Requirement of Rac1 and Rac2 expression by mature dendritic cells for T cell priming

Science

Volumn 305, Issue 5687, 2004, Pages 1150-1153

  Benvenuti, Federica ^a,e   Hugues, Stephanie ^a   Walmsley, Marita ^b   Ruf, Sandra ^b   Fetler, Luc ^c   Popoff, Michel ^d   Tybulewicz, Victor L J ^b   Amigorena, Sebastian ^a  

^a INSTITUT CURIE   (France)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c INSTITUT CURIE   (France)

^d INSTITUT PASTEUR   (France)

^e INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; PHOTONS; PROTEINS;

DENDRITIC CELLS (DC); MATURATION;

BIOMEDICAL ENGINEERING;

GUANOSINE TRIPHOSPHATASE; RAC PROTEIN; RAC1 PROTEIN; RAC2 PROTEIN; RHO FACTOR; UNCLASSIFIED DRUG;

CELLS AND CELL COMPONENTS;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DENDRITIC CELL; LYMPH NODE; MEMBRANE BINDING; MICROSCOPY; MOUSE; NONHUMAN; PHOTON; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; TIME LAPSE VIDEO MICROSCOPY;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; CELL POLARITY; CELL SURFACE EXTENSIONS; CYTOSKELETON; DENDRITIC CELLS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, VIDEO; RAC GTP-BINDING PROTEINS; RAC1 GTP-BINDING PROTEIN; RHO GTP-BINDING PROTEINS;

ANIMALIA;

EID: 4143132014     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1099159     Document Type: Article

References (18)

1. A. Lanzavecchia, F. Sallusto, Curr. Opin. Immunol. 13, 291 (2001).
2. S. J. Turley et al., Science 288, 522 (2000).
3. F. Granucci et al., Blood 102, 2940 (2003).
4. T. R. Mempel, S. E. Henrickson, U. H. Von Andrian, Nature 427, 154 (2004).
5. M. J. Miller, A. S. Hejazi, S. H. Wei, M. D. Cahalan, I. Parker, Proc. Natl. Acad. Sci. U.S.A. 101, 998 (2004).
6. K. Burridge, K. Wennerberg, Cell 116, 167 (2004).
7. M. L. Dustin, J. A. Cooper, Nature Immunol. 1, 23 (2000).
8. M. M. Al-Alwan, G. Rowden, T. D. Lee, K. A. West, J. Immunol. 166, 1452 (2001).
9. M. M. Al-Alwan et al., J. Immunol. 171, 4479 (2003).
10. M. Kobayashi et al., J. Immunol. 167, 3585 (2001).
11. F. Benvenuti et al., J. Immunol. 172, 292 (2004).
12. M. J. Walmsley et al., Science 302, 459 (2003).
13. R. Kuhn, F. Schwenk, M. Aguet, K. Rajewsky, Science 269, 1427 (1995).
14. C. M. Wells, M. Walmstey, S. Ool, V. Tybulewicz, A. J. Ridley, J. Cell Sci. 117, 1259 (2004).
15. A. W. Roberts et al., Immunity 10, 183 (1999).
16. O. Lantz, I. Grandjean, P. Matzinger, J. P. Di Santo, Nature Immunol. 1, 54 (2000).
17. Number of pixels corresponding to dendrites or membrane extension was quantified after applying on differential interference contrast (DIC) images a filter created with the Metamorph software [multidimensional image analysis (mia)].
18. -/- mice were kindly provided by D. A. Williams (Howard Hughes Medical Institute, Indiana University School of Medicine, USA).