-
1
-
-
0020009682
-
Evolution in the treatment strategy of Hodgkin's disease
-
Bonadonna,G. et al. (1982) Evolution in the treatment strategy of Hodgkin's disease. Adv. Cancer Res., 36, 257-293.
-
(1982)
Adv. Cancer Res
, vol.36
, pp. 257-293
-
-
Bonadonna, G.1
-
2
-
-
0036844629
-
Phase II study of chemotherapy with ACNU plus cisplatin followed by cranial irradiation in patients with newly diagnosed glioblastoma multiforme
-
Choi,I.S. et al. (2002) Phase II study of chemotherapy with ACNU plus cisplatin followed by cranial irradiation in patients with newly diagnosed glioblastoma multiforme. J. Neurooncol., 60, 171-176.
-
(2002)
J. Neurooncol
, vol.60
, pp. 171-176
-
-
Choi, I.S.1
-
3
-
-
0028690472
-
DNA adducts of N-nitrosoureas
-
Eisenbrand,G. et al. (1994) DNA adducts of N-nitrosoureas. IARC Sci. Publ., 125, 277-293.
-
(1994)
IARC Sci. Publ
, vol.125
, pp. 277-293
-
-
Eisenbrand, G.1
-
4
-
-
29244438142
-
ACNU-cisplatin continuous infusion chemotherapy as salvage therapy for recurrent glioblastomas: Phase II study
-
Gwak,H.S. et al. (2005) ACNU-cisplatin continuous infusion chemotherapy as salvage therapy for recurrent glioblastomas: Phase II study. J. Neurooncol., 75, 173-180.
-
(2005)
J. Neurooncol
, vol.75
, pp. 173-180
-
-
Gwak, H.S.1
-
5
-
-
0019217153
-
5-(3-Hydroxymethyl-3-methyl-1-triazeno) imidazole-4-carboxamide is a metabolite of 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide (DIC, DTIC NSC-45388)
-
Kolar,G.F. et al. (1980) 5-(3-Hydroxymethyl-3-methyl-1-triazeno) imidazole-4-carboxamide is a metabolite of 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide (DIC, DTIC NSC-45388). Cancer Lett., 10 235-241.
-
(1980)
Cancer Lett
, vol.10
, pp. 235-241
-
-
Kolar, G.F.1
-
6
-
-
0022449557
-
In vivo metabolism and reaction with DNA of the cytostatic agent, 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC)
-
Meer,L. et al. (1986) In vivo metabolism and reaction with DNA of the cytostatic agent, 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC). Biochem. Pharmacol., 35, 3243-3247.
-
(1986)
Biochem. Pharmacol
, vol.35
, pp. 3243-3247
-
-
Meer, L.1
-
7
-
-
0028694685
-
DNA alkylation by triazenes and related compounds
-
Michejda,C.J. et al. (1994) DNA alkylation by triazenes and related compounds. IARC Sci. Publ., 125, 323-337.
-
(1994)
IARC Sci. Publ
, vol.125
, pp. 323-337
-
-
Michejda, C.J.1
-
8
-
-
0033782928
-
Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase
-
Shiraishi,A. et al. (2000) Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase. Carcinogenesis, 21, 1879-1883.
-
(2000)
Carcinogenesis
, vol.21
, pp. 1879-1883
-
-
Shiraishi, A.1
-
9
-
-
0034646126
-
6-methylguanine-DNA methyltransferase
-
6-methylguanine-DNA methyltransferase. Mutat. Res., 447, 257-265.
-
(2000)
Mutat. Res
, vol.447
, pp. 257-265
-
-
Psaroudi, M.C.1
-
10
-
-
1542269016
-
Killing and mutagenic actions of dacarbazine, a chemotherapeutic alkylating agent on human and mouse cells: Effects of Mgmt and Mlh1 mutations
-
Sanada,M. et al. (2004) Killing and mutagenic actions of dacarbazine, a chemotherapeutic alkylating agent on human and mouse cells: Effects of Mgmt and Mlh1 mutations. DNA Repair (Amst.), 3, 413-420.
-
(2004)
DNA Repair (Amst.)
, vol.3
, pp. 413-420
-
-
Sanada, M.1
-
11
-
-
0019957212
-
Formation of the cross-link 1-[N3-deoxycytidyl),2-[N1-deoxyguanosinyl]ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea
-
Tong,W.P. et al. (1982) Formation of the cross-link 1-[N3-deoxycytidyl),2-[N1-deoxyguanosinyl]ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea. Cancer Res., 42, 3102-3105.
-
(1982)
Cancer Res
, vol.42
, pp. 3102-3105
-
-
Tong, W.P.1
-
12
-
-
1542366109
-
Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis
-
Takagi,Y. et al. (2003) Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis. DNA Repair (Amst.), 2, 1135-1146.
-
(2003)
DNA Repair (Amst.)
, vol.2
, pp. 1135-1146
-
-
Takagi, Y.1
-
13
-
-
33646503204
-
6-methylguanine adducts
-
6-methylguanine adducts. Mol. Cell, 22, 501-510.
-
(2006)
Mol. Cell
, vol.22
, pp. 501-510
-
-
Yoshioka, K.1
-
14
-
-
0025116511
-
DNA alkylation by the haloethylnitrosoureas: Nature of modifications produced and their enzymatic repair or removal
-
Ludlum,D.B. (1990) DNA alkylation by the haloethylnitrosoureas: Nature of modifications produced and their enzymatic repair or removal. Mutat. Res., 233, 117-126.
-
(1990)
Mutat. Res
, vol.233
, pp. 117-126
-
-
Ludlum, D.B.1
-
15
-
-
0019202685
-
Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains
-
Day,R.S., 3rd et al. (1980) Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains. Nature, 288, 724-727.
-
(1980)
Nature
, vol.288
, pp. 724-727
-
-
Day 3rd, R.S.1
-
16
-
-
0036753005
-
+ human melanoma cells
-
+ human melanoma cells. Melanoma Res., 12, 417-427.
-
(2002)
Melanoma Res
, vol.12
, pp. 417-427
-
-
Debiton, E.1
-
17
-
-
0032851842
-
Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents
-
Hickman,M.J. et al. (1999) Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents. Proc. Natl Acad. Sci. USA, 96, 10764-10769.
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 10764-10769
-
-
Hickman, M.J.1
-
18
-
-
0025941670
-
6- methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: The role of MGMT in protection against the genotoxic effects of alkylating agents
-
6- methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: The role of MGMT in protection against the genotoxic effects of alkylating agents. Carcinogenesis, 12, 1857-1867.
-
(1991)
Carcinogenesis
, vol.12
, pp. 1857-1867
-
-
Kaina, B.1
-
19
-
-
0028533694
-
DNA damage tolerance, mismatch repair and genome instability
-
Karran,P. et al. (1994) DNA damage tolerance, mismatch repair and genome instability. Bioessays, 16, 833-839.
-
(1994)
Bioessays
, vol.16
, pp. 833-839
-
-
Karran, P.1
-
20
-
-
0142148138
-
6- methylguanine DNA-methyltransferase expression
-
6- methylguanine DNA-methyltransferase expression. J. Pharmacol. Exp. Ther., 307, 816-823.
-
(2003)
J. Pharmacol. Exp. Ther
, vol.307
, pp. 816-823
-
-
Passagne, I.1
-
21
-
-
0037310904
-
6-alkylguanine-DNA alkyltransferase and mismatch repair activities on the sensitivity of human melanoma cells to temozolomide, 1,3-bis(2-chloroethyl)1-nitrosourea, and cisplatin
-
6-alkylguanine-DNA alkyltransferase and mismatch repair activities on the sensitivity of human melanoma cells to temozolomide, 1,3-bis(2-chloroethyl)1-nitrosourea, and cisplatin. J. Pharmacol. Exp. Ther., 304, 661-668.
-
(2003)
J. Pharmacol. Exp. Ther
, vol.304
, pp. 661-668
-
-
Pepponi, R.1
-
22
-
-
0020644782
-
- human tumor cell strains
-
- human tumor cell strains. Carcinogenesis, 4, 199-205.
-
(1983)
Carcinogenesis
, vol.4
, pp. 199-205
-
-
Yarosh, D.B.1
-
23
-
-
26944502414
-
PCNA-MutSalpha-mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cells
-
Hidaka,M. et al. (2005) PCNA-MutSalpha-mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cells. Nucleic Acids Res., 33, 5703-5712.
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 5703-5712
-
-
Hidaka, M.1
-
24
-
-
0035909923
-
Functional significance of concomitant inactivation of hMLH1 and hMSH6 in tumor cells of the microsatellite mutator phenotype
-
Baranovskaya,S. et al. (2001) Functional significance of concomitant inactivation of hMLH1 and hMSH6 in tumor cells of the microsatellite mutator phenotype. Proc. Natl Acad. Sci. USA, 98 15107-15112.
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 15107-15112
-
-
Baranovskaya, S.1
-
25
-
-
0031017268
-
Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
-
Kane,M.F. et al. (1997) Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res., 57, 808-811.
-
(1997)
Cancer Res
, vol.57
, pp. 808-811
-
-
Kane, M.F.1
-
26
-
-
0033559182
-
Detection of mutations in the DNA polymerase delta gene of human sporadic colorectal cancers and colon cancer cell lines
-
Flohr,T. et al. (1999) Detection of mutations in the DNA polymerase delta gene of human sporadic colorectal cancers and colon cancer cell lines. Int. J. Cancer, 80, 919-929.
-
(1999)
Int. J. Cancer
, vol.80
, pp. 919-929
-
-
Flohr, T.1
-
27
-
-
0030849060
-
Mutation analysis of the transforming growth factor-beta type II receptor in human cell lines resistant to growth inhibition by transforming growth factor-beta
-
Vincent,F. et al. (1997) Mutation analysis of the transforming growth factor-beta type II receptor in human cell lines resistant to growth inhibition by transforming growth factor-beta. Oncogene, 15, 117-122.
-
(1997)
Oncogene
, vol.15
, pp. 117-122
-
-
Vincent, F.1
-
28
-
-
0033527450
-
Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1
-
Räschle,M. et al. (1999) Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1. J. Biol. Chem., 274, 32368-32375.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 32368-32375
-
-
Räschle, M.1
-
29
-
-
0033535944
-
Different mutator phenotypes in Mlh1 - versus Pms2- deficient mice
-
Yao,X. et al. (1999) Different mutator phenotypes in Mlh1 - versus Pms2- deficient mice. Proc. Natl Acad. Sci. USA, 96, 6850-6855.
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 6850-6855
-
-
Yao, X.1
-
30
-
-
17644432403
-
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
-
Liu,Q. et al. (2000) Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev. 14, 1448-1459.
-
(2000)
Genes Dev
, vol.14
, pp. 1448-1459
-
-
Liu, Q.1
-
31
-
-
2442670292
-
Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase
-
Stojic,L. et al. (2004) Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase. Genes Dev., 18, 1331-1344.
-
(2004)
Genes Dev
, vol.18
, pp. 1331-1344
-
-
Stojic, L.1
-
32
-
-
0034707047
-
The DNA damage response: Putting checkpoints in perspective
-
Zhou,B.B. et al. (2000) The DNA damage response: Putting checkpoints in perspective. Nature, 408, 433-439.
-
(2000)
Nature
, vol.408
, pp. 433-439
-
-
Zhou, B.B.1
-
33
-
-
0032892044
-
DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents
-
Glassner,B.J. et al. (1999) DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents. Mutagenesis, 14, 339-347.
-
(1999)
Mutagenesis
, vol.14
, pp. 339-347
-
-
Glassner, B.J.1
-
34
-
-
0021112746
-
6-methylguanine-DNA methyltransferase
-
6-methylguanine-DNA methyltransferase. Nucleic Acids Res., 11, 7743-7758.
-
(1983)
Nucleic Acids Res
, vol.11
, pp. 7743-7758
-
-
Robins, P.1
-
35
-
-
0033955906
-
A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice
-
Kawate,H. et al. (2000) A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice. Carcinogenesis, 21, 301-305.
-
(2000)
Carcinogenesis
, vol.21
, pp. 301-305
-
-
Kawate, H.1
-
36
-
-
0031743804
-
Eukaryotic mismatch repair: An update
-
Jiricny,J. (1998) Eukaryotic mismatch repair: An update. Mutat. Res. 409, 107-121.
-
(1998)
Mutat. Res
, vol.409
, pp. 107-121
-
-
Jiricny, J.1
-
37
-
-
0033039014
-
Eukaryotic DNA mismatch repair
-
Kolodner,R.D. et al. (1999) Eukaryotic DNA mismatch repair. Curr. Opin. Genet. Dev., 9, 89-96.
-
(1999)
Curr. Opin. Genet. Dev
, vol.9
, pp. 89-96
-
-
Kolodner, R.D.1
-
38
-
-
0029665878
-
4-methylthymine, or the cisplatin-d(GpG) adduct
-
4-methylthymine, or the cisplatin-d(GpG) adduct. Proc. Natl Acad. Sci. USA, 93, 6443-6447.
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 6443-6447
-
-
Duckett, D.R.1
-
39
-
-
4944242445
-
DNA damage induced by temozolomide signals to both ATM and ATR: Role of the mismatch repair system
-
Caporali,S. et al. (2004) DNA damage induced by temozolomide signals to both ATM and ATR: Role of the mismatch repair system. Mol. Pharmacol., 66, 478-491.
-
(2004)
Mol. Pharmacol
, vol.66
, pp. 478-491
-
-
Caporali, S.1
-
40
-
-
0034667383
-
Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent
-
Ochs,K. et al. (2000) Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent. Cancer Res., 60, 5815-5824.
-
(2000)
Cancer Res
, vol.60
, pp. 5815-5824
-
-
Ochs, K.1
-
41
-
-
0037374586
-
Combined loss of expression of O6-methylguanine-DNA methyltransferase and hMLH1 accelerates progression of hepatocellular carcinoma
-
Matsukura,S. et al. (2003) Combined loss of expression of O6-methylguanine-DNA methyltransferase and hMLH1 accelerates progression of hepatocellular carcinoma. J. Surg. Oncol., 82, 194-200.
-
(2003)
J. Surg. Oncol
, vol.82
, pp. 194-200
-
-
Matsukura, S.1
-
42
-
-
2442684173
-
Blockage of abasic site repair enhances antitumor efficacy of 1,3-bis-(2-chloroethyl)-1-nitrosourea in colon tumor xenografts
-
Liu,L. et al. (2003) Blockage of abasic site repair enhances antitumor efficacy of 1,3-bis-(2-chloroethyl)-1-nitrosourea in colon tumor xenografts. Mol. Cancer Ther., 2, 1061-1066.
-
(2003)
Mol. Cancer Ther
, vol.2
, pp. 1061-1066
-
-
Liu, L.1
-
43
-
-
22244448679
-
The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death
-
Trivedi,R.N. et al. (2005) The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death. Cancer Res., 65, 6394-6400.
-
(2005)
Cancer Res
, vol.65
, pp. 6394-6400
-
-
Trivedi, R.N.1
|