Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase

Carcinogenesis

Volumn 21, Issue 10, 2000, Pages 1879-1883

  Shiraishi, Akiko ^a,b   Sakumi, Kunihiko ^a   Sekiguchi, Mutsuo ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b FUKUOKA DENTAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 O ALKYLGUANINE; ALKYLATING AGENT; CHLORMETHINE; CYCLOPHOSPHAMIDE; DACARBAZINE; GENE PRODUCT; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; METHYLNITROSOUREA; NIMUSTINE; NITROSOUREA; SODIUM CHLORIDE; TRIAZENE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER PREVENTION; CANCER SURVIVAL; CARCINOGENESIS; CARCINOGENICITY; CELL DEATH; CONTROLLED STUDY; DNA MODIFICATION; DNA REPAIR; DOSE RESPONSE; DRUG SENSITIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME DEFICIENCY; FEMALE; GENETIC CODE; GENETIC DISORDER; LD 50; MALE; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL;

EID: 0033782928     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/21.10.1879     Document Type: Article

References (28)

1. Covalent modification of DNA by antineoplastic agents
2. DNA adducts of N-nitrosoureas
3. Possible relevance of O-6 alkylation of deoxyguanosine to the mutagenicity and carcinogenicity of nitrosamines and nitrosamides
4. 6-ethylguanine in rat brain DNA: Correlation with nervous system-specific carcinogenesis by ethylnitrosourea
5. DNA-repair methyltransferase as a molecular device for preventing mutation and cancer
6. Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting
7. 4-methylthymine in DNA
8. Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent
9. DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents
10. Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice
11. High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase
12. DNA adducts of nitrogen mustards and ethylene imines
13. DNA alkylation by triazenes and related compounds
14. Identification of three alkylated nucleotide adducts from the reaction of guanosine 5'-monophosphate with phosphoramide mustard
15. Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes
16. DTIC (NSC-45388) in malignant melanoma: A perspective
17. In vivo metabolism and reaction with DNA of the cytostatic agent, 5-(3,3-dimethyl-1- triazeno)imidazole-4-carboxamide (DTIC)
18. N-demethylation of the antineoplastic agent 4(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide by rats and man
19. 14C-labeled 7-methylguanine by rats and man after administration of 4(5)-(3,3-dimethyl-1-triazeno)-imidazole 5(4)-carboxomide
20. The carcinogenic properties of some of the principal drugs used in clinical cancer chemotherapy
21. 6-methylguanine in humans and rodents treated with dacarbazine
22. 6-methylguanine-DNA methyltransferase in human normal and tumor tissue from brain, lung, and ovary
23. 6-methylguanine-DNA methyltransferase gene detected by PCR-SSCP analysis
24. The nitrosoureas: An outline of clinical schedules and toxic effects
25. Pharmacology of the nitrosoureas: An overview
26. 1-deoxyguanosinyl]-ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea
27. 6-methylguanine-DNA methyltransferase
28. Suppression of cross-link formation in chloroethylnitrosourea-treated DNA by an activity in extracts of human leukemic lymphoblasts