Adenosine A1 receptor: Functional receptor-receptor interactions in the brain

Purinergic Signalling

Volumn 3, Issue 4, 2007, Pages 285-298

  Sichardt, Kathrin ^a   Nieber, Karen ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Adenosine; Adenosine receptors; G protein coupled receptors; Ionotropic receptors; Neurotransmission; Receptor interactions

Indexed keywords

EID: 36348953234     PISSN: 15739538     EISSN: 15739546     Source Type: Journal    
DOI: 10.1007/s11302-007-9065-z     Document Type: Review

References (134)

1. Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (2002) Identification of G protein-coupled receptor genes from the human genome sequence. FEBS Lett 520:97-101
2. Brink CB, Harvey BH, Bodenstein J, Venter DP, Oliver DW (2004) Recent advances in drug action and therapeutics: Relevance of novel concepts in G-protein-coupled receptor and signal transduction pharmacology. Br J Clinical Pharmacol 57:373-387
3. Franco R, Casado V, Mallol J, Ferrada C, Ferre S, Fuxe K, Cortes A, Ciruela F, Lluis C, Canela EI (2006) The two-state dimer receptor model: a general model for receptor dimers. Mol Pharmacol 69:1905-1912
4. Maudsley S, Martin B, Luttrell LM (2005) The origins of diversity and specificity in G protein-coupled receptor signaling. J Pharmacol Exp Ther 314:485-494
5. Agnati LF, Fuxe K, Benfenati F, Zini I, Hokfelt T (1983) On the functional role of coexistence of 5-HT and substance P in bulbospinal 5-HT neurons. Substance P reduces affinity and increases density of 3H-5-HT binding sites. Acta Physiol Scand 117:299-301
6. Agnati LF, Ferre S, Lluis C, Franco R, Fuxe K (2003) Molecular mechanisms and therapeutical implications of intramembrane receptor/ receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons. Pharmacol Rev 55:509-550
7. Latini S, Pedata F (2001) Adenosine in the central nervous system: release mechanisms and extracellular concentrations. J Neurochem 79:463-484
8. Ribeiro JA, Sebastiao AM, de Mendonca A (2003) Participation of adenosine receptors in neuroprotection. Drug News Perspect 16:80-86
9. Sebastiao AM, Stone TW, Ribeiro JA (1990) The inhibitory adenosine receptor at the neuromuscular junction and hippocampus of the rat: antagonism by 1,3,8-substituted xanthines. Br J Pharmacol 101:453-459
10. De Mendonca A, Almeida T, Bashir ZI, Ribeiro JA (1997) Endogenous adenosine attenuates long-term depression and depotentiation in the CA1 region of the rat hippocampus. Neuropharmacology 36:161-167
11. De Mendonca A, Ribeiro JA (2000) Long-term potentiation observed upon blockade of adenosine A(1) receptors in rat hippocampus is N-methyl-D-aspartate receptor-dependent. Neurosci Lett 291:81-84
12. Jacoby E, Bouhelal R, Gerspacher M, Seuwen K (2006) The 7 TM G-protein-coupled receptor target family. Chem Med Chem 1:761-782
13. Kostenis E (2006) G proteins in drug screening: From analysis of receptor-G protein specificity to manipulation of GPCR-mediated signalling pathways. Curr Pharm Design 12:1703-1715
14. Biber K, Klotz KN, Berger M, Gebicke-Harter PJ, van Calker D (1997) Adenosine A1 receptor-mediated activation of phospholipase C in cultured astrocytes depends on the level of receptor expression. J Neurosci 17:4956-4964
15. Basheer R, Arrigoni E, Thatte HS, Greene RW, Ambudkar IS, McCarley RW (2002) Adenosine induces inositol 1,4,5-triphosphate receptor-mediated mobilization of intracellular calcium stores in basal forebrain cholinergic neurons. J Neurosci 22:7680-7686
16. Ciruela F, Ferre S, Casado V, Cortes A, Cunha RA, Lluis C, Franco R (2006) Heterodimeric adenosine receptors: A device to regulate neurotransmitter release. Cell Mol Life Sci 63:2427-2431
17. Ciruela F, Casado V, Rodrigues RJ, Lujan R, Burgueno J, Canals M, Borycz J, Rebola N, Goldberg SR, Mallol J, Cortes A, Canela EI, Lopez-Gimenez JF, Milligan G, Lluis C, Cunha RA, Ferre S, Franco R (2006) Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers. J Neurosci 26:2080-2087
18. Ferre S, Agnati LF, Ciruela F, Lluis C, Woods AS, Fuxe K, Franco R. Neurotransmitter receptor heteromers an their integrative role in 'local modules': The striatal spine module. Brain Res Rev 2007 (in press)
19. Fragata IR, Ribeiro JA, Sebastiao AM (2006) Nitric oxide mediates interactions between GABA(A) receptors and adenosine A(1) receptors in the rat hippocampus. Eur J Pharmacol 543:32-39
20. Franco R, Ciruela F, Casado V, Cortes A, Canela EI, Mallol J, Agnati LF, Ferre S, Fuxe K, Lluis C (2005) Partners for adenosine A1 receptors. J Mol Neurosci 26:221-232
21. Zhou QY, Li C, Olah ME, Johnson RA, Stiles GL, Civelli O (1992) Molecular cloning and characterization of an adenosine receptor: The A3 adenosine receptor. Proc Natl Acad Sci USA 89:7432-7436
22. Von Lubitz DK, Lin RC, Popik P, Carter MF, Jacobson KA (1994) Adenosine A3 receptor stimulation and cerebral ischemia. Eur J Pharmacol 263:59-67
23. Von Lubitz DK, Ye W, McClellan J, Lin RC (1999) Stimulation of adenosine A3 receptors in cerebral ischemia. Neuronal death, recovery, or both? Ann N Y Acad Sci 890:93-106
24. Von Lubitz DKJE (1999) Adenosine and cerebral ischemia: Therapeutic future or death of a brave concept? Eur J Pharmacol 365:9-25
25. Von Lubitz DKJE (2001) Adenosine in the treatment of stroke: Yes, maybe, or absolutely not? Expert Opin Invest Drugs 10:619-632
26. Rubaj A, Zgodzinski W, Sieklucka-Dziuba M (2003) The influence of adenosine A3 receptor agonist: IB-MECA, on scopolamine- and MK-801-induced memory impairment. Behav Brain Res 141:11-17
27. 3 receptor agonist-induced neurotoxicity in rat cerebellar granule neurons. Drug Dev Res 40:267-273
28. Pugliese AM, Latini S, Corradetti R, Pedata F (2003) Brief, repeated, oxygen-glucose deprivation episodes protect neurotransmission from a longer ischemic episode in the in vitro hippocampus: Role of adenosine receptors. Br J Pharmacol 140:305-314
29. Pugliese AM, Coppi E, Spalluto G, Corradetti R, Pedata F (2006) A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro. Br J Pharmacol 147:524-532
30. Ramkumar V, Stiles GL, Beaven MA, Ali H (1993) The A(3) adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells. J Biol Chem 268:16887-16890
31. Abbracchio MP, Brambilla R, Ceruti S, Kim HO, von Lubitz DK, Jacobson KA, Cattabeni F (1995) G protein-dependent activation of phospholipase C by adenosine A3 receptors in rat brain. Mol Pharmacol 48:1038-1045
32. Gessi S, Varani K, Merighi S, Cattabriga E, Iannotta V, Leung E, Baraldi PG, Borea PA (2002) A(3) adenosine receptors in human neutrophils and promyelocytic HL60 cells: A pharmacological and biochemical study. Mol Pharmacol 61:415-424
33. Kohno Y, Ji X, Mawhorter SD, Koshiba M, Jacobson KA (1996) Activation of A3 adenosine receptors on human eosinophils elevates intracellular calcium. Blood 88:3569-3574
34. Dunwiddie TV, Diao L, Kim HO, Jiang JL, Jacobson KA (1997) Activation of hippocampal adenosine A3 receptors produces a desensitization of A1 receptor-mediated responses in rat hippocampus. J Neurosci 17:607-614
35. Brand A, Vissiennon Z, Eschke D, Nieber K (2000) Adenosine A(1) and A(3) receptors mediate inhibition of synaptic transmission in rat cortical neurons. Neuropharmacology 40:85-95
36. Hentschel S, Lewerenz A, Nieber K (2003) Activation of A(3) receptors by endogenous adenosine inhibits synaptic transmission during hypoxia in rat cortical neurons. Restor Neurol Neurosci 21:55-63
37. Lopes LV, Rebola N, Costenla AR, Halldner L, Jacobson MA, Oliveira CR, Richardson PJ, Fredholm BB, Ribeiro JA, Cunha RA (2003) Adenosine A(3) receptors in the rat hippocampus: Lack of interaction with A(1) receptors. Drug Dev Res 58:428-438
38. Fredholm BB, Chen JF, Cunha RA, Svenningsson P, Vaugeois JM (2005) Adenosine and brain function. Int Rev Neurobiol 63:191-270
39. Rebola N, Rodrigues RJ, Lopes LV, Richardson PJ, Oliveira CR, Cunha RA (2005) Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus 1. Neuroscience 133:79-83
40. Cunha RA (2005) Neuroprotection by adenosine in the brain: From A 1 receptor activation to A2A receptor blockade. Purinergic Signalling 1:111-134
41. Popoli P, Betto P, Reggio R, Riccaiarello G (1995) Adenosine A2A receptor stimulation enhances striatal extracellular glutamate levels in rats. Eur J Pharmacol 287:215-217
42. Corsi C, Melani A, Biachi L, Pedata F (2000) Striatal A2A adenosine receptor antagonism differentially modifies striatal glutamate outflow in vivo in young and aged rats. Neuroreport 11:2591-2595
43. Xu K, Xu YH, Chen JF, Schwarzschild MA (2002) Caffeine's neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity shows no tolerance to chronic caffeine administration in mice. Neurosci Lett 322:13-16
44. Popoli P, Reggio R, Pezzola A (2000) Effects of SCH 58261, an adenosine A2A receptor antagonist, on quinpirole-induced turning in 6-hydroxydopamine-lesioned rats. Lack of tolerance after chronic caffeine intake. Neuropsychopharmacology 22:522-529
45. Dixon AK, Widdowson L, Richardson PJ (1997) Desensitisation of the adenosine A1 receptor by the A2A receptor in the rat striatum. J Neurochem 69:315-321
46. Lopes LV, Cunha RA, Ribeiro JA (1999) Cross talk between A(1) and A(2A) adenosine receptors in the hippocampus and cortex of young adult and old rats. J Neurophysiol 82:3196-3203
47. Lopes LV, Cunha RA, Kull B, Fredholm BB, Ribeiro JA (2002) Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition. Neuroscience 112:319-329
48. Quarta D, Borycz J, Solinas M, Patkar K, Hockemeyer J, Ciruela F, Lluis C, Franco R, Woods AS, Goldberg SR, Ferre S (2004) Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation. J Neurochem 91:873-880
49. Latini S, Bordoni F, Corradetti R, Pepeu G, Pedata F (1999) Effect of A2A adenosine receptor stimulation and antagonism on synaptic depression induced by in vitro ischaemia in rat hippocampal slices. Br J Pharmacol 128:1035-1044
50. Gines S, Hillion J, Torvinen M, Le Crom S, Casado V, Canela EI, Rondin S, Lew JY, Watson S, Zoli M, Agnati LF, Vernier P, Lluis C, Ferre S, Fuxe K, Franco R (2000) Dopamine D-1 and adenosine A(1) receptors form functionally interacting heteromeric complexes. Proc Natl Acad Sci 97:8606-8611
51. Ferre S, Popoli P, Gimenez-Llort L, Finnman UB, Martinez E, Scotti de Carolis A, Fuxe K (1994) Postsynaptic antagonistic interaction between adenosine A1 and dopamine D1 receptors. Neuroreport 6:73-76
52. Mayfield RD, Jones BA, Miller HA, Simosky JK, Larson GA, Zahniser NR (1999) Modulation of endogenous GABA release by an antagonistic adenosine A1/dopamine D1 receptor interaction in rat brain limbic regions but not basal ganglia. Synapse 33:274-281
53. Floran B, Barajas C, Floran L, Erlij D, Aceves J (2002) Adenosine A1 receptors control dopamine D1-dependent [(3)H]GABA release in slices of substantia nigra pars reticulata and motor behavior in the rat. Neuroscience 115:743-751
54. Ferre S, Popoli P, Gimenez-Llort L, Rimondini R, Muller CE, Stromberg I, Ogren SO, Fuxe K (2001) Adenosine/dopamine interaction: Implications for the treatment of Parkinson's disease. Parkinsonism Relat Disord 7:235-241
55. Savitt JM, Dawson VL, Dawson TM (2006) Diagnosis and treatment of Parkinson disease: Molecules to medicine. J Clin Invest 116:1744-1754
56. Migita K, Loewy AD, Ramabhadran TV, Krause JE, Waters SM (2001) Immunohistochemical localization of the neuropeptide Y Y1 receptor in rat central nervous system. Brain Res 889:23-37
57. Kopp J, Xu ZQ, Zhang X, Pedrazzini T, Herzog H, Kresse A, Wong H, Walsh JH, Hokfelt T (2002) Expression of the neuropeptide Y Y1 receptor in the CNS of rat and of wild-type and Y1 receptor knock-out mice. Focus on immunohistochemical localization. Neuroscience 111:443-532
58. Wolak ML, DeJoseph MR, Cator AD, Mokashi AS, Brownfield MS, Urban JH (2003) Comparative distribution of neuropeptide Y Y1 and Y5 receptors in the rat brain by using immunohistochemistry. J Comp Neurol 464:285-311
59. Bijak M (2000) Neuropeptide Y reduces epileptiform discharges and excitatory synaptic transmission in rat frontal cortex in vitro. Neuroscience 96:487-494
60. Cabrele C, Beck-Sickinger AG (2000) Molecular characterization of the ligand-receptor interaction of the neuropeptide Y family. J Pept Sci 6:97-122
61. Parrado C, Diaz-Cabiale Z, Garcia-Coronel M, Agnati LF, Covenas R, Fuxe K, Narvaez JA (2007) Region specific galanin receptor/neuropeptide YY1 receptor interactions in the tel- and diencephalon of the rat. Relevance for food consumption. Neuropharmacology 52:684-692
62. 1 and NPY receptors on rat cortical neurons. Purinergic Signalling 2:258-259
63. Burnstock G (2007) Purine and pyrimidine receptors. Cell Mol Life Sci 64:1471-1483
64. Yoshioka K, Hosoda R, Kuroda Y, Nakata H (2002) Hetero-oligomerization of adenosine A1 receptors with P2Y1 receptors in rat brains. FEBS Lett 531:299-303
65. Ikeuchi Y, Nishizaki T, Mori M, Okada Y (1996) Adenosine activates the K+ channel and enhances cytosolic Ca2+ release via a P2Y purinoceptor in hippocampal neurons. Eur J Pharmacol 304:191-199
66. Yoshioka K, Saitoh O, Nakata H (2001) Heteromeric association creates a P2Y-like adenosine receptor. Proc Natl Acad Sci USA 98:7617-7622
67. Yoshioka K, Saitoh O, Nakata H (2002) Agonist-promoted heteromeric oligomerization between adenosine A(1) and P2Y(1) receptors in living cells. FEBS Lett 523:147-151
68. Nakata H, Yoshioka K, Saitoh S (2003) Hetero-oligomerization between adenosine A(1) and P2Y(1) receptors in living cells: Formation of ATP-sensitive adenosine receptors. Drug Dev Res 58:340-349
69. Nakata H, Yoshioka K, Kamiya T (2004) Purinergic-receptor oligomerization: Implications for neural functions in the central nervous system. Neurotox Res 6:291-297
70. Nakata H, Yoshioka K, Kamiya T, Tsuga H, Oyanagi K (2005) Functions of heteromeric association between adenosine and P2Y receptors. J Mol Neurosci 26:233-238
71. Mori M, Heuss C, Gahwiler BH, Gerber U (2001) Fast synaptic transmission mediated by P2X receptors in CA3 pyramidal cells of rat hippocampal slice cultures. J Physiol 535:115-123
72. Nieber K, Poelchen W, Illes P (1997) Role of ATP in fast excitatory synaptic potentials in locus coeruleus neurones of the rat. Br J Pharmacol 122:423-430
73. Poelchen W, Sieler D, Wirkner K, Illes P (2001) Co-transmitter function of ATP in central catecholaminergic neurons of the rat. Neuroscience 102:593-602
74. Halliwell RF (2007) A short history of the rise of the molecular pharmacology of ionotropic drug receptors. Trends Pharmacol Sci 28:214-219
75. Romanelli MN, Gratteri P, Guandalini L, Martini E, Bonaccini C, Gualtieri F (2007) Central nicotinic receptors: Structure, function, ligands, and therapeutic potential. Chem Med Chem 2:746-767
76. Boehm S, Kubista H (2002) Fine tuning of sympathetic transmitter release via ionotropic and metabotropic presynaptic receptors. Pharmacol Rev 54:43-99
77. Gundlfinger A, Bischofberger J, Johenning FW, Torvinen M, Schmitz D, Breustedt J (2007) Adenosine modulates transmission at the hippocampal mossy fibre synapse via direct inhibition of presynaptic calcium channels. J Physiol 582(Pt 1):263-277
78. Dunwiddie TV, Masino SA (2001) The role and regulation of adenosine in the central nervous system. Annu Rev Neurosci 24:31-55
79. Abbracchio MP, Cattabeni F (1999) Brain adenosine receptors as targets for therapeutic intervention in neurodegenerative diseases. Ann N Y Acad Sci 890:79-92
80. Sebastiao AM, Ribeiro JA (2000) Fine-tuning neuromodulation by adenosine. Trends Pharmacol Sci 21:341-346
81. Li H, Henry JL (2000) Adenosine receptor blockade reveals N-methyl-D-aspartate receptor- and voltage-sensitive dendritic spikes in rat hippocampal CA1 pyramidal cells in vitro. Neuroscience 100:21-31
82. Nikbakht MR, Stone TW (2001) Suppression of presynaptic responses to adenosine by activation of NMDA receptors. Eur J Pharmacol 427:13-25
83. Boeck CR, Kroth EH, Bronzatto MJ, Vendite D (2005) Adenosine receptors co-operate with NMDA preconditioning to protect cerebellar granule cells against glutamate neurotoxicity. Neuropharmacology 49:17-24
84. Schotanus SM, Fredholm BB, Chergui K (2006) NMDA depresses glutamatergic synaptic transmission in the striatum through the activation of adenosine A(1) receptors: Evidence from knockout mice. Neuropharmacology 51:272-282
85. Heinbockel T, Pape HC (1999) Modulatory effects of adenosine on inhibitory postsynaptic potentials in the lateral amygdala of the rat. Br J Pharmacol 128:190-196
86. Shen KZ, Johnson SW (1997) Presynaptic GABAB and adenosine A1 receptors regulate synaptic transmission to rat substantia nigra reticulata neurones. J Physiol 505(Pt 1):153-163
87. Ulrich D, Huguenard JR (1995) Purinergic inhibition of GABA and glutamate release in the thalamus: Implications for thalamic network activity. Neuron 15:909-918
88. Chen G, van den Pol AN (1997) Adenosine modulation of calcium currents and presynaptic inhibition of GABA release in suprachiasmatic and arcuate nucleus neurons. J Neurophysiol 77:3035-3047
89. Neary JT, Zhu Q, Kang Y, Dash PK (1996) Extracellular ATP induces formation of AP-1 complexes in astrocytes via P2 purinoceptors. Neuroreport 7:2893-2896
90. Cunha RA (2001) Regulation of the ecto-nucleotidase pathway in rat hippocampal nerve terminals. Neurochem Res 26:979-991
91. Illes P, Ribeiro JA (2001) Molecular physiology of P2 receptors in the central nervous system. Eur J Pharmacol 483:5-17
92. Hebb MO, White TD (1998) Co-administration of adenosine kinase and deaminase inhibitors produces supra-additive potentiation of N-methyl-D-aspartate-evoked adenosine formation in cortex. Eur J Pharmacol 344:121-125
93. Cunha RA, Correia-de-Sa P, Sebastiao AM, Ribeiro JA (1996) Preferential activation of excitatory adenosine receptors at rat hippocampal and neuromuscular synapses by adenosine formed from released adenine nucleotides. Br J Pharmacol 119:253-260
94. Masino SA, Diao L, Illes P, Zahniser NR, Larson GA, Johansson B, Fredholm BB, Dunwiddie TV (2002) Modulation of hippocampal glutamatergic transmission by ATP is dependent on adenosine a(1) receptors. J Pharmacol Exp Ther 303:356-363
95. De Mendonca A, Sebastiao AM, Ribeiro JA (1995) Inhibition of NMDA receptor-mediated currents in isolated rat hippocampal neurones by adenosine A1 receptor activation. Neuroreport 6:1097-1100
96. Costenla AR, de Mendonca A, Sebastiao A, Ribeiro JA (1999) An adenosine analogue inhibits NMDA receptor-mediated responses in bipolar cells of the rat retina. Exp Eye Res 68:367-370
97. Dunwiddie TV, Hoffer BJ, Fredholm BB (1981) Alkylxanthines elevate hippocampal excitability. Evidence for a role of endogenous adenosine. Naunyn Schmiedebergs Arch Pharmacol 316:326-330
98. Mori A, Shindou T, Ichimura M, Nonaka H, Kase H (1996) The role of adenosine A2A receptors in regulating GABAergic synaptic transmission in striatal medium spiny neurons. J Neurosci 16:605-611
99. Huang CC, Liang YC, Hsu KS (2001) Characterization of the mechanism underlying the reversal of long term potentiation by low frequency stimulation at hippocampal CA1 synapses. J Biol Chem 276:48108-48117
100. Scammell TE, Arrigoni E, Thompson MA, Ronan PJ, Saper CB, Greene RW (2003) Focal deletion of the adenosine A1 receptor in adult mice using an adeno-associated viral vector. J Neurosci 23:5762-5770
101. Wardas J (2002) Neuroprotective role of adenosine in the CNS. Polh J Pharmacol 54:313-326
102. Kittler JT, Moss SJ (2003) Modulation of GABA(A) receptor activity by phosphorylation and receptor trafficking: Implications for the efficacy of synaptic inhibition. Curr Opin Neurobiol 13:341-347
103. Li H, Wu L, Li YQ (2004) Adenosine suppresses GABAA receptor-mediated responses in rat sacral dorsal commissural neurons. Auton Neurosci 111:71-79
104. Akhondzadeh S, Stone TW (1994) Interaction between adenosine and GABAA receptors on hippocampal neurones. Brain Res 665:229-236
105. Madden KP (1994) Effect of gamma-aminobutyric acid modulation on neuronal ischemia in rabbits. Stroke 25:2271-2274
106. O'Regan MH, Simpson RE, Perkins LM, Phillis JW (1992) Adenosine receptor agonists inhibit the release of gamma-aminobutyric acid (GABA) from the ischemic rat cerebral cortex. Brain Res 582:22-26
107. Heron A, Lekieffre D, Le Peillet E, Lasbennes F, Seylaz J, Plotkine M, Boulu RG (1994) Effects of an A1 adenosine receptor agonist on the neurochemical, behavioral and histological consequences of ischemia. Brain Res 641:217-224
108. Lucchi R, Latini S, deMendonca A, Sebastiao AM, Ribeiro JA (1996) Adenosine by activating A(1) receptors prevents GABA(A)-mediated actions during hypoxia in the rat hippocampus. Brain Res 732:261-266
109. 1 receptors after exposure to adenosine analogues. Arch Pharm 372:117/41
110. Wetherington JP, Lambert NA (2002) Differential desensitization of responses mediated by presynaptic and postsynaptic A1 adenosine receptors. J Neurosci 22:1248-1255
111. Dar MS (2002) Mouse cerebellar adenosine-glutamate interactions and modulation of ethanol-induced motor incoordination. Alcohol Clin Exp Res 26:1395-1403
112. North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82:1013-1067
113. Burnstock G (2007) Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev 87:659-797
114. Sneddon P, Westfall TD, Todorov LD, Mihaylova-Todorova S, Westfall DP, Kennedy C (1999) Modulation of purinergic neurotransmission. Prog Brain Res 120:11-20
115. Proctor WR, Dunwiddie TV (1987) Pre- and postsynaptic actions of adenosine in the in vitro rat hippocampus. Brain Res 426:187-190
116. Cunha RA, Vizi ES, Ribeiro JA, Sebastiao AM (1996) Preferential release of ATP and its extracellular catabolism as a source of adenosine upon high- but not low-frequency stimulation of rat hippocampal slices. J Neurochem 67:2180-2187
117. Zimmermann H (2000) Extracellular metabolism of ATP and other nucleotides. Naunyn Schmiedebergs Arch Pharmacol 362:299-309
118. Cunha RA, Sebastiao AM, Ribeiro JA (1998) Inhibition by ATP of hippocampal synaptic transmission requires localized extracellular catabolism by ecto-nucleotidases into adenosine and channeling to adenosine A1 receptors. J Neurosci 18:1987-1995
119. Sebastiao AM, Cunha RA, Cascalheira JF, Ribeiro JA (1999) Adenine nucleotides as inhibitors of synaptic transmission: Role of localised ectonucleotidases. Prog Brain Res 120:183-192
120. Coppi E, Pugliese AM, Stephan H, Mueller CE, Pedata F (2007) Role of P2 purinergic receptors in synaptic transmission under normoxic and ischaemic conditions in the CA1 region of rat hippocampal slices. Purinergic Signalling 3:203-219
121. Lazdunski M (1994) ATP-sensitive potassium channels: An overview. J Cardiovasc Pharmacol 24(Suppl 4):S1-S5
122. Pissarek M, Garcia de Arriba S, Schäfer M, Sieler D, Nieber K, Illes P (1998) Changes by short-term hypoxia in the membrane properties of pyramidal cells and the levels of purine and pyrimidine nucleotides in slices of rat neocortex; effects of agonists and antagonists of ATP-dependent potassium channels. Naunyn Schmiedebergs Arch Pharmacol 358:430-439
123. Mironov SL, Langohr K, Richter DW (1999) A1 adenosine receptors modulate respiratory activity of the neonatal mouse via the cAMP-mediated signaling pathway. J Neurophysiol 81:247-255
124. Andoh T, Ishiwa D, Kamiya Y, Echigo N, Goto T, Yamada Y (2006) A1 adenosine receptor-mediated modulation of neuronal ATP-sensitive K channels in rat substantia nigra. Brain Res 1124:55-61
125. Shan HQ, Cheng JS (2000) Effect of adenosine on adenosine triphosphate-sensitive potassium channel during hypoxia in rat hippocampal neurons. Neurosci Lett 286:45-48
126. Hu K, Huang CS, Jan YN, Jan LY (2003) ATP-sensitive potassium channel traffic regulation by adenosine and protein kinase C. Neuron 38:417-432
127. Svenningsson P, Le Moine C, Fisone G, Fredholm BB (1999) Distribution, biochemistry and function of striatal adenosine A2A receptors. Prog Neurobiol 59:355-396
128. Boison D (2005) Adenosine and epilepsy: From therapeutic rationale to new therapeutic strategies. Neuroscientist 11:25-36
129. Pagonopoulou O, Efthimiadou A, Asimakopoulos B, Nikolettos NK (2006) Modulatory role of adenosine and its receptors in epilepsy: Possible therapeutic approaches. Neurosci Res 56:14-20
130. Sadigh-Lindell B, Sylven C, Berglund M, Eriksson BE (2003) Role of adenosine and opioid-receptor mechanisms for pain in patients with silent myocardial ischemia or angina pectoris: A double-blind, placebo-controlled study. J Cardiovasc Pharmacol 42:757-763
131. Porkka-Heiskanen T, Kalinchuk A, Alanko L, Urrila A, Stenberg D (2003) Adenosine, energy metabolism, and sleep. Sci World J 3:790-798
132. Franco R, Lluis C, Canela EI, Mallol J, Agnati L, Casado V, Ciruela F, Ferre S, Fuxe K (2007) Receptor-receptor interactions involving adenosine A(1) or dopamine D (1) receptors and accessory proteins. J Neural Transm 114:93-104
133. Guttinger M, Padrun V, Pralong WF, Boison D (2005) Seizure suppression and lack of adenosine A(1) receptor desensitization after focal long-term delivery of adenosine by encapsulated myoblasts. Exp Neurol 193:53-64
134. Johansson B, Halldner L, Dunwiddie TV, Masino SA, Poelchen W, Gimenez-Llort L, Escorihuela RM, Fernandesz-Teruel A, Wiesenfeld-Hallin Z, Xu XJ, Hardemark A, Betshotz C, Herlenius E, Fredholm BB (2001) Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proc Natl Acad Sci USA 98:9407-9412