The role of lipolysis in mediating the proinflammatory effects of very low density lipoproteins in mouse peritoneal macrophages

Journal of Lipid Research

Volumn 47, Issue 7, 2006, Pages 1406-1415

  Saraswathi, Viswanathan ^a   Hasty, Alyssa H ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gene expression; Inflammation; Mitogen activated protein kinases

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; FATTY ACID; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; STRESS ACTIVATED PROTEIN KINASE; STROMELYSIN; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; GENE EXPRESSION; HYDROLYSIS; INCUBATION TIME; INFLAMMATION; LIPID STORAGE; LIPOLYSIS; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ESTERIFICATION; FEMALE; GENE EXPRESSION; HUMANS; HYDROLYSIS; INFLAMMATION MEDIATORS; LIPID METABOLISM; LIPOLYSIS; LIPOPROTEINS, VLDL; MACROPHAGE INFLAMMATORY PROTEIN-1; MACROPHAGES, PERITONEAL; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; TRIGLYCERIDES;

EID: 33746098574     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M600159-JLR200     Document Type: Article

References (50)

1. Moller, D. E., and K. D. Kaufman. 2005. Metabolic syndrome: a clinical and molecular perspective. Annu. Rev. Med. 56: 45-62.
2. Fruchart, J. C., M. C. Nierman, E. S. Stroes, J. J. Kastelein, and P. Duriez. 2004. New risk factors for atherosclerosis and patient risk assessment. Circulation. 109: III15-III19.
3. Proctor, S. D., and J. C. Mamo. 1998. Retention of fluorescentlabelled chylomicron remnants within the intima of the arterial wall - evidence that plaque cholesterol may be derived from postprandial lipoproteins. Eur. J. Clin. Invest. 28: 497-503.
4. Rapp, J. H., A. Lespine, R. L. Hamilton, N. Colyvas, A. H. Chaumeton, J. Tweedie-Hardman, L. Kotite, S. T. Kunitake, R. J. Havel, and J. P. Kane. 1994. Triglyceride-rich lipoproteins isolated by selected-affinity anti-apolipoprotein B immunosorption from human atherosclerotic plaque. Arterioscler. Thromb. 14: 1767-1774.
5. Bates, S. R., P. L. Murphy, Z. C. Feng, T. Kanazawa, and G. S. Getz. 1984. Very low density lipoproteins promote triglyceride accumulation in macrophages. Arteriosclerosis. 4: 103-114.
6. Huff, M. W., A. J. Evans, C. G. Sawyez, B. M. Wolfe, and P. J. Nestel. 1991. Cholesterol accumulation in J774 macrophages induced by triglyceride-rich lipoproteins. Comparison of very low density lipoprotein from subjects with type III, IV, and V hyperlipoproteinemias. Arterioscler. Thromb. 11: 221-233.
7. Gianturco, S. H., S. A. Brown, D. P. Via, and W. A. Bradley. 1986. The beta-VLDL receptor pathway of murine P388D1 macrophages. J. Lipid Res. 27: 412-420.
8. Jong, M. C., W. L. Hendriks, L. C. van Vark, V. E. Dahlmans, J. E. Groener, and L. M. Havekes. 2000. Oxidized VLDL induces less triglyceride accumulation in J774 macrophages than native VLDL due to an impaired extracellular lipolysis. Arterioscler. Thromb. Vasc. Biol. 20: 144-151.
9. Batt, K. V., M. Avella, E. H. Moore, B. Jackson, K. E. Suckling, and K. M. Botham. 2004. Differential effects of low-density lipoprotein and chylomicron remnants on lipid accumulation in human macrophages. Exp. Biol. Med. (Maywood). 229: 528-537.
10. Li, Y., R. F. Schwabe, T. Devries-Seimon, P. M. Yao, M. C. Gerbod-Giannone, A. R. Tall, R. J. Davis, R. Flavell, D. A. Brenner, and I. Tabas. 2005. Free cholesterol-loaded macrophages are an abundant source of TNF-alpha and interleukin-6. Model of NF-kappaB-and MAP kinase-dependent inflammation in advanced atherosclerosis. J. Biol. Chem. 280: 21763-21772.
11. Stollenwerk, M. M., A. Schiopu, G. N. Fredrikson, W. Dichtl, J. Nilsson, and M. P. Ares. 2005. Very low density lipoprotein potentiates tumor necrosis factor-alpha expression in macrophages. Atherosclerosis. 179: 247-254.
12. Stollenwerk, M. M., M. W. Lindholm, M. I. Porn-Ares, A. Larsson, J. Nilsson, and M. P. Ares. 2005. Very low-density lipoprotein induces interleukin-1beta expression in macrophages. Biochem. Biophys. Res. Commun. 335: 603-608.
13. Wang, G. P., Z. D. Deng, J. Ni, and Z. L. Qu. 1997. Oxidized low density lipoprotein and very low density lipoprotein enhance expression of monocyte chemoattractant protein-1 in rabbit peritoneal exudate macrophages. Atherosclerosis. 133: 31-36.
14. Ross, R. 1999. Atherosclerosis - an inflammatory disease. N. Engl. J. Med. 340: 115-126.
15. Sheikine, Y., and G. K. Hansson. 2004. Chemokines and atherosclerosis. Ann. Med. 36: 98-118.
16. Nelken, N. A., S. R. Coughlin, D. Gordon, and J. N. Wilcox. 1991. Monocyte chemoattractant protein-1 in human atheromatous plaques. J. Clin. Invest. 88: 1121-1127.
17. Lynn, E. G., Y. L. Siow, and K. O. 2000. Very low-density lipoprotein stimulates the expression of monocyte chemoattractant protein-1 in mesangial cells. Kidney Int. 57: 1472-1483.
18. Wilcox, J. N., N. A. Nelken, S. R. Coughlin, D. Gordon, and T. J. Schall. 1994. Local expression of inflammatory cytokines in human atherosclerotic plaques. J. Atheroscler. Thromb. 1 (Suppl. 1): 10-13.
19. Frangogiannis, N. G., and M. L. Entman. 2004. Targeting the chemokines in myocardial inflammation. Circulation. 110: 1341-1342.
20. Dol, F., G. Martin, B. Staels, A. M. Mares, C. Cazaubon, D. Nisato, J. P. Bidouard, P. Janiak, P. Schaeffer, and J. M. Herbert. 2001. Angiotensin AT1 receptor antagonist irbesartan decreases lesion size, chemokine expression, and macrophage accumulation in apolipoprotein E-deficient mice. J. Cardiovasc. Pharmacol. 38: 395-405.
21. Farkas, M. H., L. L. Swift, A. H. Hasty, M. F. Linton, and S. Fazio. 2003. The recycling of apolipoprotein E in primary cultures of mouse hepatocytes. Evidence for a physiologic connection to high density lipoprotein metabolism. J. Biol. Chem. 278: 9412-9417.
22. Folch, J., M. Lees, and G. H. Sloane Stanley. 1957. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226: 497-509.
23. Morrison, W. R., and L. M. Smith. 1964. Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol. J. Lipid Res. 53: 600-608.
24. Rudel, L. L., K. Kelley, J. K. Sawyer, R. Shah, and M. D. Wilson. 1998. Dietary monounsaturated fatty acids promote aortic atherosclerosis in LDL receptor-null, human apoB100-overexpressing transgenic mice. Arterioscler. Thromb. Vasc. Biol. 18: 1818-1827.
25. Choi, C. Y., J. Y. Kim, Y. S. Kim, Y. C. Chung, K. S. Hahm, and H. G. Jeong. 2001. Augmentation of macrophage functions by an aqueous extract isolated from Platycodon grandiflorum. Cancer Lett. 166: 17-25.
26. Yang, J., P. J. Lindsberg, V. Hukkanen, R. Seljelid, C. G. Gahmberg, and S. Meri. 2002. Differential expression of cytokines (IL-2, IFN-gamma, IL-10) and adhesion molecules (VCAM-1, LFA-1, CD44) between spleen and lymph nodes associates with remission in chronic relapsing experimental autoimmune encephalomyelitis. Scand. J. Immunol. 56: 286-293.
27. Getchell, T. V., N. K. Subhedar, D. S. Shah, G. Hackley, J. V. Partin, G. Sen, and M. L. Getchell. 2002. Chemokine regulation of macrophage recruitment into the olfactory epithelium following target ablation: involvement of macrophage inflammatory protein-1alpha and monocyte chemoattractant protein-1. J. Neurosci. Res. 70: 784-793.
28. Haro, H., H. C. Crawford, B. Fingleton, J. R. MacDougall, K. Shinomiya, D. M. Spengler, and L. M. Matrisian. 2000. Matrix metalloproteinase-3-dependent generation of a macrophage chemoattractant in a model of herniated disc resorption. J. Clin. Invest. 105: 133-141.
29. Su, B., and M. Karin. 1996. Mitogen-activated protein kinase cascades and regulation of gene expression. Curr. Opin. Immunol. 8: 402-411.
30. Milosavljevic, D., A. Kontush, S. Griglio, G. Le Naour, J. Thillet, and M. J. Chapman. 2003. VLDL-induced triglyceride accumulation in human macrophages is mediated by modulation of LPL lipolytic activity in the absence of change in LPL mass. Biochim. Biophys. Acta. 1631: 51-60.
31. Brown, M. S., and J. L. Goldstein. 1983. Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annu. Rev. Biochem. 52: 223-261.
32. Gianturco, S. H., W. A. Bradley, A. M. Gotto, Jr., J. D. Morrisett, and D. L. Peavy. 1982. Hypertriglyceridemic very low density lipoproteins induce triglyceride synthesis and accumulation in mouse peritoneal macrophages. J. Clin. Invest. 70: 168-178.
33. Palmer, A. M., E. Nova, E. Anil, K. Jackson, P. Bateman, E. Wolstencroft, C. M. Williams, and P. Yaqoob. 2005. Differential uptake of subfractions of triglyceride-rich lipoproteins by THP-1 macrophages. Atherosclerosis. 180: 233-244.
34. Kamp, F., W. Guo, R. Souto, P. F. Pilch, B. E. Corkey, and J. A. Hamilton. 2003. Rapid flip-flop of oleic acid across the plasma membrane of adipocytes. J. Biol. Chem. 278: 7988-7995.
35. Braun, J. E., and D. L. Severson. 1992. Regulation of the synthesis, processing and translocation of lipoprotein lipase. Biochem. J. 287: 337-347.
36. Ishibashi, S., N. Yamada, H. Shimano, N. Mori, H. Mokuno, T. Gotohda, M. Kawakami, T. Murase, and F. Takaku. 1990. Apolipoprotein E and lipoprotein lipase secreted from human monocyte-derived macrophages modulate very low density lipoprotein uptake. J. Biol. Chem. 265: 3040-3047.
37. Mohrschladt, M. F., A. W. Weverling-Rijnsburger, F. H. de Man, D. J. Stoeken, A. Sturk, A. H. Smelt, and R. G. Westendorp. 2000. Hyperlipoproteinemia affects cytokine production in whole blood samples ex vivo. The influence of lipid-lowering therapy. Atherosclerosis. 148: 413-419.
38. Moos, M. P., N. John, R. Grabner, S. Nossmann, B. Gunther, R. Vollandt, C. D. Funk, B. Kaiser, and A. J. Habenicht. 2005. The lamina adventitia is the major site of immune cell accumulation in standard chow-fed apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 25: 2386-2391.
39. Zhao, L., M. P. Moos, R. Grabner, F. Pedrono, J. Fan, B. Kaiser, N. John, S. Schmidt, R. Spanbroek, K. Lotzer, et al. 2004. The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Nat. Med. 10: 966-973.
40. Veillard, N. R., S. Steffens, F. Burger, G. Pelli, and F. Mach. 2004. Differential expression patterns of proinflammatory and antiinflammatory mediators during atherogenesis in mice. Arterioscler. Thromb. Vasc. Biol. 24: 2339-2344.
41. Means, T. K., R. P. Pavlovich, D. Roca, M. W. Vermeulen, and M. J. Fenton. 2000. Activation of TNF-alpha transcription utilizes distinct MAP kinase pathways in different macrophage populations. J. Leukoc. Biol. 67: 885-893.
42. Valledor, A. F., M. Comalada, J. Xaus, and A. Celada. 2000. The differential time-course of extracellular-regulated kinase activity correlates with the macrophage response toward proliferation or activation. J. Biol. Chem. 275: 7403-7409.
43. Deigner, H. P., and R. Claus. 1996. Stimulation of mitogen activated protein kinase by LDL and oxLDL in human U-937 macrophage-like cells. FEBS Lett. 385: 149-153.
44. Senokuchi, T., T. Matsumura, M. Sakai, T. Matsuo, M. Yano, S. Kiritoshi, K. Sonoda, D. Kukidome, T. Nishikawa, and E. Araki. 2004. Extracellular signal-regulated kinase and p38 mitogen-activated protein kinase mediate macrophage proliferation induced by oxidized low-density lipoprotein. Atherosclerosis. 176: 233-245.
45. Miller, Y. I., S. Viriyakosol, D. S. Worrall, A. Boullier, S. Butler, and J. L. Witztum. 2005. Toll-like receptor 4-dependent and -independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages. Arterioscler. Thromb. Vasc. Biol. 25: 1213-1219.
46. Lutz, C., J. Nimpf, M. Jenny, K. Boecklinger, C. Enzinger, G. Utermann, G. Baier-Bitterlich, and G. Baier. 2002. Evidence of functional modulation of the MEKK/JNK/cJun signaling cascade by the low density lipoprotein receptor-related protein (LRP). J. Biol. Chem. 277: 43143-43151.
47. Grey, A., T. Banovic, Q. Zhu, M. Watson, K. Callon, K. Palmano, J. Ross, D. Naot, I. R. Reid, and J. Cornish. 2004. The low-density lipoprotein receptor-related protein 1 is a mitogenic receptor for lactoferrin in osteoblastic cells. Mol. Endocrinol. 18: 2268-2278.
48. Qiu, Z., B. T. Hyman, and G. W. Rebeck. 2004. Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons. J. Biol. Chem. 279: 34948-34956.
49. Babaev, V. R., M. B. Patel, C. F. Semenkovich, S. Fazio, and M. F. Linton. 2000. Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice. J. Biol. Chem. 275: 26293-26299.
50. Babaev, V. R., S. Fazio, L. A. Gleaves, K. J. Carter, C. F. Semenkovich, and M. F. Linton. 1999. Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo. J. Clin. Invest. 103: 1697-1705.