JNK/SAPK and p38 SAPK-2 mediate mechanical stretch-induced apoptosis via caspase-3 and -9 in NRK-52E renal epithelial cells

Nephron - Experimental Nephrology

Volumn 102, Issue 2, 2006, Pages

  Nguyen, Hiep T ^a,b   Hsieh, Michael H ^a   Gaborro, Anna ^a   Tinloy, Bradford ^a   Phillips, Courtney ^a   Adam, Rosalyn M ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Apoptosis; c Jun kinase; Caspases; Obstruction; p38 stress activated protein kinase 2; Renal epithelial cells

Indexed keywords

CASPASE 2; CASPASE 3; CASPASE 8; CASPASE 9; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL IMMORTALIZATION; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; HUMAN; HUMAN CELL; KIDNEY EPITHELIUM; MOUSE; NEPHRON; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; URINARY TRACT OBSTRUCTION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 9; CASPASES; CELLS, CULTURED; ENZYME INHIBITORS; EPITHELIAL CELLS; HUMANS; ISOENZYMES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KIDNEY; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; SIGNAL TRANSDUCTION; STRESS, MECHANICAL;

EID: 30644468596     PISSN: 16602129     EISSN: None     Source Type: Journal    
DOI: 10.1159/000088401     Document Type: Article

References (42)

1. Chevalier RL: Molecular and cellular pathophysiology of obstructive nephropathy. Pediatr Nephrol 1999;13:612-619.
2. Truong LD, Petrusevska G, Yang G, Gurpinar T, Shappell S, Lechago J, Rouse D, Suki WN: Cell apoptosis and proliferation in experimental chronic obstructive uropathy. Kidney Int 1996;50:200-207.
3. Harris KP, Klahr S, Schreiner G: Obstructive nephropathy: from mechanical disturbance to immune activation? Exp Nephrol 1993;1:198-204.
4. Cachat F, Lange-Sperandio B, Chang AY, Kiley SC, Thornhill BA, Forbes MS, Chevalier RL: Ureteral obstruction in neonatal mice elicits segment-specific tubular cell responses leading to nephron loss. Kidney Int 2003;63:564-575.
5. Nguyen HT, Bride SH, Badawy AB, Adam RM, Lin J, Orsola A, Guthrie PD, Freeman MR, Peters CA: Heparin-binding EGF-like growth factor is up-regulated in the obstructed kidney in a cell- and region-specific manner and acts to inhibit apoptosis. Am J Pathol 2000;156:889-898.
6. Miyajima A, Chen J, Lawrence C, Ledbetter S, Soslow RA, Stern J, Jha S, Pigato J, Lemer ML, Poppas DP, Vaughan ED, Felsen D: Antibody to transforming growth factor-beta ameliorates tubular apoptosis in unilateral ureteral obstruction. Kidney Int 2000;58:2301-2313.
7. Fortuno MA, Ravassa S, Fortuno A, Zalba G, Diez J: Cardiomyocyte apoptotic cell death in arterial hypertension: mechanisms and potential management. Hypertension 2001;38:1406-1412.
8. Danciu TE, Gagari E, Adam RM, Damoulis PD, Freeman MR: Mechanical strain delivers anti-apoptotic and proliferative signals to gingival fibroblasts. J Dent Res 2004;83:596-601.
9. Sironen RK, Karjalainen HM, Torronen KJ, Elo MA, Hyttinen MM, Helminen HJ, Lammi MJ: Reticulon 4 in chondrocytic cells: barosensitivity and intracellular localization. Int J Biochem Cell Biol 2004;36:1521-1531.
10. MacQuarrie RA, Fang Chen Y, Coles C, Anderson GI: Wear-particle-induced osteoclast osteolysis: the role of particulates and mechanical strain. J Biomed Mater Res 2004;69B:104-112.
11. Sotoudeh M, Li YS, Yajima N, Chang CC, Tsou TC, Wang Y, Usami S, Ratcliffe A, Chien S, Shyy JY: Induction of apoptosis in vascular smooth muscle cells by mechanical stretch. Am J Physiol Heart Circ Physiol 2002;282:H1709-1716.
12. Wang Y, Su B, Sah VP, Brown JH, Han J, Chien KR: Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. J Biol Chem 1998;273:5423-5426.
13. Guo YL, Kang B, Yang LJ, Williamson JR: Tumor necrosis factor-alpha and ceramide induce cell death through different mechanisms in rat mesangial cells. Am J Physiol 1999;276:F390-397.
14. Liu ZG, Hsu H, Goeddel DV, Karin M: Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 1996;87:565-576.
15. Slee EA, Adrain C, Martin SJ: Serial killers: ordering caspase activation events in apoptosis. Cell Death Differ 1999;6:1067-1074.
16. 2+ signaling in initiation of stretch-induced apoptosis in neonatal heart cells. Biochem Biophys Res Commun 2003;310:405-411.
17. Goldman J, Zhong L, Liu SQ: Degradation of alpha-actin filaments in venous smooth muscle cells in response to mechanical stretch. Am J Physiol 2003;284:H1839-1847.
18. Thorburn A: Death receptor-induced cell killing. Cell Signal 2004;16:139-144.
19. Kuwabara M, Takahashi K, Inanami O: Induction of apoptosis through the activation of SAPK/JNK followed by the expression of death receptor Fas in X-irradiated cells. J Radiat Res (Tokyo) 2003;44:203-209.
20. Ferrer I, Planas AM: Signaling of cell death and cell survival following focal cerebral ischemia: Life and death struggle in the penumbra. J Neuropathol Exp Neurol 2003;62:329-339.
21. Schmitz I, Kirchhoff S, Krammer PH: Regulation of death receptor-mediated apoptosis pathways. Int J Biochem Cell Biol 2000;32:1123-1136.
22. Graf R, Apenberg S, Freyberg M, Friedl P: A common mechanism for the mechanosensitive regulation of apoptosis in different cell types and for different mechanical stimuli. Apoptosis 2003;8:531-538.
23. Sadoshima J, Izumo S: The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol 1997;59:551-571.
24. Wada T, Penninger JM: Mitogen-activated protein kinases in apoptosis regulation. Oncogene 2004;23:2838-2849.
25. Dunn C, Wiltshire C, MacLaren A, Gillespie DA: Molecular mechanism and biological functions of c-Jun N-terminal kinase signalling via the c-Jun transcription factor. Cell Signal 2002;14:585-593.
26. Kyriakis JM, Avruch J: Protein kinase cascades activated by stress and inflammatory cytokines. Bioassays 1996;18:567-577.
27. Wang L, Matsushita K, Araki I, Takeda M: Inhibition of c-Jun N-terminal kinase ameliorates apoptosis induced by hydrogen peroxide in the kidney tubule epithelial cells (NRK-52E). Nephron 2002;91:142-147.
28. Garay M, Gaarde W, Monia BP, Nero P, Cioffi CL: Inhibition of hypoxia/reoxygenation-induced apoptosis by an antisense oligonucleotide targeted to JNK1 in human kidney cells. Biochem Pharmacol 2000;59:1033-1043.
29. Collett GP, Campbell FC: Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells. Carcinogenesis 2004;25:2183-2189.
30. Chaturvedi LS, Koul S, Sekhon A, Bhandari A, Menon M, Koul HK: Oxalate selectively activates p38 mitogen-activated protein kinase and c-Jun N-terminal kinase signal transduction pathways in renal epithelial cells. J Biol Chem 2002;277:13321-13330.
31. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S: The protein kinase complement of the human genome. Science 2002;298: 1912-1934.
32. Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Derijard B, Davis RJ: Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J 1996;15:2760-2770.
33. Behrens A, Sibilia M, Wagner EF: Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat Genet 1999;21:326-329.
34. Tournier C, Hess P, Yang DD, Xu J, Turner TK, Nimnual A, Bar-Sagi D, Jones SN, Flavell RA, Davis RJ: Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 2000;288:870-874.
35. Cattaruzza M, Dimigen C, Ehrenreich H, Hecker M: Stretch-induced endothelin B receptor-mediated apoptosis in vascular smooth muscle cells. FASEB J 2000;14:991-998.
36. Hammerschmidt S, Kuhn H, Grasenack T, Gessner C, Wirtz H: Apoptosis and necrosis induced by cyclic mechanical stretching in alveolar type II cells. Am J Respir Cell Mol Biol 2004;30:396-402.
37. Sanchez-Esteban J, Wang Y, Cicchiello LA, Rubin LP: Cyclic mechanical stretch inhibits cell proliferation and induces apoptosis in fetal rat lung fibroblasts. Am J Physiol 2002;282:L448-456.
38. Pike BR, Zhao X, Newcomb JK, Glenn CC, Anderson DK, Hayes RL: Stretch injury causes calpain and caspase-3 activation and necrotic and apoptotic cell death in septo-hippocampal cell cultures. J Neurotrauma 2000;17:283-298.
39. Power RE, Doyle BT, Higgins D, Brady HR, Fitzpatrick JM, Watson RW: Mechanical deformation induced apoptosis in human proximal renal tubular epithelial cells is caspase dependent. J Urol 2004;171:457-461.
40. Truong LD, Choi YJ, Tsao CC, Ayala G, Sheikh-Hamad D, Nassar G, Suki WN: Renal cell apoptosis in chronic obstructive uropathy: the roles of caspases. Kidney Int 2001;60:924-934.
41. Chevalier RL: Perinatal obstructive nephropathy. Semin Perinatal 2004;28:124-131.
42. Rannou F, Lee TS, Zhou RH, Chin J, Lotz JC, Mayoux-Benhamou MA, Barbet JP, Chevrot A, Shyy JY: Intervertebral disc degeneration: the role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload. Am J Pathol 2004;164:915-924.