Phase II study of chemotherapy with ACNU plus cisplatin followed by cranial irradiation in patients with newly diagnosed glioblastoma multiforme

Journal of Neuro-Oncology

Volumn 60, Issue 2, 2002, Pages 171-176

  Sil Choi, I ^a   Hoon Lee, S ^a   Kim, T Y ^a   Seug Bang, J ^a   Ha Paek, S ^a   Kim, S ^a   Han Kim, I ^b   Seog Heo, D ^a   Bang, Y J ^a   Gyu Kim, D ^a   Jung, H W ^a   Kyeong Kim, N ^a  

^a Seoul National University   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

Author keywords

Chemotherapy; Glioblastoma; Phase II trial; Radiotherapy

Indexed keywords

ANTICONVULSIVE AGENT; CISPLATIN; NIMUSTINE; SEROTONIN 3 ANTAGONIST;

ADULT; AGED; ANEMIA; ARTICLE; BRAIN RADIATION; BRAIN SURGERY; CANCER COMBINATION CHEMOTHERAPY; CANCER DIAGNOSIS; CANCER GROWTH; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTINUOUS INFUSION; COVARIANCE; DISEASE ACTIVITY; DISEASE SEVERITY; DRUG EFFICACY; DRUG EXPOSURE; DRUG FATALITY; DRUG RESPONSE; DRUG TOXICITY; FEASIBILITY STUDY; FEBRILE NEUTROPENIA; FEMALE; GLIOBLASTOMA; HISTOPATHOLOGY; HUMAN; LEUKOPENIA; LIVER TOXICITY; NAUSEA AND VOMITING; NEPHROTOXICITY; NEWBORN; PHASE 2 CLINICAL TRIAL; PROGNOSIS; RADIATION RESPONSE; SEIZURE; SURVIVAL RATE; SURVIVAL TIME; THROMBOCYTOPENIA;

ADOLESCENT; ADULT; AGED; ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; CISPLATIN; COMBINED MODALITY THERAPY; FEMALE; GLIOBLASTOMA; HUMANS; MALE; MIDDLE AGED; NIMUSTINE; SURVIVAL ANALYSIS;

EID: 0036844629     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020605617452     Document Type: Article

References (19)

1. Lesser GJ, Grossman S: The chemotherapy of high-grade astrocytoma. Semin Oncol 21: 220-235, 1994
2. Vecht CJ, Avezaat CJJ, van Putten WLJ: The influence of the extent of surgery on the neurological function and survival in malignant glioma. A retrospective analysis in 243 patients. J Neurosurg Neuropsych 53: 466-471, 1999
3. Salazar OM, Rubin P: The spread of glioblastoma as a determining factor in the radiation treated volume. Int J Radiat Oncol Biol Phys 1: 627-637, 1996
4. Burger PC, Heinz ER, Shibata T, Kleihues P: Topographic anatomy and CT correlations in the untreated glioblastoma multiforme. J Neurosurg 68: 698-704, 1998
5. Walker MD, Green SB, Byar DP: Randomized comparison of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. New Engl J Med 303(23): 1323-1329, 1980
6. Bamberg M, Hess CF: Radiation therapy of malignant gliomas. Onkologie 15: 178-189, 1992
7. Kristiansen K, Hagen S, Kollwvoid T: Combined modality therapy of operated astrocytomas grade III and IV. Confirmation of the value of postoperative irradiation and lack of potentiation of bleomycin on survival time: a prospective multicenter trial of the Scandinavian glioblastoma study group. Cancer 47: 649-652, 1981
8. Fine HA, Dear KBG, Loeffler JS, Black PMcL, Canellos G: Meta-analysis of radiation therapy with or without adjuvant chemotherapy for malignant gliomas in adults. Cancer 71: 2585-2597, 1993
9. Greenburg HS, Ensminger WD, Chandler WF: Intraarterial BCNU chemotherapy in the treatment of malignant gliomas of the central nervous system. J Neurosurg 61: 423-429, 1984
10. Duffner PK, Horowitz ME, Krischer JP, Friedman HS, Burger PC, Cohen ME, Sanford RA, Mulhern RK, James HE, Freeman CR, Seidel FG, Kun LE: Post-operative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. N Engl J Med 328: 1725-1731, 1993
11. Hanauske AR: New approaches to chemotherapy of brain tumors with or without radiation. Crit Rev Neurosurg 3: 45-49, 1993
12. Grossman SA, Wharam M, Sheidler V, Kleinberg L, Zeltman M, Yue N, Piantadosi S: Phase II study of continuous infusion carmustine and Cisplatin followed by cranial irradiation in adults with newly diagnosed high-grade astrocytoma. J Clin Oncol 15: 2596-2603, 1997
13. Gilbert MR, Lunsford LD, Kondziolka D: A phase II trial of continuous infusion chemotherapy, external beam radiotherapy and local boots radiotherapy for malignant gliomas (Abstract). Proc Am Soc Clin Oncol 12: 176, 1993
14. Harada K, Kiya K, Uozumi T: Pharmacokinetics of a new water-soluble nitrosourea derivative (ACNU) in human gliomas. Surg Neurol 113(6): 410-414, 1981
15. Yoshida J, Kajita Y, Wakabayashi T, Sugita K: Long-term follow-up results of 175 patients with malignant glioma. importance of radical tumor resection and postoperative adjuvant therapy with interferon, ACNU and radiation. Acta Neurochir (Wien) 127: 55-59, 1994
16. Genka S, Shitara N, Nakamura H, Takakura, K: Effect of chemoradiotherapy using ACNU, vincristine, and nicardipine with high-dose irradiation on malignant astrocytoma. Neurol Med Chir (Tokyo) 33: 295-299, 1993
17. Matsutani M, Nakamura O, Nakamura M, Nagashima T, Asai A, Fujimaki T, Tanaka H, Ueki K, Tanaka Y: Radiation therapy combined with radiosensitizing agents for cerebral glioblastoma in adults. J Neuro-Oncol 19: 227-237, 1994
18. Volk PE, Dilon WP: Radiation injury of the brain. Amer J Neurol Radiol 12: 45-62, 1991
19. Kirby SD, Macdonald DR, Fisher B, Gaspar L, Cairncross G: Preradiation chemotherapy for malignant gliomas in adults. Can J Neurol Sci 23: 123-127, 1996