메뉴 건너뛰기




Volumn 29, Issue 1, 2008, Pages 104-111

A derivative of the melanocortin receptor antagonist SHU9119 (PG932) increases food intake when administered peripherally

Author keywords

Anorexia; Antagonist; Appetite; Endotoxin; Melanocortin receptor; Proopiomelanocortin

Indexed keywords

ALPHA INTERMEDIN; APPETITE STIMULANT; BETA INTERMEDIN; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; PG 932; PG 946; UNCLASSIFIED DRUG;

EID: 37249004682     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2007.10.014     Document Type: Article
Times cited : (19)

References (37)
  • 1
    • 1042275338 scopus 로고    scopus 로고
    • Impaired coordination of nutrient intake and substrate oxidation in melanocortin-4 receptor knockout mice
    • Albarado D.C., McClaine J., Stephens J.M., Mynatt R.L., Ye J., Bannon A.W., et al. Impaired coordination of nutrient intake and substrate oxidation in melanocortin-4 receptor knockout mice. Endocrinology 145 (2004) 243-252
    • (2004) Endocrinology , vol.145 , pp. 243-252
    • Albarado, D.C.1    McClaine, J.2    Stephens, J.M.3    Mynatt, R.L.4    Ye, J.5    Bannon, A.W.6
  • 2
    • 15544362925 scopus 로고    scopus 로고
    • The gut and energy balance: visceral allies in the obesity wars
    • Badman M.K., and Flier J.S. The gut and energy balance: visceral allies in the obesity wars. Science 307 (2005) 1909-1914
    • (2005) Science , vol.307 , pp. 1909-1914
    • Badman, M.K.1    Flier, J.S.2
  • 3
    • 0043068115 scopus 로고    scopus 로고
    • Structure-activity relationships of novel cyclic alpha-MSH/beta-MSH hybrid analogues that lead to potent and selective ligands for the human MC3R and human MC5R
    • Balse-Srinivasan P., Grieco P., Cai M., Trivedi D., and Hruby V.J. Structure-activity relationships of novel cyclic alpha-MSH/beta-MSH hybrid analogues that lead to potent and selective ligands for the human MC3R and human MC5R. J Med Chem 46 (2003) 3728-3733
    • (2003) J Med Chem , vol.46 , pp. 3728-3733
    • Balse-Srinivasan, P.1    Grieco, P.2    Cai, M.3    Trivedi, D.4    Hruby, V.J.5
  • 4
    • 27544450765 scopus 로고    scopus 로고
    • Divergence of melanocortin pathways in the control of food intake and energy expenditure
    • Balthasar N., Dalgaard L.T., Lee C.E., Yu J., Funahashi H., Williams T., et al. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123 (2005) 493-505
    • (2005) Cell , vol.123 , pp. 493-505
    • Balthasar, N.1    Dalgaard, L.T.2    Lee, C.E.3    Yu, J.4    Funahashi, H.5    Williams, T.6
  • 5
    • 31544465224 scopus 로고    scopus 로고
    • The melanocortin system and energy balance
    • Butler A.A. The melanocortin system and energy balance. Peptides 27 (2006) 301-309
    • (2006) Peptides , vol.27 , pp. 301-309
    • Butler, A.A.1
  • 7
    • 0033818103 scopus 로고    scopus 로고
    • Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
    • Chen A.S., Marsh D.J., Trumbauer M.E., Frazier E.G., Guan X.M., Yu H., et al. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 26 (2000) 97-102
    • (2000) Nat Genet , vol.26 , pp. 97-102
    • Chen, A.S.1    Marsh, D.J.2    Trumbauer, M.E.3    Frazier, E.G.4    Guan, X.M.5    Yu, H.6
  • 9
    • 17844401704 scopus 로고    scopus 로고
    • Anatomy and regulation of the central melanocortin system
    • Cone R.D. Anatomy and regulation of the central melanocortin system. Nat Neurosci 8 (2005) 571-578
    • (2005) Nat Neurosci , vol.8 , pp. 571-578
    • Cone, R.D.1
  • 10
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    • Fan W., Boston B.A., Kesterson R.A., Hruby V.J., and Cone R.D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385 (1997) 165-168
    • (1997) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 11
    • 0034456475 scopus 로고    scopus 로고
    • The central melanocortin system can directly regulate serum insulin levels
    • Fan W., Dinulescu D.M., Butler A.A., Zhou J., Marks D.L., and Cone R.D. The central melanocortin system can directly regulate serum insulin levels. Endocrinology 141 (2000) 3072-3079
    • (2000) Endocrinology , vol.141 , pp. 3072-3079
    • Fan, W.1    Dinulescu, D.M.2    Butler, A.A.3    Zhou, J.4    Marks, D.L.5    Cone, R.D.6
  • 13
    • 0842324779 scopus 로고    scopus 로고
    • Obesity wars. Molecular progress confronts an expanding epidemic
    • Flier J.S. Obesity wars. Molecular progress confronts an expanding epidemic. Cell 116 (2004) 337-350
    • (2004) Cell , vol.116 , pp. 337-350
    • Flier, J.S.1
  • 14
    • 0036790520 scopus 로고    scopus 로고
    • The function of leptin in nutrition, weight and physiology
    • discussion S68-84, 85-7
    • Friedman J.M. The function of leptin in nutrition, weight and physiology. Nutr Rev 60 (2002) S1-S14 discussion S68-84, 85-7
    • (2002) Nutr Rev , vol.60
    • Friedman, J.M.1
  • 15
    • 0242364779 scopus 로고    scopus 로고
    • Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3,4 and 5
    • Grieco P., Balse-Srinivasan P., Han G., Weinberg D., MacNeil T., Van der Ploeg L.H., et al. Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3,4 and 5. J Pept Res 62 (2003) 199-206
    • (2003) J Pept Res , vol.62 , pp. 199-206
    • Grieco, P.1    Balse-Srinivasan, P.2    Han, G.3    Weinberg, D.4    MacNeil, T.5    Van der Ploeg, L.H.6
  • 16
    • 0035094232 scopus 로고    scopus 로고
    • Immediate and prolonged patterns of Agouti-related peptide-(83-132)-induced c-Fos activation in hypothalamic and extrahypothalamic sites
    • Hagan M.M., Benoit S.C., Rushing P.A., Pritchard L.M., Woods S.C., and Seeley R.J. Immediate and prolonged patterns of Agouti-related peptide-(83-132)-induced c-Fos activation in hypothalamic and extrahypothalamic sites. Endocrinology 142 (2001) 1050-1056
    • (2001) Endocrinology , vol.142 , pp. 1050-1056
    • Hagan, M.M.1    Benoit, S.C.2    Rushing, P.A.3    Pritchard, L.M.4    Woods, S.C.5    Seeley, R.J.6
  • 18
    • 0035810771 scopus 로고    scopus 로고
    • Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor
    • Haskell-Luevano C., and Monck E.K. Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor. Regul Pept 99 (2001) 1-7
    • (2001) Regul Pept , vol.99 , pp. 1-7
    • Haskell-Luevano, C.1    Monck, E.K.2
  • 19
    • 0029154516 scopus 로고
    • Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, d-Phe7, Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high-antagonist potency and selectivity at specific melanocortin receptors
    • Hruby V.J., Lu D., Sharma S.D., Castrucci A.L., Kesterson R.A., al-Obeidi F.A., et al. Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, d-Phe7, Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high-antagonist potency and selectivity at specific melanocortin receptors. J Med Chem 38 (1995) 3454-3461
    • (1995) J Med Chem , vol.38 , pp. 3454-3461
    • Hruby, V.J.1    Lu, D.2    Sharma, S.D.3    Castrucci, A.L.4    Kesterson, R.A.5    al-Obeidi, F.A.6
  • 20
    • 0032949410 scopus 로고    scopus 로고
    • Role of central melanocortins in endotoxin-induced anorexia
    • Huang Q.H., Hruby V.J., and Tatro J.B. Role of central melanocortins in endotoxin-induced anorexia. Am J Physiol 276 (1999) R864-R871
    • (1999) Am J Physiol , vol.276
    • Huang, Q.H.1    Hruby, V.J.2    Tatro, J.B.3
  • 23
    • 0041624549 scopus 로고    scopus 로고
    • Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter
    • Liu H., Kishi T., Roseberry A.G., Cai X., Lee C.E., Montez J.M., et al. Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J Neurosci 23 (2003) 7143-7154
    • (2003) J Neurosci , vol.23 , pp. 7143-7154
    • Liu, H.1    Kishi, T.2    Roseberry, A.G.3    Cai, X.4    Lee, C.E.5    Montez, J.M.6
  • 24
    • 0036100090 scopus 로고    scopus 로고
    • Melanocortin pathway: animal models of obesity and disease
    • Marks D.L., Butler A.A., and Cone R.D. Melanocortin pathway: animal models of obesity and disease. Ann Endocrinol (Paris) 63 (2002) 121-124
    • (2002) Ann Endocrinol (Paris) , vol.63 , pp. 121-124
    • Marks, D.L.1    Butler, A.A.2    Cone, R.D.3
  • 25
  • 26
    • 37249076146 scopus 로고    scopus 로고
    • The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R)
    • Marks D.L., Hruby V., Brookhart G., and Cone R.D. The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R). Peptides (2005)
    • (2005) Peptides
    • Marks, D.L.1    Hruby, V.2    Brookhart, G.3    Cone, R.D.4
  • 27
    • 0035866377 scopus 로고    scopus 로고
    • Role of the central melanocortin system in cachexia
    • Marks D.L., Ling N., and Cone R.D. Role of the central melanocortin system in cachexia. Cancer Res 61 (2001) 1432-1438
    • (2001) Cancer Res , vol.61 , pp. 1432-1438
    • Marks, D.L.1    Ling, N.2    Cone, R.D.3
  • 28
    • 0032900284 scopus 로고    scopus 로고
    • Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides
    • Marsh D.J., Hollopeter G., Huszar D., Laufer R., Yagaloff K.A., Fisher S.L., et al. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet 21 (1999) 119-122
    • (1999) Nat Genet , vol.21 , pp. 119-122
    • Marsh, D.J.1    Hollopeter, G.2    Huszar, D.3    Laufer, R.4    Yagaloff, K.A.5    Fisher, S.L.6
  • 29
    • 0033429342 scopus 로고    scopus 로고
    • Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues
    • Marsh D.J., Miura G.I., Yagaloff K.A., Schwartz M.W., Barsh G.S., and Palmiter R.D. Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues. Brain Res 848 (1999) 66-77
    • (1999) Brain Res , vol.848 , pp. 66-77
    • Marsh, D.J.1    Miura, G.I.2    Yagaloff, K.A.3    Schwartz, M.W.4    Barsh, G.S.5    Palmiter, R.D.6
  • 30
    • 0028134706 scopus 로고
    • Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
    • Mountjoy K.G., Mortrud M.T., Low M.J., Simerly R.B., and Cone R.D. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 8 (1994) 1298-1308
    • (1994) Mol Endocrinol , vol.8 , pp. 1298-1308
    • Mountjoy, K.G.1    Mortrud, M.T.2    Low, M.J.3    Simerly, R.B.4    Cone, R.D.5
  • 31
    • 0035130843 scopus 로고    scopus 로고
    • AgRP (83-132) acts as an inverse agonist on the human-melanocortin-4 receptor
    • Nijenhuis W.A., Oosterom J., and Adan R.A. AgRP (83-132) acts as an inverse agonist on the human-melanocortin-4 receptor. Mol Endocrinol 15 (2001) 164-171
    • (2001) Mol Endocrinol , vol.15 , pp. 164-171
    • Nijenhuis, W.A.1    Oosterom, J.2    Adan, R.A.3
  • 32
    • 15144357684 scopus 로고    scopus 로고
    • A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo
    • Rossi M., Kim M.S., Morgan D.G., Small C.J., Edwards C.M., Sunter D., et al. A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo. Endocrinology 139 (1998) 4428-4431
    • (1998) Endocrinology , vol.139 , pp. 4428-4431
    • Rossi, M.1    Kim, M.S.2    Morgan, D.G.3    Small, C.J.4    Edwards, C.M.5    Sunter, D.6
  • 34
    • 0038169077 scopus 로고    scopus 로고
    • Exploring the site of anorectic action of peripherally administered synthetic melanocortin peptide MT-II in rats
    • Trivedi P., Jiang M., Tamvakopoulos C.C., Shen X., Yu H., Mock S., et al. Exploring the site of anorectic action of peripherally administered synthetic melanocortin peptide MT-II in rats. Brain Res 977 (2003) 221-230
    • (2003) Brain Res , vol.977 , pp. 221-230
    • Trivedi, P.1    Jiang, M.2    Tamvakopoulos, C.C.3    Shen, X.4    Yu, H.5    Mock, S.6
  • 35
    • 0034919731 scopus 로고    scopus 로고
    • Reversal of cancer anorexia by blockade of central melanocortin receptors in rats
    • Wisse B.E., Frayo R.S., Schwartz M.W., and Cummings D.E. Reversal of cancer anorexia by blockade of central melanocortin receptors in rats. Endocrinology 142 (2001) 3292-3301
    • (2001) Endocrinology , vol.142 , pp. 3292-3301
    • Wisse, B.E.1    Frayo, R.S.2    Schwartz, M.W.3    Cummings, D.E.4
  • 36
    • 0038389368 scopus 로고    scopus 로고
    • Melanocortin signaling and anorexia in chronic disease states
    • Wisse B.E., Schwartz M.W., and Cummings D.E. Melanocortin signaling and anorexia in chronic disease states. Ann NY Acad Sci 994 (2003) 275-281
    • (2003) Ann NY Acad Sci , vol.994 , pp. 275-281
    • Wisse, B.E.1    Schwartz, M.W.2    Cummings, D.E.3
  • 37
    • 0043030280 scopus 로고    scopus 로고
    • Minireview: From anorexia to obesity-the yin and yang of body weight control
    • Zigman J.M., and Elmquist J.K. Minireview: From anorexia to obesity-the yin and yang of body weight control. Endocrinology 144 (2003) 3749-3756
    • (2003) Endocrinology , vol.144 , pp. 3749-3756
    • Zigman, J.M.1    Elmquist, J.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.