-1793 (2006).
59. Catalano, A. et al. Semaphorin-3A is expressed by tumor cells and alters T-cell signal transduction and function. Blood 107, 3321-3329 (2006).
60. Czopik, A.K., Bynoe, M.S., Palm, N., Raine, C.S. & Medzhitov, R. Semaphorin 7A is a negative regulator of T cell responses. Immunity 24, 591-600 (2006).
61. Janeway, C.A. Jr, Travers, R, Walport, M. & Schlomchik, M.J. in Immunobiology: The Immune System in Health and Disease 6th edn. (ed. Janeway, C.A., Jr.) 357-361 (Garland Science Publishing, New York, 2005).
62. Mine, T. et al. CDw108 expression during T-cell development. Tissue Antigens 55, 429-436 (2000).
63. Xu, X. et al. Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins. J. Biol. Chem. 273, 22428-22434(1998).
64. Yamada, A. et al. Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108. J. Immunol. 162, 4094-4100 (1999).
65. Hynes, R.O. Integrins: Bidirectional, allosteric signaling machines. Cell 110, 673-687 (2002).
66. 1, on virus-activated T cells. J. Immunol. 171, 2804-2811 (2003).
67. Ben-Horin, S. & Bank, I. The role of very late antigen-1 in immune-mediated inflammation. Clin. Immunol. 113, 119-129 (2004).
68. Hemler, M.E. VLA proteins in the integrin family: Structures, functions, and their role on leukocytes. Annu. Rev. Immunol. 8, 365-400 (1990).
69. 1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection. Immunity 20, 167-179 (2004).
70. Kang, H.R., Lee, C.G., Homer, R.J. & Elias, J.A. Semaphorin 7A plays a critical role in TGF-β1-induced pulmonary fibrosis. J. Exp. Med. 204, 1083-1093 (2007).
71. Alderson, M.R. et al. CD40 expression by human monocytes: regulation by cytokines; and activation of monocytes by the ligand for CD40. J. Exp. Med. 178, 669-674 (1993).
72. Holmes, S. et al. Sema7A is a potent monocyte stimulator. Scand. J. Immunol. 56, 270-275(2002).
73. Ishida, I. et al. Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: Implications for the regulation of immune and inflammatory responses. Int. Immunol. 15, 1027-1034 (2003).
74. Billadeau, D.D., Nolz, J.C. & Gomez, T.S. Regulation of T-cell activation by the cytoskeleton. Nat. Rev. Immunol. 7, 131-143 (2007).
75. Ley, K., Laudanna, C., Cybulsky, M.I. & Nourshargh, S. Getting to the site of inflammation: The leukocyte adhesion cascade updated. Nat. Rev. Immunol. 7, 678-689 (2007).
76. Vicente-Manzanares, M. & Sanchez-Madrid, F. Role of the cytoskeleton during leukocyte responses. Nat. Rev. Immunol. 4, 110-122 (2004).
77. Chabbert-de Ponnat, I. et al. Soluble CD100 functions on human monocytes and immature dendritic cells require plexin C1 and plexin B1, respectively. Int, Immunol. 17, 439-447 (2005).
78. Delaire, S. et al. Biological activity of soluble CD100. 11. Soluble CD100, similarly to H-Semalll, inhibits immune cell migration. J. Immunol. 166, 4348-4354 (2001).
79. Walzer, T., Galibert, L., Comeau, M.R. & De Smedt, T. Plexin C1 engagement on mouse dendritic cells by viral semaphorin A39R induces actin cytoskeleton rearrangement and inhibits integrin-mediated adhesion and chemokine-induced migration. J. Immunol. 174, 51-59 (2005).
80. Benvenuti, F. et al. Requirement of Rac1 and Rac2 expression by mature dendritic cells for T cell priming. Science 305, 1150-1153 (2004).
81. Germain, R.N., Miller, M.J., Dustin, M.L. & Nussenzweig, M.C. Dynamic imaging of the immune system: Progress, pitfalls and promise. Nat. Rev. Immunol. 6, 497-507 (2006).
82. Allen, C.D., Okada, T. & Cyster, J.G. Germinal-center organization and cellular dynamics. Immunity 27, 190-202 (2007).
83. Mempel, T.R., Scimone, M.L., Mora, J.R. & von Andrian, U.H. In vivo imaging of leukocyte trafficking in blood vessels and tissues. Curr. Opin. Immunol. 16, 406-417 (2004).