Suppression of Extracellular Signal-related Kinase and Activation of p38 MAPK Are Two Critical Events Leading to Caspase-8- and Mitochondria-mediated Cell Death in Phytosphingosine-treated Human Cancer Cells

Journal of Biological Chemistry

Volumn 278, Issue 50, 2003, Pages 50624-50634

  Park, Moon Taek ^a,b   Choi, Jung A ^a,b   Kim, Min Jeong ^a,b   Um, Hong Duck ^a   Bae, Sangwoo ^a   Kang, Chang Mo ^a   Cho, Chul Koo ^a   Kang, Seongman ^b   Chung, Hee Yong ^c   Lee, Yun Sil ^a   Lee, Su Jae ^a  

^a Korea Institute of Radiation and Medical Science   (South Korea)

^b Korea University   (South Korea)

^c Hanyang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYMES; METABOLITES; TUMORS;

APOPTOSIS;

BIOCHEMISTRY;

CASPASE 8; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PHYTOSPHINGOSINE; PROTEIN BAX; PROTEIN BCL 2; SYNAPTOPHYSIN;

APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CELL TYPE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MEDIATOR RELEASE; MITOCHONDRIAL MEMBRANE; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; RECEPTOR DOWN REGULATION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CASPASE 8; CASPASE 9; CASPASES; CELL DEATH; CELL LINE; CELL LINE, TUMOR; CYTOCHROMES C; CYTOSOL; DOWN-REGULATION; ENZYME ACTIVATION; ENZYME INHIBITORS; FLOW CYTOMETRY; HUMANS; JURKAT CELLS; MEMBRANE POTENTIALS; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLASMIDS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SPHINGOSINE; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS;

EID: 10744222950     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M309011200     Document Type: Article

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