Differential desensitization of responses mediated by presynaptic and postsynaptic A1 adenosine receptors

Journal of Neuroscience

Volumn 22, Issue 4, 2002, Pages 1248-1255

  Wetherington, Jonathon P ^a   Lambert, Nevin A ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Adenosine; Desensitization; Downregulation; GABAB; GIRK; GPCR; Presynaptic inhibition

Indexed keywords

ADENOSINE A1 RECEPTOR;

ANIMAL TISSUE; ARTICLE; CELL POLARITY; CONCENTRATION RESPONSE; DESENSITIZATION; DRUG DEPENDENCE; ENDOCYTOSIS; INTERNALIZATION; NERVE EXCITABILITY; NEUROTRANSMITTER RELEASE; NONHUMAN; POSTSYNAPTIC POTENTIAL; PRESYNAPTIC INHIBITION; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR DOWN REGULATION;

EID: 0037083577     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-04-01248.2002     Document Type: Article

References (45)

1. Prolonged in vitro exposure of rat brain slices to adenosine analogues: Selective desensitization of adenosine A1 but not A2 receptors
2. Excitatory and inhibitory autaptic currents in isolated hippocampal neurons maintained in cell culture
3. Beta-adrenergic receptor kinase: Identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor
4. Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence
5. Increased probability of GABA release during withdrawal from morphine
6. G-protein-coupled receptors: Turn-ons and turn-offs
7. Cellular mechanisms of opioid tolerance: Studies in single brain neurons
8. Ligand-induced phosphorylation, clustering, and desensitization of A1 adenosine receptors
9. The stoichiometry of Gβγ binding to G-protein-regulated inwardly rectifying K+ channels (GIRKs)
10. Direct binding of G-protein betagamma complex to voltage-dependent calcium channels
11. Adenosine increases synaptic facilitation in the in vitro rat hippocampus: Evidence for a presynaptic site of action
12. Recombinant adenovirus-mediated expression in nervous system of genes coding for ion channels and other molecules involved in synaptic function
13. Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling
14. G protein-coupled receptor adaptation mechanisms
15. Adaptive changes in adenosine receptors following long-term treatment with the adenosine receptor agonist R-phenylisopropyl adenosine
16. Cyclopentyladenosine-induced homologous down-regulation of A1 adenosine receptors (A1AR) in intact neurons is accompanied by receptor sequestration but not a reduction in A1AR mRNA expression or G protein alpha-subunit content
17. Chronic exposure to adenosine receptor agonists and antagonists reciprocally regulates the A1 adenosine receptor-adenylyl cyclase system in cerebellar granule cells
18. Voltage-dependent modulation of N-type calcium channels by G-protein beta gamma subunits
19. Voltage-gated and inwardly rectifying potassium channels
20. Hyperalgesia, anxiety, decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor
21. Dominant role of the cytosolic C-terminal domain of the rat 5-HT1B receptor in axonal-apical targeting
22. G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization
23. The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart
24. Beta-Arrestin: A protein that regulates beta-adrenergic receptor function
25. Chronic theophylline treatment in vivo increases high affinity adenosine A1 receptor binding and sensitivity to exogenous adenosine in the in vitro hippocampal slice
26. Molecular basis of long-term plasticity underlying addiction
27. Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system
28. Short term desensitization of the Al adenosine receptors in DDT1MF-2 cells
29. The role of receptor structure in determining adenosine receptor activity
30. G protein-coupled receptor kinases
31. Pre- and postsynaptic actions of adenosine in the in vitro rat hippocampus
32. Functional consequences of A1 adenosine-receptor phosphorylation by the beta-adrenergic receptor kinase
33. Analysis of adenosine actions on Ca2+ currents and synaptic transmission in cultured rat hippocampal pyramidal neurones
34. GABAB receptor-mediated inhibition of Ca2+ currents and synaptic transmission in cultured rat hippocampal neurones
35. Epileptiform activity in microcultures containing small numbers of hippocampal neurons
36. Polarity of A2b adenosine receptor expression determines characteristics of receptor desensitization
37. Neurotransmitter activation of inwardly rectifying potassium current in dissociated hippocampal CA3 neurons: Interactions among multiple receptors
38. Axon/dendrite targeting of metabotropic glutamate receptors by their cytoplasmic carboxy-terminal domains
39. Comparison of the actions of baclofen at pre- and postsynaptic receptors in the rat hippocampus in vitro
40. Comparison of the actions of adenosine at pre- and postsynaptic receptors in the rat hippocampus in vitro
41. Presynaptic inhibition in the hippocampus
42. Role of endocytosis in mediating downregulation of G-protein-coupled receptors
43. Desensitization of adenosine A1 receptor-mediated inhibition of adenylyl cyclase in cerebellar granule cells
44. Morphine-activated opioid receptors elude desensitization by beta- arrestin
45. Cellular and synaptic adaptations mediating opioid dependence